ATE82681T1 - 2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen. - Google Patents

2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen.

Info

Publication number
ATE82681T1
ATE82681T1 AT88307689T AT88307689T ATE82681T1 AT E82681 T1 ATE82681 T1 AT E82681T1 AT 88307689 T AT88307689 T AT 88307689T AT 88307689 T AT88307689 T AT 88307689T AT E82681 T1 ATE82681 T1 AT E82681T1
Authority
AT
Austria
Prior art keywords
dideoxy
fluorothymidine
treatment
related compounds
adenovirus infections
Prior art date
Application number
AT88307689T
Other languages
English (en)
Inventor
John William Talbot Selway
Iii Lowrie Miller Beacham
Susan Mary Daluge
Joel Van Tuttle
Thomas Anthony Krenitsky
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE82681T1 publication Critical patent/ATE82681T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
AT88307689T 1987-08-22 1988-08-19 2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen. ATE82681T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878719877A GB8719877D0 (en) 1987-08-22 1987-08-22 Antiviral compounds
EP88307689A EP0305117B1 (de) 1987-08-22 1988-08-19 2',3'-Dideoxy-3'-fluorothymidin und verwandte Verbindungen zur Behandlung von Adenovirus-Infektionen

Publications (1)

Publication Number Publication Date
ATE82681T1 true ATE82681T1 (de) 1992-12-15

Family

ID=10622673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88307689T ATE82681T1 (de) 1987-08-22 1988-08-19 2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen.

Country Status (19)

Country Link
US (2) US5070078A (de)
EP (2) EP0305117B1 (de)
JP (1) JP2634202B2 (de)
KR (1) KR890003382A (de)
AT (1) ATE82681T1 (de)
AU (1) AU613659B2 (de)
CA (1) CA1333361C (de)
DE (1) DE3876174T2 (de)
DK (3) DK169657B1 (de)
ES (1) ES2052732T3 (de)
GB (1) GB8719877D0 (de)
GR (1) GR3006510T3 (de)
HU (1) HU211666A9 (de)
IE (2) IE63655B1 (de)
MX (1) MX9203416A (de)
NZ (1) NZ225881A (de)
PT (1) PT88306B (de)
SG (1) SG26364G (de)
ZA (1) ZA886182B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
GB8726136D0 (en) * 1987-11-07 1987-12-09 Wellcome Found Therapeutic nucleosides
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application
GB9003543D0 (en) * 1990-02-16 1990-04-11 Wellcome Found Therapeutic nucleosides
US5166327A (en) * 1990-07-31 1992-11-24 Yuki Gosei Kogyo Co., Ltd. Process for producing 3'-deoxy-3-'-fluorothymidine
JP2804184B2 (ja) * 1991-05-14 1998-09-24 シャープ株式会社 ファクシミリ装置
DE4121001C1 (de) * 1991-06-21 1993-05-06 Max-Delbrueck-Centrum Fuer Molekulare Medizin Berlin-Buch, O-1115 Berlin, De
US5341595A (en) * 1992-06-15 1994-08-30 Environmental Growth Chambers Environmental chamber for plant growth analysis
GB9309787D0 (en) * 1993-05-12 1993-06-23 Rhone Poulenc Chemicals Purification of fluoronucleosides
DE69412090T2 (de) * 1993-05-12 1999-01-07 Rhodia Ltd., Watford Herstellung von fluoro-nukleosiden und dafür geeignete zwischenprodukte
SE503787C2 (sv) * 1994-12-07 1996-09-02 Electrolux Ab Anordning för att tillhandahålla kylda eller frysta varor
US5690202A (en) * 1996-04-15 1997-11-25 Myers; John E. Overrunning clutch mechanism
US6514979B1 (en) 1999-03-03 2003-02-04 University Of Maryland Biotechnology Institute Synergistic combinations of guanosine analog reverse transcriptase inhibitors and inosine monophosphate dehydrogenese inhibitors and uses therefor
US6855561B2 (en) * 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US20030236218A1 (en) * 2002-06-12 2003-12-25 Uckun Fatih M. Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV
US20060084627A1 (en) * 2002-06-27 2006-04-20 Medivir Ab Synergistic interaction of abacavir and alovudine
CN1248266C (zh) * 2002-12-26 2006-03-29 邱智铭 一种转动式电开关结构
US7160537B2 (en) * 2003-12-15 2007-01-09 Siemens Medical Solutions Usa, Inc. Method for preparing radiolabeled thymidine having low chromophoric byproducts
US20050131224A1 (en) * 2003-12-15 2005-06-16 Cti Pet Systems, Inc. Method for preparing radiolabeled thymidine
RU2628456C1 (ru) * 2016-06-29 2017-08-17 Федеральное Государственное Бюджетное Учреждение Науки Институт Молекулярной Биологии Им. В.А. Энгельгардта Российской Академии Наук (Имб Ран) Новые пиримидиновые ингибиторы репликации аденовируса человека

