KR890003382A - 항 비루스성 화합물 - Google Patents

항 비루스성 화합물 Download PDF

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Publication number
KR890003382A
KR890003382A KR1019880010598A KR880010598A KR890003382A KR 890003382 A KR890003382 A KR 890003382A KR 1019880010598 A KR1019880010598 A KR 1019880010598A KR 880010598 A KR880010598 A KR 880010598A KR 890003382 A KR890003382 A KR 890003382A
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KR
South Korea
Prior art keywords
compound
formula
adenovirus
dideoxy
prevention
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Application number
KR1019880010598A
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English (en)
Inventor
윌리암 탈보트 셀웨이 존
밀러 비치암 Ⅲ 로우리
메리 달라지 수잔
반 투틀 조엘
안토니 크레니쓰키 토마스
Original Assignee
엠.피.잭슨
더 웰컴 화운데이숀 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 엠.피.잭슨, 더 웰컴 화운데이숀 리미티드 filed Critical 엠.피.잭슨
Publication of KR890003382A publication Critical patent/KR890003382A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

항 비루스성 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 아세노 비루스 감염의 예방 또는 치료에 사용되는 하기식(I)의 화합물 또는 이것의 생리학적 허용 염 또는 에스테르
    상기식에서, R은 수소원자, C1-4알킬기 또는 할로겐원자이다.
  2. 제1항에 있어서, R은 메틸인 것을 특징으로 하는 화합물.
  3. 제1항 또는 제2항에 있어서, 스크로타입 8의 아데노 비루스에 의해 유발된 아데노 비루스 감염의 예방 또는 치료에 사용되는 것을 특징으로 하는 화합물.
  4. 아데노 비루스 감염의 예방 또는 치료용 약물의 제조에 사용되는 하기식(I)의 화합물 또는 이것의 생리학적 허용 염 또는 에스테르의 용도.
    상기식에서, R은 수소원자, C1-4알킬리 또는 할로겐원자이다.
  5. 제4항에 있어서, 상기식(I)의 화합물 2',3'-디데옥시-3'-플루오로티미딘인 것을 특징으로 하는 용도.
  6. 제4항 또는 제5항에 있어서, 아데노 비루스 감염은 스크로타입 8의 아데노 비루스에 의해 유발되는 것을 특징으로 하는 용도.
  7. 하기식(I)화합물 또는 이것의 생리학적 허용염 또는 에스테르와 약학적 허용 담체로 구성되는 눈 투여용의 약학적 제제.
    상기식에서, R은 수소원자, C1-4알킬기 또는 할로겐원자이다.
  8. 제7항에 있어서, 상기식(I)의 화합물은 2'3'-디데옥시-3'-플루오로티미딘인을 특징으로 하는 약학적 제제.
  9. 제7항 또는 제8항에 있어서, 눈약 또는 눈에 사용되는 안연고, 크림, 현탁액 또는 로숀 형태로 제제되는 것을 특지으로 하는 제제.
  10. 제1항에 있어서, R은 염수 또는 요오드원자인 것을 특징으로 하는 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880010598A 1987-08-22 1988-08-19 항 비루스성 화합물 KR890003382A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719877A GB8719877D0 (en) 1987-08-22 1987-08-22 Antiviral compounds
GB8719877 1987-08-22

Publications (1)

Publication Number Publication Date
KR890003382A true KR890003382A (ko) 1989-04-14

Family

ID=10622673

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880010598A KR890003382A (ko) 1987-08-22 1988-08-19 항 비루스성 화합물

Country Status (19)

