FR2451918A1 - Composes de 6-aryl pyrimidine, leur preparation et leur utilisation comme medicament - Google Patents

Composes de 6-aryl pyrimidine, leur preparation et leur utilisation comme medicament

Info

Publication number
FR2451918A1
FR2451918A1 FR8006015A FR8006015A FR2451918A1 FR 2451918 A1 FR2451918 A1 FR 2451918A1 FR 8006015 A FR8006015 A FR 8006015A FR 8006015 A FR8006015 A FR 8006015A FR 2451918 A1 FR2451918 A1 FR 2451918A1
Authority
FR
France
Prior art keywords
preparation
aryl pyrimidine
medicinal products
pyrimidine compounds
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8006015A
Other languages
English (en)
Other versions
FR2451918B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2451918A1 publication Critical patent/FR2451918A1/fr
Application granted granted Critical
Publication of FR2451918B1 publication Critical patent/FR2451918B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENTION EST RELATIVE A DES COMPOSES DE 6-ARYL PYRIMIDINE, A LEURS SELS, A LEUR PREPARATION AINSI QU'A LEUR UTILISATION. SUIVANT L'INVENTION, CES COMPOSES REPONDENT A LA FORMULE: (CF DESSIN DANS BOPI) DANS LAQUELLE LES DIFFERENTS SYMBOLES ONT DIFFERENTES SIGNIFICATIONS. CES COMPOSES DE 6-ARYL PYRIMIDINE ET LEUR SELS SONT DES AGENTS PARTICULIEREMENT INTERESSANTS POUR LE TRAITEMENT DES INFECTION VIRALES ET POUR LA PRODUCTION D'INTERFERONS.
FR8006015A 1979-03-19 1980-03-18 Composes de 6-aryl pyrimidine, leur preparation et leur utilisation comme medicament Granted FR2451918A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2220579A 1979-03-19 1979-03-19
US7985079A 1979-09-28 1979-09-28

Publications (2)

Publication Number Publication Date
FR2451918A1 true FR2451918A1 (fr) 1980-10-17
FR2451918B1 FR2451918B1 (fr) 1984-01-06

Family

ID=26695670

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8006015A Granted FR2451918A1 (fr) 1979-03-19 1980-03-18 Composes de 6-aryl pyrimidine, leur preparation et leur utilisation comme medicament

Country Status (7)

Country Link
JP (1) JPH0627070B2 (fr)
CH (1) CH646958A5 (fr)
DE (1) DE3008693A1 (fr)
FR (1) FR2451918A1 (fr)
GB (1) GB2048250B (fr)
IT (1) IT1143012B (fr)
NL (1) NL8001568A (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0111440A1 (fr) * 1982-10-15 1984-06-20 Ciba-Geigy Ag Amino-2-pyrimidines, leur préparation et leur utilisation
US4795812A (en) * 1985-02-05 1989-01-03 The Upjohn Company 4-substituted-6-aryl-pyrimidine compounds
GB9012311D0 (en) * 1990-06-01 1990-07-18 Wellcome Found Pharmacologically active cns compounds
WO1998025596A2 (fr) * 1996-12-12 1998-06-18 Pharmacia & Upjohn Company Methode de traitement de la sclerose en plaques
US6495558B1 (en) 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
EP1144390A2 (fr) * 1999-01-22 2001-10-17 Amgen Inc., Inhibiteurs de kinase

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688019A (en) * 1951-08-25 1954-08-31 Burroughs Wellcome Co 6-aryl-2,4-diamino pyrimidines and process of preparing same
US2704285A (en) * 1954-06-17 1955-03-15 Searle & Co 2-amino-5-(lower alkyl)-6-substituted phenyl-4-pyrimidols
US2710867A (en) * 1954-03-12 1955-06-14 Searle & Co New 2-amino-4-pyrimidol derivatives
US2723978A (en) * 1954-01-14 1955-11-15 Searle & Co 2-amino-5-alkenyl-6-phenyl-4-pyrimidols
US2723977A (en) * 1953-07-29 1955-11-15 Searle & Co 5, 6-disubstituted 2-amino-4-pyrimidols
US2748121A (en) * 1954-06-17 1956-05-29 Searle & Co 6-nitroaryl derivatives of 2-amino-4-pyrimidols
US3281420A (en) * 1966-01-27 1966-10-25 Searle & Co Carboxylic acid [2-(2-amino-4-azido-6-phenyl-5-pyrimidinyl)-1-methylethylidene] hydrazides and intermediate
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3932617A (en) * 1974-05-24 1976-01-13 The Upjohn Company Interferon induction