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE103241C (de) *
GB1251828A (de) * 1968-12-19 1971-11-03
DE1913384C2 (de) * 1968-12-20 1982-12-16 Akademie Der Wissenschaften Der Ddr, Ddr 1199 Berlin 1-(2',3'-Didesoxy-3'-fluor-β-D-xylofuranosyl)-thymin, Verfahren zu seiner Herstellung und dieses enthaltende Cytostatica
GB1189973A (en) * 1969-02-14 1970-04-29 Akad Wissenschaften Ddr Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides
US3775397A (en) * 1969-11-12 1973-11-27 Akad Wissenschaften Ddr Novel cytostatic 2',3'-dideoxy-3'-fluoropyrimidine-nucleosides
DD103241A1 (de) * 1972-12-12 1974-01-12
EP0265431A1 (de) * 1985-07-23 1988-05-04 WOLF, Karl Schaltungsanordnung zum starten und zum betrieb mindestens einer niederdruck- oder hochdruck-gasentladungslampe mit hochfrequenten schwingungen
GB2181128A (en) * 1985-09-17 1987-04-15 Wellcome Found 3'-azidonucleosides
US4710492A (en) * 1986-06-23 1987-12-01 Yale University 3'-azido-2',3'-dideoxy-5-halouridine and its use in treating patients infected with retroviruses
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
DD279407A1 (de) * 1986-07-24 1990-06-06 Akad Wissenschaften Ddr Verfahren zur herstellung eines mittels gegen aids
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
FI892451L (fi) * 1986-11-21 1989-05-19 Max Planck Gesellschaft Foerfarande med vilket virusinfektioner i maenniskor kan skoetas och kompositioner anvaenda daeri.
GB8719877D0 (en) * 1987-08-22 1987-09-30 Wellcome Found Antiviral compounds
WO1990003978A1 (en) * 1988-10-03 1990-04-19 Stichting Rega Vzw 5-halogeno-3'-fluoro-2',3'-dideoxyuridine compounds and their therapeutic application

Also Published As

Publication number Publication date
KR890003382A (ko) 1989-04-14
JP2634202B2 (ja) 1997-07-23
IE63655B1 (en) 1995-05-31
ZA886182B (en) 1990-04-25
GB8719877D0 (en) 1987-09-30
NZ225881A (en) 1991-03-26
SG26364G (en) 1995-09-18
IE940696L (en) 1989-02-22
DK169657B1 (da) 1995-01-09
US5070078A (en) 1991-12-03
AU2142988A (en) 1989-05-25
JPS6468325A (en) 1989-03-14
US5376644A (en) 1994-12-27
CA1333361C (en) 1994-12-06
DK140393D0 (da) 1993-12-17
DE3876174T2 (de) 1993-04-01
IE882533L (en) 1989-02-22
EP0305117A3 (en) 1989-12-27
EP0305117B1 (de) 1992-11-25
DK140393A (da) 1993-12-17
EP0305117A2 (de) 1989-03-01
HU211666A9 (en) 1995-12-28
EP0479336A1 (de) 1992-04-08
DK169437B1 (da) 1994-10-31
DK91692D0 (da) 1992-07-14
AU613659B2 (en) 1991-08-08
PT88306B (pt) 1995-12-29
DK91692A (da) 1992-07-14
GR3006510T3 (de) 1993-06-30
MX9203416A (es) 1992-07-01
PT88306A (pt) 1989-06-30
ES2052732T3 (es) 1994-07-16
DE3876174D1 (de) 1993-01-07
DK468288A (da) 1989-02-23
DK468288D0 (da) 1988-08-19

Similar Documents

Publication Publication Date Title
ATE82681T1 (de) 2',3'-dideoxy-3'-fluorothymidin und verwandte verbindungen zur behandlung von adenovirusinfektionen.
BG101118A (en) Therapeutical compounds
RU94038043A (ru) Применение замещенных производных аденина для лечения множественного склероза
UA41297C2 (uk) Похідні індолу, фармацевтична композиція і спосіб лікування
DK118286D0 (da) Terapeutisk aktive nucleosider, deres anvendelse og farmaceutiske kompositioner indeholdende forbindelserne
EE03253B1 (et) (R)-5-karbamoüül-8-fluoro-3-N,N-diasendatud-amino-3,4-dihüdro-2H-1-bensopüraani d, nende valmistamise protsess ja neid sisaldavad ravimkoostised
MA26435A1 (fr) Derives de benzylamine amido-substitues, leurs derives precurseurs de medicaments, leur procede de preparation, compositions pharmaceutiques les contenant et methode de traitement les utilisant.
NO173998C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
FI913943A0 (fi) Nya kroman- och tiokromanderivat.
ES468525A1 (es) Procedimiento para la obtencion de nuevas 2-alquilenaminodi-hidropiridinas
TNSN90021A1 (fr) Procede de preparation de tetrahydroimidazo (1,4) benzodiazepin -2- thiones antivirales
ZA859382B (en) New pyrrolobenzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing them
ES2144054T3 (es) Complejos de tri(platino).
MX9403088A (es) Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso.
UA48958C2 (uk) 9-o-оксимові похідні еритроміцину а та фармацевтична композиція на їх основі
NZ324380A (en) Therapeutic benzimidazole compounds and their use in treatment of virus infections
ES8301244A1 (es) Procedimiento para la obtencion de derivados de sisomicina.
FR2685325B1 (fr) Nouveaux derives de pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
RU94046300A (ru) Химические соединения, способ их получения, фармкомпозиция, способ лечения, промежуточный продукт
MY103593A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
RU94046312A (ru) Применение биологически активных уреидопроизводных для лечения индуцируемых лентивирусами заболеваний, продукты, содержащие уреидопроизводные
MY111746A (en) Therapeutic nucleosides.
FI872459A7 (fi) Farmaseuttinen valmiste bakteeri-infektioiden hoitoon.
ATE87482T1 (de) Pharmazeutische praeparate zur behandlung von zereberalen psycho-organischen syndromen.
SE8704049D0 (sv) Novel pharmacological compounds

Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee