BE904796A - NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. - Google Patents

NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Info

Publication number
BE904796A
BE904796A BE1/011493A BE1011493A BE904796A BE 904796 A BE904796 A BE 904796A BE 1/011493 A BE1/011493 A BE 1/011493A BE 1011493 A BE1011493 A BE 1011493A BE 904796 A BE904796 A BE 904796A
Authority
BE
Belgium
Prior art keywords
morphinane
medicaments
novel
preparation
application
Prior art date
Application number
BE1/011493A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE904796A publication Critical patent/BE904796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composés de formule ci-dessous, dans laquelle X et Y signifient l'hydrogène ou forment ensemble un groupe -O- et R1, R2, R3, R4 et R5 représentent des restes organiques variés. Ces composés peuvent etre utilisés comme médicaments.Compounds of the formula below, in which X and Y signify hydrogen or together form a group -O- and R1, R2, R3, R4 and R5 represent various organic residues. These compounds can be used as drugs.

BE1/011493A 1985-05-23 1986-05-21 NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. BE904796A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3518525 1985-05-23

Publications (1)

Publication Number Publication Date
BE904796A true BE904796A (en) 1986-11-21

Family

ID=6271435

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011493A BE904796A (en) 1985-05-23 1986-05-21 NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.

Country Status (18)

Country Link
JP (1) JPS61271275A (en)
AU (1) AU594954B2 (en)
BE (1) BE904796A (en)
DK (1) DK240386A (en)
ES (1) ES8802318A1 (en)
FI (1) FI862124A (en)
FR (1) FR2582309B1 (en)
GB (1) GB2175898B (en)
GR (1) GR861318B (en)
HU (1) HU196376B (en)
IL (1) IL78872A0 (en)
IT (1) IT1203791B (en)
LU (1) LU86435A1 (en)
NL (1) NL8601188A (en)
NZ (1) NZ216250A (en)
PH (1) PH23341A (en)
SE (1) SE8602308L (en)
ZA (1) ZA863873B (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857533A (en) * 1988-12-15 1989-08-15 Baker Cummins Pharmaceuticals, Inc. Method of treatment for autoimmune diseases
US4863928A (en) * 1989-01-04 1989-09-05 Baker Cummins Pharmaceuticals, Inc. Method of treatment for arthritic and inflammatory diseases
US4923875A (en) * 1989-07-10 1990-05-08 Baker Cummins Pharmaceuticals, Inc. Method for treatment of mast cell-mediated dermatologic disorders
JP2906654B2 (en) * 1989-11-28 1999-06-21 東レ株式会社 Immunosuppressant and method for producing the same
US5057322A (en) * 1990-08-10 1991-10-15 Baker Cummins Dermatologicals, Inc. Method of treating mast cell disease
CA2105072C (en) * 1992-01-23 1998-07-28 Hiroshi Nagase Morphinan derivative and its pharmaceutical applications
DE69414085T2 (en) * 1993-07-19 1999-03-18 Toray Industries, Inc., Tokio/Tokyo ACTIVE SUBSTANCE TO PROTECT BRAIN CELLS
JP3843456B2 (en) * 1993-07-23 2006-11-08 東レ株式会社 Morphinan derivatives and pharmaceutical applications
PL327943A1 (en) 1996-01-10 1999-01-04 Smithkline Beecham Spa Condensed heterocyclic derivatives of morphonoide (ii)
DK0897726T3 (en) * 1996-11-25 2007-08-13 Toray Industries Antipruritic agent
AU6117298A (en) * 1997-07-25 1999-02-16 Toray Industries, Inc. Hyponatremia remedies
US7501433B2 (en) 2002-05-17 2009-03-10 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
US7923454B2 (en) 2002-05-17 2011-04-12 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
MXPA04011327A (en) 2002-05-17 2005-08-15 Jenken Biosciences Inc Opioid and opioid-like compounds and uses thereof.
JP4957489B2 (en) * 2002-10-09 2012-06-20 東レ株式会社 Pharmaceutical containing morphinan derivative having nitrogen-containing cyclic substituent or pharmacologically acceptable acid addition salt thereof
US8017622B2 (en) 2003-05-16 2011-09-13 Jenken Biosciences, Inc. Opioid and opioid-like compounds and uses thereof
ES2671897T3 (en) * 2008-02-14 2018-06-11 Alkermes, Inc. Selective opioid compounds
US8987287B2 (en) * 2012-12-14 2015-03-24 Purdue Pharma L.P. Spirocyclic morphinans and their use
ES2631197T3 (en) * 2012-12-14 2017-08-29 Purdue Pharma Lp Pyridonamorfinan analogs and biological activity on opioid receptors
AR096851A1 (en) * 2013-07-11 2016-02-03 H Lundbeck As SALTS THAT DO NOT FORM HYDRATS OR SOLVATOS DE NALMEFENO
US10202382B2 (en) * 2014-06-13 2019-02-12 Purdue Pharma L.P. Azamorphinan derivatives and use thereof

