FR2438651A1 - Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant - Google Patents

Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2438651A1
FR2438651A1 FR7925446A FR7925446A FR2438651A1 FR 2438651 A1 FR2438651 A1 FR 2438651A1 FR 7925446 A FR7925446 A FR 7925446A FR 7925446 A FR7925446 A FR 7925446A FR 2438651 A1 FR2438651 A1 FR 2438651A1
Authority
FR
France
Prior art keywords
group
hydrogen atom
atom
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7925446A
Other languages
English (en)
Other versions
FR2438651B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2438651A1 publication Critical patent/FR2438651A1/fr
Application granted granted Critical
Publication of FR2438651B1 publication Critical patent/FR2438651B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX ET DES PROCEDES POUR LEUR PREPARATION. IL S'AGIT DE DERIVES D'INDOLE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE LES DIFFERENTS SYMBOLES PEUVENT AVOIR, ENTRE AUTRES, LES SIGNFICATIONS SUIVANTES: R REPRESENTE UN ATOME D'HYDROGENE; RREPRESENTE UN ATOME D'HYDROGENE, OU UN GROUPE ARALCOYLE, CYCLOALCOYLE, OU ALCOYLE, LEQUEL GROUPE ALCOYLE PEUT ETRE NON SUBSTITUE OU SUBSTITUE PAR UN GROUPE ALCENYLE OU PAR LE GROUPE -OR; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALCOYLE; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ARALCOYLE, FLUOROALCOYLE OU ALCOYLE NON SUBSTITUE OU R ET R FORMENT ENSEMBLE UN GROUPE ARALCOYLIDENE OU ENSEMBLE AVEC L'ATOME D'AZOTE AUQUEL ILS SONT ATTACHES FORMENT UN NOYAU MONOCYCLIQUE SATURE A 5 A 7 CHAINONS CONTENANT UNE AUTRE HETERO-FONCTION; R REPRESENTE UN ATOME D'HYDROGENE, UN GROUPE ALCOYLE OU UN GROUPE BENZYLE; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALCOYLE; ALC REPRESENTE UN GROUPE ALCOYLENE CONTENANT 2 OU 3 ATOMES DE CARBONE; ET XREPRESENTE UN ATOME D'OXYGENE OU DE SOUFRE. CES COMPOSES SONT UTILES COMME MEDICAMENTS.
FR7925446A 1978-10-12 1979-10-12 Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant Granted FR2438651A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7840279 1978-10-12

Publications (2)

Publication Number Publication Date
FR2438651A1 true FR2438651A1 (fr) 1980-05-09
FR2438651B1 FR2438651B1 (fr) 1983-03-04

Family

ID=10500283

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925446A Granted FR2438651A1 (fr) 1978-10-12 1979-10-12 Nouveaux derives d'indole utiles comme medicaments, procedes pour leur preparation et compositions pharmaceutiques les contenant

Country Status (18)

Country Link
US (1) US4252803A (fr)
JP (1) JPS5562063A (fr)
AU (1) AU531783B2 (fr)
BE (1) BE879381A (fr)
CA (1) CA1146550A (fr)
CH (1) CH646151A5 (fr)
DE (1) DE2940687A1 (fr)
DK (1) DK425579A (fr)
ES (2) ES8100261A1 (fr)
FI (1) FI793071A (fr)
FR (1) FR2438651A1 (fr)
GB (1) GB2035310B (fr)
IE (1) IE49304B1 (fr)
IT (1) IT1142170B (fr)
NL (1) NL7907583A (fr)
NZ (1) NZ191802A (fr)
SE (1) SE448628B (fr)
ZA (1) ZA795239B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488607A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives de l'indole, leur preparation et leurs utilisations pharmaceutiques
FR2488605A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives de l'indole, leur preparation et leurs utilisations therapeutiques
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F

