SE8602308D0 - MORPHINAN DERIVATIVES - Google Patents
MORPHINAN DERIVATIVESInfo
- Publication number
- SE8602308D0 SE8602308D0 SE8602308A SE8602308A SE8602308D0 SE 8602308 D0 SE8602308 D0 SE 8602308D0 SE 8602308 A SE8602308 A SE 8602308A SE 8602308 A SE8602308 A SE 8602308A SE 8602308 D0 SE8602308 D0 SE 8602308D0
- Authority
- SE
- Sweden
- Prior art keywords
- denotes
- atoms
- hydrogen
- alkyl
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Compounds of formula I <IMAGE> wherein X and Y each denote hydrogen or together denote -O-, R1 denotes allyl optionally substituted by 1 to 3 alkyl groups, the substituent or substituents having in total a maximum of 3 C-atoms, cyclopropylalkyl with 7 to 12 C-atoms, R2 denotes hydrogen, C1-10 alkyl, C5-6 cycloalkyl, or optionally substituted pheny or phenyl-C7-12 alkyl, R3 denotes hydrogen, alkyl with 1 to 10 C-atoms or phenyl, R4 denotes hydrogen, OH, NR6R7, NHCOR, NHSO2R min or NHCOOR sec , R6 and R7, independently of one another, denote hydrogen or alkyl with 1 to 3 C-atoms, R denotes alkyl with 1 to 6 C-atoms, phenyl or -A-COOR sec , A denotes alkylene or alkenylene each with 2 to 4 C-atoms, R min denotes alkyl with 1 to 6 C-atoms or phenyl, R sec denotes methyl or ethyl and wherein either R3 is in the alpha -position and R4 is in the beta -position, or R3 is in the beta -position and R4 is in the alpha -position, or R3 and R4 together are =O, or =CH2, and R5 denotes hydrogen or methyl, with the provisos that when X and Y denotes -O-, R2 denotes hydrogen, R4 denotes a alpha -OH group and R3 and R5 denote hydrogen, R1 is other than cyclopropylmethyl or allyl, and that when R2,R3,R4 and R5 are each hydrogen, R1 is other than cyclopropylmethyl, in free base form or in acid addition salt form, as well as the physiologically hydrolysable, pharmaceutically acceptable esters of such compounds, which contain a free OH group, in free base form or in acid addition salt form. The compounds according to the invention are opiate agonists/antagonists and LH secretion stimulators. Intermediates of the formula III to XIV are claimed per se.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3518525 | 1985-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8602308D0 true SE8602308D0 (en) | 1986-05-21 |
| SE8602308L SE8602308L (en) | 1986-11-24 |
Family
ID=6271435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8602308A SE8602308L (en) | 1985-05-23 | 1986-05-21 | morphinan |
Country Status (18)
| Country | Link |
|---|---|
| JP (1) | JPS61271275A (en) |
| AU (1) | AU594954B2 (en) |
| BE (1) | BE904796A (en) |
| DK (1) | DK240386A (en) |
| ES (1) | ES8802318A1 (en) |
| FI (1) | FI862124A (en) |
| FR (1) | FR2582309B1 (en) |
| GB (1) | GB2175898B (en) |
| GR (1) | GR861318B (en) |
| HU (1) | HU196376B (en) |
| IL (1) | IL78872A0 (en) |
| IT (1) | IT1203791B (en) |
| LU (1) | LU86435A1 (en) |
| NL (1) | NL8601188A (en) |
| NZ (1) | NZ216250A (en) |
| PH (1) | PH23341A (en) |
| SE (1) | SE8602308L (en) |
| ZA (1) | ZA863873B (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4857533A (en) * | 1988-12-15 | 1989-08-15 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for autoimmune diseases |
| US4863928A (en) * | 1989-01-04 | 1989-09-05 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for arthritic and inflammatory diseases |
| US4923875A (en) * | 1989-07-10 | 1990-05-08 | Baker Cummins Pharmaceuticals, Inc. | Method for treatment of mast cell-mediated dermatologic disorders |
| JP2906654B2 (en) * | 1989-11-28 | 1999-06-21 | 東レ株式会社 | Immunosuppressant and method for producing the same |
| US5057322A (en) * | 1990-08-10 | 1991-10-15 | Baker Cummins Dermatologicals, Inc. | Method of treating mast cell disease |
| JP2525552B2 (en) | 1992-01-23 | 1996-08-21 | 東レ株式会社 | Morphine derivative and pharmaceutical use |
| KR100341950B1 (en) * | 1993-07-19 | 2002-11-29 | 도레이 가부시끼가이샤 | Brain cell protection agent |
| CA2143864C (en) | 1993-07-23 | 2006-01-24 | Hiroshi Nagase | Morphinan derivatives and pharmaceutical use thereof |
| JP2000503019A (en) | 1996-01-10 | 2000-03-14 | スミスクライン・ビーチャム・ソシエタ・ペル・アチオニ | Heterocyclic fused morphinoid derivative (II) |
| ATE359076T1 (en) * | 1996-11-25 | 2007-05-15 | Toray Industries | REMEDIES FOR ITCHING |
| AU6117298A (en) * | 1997-07-25 | 1999-02-16 | Toray Industries, Inc. | Hyponatremia remedies |
| JP5438250B2 (en) | 2002-05-17 | 2014-03-12 | ジェンケン バイオサイエンスィズ，インコーポレイテッド | Opioids and opioid-like compounds and their use |
| US7501433B2 (en) | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US7923454B2 (en) | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| JP4957489B2 (en) * | 2002-10-09 | 2012-06-20 | 東レ株式会社 | Pharmaceutical containing morphinan derivative having nitrogen-containing cyclic substituent or pharmacologically acceptable acid addition salt thereof |
| US8017622B2 (en) | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| AU2009214500B2 (en) | 2008-02-14 | 2014-10-23 | Alkermes, Inc. | Selective opioid compounds |
| ES2621305T3 (en) * | 2012-12-14 | 2017-07-03 | Purdue Pharma Lp | Spirocyclic morphinans and their use |
| WO2014091295A1 (en) * | 2012-12-14 | 2014-06-19 | Purdue Pharma L.P. | Pyridonemorphinan analogs and biological activity on opioid receptors |
| AR096851A1 (en) * | 2013-07-11 | 2016-02-03 | H Lundbeck As | SALTS THAT DO NOT FORM HYDRATS OR SOLVATOS DE NALMEFENO |
| MA40171A (en) * | 2014-06-13 | 2017-04-19 | Purdue Pharma Lp | Azamophinan derivatives and use thereof |
-
1986
- 1986-05-09 HU HU861934A patent/HU196376B/en not_active IP Right Cessation
- 1986-05-12 NL NL8601188A patent/NL8601188A/en not_active Application Discontinuation
- 1986-05-19 PH PH33785A patent/PH23341A/en unknown
- 1986-05-19 GB GB8612159A patent/GB2175898B/en not_active Expired
- 1986-05-21 BE BE1/011493A patent/BE904796A/en not_active IP Right Cessation
- 1986-05-21 IL IL78872A patent/IL78872A0/en unknown
- 1986-05-21 ES ES555200A patent/ES8802318A1/en not_active Expired
- 1986-05-21 FI FI862124A patent/FI862124A/en not_active Application Discontinuation
- 1986-05-21 AU AU57637/86A patent/AU594954B2/en not_active Expired - Fee Related
- 1986-05-21 NZ NZ216250A patent/NZ216250A/en unknown
- 1986-05-21 GR GR861318A patent/GR861318B/en unknown
- 1986-05-21 SE SE8602308A patent/SE8602308L/en not_active Application Discontinuation
- 1986-05-22 JP JP61118984A patent/JPS61271275A/en active Pending
- 1986-05-22 LU LU86435A patent/LU86435A1/en unknown
- 1986-05-22 DK DK240386A patent/DK240386A/en not_active Application Discontinuation
- 1986-05-23 IT IT48050/86A patent/IT1203791B/en active
- 1986-05-23 ZA ZA863873A patent/ZA863873B/en unknown
- 1986-05-23 FR FR8607367A patent/FR2582309B1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK240386D0 (en) | 1986-05-22 |
| SE8602308L (en) | 1986-11-24 |
| NZ216250A (en) | 1990-04-26 |
| LU86435A1 (en) | 1986-12-05 |
| FI862124A0 (en) | 1986-05-21 |
| PH23341A (en) | 1989-07-14 |
| GB2175898A (en) | 1986-12-10 |
| NL8601188A (en) | 1986-12-16 |
| FI862124A (en) | 1986-11-24 |
| GB2175898B (en) | 1989-07-05 |
| IT1203791B (en) | 1989-02-23 |
| AU5763786A (en) | 1986-11-27 |
| ZA863873B (en) | 1988-01-27 |
| FR2582309B1 (en) | 1989-08-18 |
| IL78872A0 (en) | 1986-09-30 |
| JPS61271275A (en) | 1986-12-01 |
| FR2582309A1 (en) | 1986-11-28 |
| GB8612159D0 (en) | 1986-06-25 |
| BE904796A (en) | 1986-11-21 |
| HU196376B (en) | 1988-11-28 |
| ES555200A0 (en) | 1988-05-01 |
| IT8648050A0 (en) | 1986-05-23 |
| AU594954B2 (en) | 1990-03-22 |
| HUT41737A (en) | 1987-05-28 |
| ES8802318A1 (en) | 1988-05-01 |
| DK240386A (en) | 1986-11-24 |
| GR861318B (en) | 1986-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
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