FR2413389A1 - Composes a tete de pont azotee ayant une action anti-allergique et procede pour leur preparation - Google Patents

Composes a tete de pont azotee ayant une action anti-allergique et procede pour leur preparation

Info

Publication number
FR2413389A1
FR2413389A1 FR7836461A FR7836461A FR2413389A1 FR 2413389 A1 FR2413389 A1 FR 2413389A1 FR 7836461 A FR7836461 A FR 7836461A FR 7836461 A FR7836461 A FR 7836461A FR 2413389 A1 FR2413389 A1 FR 2413389A1
Authority
FR
France
Prior art keywords
hydrogen
compounds
nitrogened
bridge
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7836461A
Other languages
English (en)
Other versions
FR2413389B1 (fr
Inventor
Istvan Hermecz
Zoltan Meszaros
Tibor Breining
Sandor Virag
Lelle Vasvari
Agnes Horvath
Gabor Nagy
Attila Mandi
Tamas Szucs
Istvan Bitter
Gyula Sebestyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2413389A1 publication Critical patent/FR2413389A1/fr
Application granted granted Critical
Publication of FR2413389B1 publication Critical patent/FR2413389B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX. IL S'AGIT DE COMPOSES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) ET LEURS SELS, HYDRATES, STEREOISOMERES, ISOMERES OPTIQUEMENT ACTIFS ET GEOMETRIQUES ET FORMES TAUTOMERES UTILISABLES EN PHARMACIE, OU R REPRESENTE UN HYDROGENE OU UN ALCOYLE INFERIEUR, R EST UN HYDROGENE, UN ALCOYLE INFERIEUR, UN STYRYLE OU UN GROUPE CARBOXYLIQUE OU UN DERIVE DE CE GROUPE; OU R ET R FORMENT ENSEMBLE UN GROUPE DE FORMULE -(CHCH)- ET, DANS CE CAS, LA LIGNE POINTILLEE REPRESENTE UNE LIAISON C-C SUPPLEMENTAIRE ALORS QUE DANS TOUS LES AUTRES CAS IL EXISTE UNE SEULE LIAISON ENTRE LES POSITIONS 6 ET 7; R EST UN HYDROGENE, UN ALCOYLE INFERIEUR OU UN HYDROXY; R EST UN HYDROGENE, UN ALCOYLE INFERIEUR, UN ARYLE, UN ALCANOYLE INFERIEUR, UN GROUPOU R EST UN HYDROGENE ET R EST UN PHENYLE EVENTUELLEMENT SUBSTITUE; Z REPRESENTE UN ATOME D'OXYGENE ET N1. CES COMPOSES SONT UTILES COMME MEDICAMENTS.
FR7836461A 1977-12-29 1978-12-27 Composes a tete de pont azotee ayant une action anti-allergique et procede pour leur preparation Granted FR2413389A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1794A HU178496B (en) 1977-12-29 1977-12-29 Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Publications (2)

Publication Number Publication Date
FR2413389A1 true FR2413389A1 (fr) 1979-07-27
FR2413389B1 FR2413389B1 (fr) 1982-03-26

Family

ID=10994683

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836461A Granted FR2413389A1 (fr) 1977-12-29 1978-12-27 Composes a tete de pont azotee ayant une action anti-allergique et procede pour leur preparation

Country Status (29)

