GB2005259A - Hexahydropyrrolo indole derivatives - Google Patents

Hexahydropyrrolo indole derivatives

Info

Publication number
GB2005259A
GB2005259A GB7837048A GB7837048A GB2005259A GB 2005259 A GB2005259 A GB 2005259A GB 7837048 A GB7837048 A GB 7837048A GB 7837048 A GB7837048 A GB 7837048A GB 2005259 A GB2005259 A GB 2005259A
Authority
GB
United Kingdom
Prior art keywords
hexahydropyrrolo
compounds
indole derivatives
indole
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7837048A
Other versions
GB2005259B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universita degli Studi di Firenze
Original Assignee
Universita degli Studi di Firenze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita degli Studi di Firenze filed Critical Universita degli Studi di Firenze
Publication of GB2005259A publication Critical patent/GB2005259A/en
Application granted granted Critical
Publication of GB2005259B publication Critical patent/GB2005259B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

New derivatives of 1,2,3,3a,8,8a- hexahydropyrrolo [2,3-b] indole having the formula <IMAGE> and the salts of these compounds with pharmaceutically acceptable acids are described. Depending on the starting material, these compounds can be prepared by various methods. The compounds have an analgesic activity and so can be used as active substances in pharmaceutical compositions when combined with a suitable carrier.
GB7837048A 1977-09-20 1978-09-15 Hexahydropyrrolo indole derivatives Expired GB2005259B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT09574/77A IT1109003B (en) 1977-09-20 1977-09-20 DERIVATIVES OF 1 2 3 8 3 A 8 A ESAI DROPIRROLO 23 B INDOLO

Publications (2)

Publication Number Publication Date
GB2005259A true GB2005259A (en) 1979-04-19
GB2005259B GB2005259B (en) 1982-06-23

Family

ID=11132370

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7837048A Expired GB2005259B (en) 1977-09-20 1978-09-15 Hexahydropyrrolo indole derivatives

Country Status (7)

Country Link
JP (1) JPS54112897A (en)
AR (1) AR222311A1 (en)
CA (1) CA1125657A (en)
DE (1) DE2839279A1 (en)
FR (1) FR2434167A1 (en)
GB (1) GB2005259B (en)
IT (1) IT1109003B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000193A1 (en) * 1986-07-02 1988-01-14 The Victoria University Of Manchester New organic compounds having opioid properties
US5206260A (en) * 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
EP0561597A1 (en) * 1992-03-16 1993-09-22 INDENA S.p.A. New derivatives of physostigmine, their use and pharmaceutical formulations containing them
US5541216A (en) * 1986-07-16 1996-07-30 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgsic 1,2,3,3A,8,8A-Hexahydro--3A, 8(And1,3A,8)-Di (and Tri) Methylpyrrolo(2,3-B Indoles
AU750964B2 (en) * 1997-10-10 2002-08-01 Chiesi Farmaceutici S.P.A. A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
WO2003059909A1 (en) * 2002-01-09 2003-07-24 Axonyx, Inc. A process for producing phenserine and its analog

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199076B (en) * 1984-03-01 1988-12-30 Consiglio Nazionale Ricerche PHYSOSTIGMINE DERIVATIVES WITH PROPERTY OF INHIBITION OF ACETICOLINESTERASI AND RELATED PRODUCTION PROCESS
IT1225462B (en) * 1987-04-03 1990-11-14 Mediolanum Farmaceutici Srl ORGANIC SALTS OF PHYSOSTIGMIN DERIVATIVES
AT400331B (en) * 1987-05-15 1995-12-27 Hoechst Roussel Pharma 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo(2,3- b)indoles, a process for their preparation and their use as pharmaceuticals
US4971992A (en) * 1989-03-27 1990-11-20 Hoechst-Roussel Pharmaceuticals Inc. Carbonate derivatives of eseroline
US4914102A (en) * 1989-09-28 1990-04-03 Hoechst Roussel Pharmaceuticals, Inc. N-aminocarbamates related to physostigmine, pharmacentical compositions and use
US5260452A (en) * 1989-11-03 1993-11-09 Hoechst-Roussel Pharmaceuticals Inc. 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000193A1 (en) * 1986-07-02 1988-01-14 The Victoria University Of Manchester New organic compounds having opioid properties
US4996223A (en) * 1986-07-02 1991-02-26 The Victoria University Of Manchester New organic compounds having opioid properties
US5621114A (en) * 1986-07-16 1997-04-15 Hoechst Marion Roussel, Inc. Method for preparing 1, 2, 3, 3A, 8, 8A-hexahydro-3A, 8 (and 1, 3A, 8)--DI (and TRI) methylpyrrolo[2,3-B] indoles
US5541216A (en) * 1986-07-16 1996-07-30 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgsic 1,2,3,3A,8,8A-Hexahydro--3A, 8(And1,3A,8)-Di (and Tri) Methylpyrrolo(2,3-B Indoles
US5541340A (en) * 1986-07-16 1996-07-30 Hoechst-Roussel Pharmaceuticals, Inc. Method of preparing 1,2,3,3a,8,8a-hexahydro-3a,8(and 1,3a,8)-Di(and Tri)methylpyrrolo[2,3,-b] indoles
US5547977A (en) * 1986-07-16 1996-08-20 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8(and 1,3A,8)-di (and Tri) methylpyrrolo (2,3-B) indoles
US5550253A (en) * 1986-07-16 1996-08-27 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgestic 1,2,3,3A,8,8A-hexahydro-3A,8(and 1,3A,8)-di (and tri)methylpyrrolo[2,3-b]-indoles
US5550254A (en) * 1986-07-16 1996-08-27 Hoechst-Roussel Pharmaceuticals, Inc. Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and 1,3A,8)-di (and tri) methylpyrrolo[2,3-B] indoles
US5639892A (en) * 1986-07-16 1997-06-17 Hoechst-Marion-Roussel, Inc. Memory enhancing and analgesic 1,2,3,3a,8,8a,-hexahydro-3a,8(and 1,3a,8)-di(and tri)methylpyrrolo[2,3-b] indoles
US5206260A (en) * 1991-11-07 1993-04-27 Merck & Co., Inc. Hexahydropyrrolo[2,3-b]indole derivatives
EP0561597A1 (en) * 1992-03-16 1993-09-22 INDENA S.p.A. New derivatives of physostigmine, their use and pharmaceutical formulations containing them
AU750964B2 (en) * 1997-10-10 2002-08-01 Chiesi Farmaceutici S.P.A. A process for the preparation of aminocarbonyl derivatives of geneseroline having selective brain anticholinesterase activity
WO2003059909A1 (en) * 2002-01-09 2003-07-24 Axonyx, Inc. A process for producing phenserine and its analog
CN1301995C (en) * 2002-01-09 2007-02-28 阿克松尼克斯公司 Process for producing phenserine and its analog

Also Published As

Publication number Publication date
FR2434167A1 (en) 1980-03-21
CA1125657A (en) 1982-06-15
AR222311A1 (en) 1981-05-15
JPS54112897A (en) 1979-09-04
DE2839279A1 (en) 1979-03-29
IT1109003B (en) 1985-12-16
FR2434167B1 (en) 1983-03-18
GB2005259B (en) 1982-06-23

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee