FR2438649A1 - Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiques - Google Patents
Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiquesInfo
- Publication number
- FR2438649A1 FR2438649A1 FR7918156A FR7918156A FR2438649A1 FR 2438649 A1 FR2438649 A1 FR 2438649A1 FR 7918156 A FR7918156 A FR 7918156A FR 7918156 A FR7918156 A FR 7918156A FR 2438649 A1 FR2438649 A1 FR 2438649A1
- Authority
- FR
- France
- Prior art keywords
- phenyl
- antihypertensors
- antithrombics
- preparation
- therapeutic uses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/19—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/34—Compounds containing oxirane rings with hydrocarbon radicals, substituted by sulphur, selenium or tellurium atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENTION EST RELATIVE A DES DERIVES DE 1-PHENYL-1-PROPANOL. CES COMPOSES REPONDENT A LA FORMULE GENERALE I: (CF DESSIN DANS BOPI) OU R H, ALKYLTHIO (C-C), ALKYLSULFINYLE (C-C), ALKYLSULFONYLE (C-C) OU MERCAPTO, ROXO-2-PYRROLIDINYL-1 EVENTUELLEMENT SUBSTITUE PAR UN GROUPE HYDROXYLE. L'INVENTION EST APPLICABLE NOTAMMENT DANS LE DOMAINE PHARMACEUTIQUE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
LU79970A LU79970A1 (fr) | 1978-07-13 | 1978-07-13 | Procede de preparation de derives de 1-phenyl-1-propanol |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2438649A1 true FR2438649A1 (fr) | 1980-05-09 |
FR2438649B1 FR2438649B1 (fr) | 1983-03-25 |
Family
ID=19728955
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7918156A Granted FR2438649A1 (fr) | 1978-07-13 | 1979-07-12 | Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiques |
FR8003187A Granted FR2443457A1 (fr) | 1978-07-13 | 1980-02-13 | Derives de 1-phenyl-2-amino-1-propanol, leur procede de preparation et leur utilisation comme medicaments |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8003187A Granted FR2443457A1 (fr) | 1978-07-13 | 1980-02-13 | Derives de 1-phenyl-2-amino-1-propanol, leur procede de preparation et leur utilisation comme medicaments |
Country Status (18)
Country | Link |
---|---|
JP (1) | JPS5943943B2 (fr) |
AT (1) | AT368491B (fr) |
BE (1) | BE877694A (fr) |
CA (1) | CA1127164A (fr) |
CH (1) | CH644355A5 (fr) |
DE (1) | DE2927789A1 (fr) |
DK (1) | DK293779A (fr) |
ES (1) | ES482432A1 (fr) |
FI (1) | FI792123A (fr) |
FR (2) | FR2438649A1 (fr) |
GB (1) | GB2025417B (fr) |
IT (1) | IT1122180B (fr) |
LU (1) | LU79970A1 (fr) |
NL (1) | NL7905507A (fr) |
NO (1) | NO148452C (fr) |
PT (1) | PT69909A (fr) |
SE (1) | SE446631B (fr) |
ZA (1) | ZA793554B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3128117A1 (de) * | 1980-07-29 | 1982-03-11 | Yamanouchi Pharmaceutical Co., Ltd., Tokyo | Neue phenyl-aethylaminderivate, verfahren zu ihrer herstellung |
LU83039A1 (fr) * | 1980-12-24 | 1982-07-07 | Continental Pharma | Procedes de synthese du 1-(4 isopropylthiophenyl)-2-n octylaminopropanol |
EP0066919B1 (fr) * | 1981-05-27 | 1985-03-20 | MAGGIONI FARMACEUTICI S.p.A. | Alcoyl-thio-4-phényl-éthanolamines, ayant une activité sur la circulation cérébrale, sur l'agrégation des plaquettes sanguines et sur la lipémie |
FR2537132B1 (fr) * | 1982-12-06 | 1987-01-09 | Lafon Labor | Nouveaux derives soufres de 2-amino-1-phenyl-1-ethanol, utilisation en therapeutique et procede de preparation |
US4582918A (en) * | 1984-09-19 | 1986-04-15 | Schering Corporation | Preparation of intermediates for (threo)-1-aryl-2-acylamido-3-fluoro-1-propanols |