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688019A (en) * 1951-08-25 1954-08-31 Burroughs Wellcome Co 6-aryl-2,4-diamino pyrimidines and process of preparing same
US2723977A (en) * 1953-07-29 1955-11-15 Searle & Co 5, 6-disubstituted 2-amino-4-pyrimidols
US2723978A (en) * 1954-01-14 1955-11-15 Searle & Co 2-amino-5-alkenyl-6-phenyl-4-pyrimidols
US2710867A (en) * 1954-03-12 1955-06-14 Searle & Co New 2-amino-4-pyrimidol derivatives
US2704285A (en) * 1954-06-17 1955-03-15 Searle & Co 2-amino-5-(lower alkyl)-6-substituted phenyl-4-pyrimidols
US2748121A (en) * 1954-06-17 1956-05-29 Searle & Co 6-nitroaryl derivatives of 2-amino-4-pyrimidols
US3281420A (en) * 1966-01-27 1966-10-25 Searle & Co Carboxylic acid [2-(2-amino-4-azido-6-phenyl-5-pyrimidinyl)-1-methylethylidene] hydrazides and intermediate
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1954 *

Also Published As

Publication number Publication date
JPH0627070B2 (ja) 1994-04-13
CH646958A5 (de) 1984-12-28
FR2451918B1 (fr) 1984-01-06
NL8001568A (nl) 1980-09-23
GB2048250B (en) 1983-04-27
IT1143012B (it) 1986-10-22
GB2048250A (en) 1980-12-10
IT8048119A0 (it) 1980-03-10
DE3008693A1 (de) 1980-10-02
JPH0517451A (ja) 1993-01-26

Similar Documents

Publication Publication Date Title
FR2441625A1 (fr) (d2-imidazolinyl-2 amino)-5 pyrimidines, procede pour les preparer, et medicaments qui en contiennent
FR2439182A1 (fr) Nouveaux derives cyclopeptidiques, leur preparation et leur application comme medicaments
BE1002436A3 (fr) Nouveaux benzo(b)pyrannes et pyrannopyridines, leur preparation et leur utilisation comme medicaments.
KR890003382A (ko) 항 비루스성 화합물
FR2359144A1 (fr) Sels de l'acide clavulanique utilisable comme medicaments
FR2354324A1 (fr) Nouveaux composes triazoliques, leur procede de preparation et leurs applications au traitement de plantes
FR2412565A1 (fr) Nouveaux derives de type n-acyl-2', n-alkyl-2', di-n-acyl-4,2', di-n-alkyl-4,2', n-acyl-4 n-alkyl-2' et n-alkyl-4 n-acyl-2', desoxy-2 fortimicine b
FR2438655A1 (fr) Nouveaux 3-dicyanomethylidene-2,3-dihydro-thiopene-1,1-dioxydes condenses et leur preparation
FR2451918A1 (fr) Composes de 6-aryl pyrimidine, leur preparation et leur utilisation comme medicament
FR2412567A1 (fr) N-acyl-2' et n-alkyl-2' o-demethyl-3 fortimicines a et b, utiles notamment comme antibiotiques
FR2457294A1 (fr) Derives de l'acide penicillanique utiles comme medicaments, compositions therapeutiques les contenant et procedes de leur preparation
FR2367750A1 (fr) Acid
FR2356642A1 (fr) La 2-bromo-6-fluoro-n-2-imidazolinylidene-benzamine, ses sels d'addition avec des acides, procedes pour leur preparation et les medicaments les renfermant
FR2417502A1 (fr) Nouvelles 2-phenylimino-imidazolidines substituees, leurs sels d'addition avec des acides, medicaments les renfermant et procedes pour leur preparation
FR2432520A1 (fr) Nouvelles imidazoquinoxalines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
FR2420346A1 (fr) Medicaments contenant des alcenylxanthines et leur procede de preparation
FR2426467A1 (fr) Composes de type acide p-aminobenzoique-n-l-rhamnoside utiles comme medicaments
FR2438649A1 (fr) Derives de 1-phenyl-1-propanol, leur preparation et leurs utilisations therapeutiques notamment comme antihypertenseurs, vasodilatateurs peripheriques et antithrombiques
FR2408605A1 (fr) Nouvelles piperazines disubstituees, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
FR2444673A1 (fr) Nouvelles trifluoroethylamines, leurs procedes d'obtention et leur emploi comme medicament
FR2442239A1 (fr) Procede de preparation de 4,l-benzoxazepines et de leur analogue thia, nouveaux produits ainsi obtenus et leur utilisation pour le traitement de troubles mentaux
FR2383176A1 (fr) Amino aryl triazines 1-2-4 utilisables dans le traitement d'algies diverses
FR2421173A1 (fr) 2-(4-ethylpiperazino)-4-phenylquinoleine et ses sels, utiles notamment comme antidepresseurs, et leur procede de preparation
FR2455569A1 (fr) Nouvelles isoprenylamines et leurs sels acides d'addition et leur utilisation comme substances actives dans des compositions pharmaceutiques antivirales pour animaux vertebres
FR2412564A1 (fr) Nouvelles 2' -n-acyl- et alkyl-6' -n-alkyl- et 6', 6' -di-n-alkyl-fortimicines a et b, utiles notamment comme antibiotiques

Legal Events

Date Code Title Description
CD Change of name or company name