Country Link
US (2) US4234586A (fr)
JP (1) JPS5495598A (fr)
AR (3) AR222985A1 (fr)
AT (1) AT375936B (fr)
AU (1) AU520428B2 (fr)
BE (1) BE873194A (fr)
CA (1) CA1130284A (fr)
CH (1) CH642078A5 (fr)
CS (1) CS244654B2 (fr)
DD (1) DD139854A5 (fr)
DE (1) DE2854115A1 (fr)
DK (1) DK157022C (fr)
ES (7) ES476442A1 (fr)
FI (1) FI66614C (fr)
FR (1) FR2413389A1 (fr)
GB (1) GB2011898B (fr)
GR (1) GR68357B (fr)
HU (1) HU178496B (fr)
IL (1) IL56078A (fr)
IT (1) IT1203210B (fr)
LU (1) LU80601A1 (fr)
NL (1) NL7812547A (fr)
NO (1) NO151287C (fr)
PL (5) PL119641B1 (fr)
PT (1) PT68935A (fr)
SE (1) SE438675B (fr)
SU (2) SU999972A3 (fr)
YU (3) YU42093B (fr)
ZA (1) ZA787385B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485534A1 (fr) * 1980-06-24 1981-12-31 Chinoin Gyogyszer Es Vegyeszet 6-hydrazono-pyrido(2,1-b)quinazoline-11-ones et procede pour leur preparation
WO2009156865A1 (fr) * 2008-06-26 2009-12-30 Mitsubishi Tanabe Pharma Corporation Dérivés de pyrimidin-4-one substitués
EP2138494A1 (fr) * 2008-06-26 2009-12-30 Sanofi-Aventis Dérivés substitués d'alkyl pyrimidin-4-one
US8202874B2 (en) 2008-06-26 2012-06-19 Mitsubishi Tanabe Pharma Corporation Substituted N-oxide pyrazine derivatives
US8211903B2 (en) 2008-06-26 2012-07-03 Mitsubishi Tanabe Pharma Corporation Substituted pyrimido isoquinoline derivatives
US8273758B2 (en) 2008-06-26 2012-09-25 Sanofi Substituted tricyclic derivatives
US8592580B2 (en) 2008-06-26 2013-11-26 Sanofi Substituted triazinone derivatives
US9073915B2 (en) 2008-06-26 2015-07-07 Sanofi Substituted pyrimidone derivatives

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
US4482557A (en) * 1979-05-11 1984-11-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity
HU176942B (hu) * 1979-05-11 1981-06-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija 2,3- i 3,4-dvuzamehhjonnykh tetragidro-pirrolo!1,2-a!-pirimidinov
HU178452B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives
HU179443B (en) * 1979-05-11 1982-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines
HU178453B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
AT381093B (de) * 1980-06-24 1986-08-25 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung neuer 6-hydrazono-pyrido(2,1-b)chinazolin-11-on-deriv te, von deren salzen sowie von deren stereomeren
HU183408B (en) 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
US4395549A (en) * 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
US5344933A (en) * 1991-09-11 1994-09-06 Fuji Photo Film Co., Ltd. Pyrrole ring-or condensed pyrrole ring-containing azomethine dye
EP1790649A1 (fr) * 2005-11-21 2007-05-30 Sanofi-Aventis Dérivés de pyrimidone substitués bicycliques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7813M (fr) * 1966-11-02 1970-05-20

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786056A (en) * 1954-05-03 1957-03-19 Merck & Co Inc Acylamido-hydroxy pteridines and preparation thereof
US2894031A (en) * 1958-09-16 1959-07-07 Grace W R & Co Process for cyclohexanone hydrazone hydrate
US3140315A (en) * 1959-02-18 1964-07-07 Bayer Ag Alkyl-substituted hydrazines and hydrazones and process for preparation thereof
FR1255365A (fr) * 1959-12-22 1961-03-10 Cfmc Nouveaux colorants basiques, leur procédé de préparation et leurs applications
US3141043A (en) * 1961-03-24 1964-07-14 Purdue Research Foundation Cyclopentadienylimines, process for their production and condensation products thereof
CH441366A (de) * 1961-06-09 1967-08-15 Hoffmann La Roche Verfahren zur Herstellung von substituierten Hydrazinverbindungen
US3417082A (en) * 1965-08-16 1968-12-17 Polaroid Corp Novel chemical compounds and syntheses
HU168014B (fr) * 1973-03-30 1976-02-28
US4024132A (en) * 1973-09-07 1977-05-17 Ciba-Geigy Corporation Azomethine pigments
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7813M (fr) * 1966-11-02 1970-05-20