BE1014245A4 (fr) * | 2001-04-03 | 2003-07-01 | Malak Jean | Composes chimiques derives de l'octopamine et leurs utilisations en tant qu'agonistes beta 3-adrenergiques. |
WO2006043710A1 (fr) * | 2004-10-19 | 2006-04-27 | Reverse Proteomics Research Institute Co., Ltd. | Protéine cible et gène cible pour le développement de médicaments et procédé de recherche par criblage |
IL187245A0 (en) * | 2007-11-08 | 2008-12-29 | Hadasit Med Res Service | Synthetic sphingolipid analogs |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1366096A (fr) * | 1962-05-28 | 1964-07-10 | Castrol Ltd | Copolymères pour utilisation dans les compositions d'huiles lubrifiantes et leurs produits intermédiaires |
FR1480780A (fr) * | 1965-05-24 | 1967-05-12 | Shell Int Research | Production de pyrrolidone |
-
1978
- 1978-07-13 LU LU79970A patent/LU79970A1/fr unknown
-
1979
- 1979-07-05 FI FI792123A patent/FI792123A/fi not_active Application Discontinuation
- 1979-07-10 DE DE19792927789 patent/DE2927789A1/de not_active Ceased
- 1979-07-10 SE SE7905992A patent/SE446631B/sv not_active Application Discontinuation
- 1979-07-10 CA CA331,500A patent/CA1127164A/fr not_active Expired
- 1979-07-11 AT AT0483579A patent/AT368491B/de not_active IP Right Cessation
- 1979-07-12 CH CH651479A patent/CH644355A5/fr not_active IP Right Cessation
- 1979-07-12 DK DK293779A patent/DK293779A/da not_active Application Discontinuation
- 1979-07-12 NO NO792329A patent/NO148452C/no unknown
- 1979-07-12 GB GB7924292A patent/GB2025417B/en not_active Expired
- 1979-07-12 ES ES482432A patent/ES482432A1/es not_active Expired
- 1979-07-12 PT PT69909A patent/PT69909A/fr unknown
- 1979-07-12 FR FR7918156A patent/FR2438649A1/fr active Granted
- 1979-07-13 NL NL7905507A patent/NL7905507A/nl not_active Application Discontinuation
- 1979-07-13 JP JP54088352A patent/JPS5943943B2/ja not_active Expired
- 1979-07-13 BE BE0/196294A patent/BE877694A/fr not_active IP Right Cessation
- 1979-07-13 ZA ZA00793554A patent/ZA793554B/xx unknown
- 1979-07-13 IT IT24357/79A patent/IT1122180B/it active
-
1980
- 1980-02-13 FR FR8003187A patent/FR2443457A1/fr active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1366096A (fr) * | 1962-05-28 | 1964-07-10 | Castrol Ltd | Copolymères pour utilisation dans les compositions d'huiles lubrifiantes et leurs produits intermédiaires |
FR1480780A (fr) * | 1965-05-24 | 1967-05-12 | Shell Int Research | Production de pyrrolidone |
Also Published As
Publication number | Publication date |
---|---|
FR2443457A1 (fr) | 1980-07-04 |
PT69909A (fr) | 1979-08-01 |
FI792123A (fi) | 1980-01-14 |
NO148452C (no) | 1983-10-12 |
AT368491B (de) | 1982-10-11 |
NL7905507A (nl) | 1980-01-15 |
BE877694A (fr) | 1979-11-05 |
NO148452B (no) | 1983-07-04 |
GB2025417B (en) | 1983-03-02 |
DK293779A (da) | 1980-01-14 |
IT7924357A0 (it) | 1979-07-13 |
SE7905992L (sv) | 1980-01-14 |
JPS5943943B2 (ja) | 1984-10-25 |
GB2025417A (en) | 1980-01-23 |
ATA483579A (de) | 1982-02-15 |
IT1122180B (it) | 1986-04-23 |
NO792329L (no) | 1980-01-15 |
DE2927789A1 (de) | 1980-01-24 |
SE446631B (sv) | 1986-09-29 |
FR2443457B1 (fr) | 1983-09-23 |
CH644355A5 (fr) | 1984-07-31 |
LU79970A1 (fr) | 1980-02-14 |
ZA793554B (en) | 1980-06-25 |
ES482432A1 (es) | 1980-04-01 |
FR2438649B1 (fr) | 1983-03-25 |
JPS5533467A (en) | 1980-03-08 |
CA1127164A (fr) | 1982-07-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
TP | Transmission of property | ||
ST | Notification of lapse |