FR2375249A1 - Nouveaux derives de la muramyldipeptide utiles notamment comme immuno-adjuvants et leur procede de preparation - Google Patents

Nouveaux derives de la muramyldipeptide utiles notamment comme immuno-adjuvants et leur procede de preparation

Info

Publication number
FR2375249A1
FR2375249A1 FR7719306A FR7719306A FR2375249A1 FR 2375249 A1 FR2375249 A1 FR 2375249A1 FR 7719306 A FR7719306 A FR 7719306A FR 7719306 A FR7719306 A FR 7719306A FR 2375249 A1 FR2375249 A1 FR 2375249A1
Authority
FR
France
Prior art keywords
muramyldipeptide
immunoadjuvants
preparation
useful
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7719306A
Other languages
English (en)
Other versions
FR2375249B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7407276A external-priority patent/JPS5914038B2/ja
Priority claimed from JP51150328A external-priority patent/JPS6033119B2/ja
Priority claimed from JP1112277A external-priority patent/JPS5398922A/ja
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of FR2375249A1 publication Critical patent/FR2375249A1/fr
Application granted granted Critical
Publication of FR2375249B1 publication Critical patent/FR2375249B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • C07K9/005—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure containing within the molecule the substructure with m, n > 0 and m+n > 0, A, B, D, E being heteroatoms; X being a bond or a chain, e.g. muramylpeptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Dérivés de muramyldipeptide, leur procédé de préparation et leurs utilisations thérapeutiques. Ces composés répondent a la formule générale :
FR7719306A 1976-06-23 1977-06-23 Nouveaux derives de la muramyldipeptide utiles notamment comme immuno-adjuvants et leur procede de preparation Granted FR2375249A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP7407276A JPS5914038B2 (ja) 1976-06-23 1976-06-23 新規ムラミルジペプチド誘導体
JP51150328A JPS6033119B2 (ja) 1976-12-16 1976-12-16 新規ムラミルジペプチド誘導体
JP1112277A JPS5398922A (en) 1977-02-03 1977-02-03 Novel melamyldipeptide derivative

Publications (2)

Publication Number Publication Date
FR2375249A1 true FR2375249A1 (fr) 1978-07-21
FR2375249B1 FR2375249B1 (fr) 1980-04-11

Family

ID=27279285

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7719306A Granted FR2375249A1 (fr) 1976-06-23 1977-06-23 Nouveaux derives de la muramyldipeptide utiles notamment comme immuno-adjuvants et leur procede de preparation

Country Status (9)