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2485534A1 (fr) * 1980-06-24 1981-12-31 Chinoin Gyogyszer Es Vegyeszet 6-hydrazono-pyrido(2,1-b)quinazoline-11-ones et procede pour leur preparation
WO2009156865A1 (fr) * 2008-06-26 2009-12-30 Mitsubishi Tanabe Pharma Corporation Dérivés de pyrimidin-4-one substitués
EP2138492A1 (fr) * 2008-06-26 2009-12-30 Sanofi-Aventis Dérivés substitués de pyrimidin-4-one
EP2138494A1 (fr) * 2008-06-26 2009-12-30 Sanofi-Aventis Dérivés substitués d'alkyl pyrimidin-4-one
WO2009156864A3 (fr) * 2008-06-26 2010-04-01 Mitsubishi Tanabe Pharma Corporation Dérivés pyrimidin-4-one à substitution alkyle
US8202874B2 (en) 2008-06-26 2012-06-19 Mitsubishi Tanabe Pharma Corporation Substituted N-oxide pyrazine derivatives
US8211903B2 (en) 2008-06-26 2012-07-03 Mitsubishi Tanabe Pharma Corporation Substituted pyrimido isoquinoline derivatives
US8273758B2 (en) 2008-06-26 2012-09-25 Sanofi Substituted tricyclic derivatives
US8592580B2 (en) 2008-06-26 2013-11-26 Sanofi Substituted triazinone derivatives
US8614219B2 (en) 2008-06-26 2013-12-24 Sanofi-Aventis Substituted pyrimidin-4-one derivatives
US9073915B2 (en) 2008-06-26 2015-07-07 Sanofi Substituted pyrimidone derivatives
US9073914B2 (en) 2008-06-26 2015-07-07 Sanofi Substituted alkyl pyrimidin-4-one derivatives

Also Published As

Publication number Publication date
YU41538B (en) 1987-08-31
GB2011898A (en) 1979-07-18
AR228949A1 (es) 1983-05-13
US4461769A (en) 1984-07-24
GR68357B (fr) 1981-12-23
CH642078A5 (de) 1984-03-30
IT7869933A0 (it) 1978-12-22
FI66614C (fi) 1984-11-12
ES481747A1 (es) 1980-07-01
YU279582A (en) 1983-10-31
FR2413389B1 (fr) 1982-03-26
YU42062B (en) 1988-04-30
YU42093B (en) 1988-04-30
ZA787385B (en) 1980-02-27
NL7812547A (nl) 1979-07-03
DE2854115A1 (de) 1979-07-12
ES481748A1 (es) 1980-07-01
FI66614B (fi) 1984-07-31
NO151287B (no) 1984-12-03
AT375936B (de) 1984-09-25
DD139854A5 (de) 1980-01-23
SU999972A3 (ru) 1983-02-23
BE873194A (fr) 1979-04-17
NO151287C (no) 1985-03-13
DK157022B (da) 1989-10-30
SU978730A3 (ru) 1982-11-30
PL122965B1 (en) 1982-09-30
PL119641B1 (en) 1982-01-30
AR227882A1 (es) 1982-12-30
DE2854115C2 (fr) 1988-07-28
PL119520B1 (en) 1982-01-30
JPS5495598A (en) 1979-07-28
ATA873678A (de) 1984-02-15
PL212212A1 (fr) 1980-02-25
CA1130284A (fr) 1982-08-24
PL119501B1 (en) 1982-01-30
DK157022C (da) 1990-04-02
AU520428B2 (en) 1982-01-28
ES481745A1 (es) 1980-07-01
PL125321B1 (en) 1983-04-30
AU4262778A (en) 1979-07-05
ES481746A1 (es) 1980-07-01
PT68935A (en) 1979-01-01
ES476442A1 (es) 1979-11-16
IL56078A (en) 1982-11-30
US4234586A (en) 1980-11-18
CS244654B2 (en) 1986-08-14
ES481744A1 (es) 1980-06-16
AR222985A1 (es) 1981-07-15
IL56078A0 (en) 1979-01-31
DK585578A (da) 1979-06-30
GB2011898B (en) 1982-04-28
NO784393L (no) 1979-07-02
FI784013A (fi) 1979-06-30
YU296478A (en) 1983-10-31
HU178496B (en) 1982-05-28
SE7813226L (sv) 1979-06-30
CS909178A2 (en) 1985-08-15
LU80601A1 (de) 1979-03-22
SE438675B (sv) 1985-04-29
IT1203210B (it) 1989-02-15
ES481749A1 (es) 1980-07-01
JPH0146514B2 (fr) 1989-10-09
YU279682A (en) 1983-10-31

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