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ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
AT381491B (de) * 1980-08-12 1986-10-27 Glaxo Group Ltd Verfahren zur herstellung von neuen indolverbindungen und ihren salzen
US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
US4582848A (en) * 1982-06-10 1986-04-15 Sandoz, Inc. 2-substituted-3-indolamines and use thereof as anti-diabetics
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
US4521606A (en) * 1983-06-30 1985-06-04 American Home Products Corp. 5-Indolyl substituted aminoethanols
US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
AU571922B2 (en) * 1984-01-26 1988-04-28 Schering Agrochemicals Limited Veterinary implants comprising melatonin and derivatives thereof
US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3537289A1 (de) * 1985-10-19 1987-04-23 Hoechst Ag 2-(3-brompropyl)-5,5-dimethyl-1,3-dioxan, sowie verfahren zur herstellung desselben und des 2-(4-brombutyl)-5,5-dimethyl-1,3-dioxans
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
AU601736B2 (en) * 1986-05-23 1990-09-20 Sanofi Sante Nutrition Animale Sa Coated veterinary implants
GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8830312D0 (en) * 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US5276045A (en) * 1989-06-16 1994-01-04 Rhone-Poulenc Sante Thioformamide derivative, process for its preparation, pharmaceutical composition thereof and treatment method
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
DE4101686A1 (de) * 1991-01-22 1992-07-23 Merck Patent Gmbh Indolderivate
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
TW288010B (fr) * 1992-03-05 1996-10-11 Pfizer
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
AU670579B2 (en) 1992-04-07 1996-07-25 Pfizer Inc. Indole derivatives as 5-HT1 agonists
DK0635015T3 (da) * 1992-04-10 1997-03-17 Pfizer Acylaminoindolderivater som 5-Htl agonister
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GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
DE69413240T2 (de) * 1993-08-31 1999-02-04 Pfizer 5-arylindolderivate
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
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CZ183198A3 (cs) 1995-12-14 1998-10-14 Merck And Co., Inc. Nepeptidové deriváty, antagonizující hormon, uvolňující gonadotropin a farmaceutický prostředek
US5756507A (en) * 1995-12-14 1998-05-26 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
EP0871624A1 (fr) * 1995-12-14 1998-10-21 Merck & Co., Inc. Antagonistes de l'hormone de liberaiton de la gonadotropine
US5780437A (en) * 1995-12-14 1998-07-14 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5849764A (en) * 1995-12-14 1998-12-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
JP2002502427A (ja) * 1997-06-05 2002-01-22 メルク エンド カンパニー インコーポレーテッド ゴナドトロピン放出ホルモンの拮抗薬
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US6159975A (en) * 1998-02-11 2000-12-12 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
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US6025366A (en) * 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
AU3514200A (en) 1999-03-10 2000-09-28 Merck & Co., Inc. 6-azaindole compounds as antagonists of gonadotropin releasing hormone
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CN1729174B (zh) * 2002-12-20 2015-10-21 西巴特殊化学品控股有限公司 胺的合成以及用于合成胺的中间体
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FR2211249A1 (en) * 1972-12-21 1974-07-19 Merck & Co Inc Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active

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US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
DE2314489A1 (de) * 1973-03-23 1974-10-03 Thomae Gmbh Dr K (+)-3-(2-dimethylamino-1-propyl)-2methyl-3-phenyl-3h-indol, dessen saeureadditionssalze und verfahren zu deren herstellung
US3997539A (en) * 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof

Patent Citations (1)

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FR2211249A1 (en) * 1972-12-21 1974-07-19 Merck & Co Inc Cyclopropyl-substd. indomethacine analogues - anti-inflammatory, anti-pyretics, anti-arthritic and dermatologically active

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488607A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives de l'indole, leur preparation et leurs utilisations pharmaceutiques
FR2488605A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives de l'indole, leur preparation et leurs utilisations therapeutiques
FR2488606A1 (fr) * 1980-08-12 1982-02-19 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
EP0875513A1 (fr) * 1997-04-14 1998-11-04 Eli Lilly And Company Composés hétéroaromatiques substitués agonistes du récepteur 5-HT1F

Also Published As

Publication number Publication date
FI793071A (fi) 1980-04-13
BE879381A (fr) 1980-02-01
JPS6358817B2 (fr) 1988-11-17
IT1142170B (it) 1986-10-08
DE2940687C2 (fr) 1991-08-01
ES484980A0 (es) 1980-11-01
IE791945L (en) 1980-04-12
IE49304B1 (en) 1985-09-18
AU5165779A (en) 1980-04-17
CH646151A5 (de) 1984-11-15
DE2940687A1 (de) 1980-04-30
NL7907583A (nl) 1980-04-15
SE448628B (sv) 1987-03-09
ES492114A0 (es) 1981-07-16
AU531783B2 (en) 1983-09-08
GB2035310B (en) 1982-12-22
GB2035310A (en) 1980-06-18
ES8100261A1 (es) 1980-11-01
DK425579A (da) 1980-04-13
CA1146550A (fr) 1983-05-17
SE7908443L (sv) 1980-04-13
US4252803A (en) 1981-02-24
ZA795239B (en) 1980-11-26
JPS5562063A (en) 1980-05-10
NZ191802A (en) 1983-02-15
ES8106142A1 (es) 1981-07-16
FR2438651B1 (fr) 1983-03-04
IT7950537A0 (it) 1979-10-11

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