FR2384775A1 - Derives de la morphine, leur procede de preparation et leur application comme medicament - Google Patents

Derives de la morphine, leur procede de preparation et leur application comme medicament

Info

Publication number
FR2384775A1
FR2384775A1 FR7808405A FR7808405A FR2384775A1 FR 2384775 A1 FR2384775 A1 FR 2384775A1 FR 7808405 A FR7808405 A FR 7808405A FR 7808405 A FR7808405 A FR 7808405A FR 2384775 A1 FR2384775 A1 FR 2384775A1
Authority
FR
France
Prior art keywords
preparation
application
medicinal product
morphine derivatives
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7808405A
Other languages
English (en)
Other versions
FR2384775B1 (fr
Inventor
Ryszard Jurek Kobylecki
Ian Geoffrey Guest
John William Lewis
Gordon William Kirby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of FR2384775A1 publication Critical patent/FR2384775A1/fr
Application granted granted Critical
Publication of FR2384775B1 publication Critical patent/FR2384775B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Abstract

L'invention concerne de nouveaux dérivés de la morphine ainsi que leur procédé de préparation. Les dérivés répondent à la formule générale :
FR7808405A 1977-03-23 1978-03-22 Derives de la morphine, leur procede de preparation et leur application comme medicament Granted FR2384775A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12342/77A GB1587831A (en) 1977-03-23 1977-03-23 Morphine derivatives

Publications (2)

Publication Number Publication Date
FR2384775A1 true FR2384775A1 (fr) 1978-10-20
FR2384775B1 FR2384775B1 (fr) 1981-04-30

Family

ID=10002756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7808405A Granted FR2384775A1 (fr) 1977-03-23 1978-03-22 Derives de la morphine, leur procede de preparation et leur application comme medicament

Country Status (25)

Country Link
US (1) US4241067A (fr)
JP (1) JPS53121798A (fr)
AR (1) AR218296A1 (fr)
AT (1) AT360664B (fr)
AU (1) AU518614B2 (fr)
BE (1) BE865182A (fr)
CA (1) CA1089455A (fr)
CH (1) CH630629A5 (fr)
CS (1) CS199522B2 (fr)
DD (1) DD135081A5 (fr)
DE (1) DE2812581A1 (fr)
DK (1) DK149753C (fr)
ES (1) ES468170A1 (fr)
FR (1) FR2384775A1 (fr)
GB (1) GB1587831A (fr)
HU (1) HU177722B (fr)
IE (1) IE46442B1 (fr)
IT (1) IT1105172B (fr)
LU (1) LU79295A1 (fr)
NL (1) NL7803084A (fr)
NZ (1) NZ186693A (fr)
PL (1) PL111722B1 (fr)
SE (1) SE436132B (fr)
SU (1) SU856381A3 (fr)
ZA (1) ZA781525B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
EP0103636B1 (fr) * 1982-03-16 1990-09-12 Rockefeller University Utilisation d'antagonistes d'opium pour la preparation de medicaments pour reduire la dysmotilite gastro-intestinale
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
WO1993015081A1 (fr) 1992-01-23 1993-08-05 Toray Industries, Inc. Derive de morphinane et utilisation en medicine
JP3948026B2 (ja) * 1993-07-19 2007-07-25 東レ株式会社 脳細胞保護剤
JP3843456B2 (ja) * 1993-07-23 2006-11-08 東レ株式会社 モルヒナン誘導体および医薬用途
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
CA2610859C (fr) 2005-06-16 2013-11-12 Peter Xianqi Wang Trajet synthetique vers 14-hydroxyl opiates 1-halo-thebaine ou analogues
ES2784690T3 (es) 2013-12-05 2020-09-29 Univ Bath Nuevos compuestos opioides y sus usos

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives

Also Published As

Publication number Publication date
AT360664B (de) 1981-01-26
BE865182A (fr) 1978-09-22
US4241067A (en) 1980-12-23
HU177722B (en) 1981-12-28
PL111722B1 (en) 1980-09-30
AU3435678A (en) 1979-09-27
NZ186693A (en) 1979-10-25
IT1105172B (it) 1985-10-28
GB1587831A (en) 1981-04-08
SE436132B (sv) 1984-11-12
IE46442B1 (en) 1983-06-15
NL7803084A (nl) 1978-09-26
CS199522B2 (en) 1980-07-31
CA1089455A (fr) 1980-11-11
SU856381A3 (ru) 1981-08-15
AU518614B2 (en) 1981-10-08
PL205497A1 (pl) 1979-06-04
ATA204378A (de) 1980-06-15
IE780514L (en) 1978-09-23
JPS53121798A (en) 1978-10-24
DD135081A5 (de) 1979-04-11
DK129978A (da) 1978-09-24
AR218296A1 (es) 1980-05-30
ZA781525B (en) 1979-04-25
ES468170A1 (es) 1979-01-01
DK149753C (da) 1987-07-06
DE2812581A1 (de) 1978-09-28
IT7848545A0 (it) 1978-03-22
SE7803329L (sv) 1978-09-24
FR2384775B1 (fr) 1981-04-30
CH630629A5 (fr) 1982-06-30
JPS6259112B2 (fr) 1987-12-09
LU79295A1 (fr) 1979-10-29
DK149753B (da) 1986-09-22

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Legal Events

Date Code Title Description
ST Notification of lapse