Also Published As

Publication number Publication date
ES555200A0 (en) 1988-05-01
ES8802318A1 (en) 1988-05-01
GB8612159D0 (en) 1986-06-25
SE8602308D0 (en) 1986-05-21
HU196376B (en) 1988-11-28
PH23341A (en) 1989-07-14
AU5763786A (en) 1986-11-27
FR2582309A1 (en) 1986-11-28
NL8601188A (en) 1986-12-16
JPS61271275A (en) 1986-12-01
GB2175898A (en) 1986-12-10
ZA863873B (en) 1988-01-27
IT1203791B (en) 1989-02-23
IL78872A0 (en) 1986-09-30
IT8648050A0 (en) 1986-05-23
DK240386D0 (en) 1986-05-22
FI862124A (en) 1986-11-24
DK240386A (en) 1986-11-24
GB2175898B (en) 1989-07-05
FI862124A0 (en) 1986-05-21
AU594954B2 (en) 1990-03-22
SE8602308L (en) 1986-11-24
NZ216250A (en) 1990-04-26
LU86435A1 (en) 1986-12-05
GR861318B (en) 1986-09-19
HUT41737A (en) 1987-05-28
FR2582309B1 (en) 1989-08-18

Similar Documents

Publication Publication Date Title
BE904796A (en) NOVEL MORPHINANE AND MORPHINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
OA08647A (en) Imidazole derivatives, processes for their preparation and pharmaceutical composition containing them.
FR2416234A1 (en) METRONIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING
FR2429593A1 (en) DRUGS CONTAINING IMIDAZOLE DERIVATIVES
FR2711993B1 (en) Drugs containing 7H-imidazol [1,2-a] pyrazine-8-one derivatives, new compounds and their preparation.
FR2405934A1 (en) NEWS 4-THIO-2-OXO AZETIDINES USEFUL IN THE SYNTHESIS OF DRUGS
BE904368A (en) NOVEL PYRIDYLMETHOXY- AND METHYLMERCAPTOANILINE DERIVATIVES USEFUL IN PARTICULAR AS ANTIASTHMATICS, THEIR MANUFACTURE AND THE MEDICINAL PRODUCTS CONTAINING THEM.
FR2391209A1 (en) AMINOALKYL THIOPHENS, USEFUL AS MEDICINAL PRODUCTS, THEIR PREPARATION AND COMPOSITIONS CONTAINING
FR2374307A1 (en) 1,4-DIHYDROPYRIDINE DERIVATIVES, THE PROCESS FOR OBTAINING THEM AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
BE1002213A5 (en) NOVEL PEPTIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.
FR2658823B1 (en) NOVEL AMINOMETHYLPIPERIDINE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
BE903846A (en) COMPOUNDS DERIVED FROM INDOLE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION.
FR2358382A1 (en) NEW NONAPEPTIDES, THEIR METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2370744A1 (en) NEW AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
FR2422640A1 (en) NEW 8B-ALKYL SUBSTITUTE MORPHINANE-6-ONES, THEIR PRODUCTION PROCESS AND THE MEDICINAL PRODUCT CONTAINING THEM
FR2376858A1 (en) NEW IMIDAZO (1,2-A) QUINOXALINES SUBSTITUTED IN POSITION 4, THEIR PROCESS OF PREPARATION AND THE MEDICINAL PRODUCT CONTAINING THEM
OA07063A (en) New derivatives of amineothoxy-4 isopropy-2-methyl-2-phenol, their preparation methods and their use as medicaments.
FR2415636A1 (en) NEW GUANIDINE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2391191A1 (en) NEW POLYPEPTIDIC COMPOUNDS, LYEPTIDIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
BE904864A (en) QUINOLEIN DERIVATIVES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2383176A1 (en) AMINO ARYL TRIAZINES 1-2-4 FOR USE IN THE TREATMENT OF MISCELLANEOUS ALGIA
FR2421181A1 (en) SPIROOXAZOLIDINONE STEROIDIAN SUBSTITUTION DERIVATIVES, THEIR PREPARATION PROCESS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
BE904588A (en) (-) - 1Beta-ETHYL-1ALPHA-HYDROXYMETHYL-1,2,3,4,6,7,12,12beta alpha-OCTAHYDROINDOLO (2,3-a) QUINOLIZINE, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME .
BE902600A (en) NAPHTOXAZINE DERIVATIVES, THEIR PREPARATION, THEIR APPLICATION AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
FR2445144A1 (en) AS DRUGS, 2-HYDROXYMETHYL-PYRAZINE HYPOLIPEMANTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: SANDOZ S.A.

Effective date: 19900531