FR2405934A1 - NEWS 4-THIO-2-OXO AZETIDINES USEFUL IN THE SYNTHESIS OF DRUGS - Google Patents

NEWS 4-THIO-2-OXO AZETIDINES USEFUL IN THE SYNTHESIS OF DRUGS

Info

Publication number
FR2405934A1
FR2405934A1 FR7900168A FR7900168A FR2405934A1 FR 2405934 A1 FR2405934 A1 FR 2405934A1 FR 7900168 A FR7900168 A FR 7900168A FR 7900168 A FR7900168 A FR 7900168A FR 2405934 A1 FR2405934 A1 FR 2405934A1
Authority
FR
France
Prior art keywords
azetidines
thio
oxo
news
drugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7900168A
Other languages
French (fr)
Other versions
FR2405934B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Publication of FR2405934A1 publication Critical patent/FR2405934A1/en
Application granted granted Critical
Publication of FR2405934B1 publication Critical patent/FR2405934B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Abstract

L'invention concerne des composés chimiques nouveaux. Il s'agit de 4-thio-2-oxo azétidines de formule :The invention relates to novel chemical compounds. They are 4-thio-2-oxo azetidines of the formula:

FR7900168A 1977-05-09 1979-01-04 NEWS 4-THIO-2-OXO AZETIDINES USEFUL IN THE SYNTHESIS OF DRUGS Granted FR2405934A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77306A LU77306A1 (en) 1977-05-09 1977-05-09

Publications (2)

Publication Number Publication Date
FR2405934A1 true FR2405934A1 (en) 1979-05-11
FR2405934B1 FR2405934B1 (en) 1980-09-05

Family

ID=19728568

Family Applications (8)

Application Number Title Priority Date Filing Date
FR7813535A Granted FR2405949A1 (en) 1977-05-09 1978-05-08 THIA-AZA COMPOUNDS WITH B-LACTAM CORE USEFUL PARTICULARLY AS MEDICINAL PRODUCTS
FR7900171A Granted FR2405946A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 3-METHYL-CROTONIC ACID AND PROCESS FOR THEIR PREPARATION
FR7900170A Granted FR2405945A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 4 DITHIO 3-METHYLENEBUTYRIC ACID AND PROCESS FOR THEIR PREPARATION
FR7900168A Granted FR2405934A1 (en) 1977-05-09 1979-01-04 NEWS 4-THIO-2-OXO AZETIDINES USEFUL IN THE SYNTHESIS OF DRUGS
FR7900167A Granted FR2405955A1 (en) 1977-05-09 1979-01-04 NEW USEFUL YLIDS IN THE SYNTHESIS OF MEDICINAL PRODUCTS
FR7900173A Granted FR2422637A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 2 (4-THIO-2-OXO-AZETIDIN-1-YL) -3-METHYLENE-BUTYRIC ACID AND METHOD OF PREPARATION
FR7900169A Granted FR2405950A1 (en) 1977-05-09 1979-01-04 NEW 1 PENICILLANIC ACID OXIDES USEFUL IN THE SYNTHESIS OF DRUGS
FR7900172A Granted FR2411179A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 2- (4-THIO-2-OXOAZETIDINE-1-YL) -3-METHYL-CROTONIC ACID AND METHODS FOR THEIR PREPARATION

Family Applications Before (3)

Application Number Title Priority Date Filing Date
FR7813535A Granted FR2405949A1 (en) 1977-05-09 1978-05-08 THIA-AZA COMPOUNDS WITH B-LACTAM CORE USEFUL PARTICULARLY AS MEDICINAL PRODUCTS
FR7900171A Granted FR2405946A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 3-METHYL-CROTONIC ACID AND PROCESS FOR THEIR PREPARATION
FR7900170A Granted FR2405945A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 4 DITHIO 3-METHYLENEBUTYRIC ACID AND PROCESS FOR THEIR PREPARATION

Family Applications After (4)

Application Number Title Priority Date Filing Date
FR7900167A Granted FR2405955A1 (en) 1977-05-09 1979-01-04 NEW USEFUL YLIDS IN THE SYNTHESIS OF MEDICINAL PRODUCTS
FR7900173A Granted FR2422637A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 2 (4-THIO-2-OXO-AZETIDIN-1-YL) -3-METHYLENE-BUTYRIC ACID AND METHOD OF PREPARATION
FR7900169A Granted FR2405950A1 (en) 1977-05-09 1979-01-04 NEW 1 PENICILLANIC ACID OXIDES USEFUL IN THE SYNTHESIS OF DRUGS
FR7900172A Granted FR2411179A1 (en) 1977-05-09 1979-01-04 NEW DERIVATIVES OF 2- (4-THIO-2-OXOAZETIDINE-1-YL) -3-METHYL-CROTONIC ACID AND METHODS FOR THEIR PREPARATION

Country Status (13)

Country Link
US (5) US4331676A (en)
JP (1) JPS53137951A (en)
AU (1) AU527917B2 (en)
BE (1) BE866845A (en)
CH (1) CH646173A5 (en)
DE (1) DE2819655A1 (en)
DK (1) DK200578A (en)
ES (1) ES469568A1 (en)
FR (8) FR2405949A1 (en)
GB (4) GB1604754A (en)
LU (1) LU77306A1 (en)
NL (1) NL7804974A (en)
SE (2) SE443980B (en)

Families Citing this family (52)

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Publication number Priority date Publication date Assignee Title
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (en) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-disubstituted azetidin-2-on compounds and process for their preparation
JPS54145692A (en) * 1978-02-16 1979-11-14 Glaxo Group Ltd Betaalactam compound
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
US4290948A (en) 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
US4331677A (en) * 1978-11-24 1982-05-25 Farmitalia Carlo Erba S.P.A. 7-Oxo-4-1-aza-bicyclo-[3,2,0]-heptane derivatives
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
ATE3041T1 (en) * 1979-01-10 1983-04-15 Schering Corporation 2-PENEM COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AU535080B2 (en) * 1979-02-24 1984-03-01 Farmitalia Carlo Erba S.R.L. Penicillins
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4683226A (en) * 1979-08-01 1987-07-28 Schering Corporation 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
US4406834A (en) 1979-09-21 1983-09-27 Bristol-Myers Company 2,6 Disubstituted penems and intermediates therefor
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
EP0031509B1 (en) * 1979-12-20 1984-10-24 Hoechst Uk Limited Penem derivatives
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS56142282A (en) * 1980-03-10 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
ATE21105T1 (en) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-OXO-4-THIA-1-AZA(3.2.0)HEPTANE AND 7-OXO-4-THIA-1-AZA-(3.2.0)HEPT-2-EN DERIVATIVES.
ES8305366A1 (en) * 1981-07-08 1983-04-01 Hoechst Uk Ltd Antibacterial penem derivatives.
EP0069378B1 (en) * 1981-07-08 1987-01-07 Hoechst Uk Limited Antibacterial penem derivatives
JPS58116487A (en) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation
JPS5835190A (en) * 1981-08-25 1983-03-01 Sankyo Co Ltd Penem-3-carboxylic acid derivative
JPS5946289A (en) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd Novel beta-lactam compound and its preparation
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
JPS60243064A (en) * 1984-05-17 1985-12-03 Taiho Yakuhin Kogyo Kk Azetidinone disulfide derivative
EP0379281A3 (en) * 1989-01-19 1991-03-20 Cosmopolitan Textile Company Limited Web inspecting method and apparatus
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
EP0666846A1 (en) * 1992-10-27 1995-08-16 Merck & Co. Inc. New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO2004039776A2 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc Broad spectrum beta-lactamase inhibitors
JP2015518854A (en) * 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド Compositions and methods for the treatment of multiple sclerosis
CN112424114A (en) * 2018-05-07 2021-02-26 科思创知识产权两合公司 Storage medium and method for separating, storing and transporting chlorine from chlorine-containing gases
CN114720591B (en) * 2022-03-22 2022-12-30 北京安胜瑞力科技有限公司 Quantitative analysis method for DMAC (dimethylacetamide) in industrial wastewater

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2061152A5 (en) * 1969-09-09 1971-06-18 Hoechst Ag
FR2124251A1 (en) * 1971-02-04 1972-09-22 Beecham Group Ltd
FR2342730A1 (en) * 1975-12-08 1977-09-30 Ciba Geigy Ag THIA-AZA TYPE UNSATURATED BICYCLIC COMPOUNDS

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE648188A (en) 1963-05-29 1964-09-16
DE2265798C2 (en) * 1971-06-24 1985-09-26 Fujisawa Pharmaceutical Co., Ltd., Osaka Process for the preparation of oxoazetidine derivatives
JPS4854056A (en) * 1971-11-12 1973-07-30
IN149747B (en) * 1977-06-07 1982-04-03 Pfizer
GB2005246A (en) * 1977-07-13 1979-04-19 Glaxo Group Ltd beta -Lactam compounds and processes for their preparation
EP0000636A1 (en) * 1977-07-13 1979-02-07 Glaxo Group Limited Penem compounds, processes for their preparation, their use in pharmaceutical compositions and azetidinones used in their preparation
US4169833A (en) * 1977-12-14 1979-10-02 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4192801A (en) * 1978-04-27 1980-03-11 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2061152A5 (en) * 1969-09-09 1971-06-18 Hoechst Ag
FR2124251A1 (en) * 1971-02-04 1972-09-22 Beecham Group Ltd
FR2342730A1 (en) * 1975-12-08 1977-09-30 Ciba Geigy Ag THIA-AZA TYPE UNSATURATED BICYCLIC COMPOUNDS

Also Published As

Publication number Publication date
SE443980B (en) 1986-03-17
GB1604754A (en) 1981-12-16
SE8305299D0 (en) 1983-09-29
CH646173A5 (en) 1984-11-15
US4524028A (en) 1985-06-18
FR2405945B1 (en) 1982-04-09
GB1604752A (en) 1981-12-16
FR2405955B1 (en) 1981-07-31
BE866845A (en) 1978-11-09
FR2405946A1 (en) 1979-05-11
US4515717A (en) 1985-05-07
LU77306A1 (en) 1979-01-18
AU527917B2 (en) 1983-03-31
FR2405949A1 (en) 1979-05-11
FR2405946B1 (en) 1983-09-30
US4447360A (en) 1984-05-08
SE8305299L (en) 1983-09-29
US4331676A (en) 1982-05-25
AU3588478A (en) 1979-11-15
FR2405949B1 (en) 1980-10-24
FR2405950A1 (en) 1979-05-11
DK200578A (en) 1978-11-10
DE2819655A1 (en) 1978-11-23
FR2405955A1 (en) 1979-05-11
NL7804974A (en) 1978-11-13
ES469568A1 (en) 1980-01-01
SE7805217L (en) 1978-11-10
FR2422637A1 (en) 1979-11-09
US4518533A (en) 1985-05-21
FR2411179B1 (en) 1982-04-23
FR2411179A1 (en) 1979-07-06
FR2405950B1 (en) 1981-07-31
FR2405934B1 (en) 1980-09-05
GB1604751A (en) 1981-12-16
FR2405945A1 (en) 1979-05-11
JPS53137951A (en) 1978-12-01
GB1604753A (en) 1981-12-16
FR2422637B1 (en) 1982-04-23

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