GB1189973A - Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides - Google Patents

Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides

Info

Publication number
GB1189973A
GB1189973A GB810769A GB810769A GB1189973A GB 1189973 A GB1189973 A GB 1189973A GB 810769 A GB810769 A GB 810769A GB 810769 A GB810769 A GB 810769A GB 1189973 A GB1189973 A GB 1189973A
Authority
GB
United Kingdom
Prior art keywords
didesoxy
nucleosides
oxygen
cytostatically
fluoropyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB810769A
Inventor
Gerhard Etzold
Rainer Hintsche
Peter Langen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akademie der Wissenschaften der DDR
Original Assignee
Akademie der Wissenschaften der DDR
Deutsche Akademie der Wissenschaften zu Berlin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akademie der Wissenschaften der DDR, Deutsche Akademie der Wissenschaften zu Berlin filed Critical Akademie der Wissenschaften der DDR
Priority to GB810769A priority Critical patent/GB1189973A/en
Publication of GB1189973A publication Critical patent/GB1189973A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Abstract

1,189,973. Pyrimidine nucleosides. DEUTSCHE AKADEMIE DER WISSENSCHAFTEN ZU BERLIN. 14 Feb., 1969, No. 8107/69. Heading C2C. Novel, cytoatatically active compounds I wherein X is oxygen, sulphur or imino and R is hydrogen, halogen, hydroxy, mercapto or unsubstituted or substituted alkyl, are obtained by reacting a corresponding pyrimidine nucleoside, appropriately substituted on the oxygen of the 3<SP>1</SP>-hydroxy group, with a fluoronation agent. 2<SP>1</SP>,3<SP>1</SP>-Didehydro-3<SP>1</SP>-desoxy-thymidine is prepared by treating 1-(2<SP>1</SP>,3<SP>1</SP>-didesoxy-3<SP>1</SP>-fluoro- #-D-pentofuranosyl)-thymine (a compound of the invention) with aqueous alcoholic sodium hydroxide solution.
GB810769A 1969-02-14 1969-02-14 Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides Expired GB1189973A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB810769A GB1189973A (en) 1969-02-14 1969-02-14 Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB810769A GB1189973A (en) 1969-02-14 1969-02-14 Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides

Publications (1)

Publication Number Publication Date
GB1189973A true GB1189973A (en) 1970-04-29

Family

ID=9845901

Family Applications (1)

Application Number Title Priority Date Filing Date
GB810769A Expired GB1189973A (en) 1969-02-14 1969-02-14 Cytostatically-Active 2',3'-Didesoxy-3'-Fluoropyrimidine-Nucleosides

Country Status (1)

Country Link
GB (1) GB1189973A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254268A2 (en) * 1986-07-24 1988-01-27 The Wellcome Foundation Limited Fluorinated nucleosides,their preparation and their pharmaceutical use against AIDS
EP0305117A2 (en) * 1987-08-22 1989-03-01 The Wellcome Foundation Limited 2',3'-Dideoxy-3'-fluorothymidine and related compounds for the treatment of adenovirus infections

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0254268A2 (en) * 1986-07-24 1988-01-27 The Wellcome Foundation Limited Fluorinated nucleosides,their preparation and their pharmaceutical use against AIDS
EP0254268A3 (en) * 1986-07-24 1988-07-13 Akademie Der Wissenschaften Der Ddr Fluorinated nucleoside, process for their preparation and their use as a pharmaceutical product against aids
AU615431B2 (en) * 1986-07-24 1991-10-03 Wellcome Foundation Limited, The Fluorinated nucleosides: method for their preparation and use as drugs against the human acquired immunodeficiency syndrome (aids)
EP0305117A2 (en) * 1987-08-22 1989-03-01 The Wellcome Foundation Limited 2',3'-Dideoxy-3'-fluorothymidine and related compounds for the treatment of adenovirus infections
EP0305117A3 (en) * 1987-08-22 1989-12-27 The Wellcome Foundation Limited 2',3'-dideoxy-3'-fluorothymidine and related compounds for the treatment of adenovirus infections
US5070078A (en) * 1987-08-22 1991-12-03 Burroughs Wellcome Co. Antiviral compounds

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee