FR2438651A1 - NOVEL INDOLE DERIVATIVES USEFUL AS MEDICAMENTS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents

NOVEL INDOLE DERIVATIVES USEFUL AS MEDICAMENTS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Info

Publication number
FR2438651A1
FR2438651A1 FR7925446A FR7925446A FR2438651A1 FR 2438651 A1 FR2438651 A1 FR 2438651A1 FR 7925446 A FR7925446 A FR 7925446A FR 7925446 A FR7925446 A FR 7925446A FR 2438651 A1 FR2438651 A1 FR 2438651A1
Authority
FR
France
Prior art keywords
group
hydrogen atom
atom
preparation
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7925446A
Other languages
French (fr)
Other versions
FR2438651B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2438651A1 publication Critical patent/FR2438651A1/en
Application granted granted Critical
Publication of FR2438651B1 publication Critical patent/FR2438651B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'INVENTION CONCERNE DES COMPOSES CHIMIQUES NOUVEAUX ET DES PROCEDES POUR LEUR PREPARATION. IL S'AGIT DE DERIVES D'INDOLE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE LES DIFFERENTS SYMBOLES PEUVENT AVOIR, ENTRE AUTRES, LES SIGNFICATIONS SUIVANTES: R REPRESENTE UN ATOME D'HYDROGENE; RREPRESENTE UN ATOME D'HYDROGENE, OU UN GROUPE ARALCOYLE, CYCLOALCOYLE, OU ALCOYLE, LEQUEL GROUPE ALCOYLE PEUT ETRE NON SUBSTITUE OU SUBSTITUE PAR UN GROUPE ALCENYLE OU PAR LE GROUPE -OR; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALCOYLE; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ARALCOYLE, FLUOROALCOYLE OU ALCOYLE NON SUBSTITUE OU R ET R FORMENT ENSEMBLE UN GROUPE ARALCOYLIDENE OU ENSEMBLE AVEC L'ATOME D'AZOTE AUQUEL ILS SONT ATTACHES FORMENT UN NOYAU MONOCYCLIQUE SATURE A 5 A 7 CHAINONS CONTENANT UNE AUTRE HETERO-FONCTION; R REPRESENTE UN ATOME D'HYDROGENE, UN GROUPE ALCOYLE OU UN GROUPE BENZYLE; RREPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE ALCOYLE; ALC REPRESENTE UN GROUPE ALCOYLENE CONTENANT 2 OU 3 ATOMES DE CARBONE; ET XREPRESENTE UN ATOME D'OXYGENE OU DE SOUFRE. CES COMPOSES SONT UTILES COMME MEDICAMENTS.THE INVENTION CONCERNS NEW CHEMICAL COMPOUNDS AND METHODS FOR THEIR PREPARATION. THESE ARE DERIVATIVES OF INDOLE OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH THE VARIOUS SYMBOLS MAY HAVE, AMONG OTHERS, THE FOLLOWING SIGNIFICATIONS: R REPRESENTS A HYDROGEN ATOM; RREPRESENTS AN ATOM OF HYDROGEN, OR AN ARALCOYL, CYCLOALCOYL, OR ALCOYL GROUP, WHICH ALCOHOL GROUP MAY NOT BE SUBSTITUTED OR SUBSTITUTED BY AN ALCENYL GROUP OR BY THE -OR GROUP; REPRESENTS A HYDROGEN ATOM OR AN ALCOHOL GROUP; REPRESENTS A HYDROGEN ATOM OR AN ARALCOYL, FLUOROALCOYL OR NON-SUBSTITUTED ALCOYL GROUP OR R AND R FORGES TOGETHER AN ARALCOYLIDENE GROUP OR TOGETHER WITH THE NITROGEN ATOM TO WHICH THEY ARE FORECAST ATTACHED TO A 5 MONKYCLA 7 NOKYCL OTHER HETERO-FUNCTION; R REPRESENTS A HYDROGEN ATOM, AN ALCOHYL GROUP OR A BENZYL GROUP; REPRESENTS A HYDROGEN ATOM OR AN ALCOHOL GROUP; ALC REPRESENTS AN ALCOYLENE GROUP CONTAINING 2 OR 3 CARBON ATOMS; AND XREPRESENTS AN ATOM OF OXYGEN OR SULFUR. THESE COMPOUNDS ARE USEFUL AS A MEDICINAL PRODUCT.

FR7925446A 1978-10-12 1979-10-12 NOVEL INDOLE DERIVATIVES USEFUL AS MEDICAMENTS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Granted FR2438651A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7840279 1978-10-12

Publications (2)

Publication Number Publication Date
FR2438651A1 true FR2438651A1 (en) 1980-05-09
FR2438651B1 FR2438651B1 (en) 1983-03-04

Family

ID=10500283

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925446A Granted FR2438651A1 (en) 1978-10-12 1979-10-12 NOVEL INDOLE DERIVATIVES USEFUL AS MEDICAMENTS, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Country Status (18)

Country Link
US (1) US4252803A (en)
JP (1) JPS5562063A (en)
AU (1) AU531783B2 (en)
BE (1) BE879381A (en)
CA (1) CA1146550A (en)
CH (1) CH646151A5 (en)
DE (1) DE2940687A1 (en)
DK (1) DK425579A (en)
ES (2) ES8100261A1 (en)
FI (1) FI793071A (en)
FR (1) FR2438651A1 (en)
GB (1) GB2035310B (en)
IE (1) IE49304B1 (en)
IT (1) IT1142170B (en)
NL (1) NL7907583A (en)
NZ (1) NZ191802A (en)
SE (1) SE448628B (en)
ZA (1) ZA795239B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488605A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES
FR2488607A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USES
FR2488606A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATIONS AS MEDICAMENTS
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists

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US4428962A (en) 1981-10-30 1984-01-31 Schering Corporation Indoles in treatment of peptic ulcers
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US4582848A (en) * 1982-06-10 1986-04-15 Sandoz, Inc. 2-substituted-3-indolamines and use thereof as anti-diabetics
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US4562200A (en) * 1983-06-30 1985-12-31 American Home Products Corporation 5(Indolyl) and 5(2,3-dihydroindolyl) substituted aminoethanols and their use as anti-hypertensives
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US4622399A (en) * 1983-06-30 1986-11-11 American Home Products Corporation Bicyclo-heterocyclic nitrogen substituted aminoethanol derivatives
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GB8614287D0 (en) * 1986-06-12 1986-07-16 Glaxo Group Ltd Chemical compounds
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2488605A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USES
FR2488607A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USES
FR2488606A1 (en) * 1980-08-12 1982-02-19 Glaxo Group Ltd INDOLIC DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATIONS AS MEDICAMENTS
EP0875513A1 (en) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituted heteroaromatic 5-HT 1F agonists

Also Published As

Publication number Publication date
GB2035310A (en) 1980-06-18
JPS5562063A (en) 1980-05-10
IE49304B1 (en) 1985-09-18
SE448628B (en) 1987-03-09
DK425579A (en) 1980-04-13
ES484980A0 (en) 1980-11-01
NZ191802A (en) 1983-02-15
ES492114A0 (en) 1981-07-16
NL7907583A (en) 1980-04-15
DE2940687A1 (en) 1980-04-30
FR2438651B1 (en) 1983-03-04
IT1142170B (en) 1986-10-08
AU531783B2 (en) 1983-09-08
ES8100261A1 (en) 1980-11-01
BE879381A (en) 1980-02-01
ZA795239B (en) 1980-11-26
ES8106142A1 (en) 1981-07-16
FI793071A (en) 1980-04-13
US4252803A (en) 1981-02-24
GB2035310B (en) 1982-12-22
DE2940687C2 (en) 1991-08-01
AU5165779A (en) 1980-04-17
IT7950537A0 (en) 1979-10-11
JPS6358817B2 (en) 1988-11-17
IE791945L (en) 1980-04-12
CH646151A5 (en) 1984-11-15
CA1146550A (en) 1983-05-17
SE7908443L (en) 1980-04-13

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