ES458264A1 - Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas. - Google Patents

Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas.

Info

Publication number
ES458264A1
ES458264A1 ES458264A ES458264A ES458264A1 ES 458264 A1 ES458264 A1 ES 458264A1 ES 458264 A ES458264 A ES 458264A ES 458264 A ES458264 A ES 458264A ES 458264 A1 ES458264 A1 ES 458264A1
Authority
ES
Spain
Prior art keywords
carbon atoms
manufacutre
pyrrolidones
hydrocarbonate
hydrocarbonate radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES458264A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES458264A1 publication Critical patent/ES458264A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos compuestos análogos a prostaglandinas de la fórmula I *** en la que R1 significa un radical hidrocarbonato alifático, de cadena recta o ramificada, saturado o insaturado, con 1-10 átomos de carbono, o un radical hidrocarbonato cicloalifático con 3-7 átomos de carbono.
ES458264A 1976-05-04 1977-04-28 Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas. Expired ES458264A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762619638 DE2619638A1 (de) 1976-05-04 1976-05-04 Pyrrolidone und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES458264A1 true ES458264A1 (es) 1978-07-16

Family

ID=5977020

Family Applications (1)

Application Number Title Priority Date Filing Date
ES458264A Expired ES458264A1 (es) 1976-05-04 1977-04-28 Procedimiento para la preparacion de nuevos compuestos ana- logos a prostaglandinas.

Country Status (9)

Country Link
JP (1) JPS52133975A (es)
BE (1) BE854268A (es)
DE (1) DE2619638A1 (es)
DK (1) DK194377A (es)
ES (1) ES458264A1 (es)
FR (1) FR2372806A1 (es)
GB (1) GB1583163A (es)
IT (1) IT1086223B (es)
NL (1) NL7704739A (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4320136A (en) 1980-08-11 1982-03-16 E. I. Du Pont De Nemours And Company 8-Aza-16,16-difluoroprostanoids
US4321201A (en) 1980-09-22 1982-03-23 E. I. Du Pont De Nemours And Company Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) heptanoates
WO1989010359A1 (fr) * 1988-04-22 1989-11-02 2 Moskovsky Gosudarstvenny Meditsinsky Institut Im Ethers de carbalkoxymethyl d'acide acetique de lactame-1 et procede pour leur obtention
AP2002002555A0 (en) 1999-12-22 2002-06-30 Pfizer Prod Inc EP4 Receptor selective agonists in the treatment of osteoporosis.
WO2002024647A1 (en) * 2000-09-21 2002-03-28 Ono Pharmaceutical Co., Ltd. Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient
EP1339678B1 (en) 2000-11-27 2007-09-26 Pfizer Products Inc. Ep4 receptor selective agonists in the treatment of osteoporosis
DK1408961T3 (da) 2001-07-16 2007-11-05 Hoffmann La Roche 2 pyrrolidon-derivater som prostanoide agonister
KR20040015364A (ko) * 2001-07-16 2004-02-18 에프. 호프만-라 로슈 아게 Ｅｐ4 수용체 작용물질로서의 프로스타글란딘 유사체
BR0211364A (pt) 2001-07-23 2004-07-13 Ono Pharmaceutical Co Composição farmacêutica para tratamento de doenças associadas com redução na massa óssea compreendendo o agonista ep4 como componente ativo
NZ535024A (en) 2002-03-05 2006-10-27 Ono Pharmaceutical Co 8-azaprostaglandin derivative compound and agent comprising the compound as active ingredient
EP1556347A4 (en) * 2002-06-10 2006-08-09 Applied Research Systems GAMMA LACTAME AS PROSTAGLAND INAGONISTS AND THEIR USE
WO2004063158A1 (en) 2003-01-10 2004-07-29 F.Hoffmann-La Roche Ag 2-piperidone derivatives as prostaglandin agonists
WO2004065365A1 (ja) * 2003-01-21 2004-08-05 Ono Pharmaceutical Co., Ltd. ８−アザプロスタグランジン誘導体およびその医薬用途
US7179820B2 (en) 2003-06-06 2007-02-20 Allergan, Inc. Piperidinyl prostaglandin E analogs
EP1806148A4 (en) * 2004-10-22 2009-12-02 Ono Pharmaceutical Co THERAPEUTIC PREPARATION FOR INHALATION
NZ704171A (en) 2012-07-19 2017-10-27 Cayman Chemical Co Inc Difluorolactam compositions for ep4-mediated osteo related diseases and conditions
US9676712B2 (en) 2013-03-15 2017-06-13 Cayman Chemical Company, Inc. Lactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions
EA201591793A1 (ru) 2013-03-15 2016-01-29 Кайман Кемикал Компани, Инк. Лактамные соединения в качестве селективных агонистов ep4-рецепторов для применения при лечении опосредованных ep4 заболеваний и состояний
US9914725B2 (en) 2013-03-15 2018-03-13 Cayman Chemical Company, Inc. Methods of synthesizing a difluorolactam analog
CA2910398A1 (en) 2013-07-19 2015-01-22 Cayman Chemical Company, Inc. Methods, systems, and compositions for promoting bone growth

Also Published As

Publication number Publication date
GB1583163A (en) 1981-01-21
BE854268A (fr) 1977-11-04
DK194377A (da) 1977-11-05
FR2372806A1 (fr) 1978-06-30
DE2619638A1 (de) 1977-11-17
IT1086223B (it) 1985-05-28
JPS52133975A (en) 1977-11-09
FR2372806B1 (es) 1980-02-29
NL7704739A (nl) 1977-11-08

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