ES8106142A1 - Un procedimiento para la preparacion de un indol - Google Patents

Un procedimiento para la preparacion de un indol

Info

Publication number
ES8106142A1
ES8106142A1 ES492114A ES492114A ES8106142A1 ES 8106142 A1 ES8106142 A1 ES 8106142A1 ES 492114 A ES492114 A ES 492114A ES 492114 A ES492114 A ES 492114A ES 8106142 A1 ES8106142 A1 ES 8106142A1
Authority
ES
Spain
Prior art keywords
group
alkyl
hydrogen atom
aryl
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES492114A
Other languages
English (en)
Other versions
ES492114A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8106142A1 publication Critical patent/ES8106142A1/es
Publication of ES492114A0 publication Critical patent/ES492114A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

METODO DE OBTENCION DE UN INDOL DE FORMULA (I), DONDE ALQ ES UN GRUPO ALQUILENO DE 1 A 4 CARBONOS, X ES OXIGENO O AZUFRE Y R1, ..., R6 PUEDEN SER DIFERENTES RADICALES. SE OBTIENE EL COMPUESTO HACIENDO REACCIONAR UN DERIVADO ACTIVADO DE ACIDO CARBOXILICO, DE FORMULA (II), DONDE T PUEDE SER UN GRUPO YOC, SIENDO Y UN GRUPO SALIENTE, CON UN REACTIVO DE FORMULA (III), SIENDO R1, R2, HIDROGENO, GRUPO ARILO, ARALQUILO, CICLOALQUILO, FLUROALQUILO O ALQUILO; EN PRESENCIA DE UN DISOLVENTE COMO AGUA O UN ALCANOL, A UNA TEMPERATURA ADECUADA, MENOR QUE LA TEMPERATURA DE REFLUJO DE LA MEZCLA. DE APLICACION EN EL TRATAMIENTO DE LOS TRASTORNOS CARDIOVASCULARES. *FORMULA*
ES492114A 1978-10-12 1980-06-03 Un procedimiento para la preparacion de un indol Granted ES492114A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7840279 1978-10-12

Publications (2)

Publication Number Publication Date
ES8106142A1 true ES8106142A1 (es) 1981-07-16
ES492114A0 ES492114A0 (es) 1981-07-16

Family

ID=10500283

Family Applications (2)

Application Number Title Priority Date Filing Date
ES484980A Granted ES484980A0 (es) 1978-10-12 1979-10-11 Un procedimiento para la preparacion de un indol
ES492114A Granted ES492114A0 (es) 1978-10-12 1980-06-03 Un procedimiento para la preparacion de un indol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES484980A Granted ES484980A0 (es) 1978-10-12 1979-10-11 Un procedimiento para la preparacion de un indol

Country Status (18)

Country Link
US (1) US4252803A (es)
JP (1) JPS5562063A (es)
AU (1) AU531783B2 (es)
BE (1) BE879381A (es)
CA (1) CA1146550A (es)
CH (1) CH646151A5 (es)
DE (1) DE2940687A1 (es)
DK (1) DK425579A (es)
ES (2) ES484980A0 (es)
FI (1) FI793071A (es)
FR (1) FR2438651A1 (es)
GB (1) GB2035310B (es)
IE (1) IE49304B1 (es)
IT (1) IT1142170B (es)
NL (1) NL7907583A (es)
NZ (1) NZ191802A (es)
SE (1) SE448628B (es)
ZA (1) ZA795239B (es)

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DE3131752A1 (de) * 1980-08-12 1982-06-16 Glaxo Group Ltd., London Heterocyclische verbindungen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
AT381491B (de) * 1980-08-12 1986-10-27 Glaxo Group Ltd Verfahren zur herstellung von neuen indolverbindungen und ihren salzen
AU548467B2 (en) * 1980-08-12 1985-12-12 Glaxo Group Limited Tryptamines and their isoindolylethyl derivatives
US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
GR79215B (es) * 1982-06-07 1984-10-22 Glaxo Group Ltd
US4582848A (en) * 1982-06-10 1986-04-15 Sandoz, Inc. 2-substituted-3-indolamines and use thereof as anti-diabetics
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4521606A (en) * 1983-06-30 1985-06-04 American Home Products Corp. 5-Indolyl substituted aminoethanols
US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8332437D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
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US5026869A (en) * 1984-02-06 1991-06-25 Eli Lilly And Company 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3537289A1 (de) * 1985-10-19 1987-04-23 Hoechst Ag 2-(3-brompropyl)-5,5-dimethyl-1,3-dioxan, sowie verfahren zur herstellung desselben und des 2-(4-brombutyl)-5,5-dimethyl-1,3-dioxans
DE3678805D1 (de) * 1985-11-08 1991-05-23 Glaxo Group Ltd Indolderivate.
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
AU601736B2 (en) * 1986-05-23 1990-09-20 Sanofi Sante Nutrition Animale Sa Coated veterinary implants
GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
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US5276045A (en) * 1989-06-16 1994-01-04 Rhone-Poulenc Sante Thioformamide derivative, process for its preparation, pharmaceutical composition thereof and treatment method
CA2042295A1 (fr) * 1990-05-15 1991-11-16 Jacques Chauveau Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant
YU48855B (sh) * 1990-06-07 2002-06-19 The Wellcome Foundation Limited Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja
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BR9206810A (pt) * 1991-11-25 1995-10-31 Pfizer Derivados de indol
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US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
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GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
AU670270B2 (en) * 1992-04-10 1996-07-11 Pfizer Inc. Acylaminoindole derivatives as 5-HT1 agonists
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GB9226566D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
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US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
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DE2314489A1 (de) * 1973-03-23 1974-10-03 Thomae Gmbh Dr K (+)-3-(2-dimethylamino-1-propyl)-2methyl-3-phenyl-3h-indol, dessen saeureadditionssalze und verfahren zu deren herstellung
US3997539A (en) * 1974-05-31 1976-12-14 American Hoechst Corporation 3-(4-Acylaminopiperazin-1-yl alkyl)indoles, precursors and processes for the preparation thereof

Also Published As

Publication number Publication date
FR2438651A1 (fr) 1980-05-09
FI793071A (fi) 1980-04-13
JPS6358817B2 (es) 1988-11-17
AU531783B2 (en) 1983-09-08
CH646151A5 (de) 1984-11-15
DK425579A (da) 1980-04-13
SE7908443L (sv) 1980-04-13
BE879381A (fr) 1980-02-01
ZA795239B (en) 1980-11-26
SE448628B (sv) 1987-03-09
NZ191802A (en) 1983-02-15
GB2035310B (en) 1982-12-22
IT7950537A0 (it) 1979-10-11
US4252803A (en) 1981-02-24
IE791945L (en) 1980-04-12
IT1142170B (it) 1986-10-08
ES8100261A1 (es) 1980-11-01
AU5165779A (en) 1980-04-17
NL7907583A (nl) 1980-04-15
ES492114A0 (es) 1981-07-16
CA1146550A (en) 1983-05-17
DE2940687A1 (de) 1980-04-30
GB2035310A (en) 1980-06-18
ES484980A0 (es) 1980-11-01
JPS5562063A (en) 1980-05-10
IE49304B1 (en) 1985-09-18
FR2438651B1 (es) 1983-03-04
DE2940687C2 (es) 1991-08-01

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