Country Link
US (1) US4101536A (fr)
CA (1) CA1105005A (fr)
CH (1) CH624124A5 (fr)
DE (1) DE2728324A1 (fr)
FR (1) FR2375249A1 (fr)
GB (1) GB1563561A (fr)
NL (1) NL171063C (fr)
SE (1) SE446740B (fr)
SU (1) SU793384A3 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU727647A1 (ru) * 1977-11-02 1980-04-15 Институт биоорганической химии им.М.М.Шемякина Гликопептиды,обладающие противоопухолевой активностью и способ их получени
US4397844A (en) * 1978-02-24 1983-08-09 Ciba-Geigy Corporation Antigen derivatives and processes for their preparation
JPS5543030A (en) * 1978-09-21 1980-03-26 Dai Ichi Seiyaku Co Ltd Prophylactic and remedy for microbial infection disease
US4335111A (en) * 1978-12-22 1982-06-15 Agence National De Valorisation De La Recherche (Anvar) Compounds associating peptidyl of aminoacyl residues to lipophilic groups and pharmaceutical compositions containing said new compounds
FR2449697A1 (fr) 1979-02-20 1980-09-19 Anvar Nouveaux muramyl-peptides substitues sur un azote peptidique et medicaments les contenant
JPS55111499A (en) * 1979-02-21 1980-08-28 Takeda Chem Ind Ltd Glucosamine derivative and its preparation
US4391800A (en) * 1979-04-27 1983-07-05 Merck & Co., Inc. Immunologically active peptidyl disaccharides and methods of preparation
FI75578C (fi) * 1979-07-25 1988-07-11 Ciba Geigy Ag Analogifoerfarande foer framstaellning av farmakologiskt verkande lipofila fosfatidylmuramylpeptider.
US4406889A (en) * 1980-02-15 1983-09-27 Ciba-Geigy Corporation Derivatives of aldohexoses, intermediates, processes for their manufacture, preparations containing such compounds, and their use
US4340588A (en) * 1980-03-28 1982-07-20 Research Corporation Brucellosis vaccine for cattle containing mycolate esters of trehalose
US4310514A (en) * 1980-05-05 1982-01-12 Merck & Co., Inc. Immunologically active dipeptidyl 5-0,6-0-acyl-2-amino-2-deoxy-D-glucofuranose derivatives and methods of preparation
US4315913A (en) * 1980-06-09 1982-02-16 Merck & Co. Inc. Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
GR78246B (fr) * 1981-01-23 1984-09-26 Ciba Geigy Ag
JPS5920297A (ja) * 1982-07-27 1984-02-01 Dai Ichi Seiyaku Co Ltd ムラミルジペプチド誘導体
US4933179A (en) * 1983-08-22 1990-06-12 Syntex (U.S.A.) Inc. Feline leukemia virus antigen vaccines
US4770874A (en) * 1983-08-22 1988-09-13 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4606918A (en) * 1983-08-22 1986-08-19 Syntex (U.S.A.) Inc. Polyoxypropylene-polyoxyethylene block polymer based adjuvants
US4772466A (en) * 1983-08-22 1988-09-20 Syntex (U.S.A.) Inc. Vaccines comprising polyoxypropylene-polyoxyethylene block polymer based adjuvants
FR2564096B1 (fr) * 1984-05-11 1988-02-19 Anvar Derives lipophiles de muramylpeptides ayant des proprietes d'activation des macrophages, compositions les contenant et procede pour les obtenir
DK585886A (da) * 1985-12-24 1987-06-25 Takeda Chemical Industries Ltd Immunstimulerende middel og anvendelse deraf
US5554372A (en) * 1986-09-22 1996-09-10 Emory University Methods and vaccines comprising surface-active copolymers
US4895835A (en) * 1987-11-20 1990-01-23 Nisshin Oil Mills, Ltd. Muramyl peptide derivatives and use thereof
US5149529A (en) * 1988-04-08 1992-09-22 Board Of Trustees Of Leland Chiron Corporation Compositions and treatment for herpes simplex
US5416070A (en) * 1988-07-08 1995-05-16 Immunotherapeutics, Inc. Composition for macrophage activation
US4950645A (en) * 1988-07-08 1990-08-21 Immunotherapeutics, Inc. Composition for macrophage activation
DE3840538A1 (de) * 1988-12-01 1990-06-07 Helopharm Petrik Co Kg Peptidoglucan-dimere, verfahren zu ihrer herstellung und ihre verwendung als immunmodulatoren
GB9320820D0 (en) * 1993-10-08 1993-12-01 Biokine Tech Ltd Compounds for medicinal use
US6156319A (en) 1994-07-25 2000-12-05 The Trustees Of The University Of Pennsylvania Soluble herpesvirus glycoprotein complex vaccine
AU4251300A (en) 1999-05-07 2000-11-21 University Of Virginia Patent Foundation Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
WO2005013918A2 (fr) 2003-02-28 2005-02-17 The Trustees Of The University Of Pennsylvania Compositions, methodes et kits de vaccins a base de sous-unite de poxvirus
CA2574572A1 (fr) * 2004-07-19 2006-10-26 Baylor College Of Medicine Modulation des regulateurs de la signalisation des cytokines et applications en immunotherapie
CA2605583C (fr) * 2005-06-08 2013-05-28 Newbiomed Pika Pte Ltd Adjuvant a base d'acide polyinosinique/polycytidylique
US7868159B2 (en) * 2005-06-23 2011-01-11 Baylor College Of Medicine Modulation of negative immune regulators and applications for immunotherapy
US20070166239A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Mucosal immunogenic substances comprising a polyinosinic acid - polycytidilic acid based adjuvant
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
EP2136832B1 (fr) 2007-03-26 2015-09-02 General Regeneratives Limited Procédés pour favoriser la protection et la régénération de la moelle osseuse au moyen de cxcl9 et d'anticorps anti-cxcl9
JP2011505144A (ja) * 2007-11-30 2011-02-24 ベイラー カレッジ オブ メディシン 樹状細胞ワクチン組成物およびその使用
WO2011038002A1 (fr) 2009-09-22 2011-03-31 Yale University Epitopes immunogènes en tant que cibles pour des vaccins universels contre le cancer
EP2741785B1 (fr) 2011-07-12 2018-09-05 Philadelphia Health and Education Corporation Nouveau vaccin à adn dirigé contre clostridium difficile
WO2015116178A1 (fr) 2014-01-31 2015-08-06 Thomas Jefferson University Protéines de fusion pour la modulation des lymphocytes t régulateurs et effecteurs
US9834610B2 (en) 2013-01-31 2017-12-05 Thomas Jefferson University Fusion proteins for modulating regulatory and effector T cells
WO2016138286A1 (fr) 2015-02-26 2016-09-01 Stc.Unm Irgm et commandes de l'autophagie de précision contre des maladies bactériennes et inflammatoires et procédés de détection de l'autophagie
WO2020140007A1 (fr) 2018-12-28 2020-07-02 University Of Rochester Thérapie génique pour mutations dominantes best1

Also Published As

Publication number Publication date
CH624124A5 (fr) 1981-07-15
NL7706948A (nl) 1977-12-28
SE446740B (sv) 1986-10-06
DE2728324A1 (de) 1978-01-12
NL171063C (nl) 1983-02-01
SU793384A3 (ru) 1980-12-30
CA1105005A (fr) 1981-07-14
DE2728324C2 (fr) 1988-07-07
GB1563561A (en) 1980-03-26
US4101536A (en) 1978-07-18
SE7707276L (sv) 1978-02-10
FR2375249B1 (fr) 1980-04-11
NL171063B (nl) 1982-09-01

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