Country Link
US (2) US5070078A (ko)
EP (2) EP0305117B1 (ko)
JP (1) JP2634202B2 (ko)
KR (1) KR890003382A (ko)
AT (1) ATE82681T1 (ko)
AU (1) AU613659B2 (ko)
CA (1) CA1333361C (ko)
DE (1) DE3876174T2 (ko)
DK (3) DK169657B1 (ko)
ES (1) ES2052732T3 (ko)
GB (1) GB8719877D0 (ko)
GR (1) GR3006510T3 (ko)
HU (1) HU211666A9 (ko)
IE (2) IE63655B1 (ko)
MX (1) MX9203416A (ko)
NZ (1) NZ225881A (ko)
PT (1) PT88306B (ko)
SG (1) SG26364G (ko)
ZA (1) ZA886182B (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
GB9003543D0 (en) * 1990-02-16 1990-04-11 Wellcome Found Therapeutic nucleosides
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
JP2804184B2 (ja) * 1991-05-14 1998-09-24 シャープ株式会社 ファクシミリ装置
DE4121001C1 (ko) * 1991-06-21 1993-05-06 Max-Delbrueck-Centrum Fuer Molekulare Medizin Berlin-Buch, O-1115 Berlin, De
US5341595A (en) * 1992-06-15 1994-08-30 Environmental Growth Chambers Environmental chamber for plant growth analysis
GB9309787D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Purification of fluoronucleosides
EP0698032B1 (en) * 1993-05-12 1998-07-29 Rhodia Limited Preparation of fluoro-nucleosides and intermediates for use therein
SE503787C2 (sv) * 1994-12-07 1996-09-02 Electrolux Ab Anordning för att tillhandahålla kylda eller frysta varor
US5690202A (en) * 1996-04-15 1997-11-25 Myers; John E. Overrunning clutch mechanism
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
KR20050013628A (ko) * 2002-06-27 2005-02-04 메디비르 아베 아바카비르와 알로부딘의 공동상승 상호작용
CN1248266C (zh) * 2002-12-26 2006-03-29 邱智铭 一种转动式电开关结构
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
RU2628456C1 (ru) * 2016-06-29 2017-08-17 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Новые пиримидиновые ингибиторы репликации аденовируса человека

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DE103241C (ko) *
GB1251828A (ko) * 1968-12-19 1971-11-03
DE1913384C2 (de) * 1968-12-20 1982-12-16 Akademie Der Wissenschaften Der Ddr, Ddr 1199 Berlin 1-(2',3'-Didesoxy-3'-fluor-β-D-xylofuranosyl)-thymin, Verfahren zu seiner Herstellung und dieses enthaltende Cytostatica
GB1189973A (en) * 1969-02-14 1970-04-29 Akad Wissenschaften Ddr Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
DD103241A1 (ko) * 1972-12-12 1974-01-12
EP0265431A1 (de) * 1985-07-23 1988-05-04 WOLF, Karl Schaltungsanordnung zum starten und zum betrieb mindestens einer niederdruck- oder hochdruck-gasentladungslampe mit hochfrequenten schwingungen
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
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WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application

Also Published As

Publication number Publication date
DK169437B1 (da) 1994-10-31
EP0479336A1 (en) 1992-04-08
DK468288A (da) 1989-02-23
DK140393A (da) 1993-12-17
IE63655B1 (en) 1995-05-31
GB8719877D0 (en) 1987-09-30
EP0305117B1 (en) 1992-11-25
EP0305117A3 (en) 1989-12-27
US5376644A (en) 1994-12-27
DK140393D0 (da) 1993-12-17
IE882533L (en) 1989-02-22
DE3876174T2 (de) 1993-04-01
ZA886182B (en) 1990-04-25
DE3876174D1 (de) 1993-01-07
JP2634202B2 (ja) 1997-07-23
NZ225881A (en) 1991-03-26
ATE82681T1 (de) 1992-12-15
IE940696L (en) 1989-02-22
MX9203416A (es) 1992-07-01
DK91692D0 (da) 1992-07-14
EP0305117A2 (en) 1989-03-01
SG26364G (en) 1995-09-18
PT88306B (pt) 1995-12-29
DK91692A (da) 1992-07-14
US5070078A (en) 1991-12-03
CA1333361C (en) 1994-12-06
PT88306A (pt) 1989-06-30
DK468288D0 (da) 1988-08-19
DK169657B1 (da) 1995-01-09
HU211666A9 (en) 1995-12-28
GR3006510T3 (ko) 1993-06-30
AU613659B2 (en) 1991-08-08
ES2052732T3 (es) 1994-07-16
JPS6468325A (en) 1989-03-14
AU2142988A (en) 1989-05-25

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