ES476124A1 - Un procedimiento para la preparacion de derivados peptidicos. - Google Patents
Un procedimiento para la preparacion de derivados peptidicos.Info
- Publication number
- ES476124A1 ES476124A1 ES476124A ES476124A ES476124A1 ES 476124 A1 ES476124 A1 ES 476124A1 ES 476124 A ES476124 A ES 476124A ES 476124 A ES476124 A ES 476124A ES 476124 A1 ES476124 A1 ES 476124A1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- amino acid
- acid derivatives
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003862 amino acid derivatives Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 4-guanidinobutyl Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento para la preparación de derivados peptídicos de la fórmula general **fórmula** en donde R1 representa un átomo de hidrógeno o el grupo de metilo o hidroximetilo o un grupo mono- di-o trihalometilico; R2 representa un grupo de alquilo inferior , hidroxi-(alquilo inferior) o guanidino-(alquilo inferior) distinto del grupo caracterizante de un alfa aminoácido del tipo que se encuentra normalmente en las proteínas; La configuración en el átomo de carbono designada como (a) es (R) cuando R1 tiene un significado distinto a un átomo de hidrógeno y La configuración en el átomo de carbono designada como (b) es (L), Y sus sales aceptables en farmacia, caracterizado porque comprende condensar un compuesto de la fórmula general **fórmula** en donde R10 tiene cualquiera de los valores acordados para R1 anterior o representa un grupo hidroximetilico protegido; R3 Y R4 representa, cada uno, un átomo de hidrógeno o un grupo protector de alquilo inferior; y la configuración en el átomo decarbono designada como (a) es (R) cuando R10 tiene un significado distinto a un átomo de hidrógeno, con un alfa aminoácido protegido de la fórmula general ** fórmula** en donde R20 tiene cualquiera de los valores acordados para R2 anterior o representa un grupo protegido de hidroxi-(alquilo inferior) o guanidino-(alquilo inferior R5 representa un grupo amínico protegido y la configuración en el átomo de carbono designado como (b) es (L) disociando el grupo protector o grupos protectores presenta en el producto de condensación y, si se desea, convirtiendo un compuesto resultante de la fórmula I en una sal aceptable en farmacia.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB5293877 | 1977-12-20 | ||
GB7842727 | 1978-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES476124A1 true ES476124A1 (es) | 1980-07-16 |
Family
ID=26267167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES476124A Expired ES476124A1 (es) | 1977-12-20 | 1978-12-19 | Un procedimiento para la preparacion de derivados peptidicos. |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0002534B1 (es) |
JP (1) | JPS5492921A (es) |
AT (1) | AT366057B (es) |
AU (1) | AU4248378A (es) |
BR (1) | BR7808342A (es) |
CS (1) | CS211394B2 (es) |
CU (1) | CU35001A (es) |
DE (2) | DE2854292A1 (es) |
DK (1) | DK536578A (es) |
ES (1) | ES476124A1 (es) |
FI (1) | FI783886A (es) |
FR (1) | FR2450260A1 (es) |
GR (1) | GR73085B (es) |
IL (1) | IL56208A0 (es) |
IT (1) | IT1102401B (es) |
LU (1) | LU80671A1 (es) |
MC (1) | MC1242A1 (es) |
NL (1) | NL7812311A (es) |
