AR007297A1 - Un compuesto derivado de 5-aroil-pirrol-2-ilmetilareno, medicamentos y composiciones farmaceuticas que lo contienen y usos del mismo. - Google Patents
Un compuesto derivado de 5-aroil-pirrol-2-ilmetilareno, medicamentos y composiciones farmaceuticas que lo contienen y usos del mismo.Info
- Publication number
- AR007297A1 AR007297A1 ARP970102246A ARP970102246A AR007297A1 AR 007297 A1 AR007297 A1 AR 007297A1 AR P970102246 A ARP970102246 A AR P970102246A AR P970102246 A ARP970102246 A AR P970102246A AR 007297 A1 AR007297 A1 AR 007297A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical compositions
- ilmetilareno
- aroil
- pirrol
- medicines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de 5-aroil-pirrol-2-ilmetilareno de fórmula (I) en donde R10 está representado por la fórmula (A), (B) o (C): R20 estárepresentado por la fórmula (U), (V) o (W) y donde los sustituyentes son como en la reivindicación 1.Est os compuestos representan actividad antiinflamatoriay analgésica. Además se refiere a medicamentos y composiciones farmacéuticas que contienen dichos compuestos y a usos del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1869196P | 1996-05-30 | 1996-05-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR007297A1 true AR007297A1 (es) | 1999-10-27 |
Family
ID=21789298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970102246A AR007297A1 (es) | 1996-05-30 | 1997-05-27 | Un compuesto derivado de 5-aroil-pirrol-2-ilmetilareno, medicamentos y composiciones farmaceuticas que lo contienen y usos del mismo. |
Country Status (21)
Country | Link |
---|---|
US (3) | US5952368A (es) |
EP (1) | EP0906279B1 (es) |
JP (1) | JP3142581B2 (es) |
KR (1) | KR100303377B1 (es) |
CN (1) | CN1225629A (es) |
AR (1) | AR007297A1 (es) |
AT (1) | ATE225333T1 (es) |
AU (1) | AU717602B2 (es) |
BR (1) | BR9709497A (es) |
CA (1) | CA2256609C (es) |
CO (1) | CO4960660A1 (es) |
DE (1) | DE69716061T2 (es) |
DK (1) | DK0906279T3 (es) |
ES (1) | ES2182090T3 (es) |
HR (1) | HRP970296A2 (es) |
MA (1) | MA24346A1 (es) |
PT (1) | PT906279E (es) |
TR (1) | TR199802456T2 (es) |
TW (1) | TW415946B (es) |
WO (1) | WO1997046524A1 (es) |
ZA (1) | ZA974538B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2003208952B2 (en) * | 2002-01-30 | 2008-04-24 | Amgen Inc. | Heterocyclic arylsulfonamidobenzylic compounds |
TWI372050B (en) * | 2003-07-03 | 2012-09-11 | Astex Therapeutics Ltd | (morpholin-4-ylmethyl-1h-benzimidazol-2-yl)-1h-pyrazoles |
WO2005123671A1 (ja) * | 2004-06-22 | 2005-12-29 | Taisho Pharmaceutical Co., Ltd. | ピロール誘導体 |
TWI427077B (zh) | 2004-12-30 | 2014-02-21 | Astex Therapeutics Ltd | 吡唑化合物及其用途和含有彼之藥學組成物 |
JP5474354B2 (ja) * | 2005-12-30 | 2014-04-16 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
WO2008001101A2 (en) * | 2006-06-29 | 2008-01-03 | Astex Therapeutics Limited | Pharmaceutical combinations |
US8435970B2 (en) * | 2006-06-29 | 2013-05-07 | Astex Therapeutics Limited | Pharmaceutical combinations of 1-cyclopropyl-3-[3-(5-morpholin-4-ylmethyl-1H-benzoimidazol-2-yl)-1H-pyrazol-4-yl]-urea |
US10358408B2 (en) * | 2017-12-22 | 2019-07-23 | Polycarbon Industries, Inc. | Synthesis of azelaic acid |
