IT8047580A0 - Derivati di 1,2-diidro-2-osso-4-fe nil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie - Google Patents

Derivati di 1,2-diidro-2-osso-4-fe nil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie

Info

Publication number
IT8047580A0
IT8047580A0 IT8047580A IT4758080A IT8047580A0 IT 8047580 A0 IT8047580 A0 IT 8047580A0 IT 8047580 A IT8047580 A IT 8047580A IT 4758080 A IT4758080 A IT 4758080A IT 8047580 A0 IT8047580 A0 IT 8047580A0
Authority
IT
Italy
Prior art keywords
quinolin
carbonitrile
nil
dihydro
oxo
Prior art date
Application number
IT8047580A
Other languages
English (en)
Other versions
IT1145403B (it
Inventor
Chester F Turk
John Krapcho
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8047580A0 publication Critical patent/IT8047580A0/it
Application granted granted Critical
Publication of IT1145403B publication Critical patent/IT1145403B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
IT8047580A 1979-01-29 1980-01-11 Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie IT1145403B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/007,069 US4232027A (en) 1979-01-29 1979-01-29 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives

Publications (2)

Publication Number Publication Date
IT8047580A0 true IT8047580A0 (it) 1980-01-11
IT1145403B IT1145403B (it) 1986-11-05

Family

ID=21724050

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8047580A IT1145403B (it) 1979-01-29 1980-01-11 Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie

Country Status (6)

Country Link
US (1) US4232027A (it)
JP (1) JPS55102568A (it)
DE (1) DE3003146A1 (it)
FR (1) FR2447376A1 (it)
GB (1) GB2041361B (it)
IT (1) IT1145403B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024638A1 (en) * 1979-08-30 1981-03-11 Byk Gulden Lomberg Chemische Fabrik GmbH Substituted quinolinone-alkanecarboxylic acids, their preparation, and medicaments containing them
JPH03181465A (ja) * 1989-12-11 1991-08-07 Takeda Chem Ind Ltd キノリン誘導体
EP0749426A1 (en) * 1994-03-08 1996-12-27 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis
EP1667973B1 (en) * 2003-09-23 2013-12-04 Merck Sharp & Dohme Corp. Quinoline potassium channel inhibitors
BR112019012976A2 (pt) 2016-12-22 2019-12-31 Amgen Inc inibidores de kras g12c e métodos de uso dos mesmos
JOP20190272A1 (ar) 2017-05-22 2019-11-21 Amgen Inc مثبطات kras g12c وطرق لاستخدامها
SG11202001499WA (en) 2017-09-08 2020-03-30 Amgen Inc Inhibitors of kras g12c and methods of using the same
EP3788053A1 (en) 2018-05-04 2021-03-10 Amgen Inc. Kras g12c inhibitors and methods of using the same
AU2019262589B2 (en) 2018-05-04 2022-07-07 Amgen Inc. KRAS G12C inhibitors and methods of using the same
JP7361720B2 (ja) 2018-05-10 2023-10-16 アムジエン・インコーポレーテツド がんの治療のためのｋｒａｓ ｇ１２ｃ阻害剤
US11096939B2 (en) 2018-06-01 2021-08-24 Amgen Inc. KRAS G12C inhibitors and methods of using the same
MX2020012204A (es) * 2018-06-11 2021-03-31 Amgen Inc Inhibidores de kras g12c para tratar el cáncer.
MX2020012261A (es) 2018-06-12 2021-03-31 Amgen Inc Inhibidores de kras g12c que comprenden un anillo de piperazina y uso de estos en el tratamiento del cancer.
JP2020090482A (ja) 2018-11-16 2020-06-11 アムジエン・インコーポレーテツド Ｋｒａｓ ｇ１２ｃ阻害剤化合物の重要な中間体の改良合成法
MA55136A (fr) 2018-11-19 2022-02-23 Amgen Inc Inhibiteurs de kras g12c et leurs procédés d'utilisation
JP7377679B2 (ja) 2018-11-19 2023-11-10 アムジエン・インコーポレーテツド がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法
EP3738593A1 (en) 2019-05-14 2020-11-18 Amgen, Inc Dosing of kras inhibitor for treatment of cancers
CR20210665A (es) 2019-05-21 2022-01-25 Amgen Inc Formas en estado sólido

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3210358A (en) * 1961-08-09 1965-10-05 Geigy Chem Corp Substituted 4-amino carbostyrils
CH471784A (de) * 1966-01-26 1969-04-30 Bayer Ag Verfahren zur Herstellung von Carbostyrilderivaten
US3763153A (en) * 1972-02-22 1973-10-02 Squibb & Sons Inc Benzothiazines
US3895006A (en) * 1974-04-19 1975-07-15 Squibb & Sons Inc 5-(Substituted amino)alkyl)-2-aryl-3-halo-1,5-benzothiazepin-4(5H)-ones
US3994900A (en) * 1976-01-23 1976-11-30 E. R. Squibb & Sons, Inc. 6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones

Also Published As

Publication number Publication date
FR2447376A1 (fr) 1980-08-22
DE3003146A1 (de) 1980-08-07
IT1145403B (it) 1986-11-05
JPS55102568A (en) 1980-08-05
GB2041361A (en) 1980-09-10
US4232027A (en) 1980-11-04
GB2041361B (en) 1982-12-08

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