NO (1) | NO784285L (es) |
NZ (1) | NZ189151A (es) |
PT (1) | PT68938A (es) |
SE (1) | SE7813069L (es) |
ZA (1) | ZA786976B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1307787C (en) * | 1986-06-11 | 1992-09-22 | Melanie J. Loots | Substituted aminoalkanoylaminoalkyl phosphonate angiotensin converting enzyme inhibitors |
CN110143896A (zh) * | 2019-06-14 | 2019-08-20 | 南京博源医药科技有限公司 | 一种n-苄氧羰基-l-己氨酸的制备方法 |
CN110156640A (zh) * | 2019-06-14 | 2019-08-23 | 南京博源医药科技有限公司 | 一种n-苄氧羰基-氨基酸的制备工艺 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1081511B (it) * | 1976-07-13 | 1985-05-21 | Hoffmann La Roche | Derivati di peptidi e loro preparazione |
DE2632188A1 (de) * | 1976-07-16 | 1978-01-26 | Hoffmann La Roche | Wirkstoffkombinationen |
GB1585275A (en) * | 1976-07-21 | 1981-02-25 | Roche Products Ltd | Peptide derivatives of phosphonic and phosphinic acids |
-
1978
- 1978-02-20 GR GR57940A patent/GR73085B/el unknown
- 1978-11-29 DK DK536578A patent/DK536578A/da unknown
- 1978-12-12 NZ NZ189151A patent/NZ189151A/xx unknown
- 1978-12-13 AU AU42483/78A patent/AU4248378A/en active Pending
- 1978-12-13 ZA ZA786976A patent/ZA786976B/xx unknown
- 1978-12-14 CS CS788344A patent/CS211394B2/cs unknown
- 1978-12-14 IL IL56208A patent/IL56208A0/xx unknown
- 1978-12-15 EP EP78101702A patent/EP0002534B1/de not_active Expired
- 1978-12-15 DE DE19782854292 patent/DE2854292A1/de not_active Withdrawn
- 1978-12-15 DE DE7878101702T patent/DE2861537D1/de not_active Expired
- 1978-12-18 FI FI783886A patent/FI783886A/fi unknown
- 1978-12-18 FR FR7835551A patent/FR2450260A1/fr not_active Withdrawn
- 1978-12-18 AT AT0904178A patent/AT366057B/de not_active IP Right Cessation
- 1978-12-18 MC MC781348A patent/MC1242A1/xx unknown
- 1978-12-18 JP JP15504978A patent/JPS5492921A/ja active Pending
- 1978-12-18 LU LU80671A patent/LU80671A1/de unknown
- 1978-12-19 IT IT31023/78A patent/IT1102401B/it active
- 1978-12-19 NL NL7812311A patent/NL7812311A/xx not_active Application Discontinuation
- 1978-12-19 NO NO784285A patent/NO784285L/no unknown
- 1978-12-19 BR BR7808342A patent/BR7808342A/pt unknown
- 1978-12-19 SE SE7813069A patent/SE7813069L/xx unknown
- 1978-12-19 PT PT68938A patent/PT68938A/pt unknown
- 1978-12-19 ES ES476124A patent/ES476124A1/es not_active Expired
- 1978-12-20 CU CU7835001A patent/CU35001A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU4248378A (en) | 1979-06-28 |
DK536578A (da) | 1979-06-21 |
LU80671A1 (de) | 1980-01-22 |
BR7808342A (pt) | 1979-08-07 |
CU35001A (en) | 1981-12-04 |
ATA904178A (de) | 1981-07-15 |
IL56208A0 (en) | 1979-03-12 |
DE2854292A1 (de) | 1979-07-05 |
MC1242A1 (fr) | 1979-10-26 |
FI783886A (fi) | 1979-06-21 |
NO784285L (no) | 1979-06-21 |
GR73085B (es) | 1984-01-31 |
EP0002534A1 (de) | 1979-06-27 |
NL7812311A (nl) | 1979-06-22 |
FR2450260A1 (fr) | 1980-09-26 |
IT7831023A0 (it) | 1978-12-19 |
IT1102401B (it) | 1985-10-07 |
ZA786976B (en) | 1980-07-30 |
JPS5492921A (en) | 1979-07-23 |
PT68938A (en) | 1979-01-01 |
CS211394B2 (en) | 1982-02-26 |
NZ189151A (en) | 1981-05-15 |
AT366057B (de) | 1982-03-10 |
SE7813069L (sv) | 1979-06-21 |
DE2861537D1 (en) | 1982-02-25 |
EP0002534B1 (de) | 1982-01-13 |
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