CA3209491A1 (en) | 2021-03-15 | 2022-09-22 | Saul Yedgar | Hyaluronic acid-conjugated dipalmitoyl phosphatidyl ethanolamine in combination with non-steroidal anti-inflammatory drugs (nsaids) for treating or alleviating inflammatory disease |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
US4089969A (en) * | 1976-07-14 | 1978-05-16 | Syntex (U.S.A.) Inc. | 5-Aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
NO822514L (no) * | 1981-07-22 | 1983-01-24 | Syntex Inc | Fremgangsmaate ved fremstilling av terapeutisk virksomme 2,5-substituerte pyrrolidinderivater |
IL86462A (en) * | 1987-05-29 | 1992-12-01 | Fujisawa Pharmaceutical Co | Alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
-
1997
- 1997-05-21 DK DK97925931T patent/DK0906279T3/da active
- 1997-05-21 WO PCT/EP1997/002587 patent/WO1997046524A1/en active IP Right Grant
- 1997-05-21 DE DE69716061T patent/DE69716061T2/de not_active Expired - Fee Related
- 1997-05-21 KR KR1019980709759A patent/KR100303377B1/ko not_active IP Right Cessation
- 1997-05-21 BR BR9709497A patent/BR9709497A/pt unknown
- 1997-05-21 TR TR1998/02456T patent/TR199802456T2/xx unknown
- 1997-05-21 PT PT97925931T patent/PT906279E/pt unknown
- 1997-05-21 CN CN97196566A patent/CN1225629A/zh active Pending
- 1997-05-21 JP JP10500147A patent/JP3142581B2/ja not_active Expired - Fee Related
- 1997-05-21 ES ES97925931T patent/ES2182090T3/es not_active Expired - Lifetime
- 1997-05-21 AT AT97925931T patent/ATE225333T1/de not_active IP Right Cessation
- 1997-05-21 EP EP97925931A patent/EP0906279B1/en not_active Expired - Lifetime
- 1997-05-21 CA CA002256609A patent/CA2256609C/en not_active Expired - Fee Related
- 1997-05-21 AU AU30913/97A patent/AU717602B2/en not_active Ceased
- 1997-05-23 ZA ZA9704538A patent/ZA974538B/xx unknown
- 1997-05-27 AR ARP970102246A patent/AR007297A1/es not_active Application Discontinuation
- 1997-05-28 US US08/864,703 patent/US5952368A/en not_active Expired - Fee Related
- 1997-05-28 CO CO97029326A patent/CO4960660A1/es unknown
- 1997-05-28 HR HR60/018,691A patent/HRP970296A2/xx not_active Application Discontinuation
- 1997-05-29 TW TW086107344A patent/TW415946B/zh not_active IP Right Cessation
- 1997-05-30 MA MA24642A patent/MA24346A1/fr unknown
-
1999
- 1999-03-24 US US09/275,540 patent/US6127402A/en not_active Expired - Fee Related
- 1999-03-24 US US09/275,542 patent/US6136844A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2182090T3 (es) | 2003-03-01 |
CA2256609A1 (en) | 1997-12-11 |
PT906279E (pt) | 2003-02-28 |
KR20000016191A (ko) | 2000-03-25 |
DE69716061T2 (de) | 2003-08-14 |
KR100303377B1 (ko) | 2001-12-12 |
JPH11511755A (ja) | 1999-10-12 |
DE69716061D1 (de) | 2002-11-07 |
US6127402A (en) | 2000-10-03 |
AU3091397A (en) | 1998-01-05 |
DK0906279T3 (da) | 2003-02-03 |
ATE225333T1 (de) | 2002-10-15 |
CA2256609C (en) | 2005-07-26 |
CN1225629A (zh) | 1999-08-11 |
TW415946B (en) | 2000-12-21 |
MA24346A1 (fr) | 1998-07-01 |
WO1997046524A1 (en) | 1997-12-11 |
EP0906279A1 (en) | 1999-04-07 |
ZA974538B (en) | 1997-12-01 |
JP3142581B2 (ja) | 2001-03-07 |
EP0906279B1 (en) | 2002-10-02 |
US5952368A (en) | 1999-09-14 |
BR9709497A (pt) | 1999-08-10 |
