ES8402268A1 - Un procedimiento para la preparacion de un derivado del indol. - Google Patents

Un procedimiento para la preparacion de un derivado del indol.

Info

Publication number
ES8402268A1
ES8402268A1 ES513933A ES513933A ES8402268A1 ES 8402268 A1 ES8402268 A1 ES 8402268A1 ES 513933 A ES513933 A ES 513933A ES 513933 A ES513933 A ES 513933A ES 8402268 A1 ES8402268 A1 ES 8402268A1
Authority
ES
Spain
Prior art keywords
group
alkyl
compounds
hydrogen atom
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513933A
Other languages
English (en)
Other versions
ES513933A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES8402268A1 publication Critical patent/ES8402268A1/es
Publication of ES513933A0 publication Critical patent/ES513933A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN DERIVADO DEL INDOL, DE FORMULA (I), EN LA QUE R1, R3, R4, R6 Y R7, PUEDEN SER IGUALES O DIFERENTES, Y REPRESENTAN CADA UNO DE ELLOS UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO; R2 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO, ARILO, ARALQUILO O ALQUENILO; R5 REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO O ALQUENILO; ALK REPRESENTA UNA CADENA ALQUILENICA QUE CONTIENE 2 O 3 ATOMOS DE CARBONO; Y X REPRESENTA UN ATOMO DE OXIGENO O DE AZUFRE, Y SUS SALES FISIOLOGICAMENTE ACEPTABLES. CONSISTE EN SOMETER A CICLACION UNA HIDRAZONA DE FORMULA GENERAL (II), EN LA QUE Q ES EL GRUPO NR4R5 O UN DERIVADO PROTEGIDO DEL MISMO; Y R1, R2, R3, R4, R5, R6, R7, X Y ALK, TIENEN EL SIGNIFICADO YA MENCIONADO. DE APLICACION EN EL TRATAMIENTO DE LA MIGRAINA. *FORMULA*.
ES513933A 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol. Granted ES513933A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8026286 1980-08-12

Publications (2)

Publication Number Publication Date
ES8402268A1 true ES8402268A1 (es) 1984-01-16
ES513933A0 ES513933A0 (es) 1984-01-16

Family

ID=10515410

Family Applications (5)

Application Number Title Priority Date Filing Date
ES504693A Granted ES504693A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.
ES513933A Granted ES513933A0 (es) 1980-08-12 1982-07-13 Un procedimiento para la preparacion de un derivado del indol.
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Granted ES520785A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES504693A Granted ES504693A0 (es) 1980-08-12 1981-08-11 Un procedimiento para la preparacion de un derivado del indol.

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES520784A Granted ES520784A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520783A Granted ES520783A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.
ES520785A Granted ES520785A0 (es) 1980-08-12 1983-03-18 Un procedimiento para la preparacion de un derivado del indol.

Country Status (16)

Country Link
US (1) US4650810A (es)
JP (1) JPS5764669A (es)
AU (1) AU548467B2 (es)
BE (1) BE889929A (es)
CA (1) CA1169428A (es)
CH (1) CH651551A5 (es)
DE (1) DE3131728A1 (es)
DK (1) DK157920C (es)
ES (5) ES504693A0 (es)
FR (1) FR2488607A1 (es)
IE (1) IE51491B1 (es)
IT (1) IT1171449B (es)
NL (1) NL8103769A (es)
NZ (1) NZ197996A (es)
SE (1) SE454880B (es)
ZA (1) ZA815540B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084560A1 (es) * 1994-03-09 1996-05-01 Almirall Lab Procedimiento de preparacion de derivados el indol

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
US4833153A (en) * 1985-11-08 1989-05-23 Glaxo Group Limited Indole derivatives
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
US5270333A (en) * 1986-01-28 1993-12-14 Glaxo Group Limited Indole derivatives
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
AU646871B2 (en) * 1990-06-07 1994-03-10 Astrazeneca Uk Limited Therapeutic heterocyclic compounds
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
US5254383A (en) * 1992-09-14 1993-10-19 Allied-Signal Inc. Composites having improved penetration resistance and articles fabricated from same
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
US20030096379A1 (en) * 2001-03-28 2003-05-22 Kilgore James L. Method for producing tryptamine derivatives
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
CA2508290C (en) * 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthesis of amines and intermediates for the synthesis thereof
WO2008097664A1 (en) 2007-02-11 2008-08-14 Map Pharmaceuticals, Inc. Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile
US8173813B2 (en) * 2007-03-23 2012-05-08 Neuraxon, Inc. Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
KR20090125799A (ko) 2007-03-29 2009-12-07 아스비오파마 가부시키가이샤 Ｃｐｌａ2 저해 활성을 가지는 인돌 유도체 및 그 용도 및 제조 방법
WO2010151804A1 (en) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration of dihydroergotamine mesylate particles using a metered dose inhaler
PL2734634T3 (pl) 2011-07-22 2020-03-31 The University Of Chicago Igf-1 do zastosowania do leczenia migreny
CA2895816C (en) 2012-12-21 2021-02-23 Map Pharmaceuticals, Inc. 8'-hydroxy-dihydroergotamine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3182071A (en) * 1961-06-27 1965-05-04 Warner Lambert Pharmaceutical Acylated indole derivatives
US3472870A (en) * 1966-08-29 1969-10-14 Mead Johnson & Co Sulfonamidotryptamines
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2084560A1 (es) * 1994-03-09 1996-05-01 Almirall Lab Procedimiento de preparacion de derivados el indol

Also Published As

Publication number Publication date
IE51491B1 (en) 1987-01-07
IE811830L (en) 1982-02-12
BE889929A (fr) 1982-02-11
ES8500903A1 (es) 1984-11-01
DK157920C (da) 1990-08-06
ES8301210A1 (es) 1982-12-01
IT1171449B (it) 1987-06-10
JPH0247462B2 (es) 1990-10-19
IT8149084A0 (it) 1981-08-11
DE3131728C2 (es) 1992-04-30
ES8500902A1 (es) 1984-11-01
NZ197996A (en) 1985-08-16
DK357081A (da) 1982-02-13
SE454880B (sv) 1988-06-06
CA1169428A (en) 1984-06-19
ZA815540B (en) 1983-03-30
JPS5764669A (en) 1982-04-19
SE8104781L (sv) 1982-02-13
ES513933A0 (es) 1984-01-16
ES520784A0 (es) 1984-11-01
DK157920B (da) 1990-03-05
FR2488607A1 (fr) 1982-02-19
US4650810A (en) 1987-03-17
ES8504706A1 (es) 1985-05-01
ES520785A0 (es) 1984-11-01
ES520783A0 (es) 1985-05-01
DE3131728A1 (de) 1982-03-11
FR2488607B1 (es) 1984-11-16
AU548467B2 (en) 1985-12-12
NL8103769A (nl) 1982-03-01
AU7399481A (en) 1982-02-18
CH651551A5 (fr) 1985-09-30
ES504693A0 (es) 1982-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19901025