FR2391191A1 - NEW POLYPEPTIDIC COMPOUNDS, LYEPTIDIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS - Google Patents

NEW POLYPEPTIDIC COMPOUNDS, LYEPTIDIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Info

Publication number
FR2391191A1
FR2391191A1 FR7814372A FR7814372A FR2391191A1 FR 2391191 A1 FR2391191 A1 FR 2391191A1 FR 7814372 A FR7814372 A FR 7814372A FR 7814372 A FR7814372 A FR 7814372A FR 2391191 A1 FR2391191 A1 FR 2391191A1
Authority
FR
France
Prior art keywords
preparation
lyeptidic
new
application
medicinal products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7814372A
Other languages
French (fr)
Inventor
Francois Cardinaux
Janos Pless
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of FR2391191A1 publication Critical patent/FR2391191A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux polypeptides et leur préparation. Les composés de l'invention répondent à la formule : A - B- Gly - D - E dans laquelle A représente un reste alpha -amino-phénéthylcarbonyle substitué; B désigne un groupe -D-Ala-,-D-Ser-, -D-Thr-, -Aib- ou -D-Met ou un reste du D-méthionine-sulfoxyde ou de la D-méthionine-sulfone; D représente un groupe alpha -amino-phénéthylcarbonyle éventuellement substitué et E signifie un reste aminé. Ces polypeptides peuvent être utilisés en thérapeutique comme substances actives de médicaments.The invention relates to novel polypeptides and their preparation. The compounds of the invention correspond to the formula: A - B- Gly - D - E in which A represents a substituted alpha -amino-phenethylcarbonyl residue; B denotes a group -D-Ala -, - D-Ser-, -D-Thr-, -Aib- or -D-Met or a residue of D-methionine-sulfoxide or of D-methionine-sulfone; D represents an optionally substituted alpha -amino-phenethylcarbonyl group and E signifies an amine residue. These polypeptides can be used therapeutically as active substances in medicaments.

FR7814372A 1977-05-16 1978-05-16 NEW POLYPEPTIDIC COMPOUNDS, LYEPTIDIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS Withdrawn FR2391191A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH606177 1977-05-16
CH740277 1977-06-16
CH751877 1977-06-20
CH757677 1977-06-21
CH757777 1977-06-21
CH771377 1977-06-23
CH1386277 1977-11-14

Publications (1)

Publication Number Publication Date
FR2391191A1 true FR2391191A1 (en) 1978-12-15

Family

ID=27561110

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7814372A Withdrawn FR2391191A1 (en) 1977-05-16 1978-05-16 NEW POLYPEPTIDIC COMPOUNDS, LYEPTIDIC, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Country Status (12)

Country Link
JP (1) JPS53141236A (en)
AU (1) AU3611378A (en)
BE (1) BE867121A (en)
DE (1) DE2819277A1 (en)
DK (1) DK199578A (en)
FR (1) FR2391191A1 (en)
GB (1) GB1601754A (en)
IL (1) IL54714A0 (en)
IT (1) IT7849374A0 (en)
NL (1) NL7805165A (en)
NZ (1) NZ187280A (en)
PT (1) PT68036B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044451A1 (en) * 1980-07-17 1982-01-27 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
EP0077122A2 (en) * 1981-09-15 1983-04-20 Imperial Chemical Industries Plc Amino-substituted tetralins and related homocyclic compounds
EP0649443A1 (en) * 1992-06-30 1995-04-26 Legomer Partners, L.P. Oxazolone derived materials
EP2419117A2 (en) * 2009-04-13 2012-02-22 ELC Management LLC Methionine sulfoxide peptide, compositions and methods of use

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604850A (en) * 1977-11-24 1981-12-16 Wellcome Found Biologically active peptides
JPS55118444A (en) * 1979-03-07 1980-09-11 Takeda Chem Ind Ltd Tetrapeptide derivative
NZ197561A (en) * 1980-07-02 1986-04-11 Merrell Dow Pharma Topical anti-viral compositions based on certain 5-amino-1-phenyl-pent-1-en-3-ones
HU185640B (en) * 1980-07-17 1985-03-28 Sandoz Ag Process for producing new pentapeptides
ATE16495T1 (en) * 1981-06-22 1985-11-15 Ici Plc PEPTIDES AND PSEUDOPEPTIDES HAVING TWO SUBSTITUENTS AT THE N-TERMINUS.

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338925A1 (en) * 1976-01-26 1977-08-19 Wellcome Found NEW PEPTIDES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
FR2339590A1 (en) * 1976-02-02 1977-08-26 Sandoz Sa NEW POLYPEPTIDIC COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2359120A1 (en) * 1976-07-19 1978-02-17 Sandoz Sa NEW POLYPEPTIDIC COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2338925A1 (en) * 1976-01-26 1977-08-19 Wellcome Found NEW PEPTIDES AND MEDICINAL PRODUCTS CONTAINING THESE SUBSTANCES
FR2339590A1 (en) * 1976-02-02 1977-08-26 Sandoz Sa NEW POLYPEPTIDIC COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS
FR2359120A1 (en) * 1976-07-19 1978-02-17 Sandoz Sa NEW POLYPEPTIDIC COMPOUNDS, THEIR PREPARATION AND THEIR APPLICATION AS MEDICINAL PRODUCTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/77 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0044451A1 (en) * 1980-07-17 1982-01-27 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
EP0077122A2 (en) * 1981-09-15 1983-04-20 Imperial Chemical Industries Plc Amino-substituted tetralins and related homocyclic compounds
EP0077122A3 (en) * 1981-09-15 1984-06-27 Imperial Chemical Industries Plc Amino-substituted tetralins and related homocyclic compounds
EP0649443A1 (en) * 1992-06-30 1995-04-26 Legomer Partners, L.P. Oxazolone derived materials
EP0649443A4 (en) * 1992-06-30 1995-11-08 Legomer Partners Lp Oxazolone derived materials.
EP2419117A2 (en) * 2009-04-13 2012-02-22 ELC Management LLC Methionine sulfoxide peptide, compositions and methods of use
EP2419117A4 (en) * 2009-04-13 2014-10-22 Elc Man Llc Methionine sulfoxide peptide, compositions and methods of use

Also Published As

Publication number Publication date
AU3611378A (en) 1979-11-22
DK199578A (en) 1978-11-17
DE2819277A1 (en) 1978-11-23
NL7805165A (en) 1978-11-20
IT7849374A0 (en) 1978-05-16
BE867121A (en) 1978-11-16
PT68036B (en) 1980-03-05
JPS53141236A (en) 1978-12-08
IL54714A0 (en) 1978-07-31
PT68036A (en) 1978-06-01
GB1601754A (en) 1981-11-04
NZ187280A (en) 1981-05-15

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