AU717602B2 (en) | 2000-03-30 |
TR199802456T2 (xx) | 1999-02-22 |
US6136844A (en) | 2000-10-24 |
CO4960660A1 (es) | 2000-09-25 |
HRP970296A2 (en) | 1998-04-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2071621T3 (es) | Enantiomero dextrogiro del alfa-(tetrahidro-4,5,6,7-tieno-(3,2-c)-piridil-5)(cloro-2-fenil) acetato de metilo, su procedimiento de preparacion y las composiciones farmaceuticas que lo contienen. | |
KR870700620A (ko) | 신규 약리학적 화합물 | |
AR012172A2 (es) | Composiciones farmaceuticas que comprenden analogos de lactacistina y uso de los mismos para la fabricacion de un medicamento | |
TR199800720T2 (xx) | Farnesil transferaz inhibe eden 2-kinolon t�revleri. | |
DE68911742D1 (de) | Substituierte flavonoide Verbindungen, ihre Salze, ihre Herstellung und die enthaltende Arnzeizusammensetzungen. | |
FR2416012A1 (fr) | Derives de l'imidazole et medicament contenant ces substances | |
AR003938A1 (es) | Compuestos triciclicos de urea utiles para la inhibicion de la funcion de la proteina g y para tratamiento de enfermedades proteoliticas, composicionfarmaceutica, y el uso de los mismos para la preparacion de medicamentos. | |
LV10954A (lv) | Benzimidazola atvasinajumi to iegusanas panemiens un tos saturosa farmaceitiska kompozicija | |
FR2361901A1 (fr) | Derives de substitution de nucleotides et medicament contenant ces substances | |
AR007297A1 (es) | Un compuesto derivado de 5-aroil-pirrol-2-ilmetilareno, medicamentos y composiciones farmaceuticas que lo contienen y usos del mismo. | |
FR2354761A1 (fr) | Acides n-aryl-anthraniliques, leurs procedes de preparation et compositions pharmaceutiques contenant lesdits acides anthraniliques | |
FI803264L (fi) | 2-hydroxialkyl-3,4,5-trihydroxipiperidiner foerfarande foer framstaellning av dem och anvaendning av dem som laekemedel | |
ES2032752T3 (es) | Procedimiento de preparacion de derivados de la 1-bencenosulfonil-2-oxo-5-alcoxi-pirrolidina. | |
ES2127263T3 (es) | Nuevos trien-derivados cromenicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
RU94038042A (ru) | Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент | |
FR2367750A1 (fr) | Acid | |
SE8600658D0 (sv) | Novel composition of matter | |
ATE40987T1 (de) | Acetylenische phenoxypropanolderivate und pharmazeutische zusammensetzungen fuer die behandlung von bluthochdruck. | |
FR2376661A1 (fr) | Medicaments anthelminthiques renfermant comme substances actives des anilinomethylene-malononitriles | |
ES2086195T3 (es) | Nuevos derivados pseudopeptidicos de actividad antagonista de la bradiquinina, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. | |
FR2430230A1 (fr) | Medicaments a base de derives de l'acide anthranilique | |
FR2361110A1 (fr) | Medicaments anthelminthiques renfermant une association synergique de substances actives | |
ES2157498T3 (es) | Derivados de triazol o sus sales. | |
ATE28647T1 (de) | Chinazolinonderivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln. | |
ES2051965T3 (es) | Derivados heterociclicos condensados de 1,2,3,4-tetrahidroacridina, un procedimiento para su preparacion y su uso como medicamentos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |