FR2447376A1 - Nouveaux derives de 1,2-dihydro-2-oxo-4-phenyl-3-quinoleinecarbonitrile, utiles notamment comme agents anti-inflammatoires - Google Patents

Nouveaux derives de 1,2-dihydro-2-oxo-4-phenyl-3-quinoleinecarbonitrile, utiles notamment comme agents anti-inflammatoires

Info

Publication number
FR2447376A1
FR2447376A1 FR8001874A FR8001874A FR2447376A1 FR 2447376 A1 FR2447376 A1 FR 2447376A1 FR 8001874 A FR8001874 A FR 8001874A FR 8001874 A FR8001874 A FR 8001874A FR 2447376 A1 FR2447376 A1 FR 2447376A1
Authority
FR
France
Prior art keywords
quinoleinecarbonitrile
dihydro
oxo
phenyl
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR8001874A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2447376A1 publication Critical patent/FR2447376A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

LES MEDICAMENTS SELON L'INVENTION REPONDENT A LA FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE (CH) EST UNE CHAINE DROITE EN C-C ET R ET R SONT IDENTIQUES OU DIFFERENTS ET REPRESENTENT CHACUN L'HYDROGENE OU UN ALKYLE INFERIEUR, AVEC LA CONDITION QUE L'UN AU MOINS DES RESTES R ET R EST UN ALKYLE INFERIEUR, OU BIEN R ET R, PRIS ENSEMBLE AVEC L'ATOME D'AZOTE, FORMENT UN RADICAL HETEROCYCLIQUE A 5 OU 6CHAINONS, ET R ET R SONT IDENTIQUES OU DIFFERENTS ET PEUVENT ETRE UN ATOME D'HYDROGENE OU D'HALOGENE OU UN GROUPE ALKYLE INFERIEUR, ALCOXY INFERIEUR OU TRIFLUOROMETHYLE. ON PEUT LES ADMINISTRER EN TABLETTES, CAPSULES OU SOLUBLES OU SUSPENSIONS INJECTABLES, POUR DES DOSES JOURNALIERES SIMPLES OU MULTIPLES D'ENVIRON1 A 150MGKG, EN UNE OU EN DEUX A QUATRE PRISES PAR JOUR.
FR8001874A 1979-01-29 1980-01-29 Nouveaux derives de 1,2-dihydro-2-oxo-4-phenyl-3-quinoleinecarbonitrile, utiles notamment comme agents anti-inflammatoires Withdrawn FR2447376A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/007,069 US4232027A (en) 1979-01-29 1979-01-29 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives

Publications (1)

Publication Number Publication Date
FR2447376A1 true FR2447376A1 (fr) 1980-08-22

Family

ID=21724050

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8001874A Withdrawn FR2447376A1 (fr) 1979-01-29 1980-01-29 Nouveaux derives de 1,2-dihydro-2-oxo-4-phenyl-3-quinoleinecarbonitrile, utiles notamment comme agents anti-inflammatoires

Country Status (6)

Country Link
US (1) US4232027A (fr)
JP (1) JPS55102568A (fr)
DE (1) DE3003146A1 (fr)
FR (1) FR2447376A1 (fr)
GB (1) GB2041361B (fr)
IT (1) IT1145403B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024638A1 (fr) * 1979-08-30 1981-03-11 Byk Gulden Lomberg Chemische Fabrik GmbH Acides quinoléinone alkylcarboxyliques substitués, leur préparation et médicaments les contenant
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
US5650410A (en) * 1994-03-08 1997-07-22 Takeda Chemical Industries, Ltd. Pharmaceutical composition containing quinoline or quinazoline derivatives and derivatives therefor
US7825131B2 (en) * 2003-09-23 2010-11-02 Merck Sharp & Dohme Corp. Quinoline potassium channel inhibitors
HUE056777T2 (hu) 2016-12-22 2022-03-28 Amgen Inc Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
MA50077A (fr) 2017-09-08 2020-07-15 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
CA3098574A1 (fr) 2018-05-04 2019-11-07 Amgen Inc. Inhibiteurs de kras g12c et leurs procedes d'utilisation
MX2020011582A (es) 2018-05-04 2020-11-24 Amgen Inc Inhibidores de kras g12c y metodos para su uso.
MA52564A (fr) 2018-05-10 2021-03-17 Amgen Inc Inhibiteurs de kras g12c pour le traitement du cancer
MA52765A (fr) 2018-06-01 2021-04-14 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
AU2019284472B2 (en) * 2018-06-11 2024-05-30 Amgen Inc. KRAS G12C inhibitors for treating cancer
CA3100390A1 (fr) 2018-06-12 2020-03-12 Amgen Inc. Inhibiteurs de kras g12c regroupant un cycle de piperazine et utilisation dans le traitement du cancer
JP7516029B2 (ja) 2018-11-16 2024-07-16 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
MX2021005700A (es) 2018-11-19 2021-07-07 Amgen Inc Inhibidores de kras g12c y metodos de uso de los mismos.
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3738593A1 (fr) 2019-05-14 2020-11-18 Amgen, Inc Dosage d'inhibiteur de kras pour le traitement de cancers
US11236091B2 (en) 2019-05-21 2022-02-01 Amgen Inc. Solid state forms
US20240190842A1 (en) * 2022-11-09 2024-06-13 Accutar Biotechnology Inc. Substituted quinolinone-8-carbonitrile derivatives having androgen degradation activity and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3210358A (en) * 1961-08-09 1965-10-05 Geigy Chem Corp Substituted 4-amino carbostyrils
CH471784A (de) * 1966-01-26 1969-04-30 Bayer Ag Verfahren zur Herstellung von Carbostyrilderivaten
US3763153A (en) * 1972-02-22 1973-10-02 Squibb & Sons Inc Benzothiazines
US3895006A (en) * 1974-04-19 1975-07-15 Squibb & Sons Inc 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CA1973 *

Also Published As

Publication number Publication date
IT8047580A0 (it) 1980-01-11
JPS55102568A (en) 1980-08-05
GB2041361B (en) 1982-12-08
IT1145403B (it) 1986-11-05
GB2041361A (en) 1980-09-10
DE3003146A1 (de) 1980-08-07
US4232027A (en) 1980-11-04

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Legal Events

Date Code Title Description
RE Withdrawal of published application