FR2453854A1 - Nouveaux derives d'o-(4-diphenylmethylpiperidino)-1-phenylalcanols, utiles notamment comme antihistaminiques, et leur procede de preparation - Google Patents

Nouveaux derives d'o-(4-diphenylmethylpiperidino)-1-phenylalcanols, utiles notamment comme antihistaminiques, et leur procede de preparation

Info

Publication number
FR2453854A1
FR2453854A1 FR8007992A FR8007992A FR2453854A1 FR 2453854 A1 FR2453854 A1 FR 2453854A1 FR 8007992 A FR8007992 A FR 8007992A FR 8007992 A FR8007992 A FR 8007992A FR 2453854 A1 FR2453854 A1 FR 2453854A1
Authority
FR
France
Prior art keywords
hydrogen
hydrogen atom
phenylalcanols
diphenylmethylpiperidino
antihistamins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR8007992A
Other languages
English (en)
Other versions
FR2453854B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2453854(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of FR2453854A1 publication Critical patent/FR2453854A1/fr
Application granted granted Critical
Publication of FR2453854B1 publication Critical patent/FR2453854B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LES NOUVEAUX MEDICAMENTS SELON L'INVENTION CONSISTENT EN COMPOSES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R REPRESENTE UN ATOME D'HYDROGENE OU UN GROUPE HYDROXY, R REPRESENTE UN ATOME D'HYDROGENE, OU BIEN R ET R, PRIS ENSEMBLE, FORMENT UNE SECONDE LIAISON ENTRE LES ATOMES DE CARBONE PORTANT R ET R, N EST UN ENTIER DE 1 A 5, R EST UN GROUPE -CH, -CHOH, -COOH OU -COO ALKYLE DANS LEQUEL LE RESTE ALKYLE EST A CHAINE DROITE OU RAMIFIEE EN C-C, A ET B REPRESENTENT CHACUN UN ATOME D'HYDROGENE OU UN GROUPE HYDROXY, AVEC LES CONDITIONS QUE L'UN AU MOINS DES RESTES A ET B EST UN ATOME D'HYDROGENE ET L'UN DES RESTES A ET B EST AUTRE QUE L'HYDROGENE LORSQUE R EST UN GROUPE CH; ET LEURS SELS ACCEPTABLES EN PHARMACIE ET LEURS ISOMERES OPTIQUES INDIVIDUELS. ON PEUT LES ADMINISTRER A DES DOSES JOURNALIERES D'ENVIRON 0,01 A 20MGKG DE POIDS CORPOREL, PAR EXEMPLE EN TABLETTES, CONTENANT 1 A 50MG D'INGREDIENT ACTIF, 1 A 4 FOIS PAR JOUR.
FR8007992A 1979-04-10 1980-04-09 Nouveaux derives d'o-(4-diphenylmethylpiperidino)-1-phenylalcanols, utiles notamment comme antihistaminiques, et leur procede de preparation Granted FR2453854A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (2)

Publication Number Publication Date
FR2453854A1 true FR2453854A1 (fr) 1980-11-07
FR2453854B1 FR2453854B1 (fr) 1983-06-24

Family

ID=21845568

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8007992A Granted FR2453854A1 (fr) 1979-04-10 1980-04-09 Nouveaux derives d'o-(4-diphenylmethylpiperidino)-1-phenylalcanols, utiles notamment comme antihistaminiques, et leur procede de preparation

Country Status (19)

Country Link
US (1) US4254129A (fr)
JP (1) JPS55141469A (fr)
AT (1) AT376208B (fr)
AU (1) AU531146B2 (fr)
BE (1) BE882703A (fr)
CA (1) CA1123438A (fr)
CH (1) CH643245A5 (fr)
DE (1) DE3007498A1 (fr)
DK (1) DK153709C (fr)
ES (1) ES8103735A1 (fr)
FR (1) FR2453854A1 (fr)
IL (1) IL59158A (fr)
IT (1) IT1143960B (fr)
NL (2) NL190580C (fr)
NO (2) NO154521C (fr)
NZ (1) NZ192653A (fr)
PH (1) PH17023A (fr)
SE (1) SE448726B (fr)
ZA (1) ZA80332B (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0310999A1 (fr) * 1987-10-07 1989-04-12 Merrell Dow Pharmaceuticals Inc. Composition pharmaceutique à base de dérivés pipéridinoalkanols
EP0508334A2 (fr) * 1991-04-08 1992-10-14 The Green Cross Corporation Nouveaux dérivés d'aminophénol et compositions pharmaceutiques qui les contiennent
WO1994003170A1 (fr) * 1992-08-03 1994-02-17 Sepracor Inc. Metabolites de terfenadine et leurs isomeres optiquement purs utilises dans le traitement des affections allergiques
WO1995010278A1 (fr) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Traitement des troubles allergiques par le carboxylate de terfenadine
WO1996026726A1 (fr) * 1995-02-28 1996-09-06 Hoechst Marion Roussel, Inc. Composition pharmaceutique pour composes de piperidinoalcanol
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6509353B1 (en) 1998-04-14 2003-01-21 Sepracor Inc. Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
EP2371817A1 (fr) * 2010-04-01 2011-10-05 Arevipharma GmbH Procédé pour la préparation de 1-[4-(1,1-diméthyléthyl)phényl]-4-[4-(diphénylméthoxy)-1-pipéridinyl]-1-butanone et de sels d'addition acides correspondant

Families Citing this family (107)

* Cited by examiner, † Cited by third party
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US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
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US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
ZA90341B (en) * 1989-01-23 1990-10-31 Merrell Dow Pharma Liquid pharmaceutical composition for piperidinoalkanol derivatives
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
AU669156B2 (en) * 1992-02-13 1996-05-30 Merrell Dow Pharmaceuticals Inc. Piperidinyl thiacyclic derivatives
WO1993021156A1 (fr) * 1992-04-10 1993-10-28 Merrell Dow Pharmaceuticals Inc. Derives de piperidine 4-diphenymethylique et leur procede de preparation
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
HU223774B1 (hu) 1992-05-11 2005-01-28 Merrell Dow Pharmaceuticals Inc. Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
DE69415319T2 (de) * 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
ATE230395T1 (de) 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CN1060040C (zh) * 1993-10-25 2001-01-03 默里尔药物公司 稳定的丁苯哌丁醇与布洛芬的药物组合物
AU689578B2 (en) * 1994-05-16 1998-04-02 Aventisub Ii Inc. Process and diastereomeric salts useful for the optical resolution of racemic alpha-(4-(1,1-dimethylethyl)phenyl)-4-(hydroxydiphenylmethyl )-1-piperidinebutanol and derivative compounds
CN101337922A (zh) * 1994-05-18 2009-01-07 阿温蒂斯药物公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
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ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
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EP0310999A1 (fr) * 1987-10-07 1989-04-12 Merrell Dow Pharmaceuticals Inc. Composition pharmaceutique à base de dérivés pipéridinoalkanols
US5308840A (en) * 1991-04-08 1994-05-03 Green Cross Corporation Substituted or unsubstituted benzhydryl heteroalkyl-substituted aminophenol compounds and pharmaceutical compositions thereof
EP0508334A2 (fr) * 1991-04-08 1992-10-14 The Green Cross Corporation Nouveaux dérivés d'aminophénol et compositions pharmaceutiques qui les contiennent
EP0508334A3 (en) * 1991-04-08 1993-07-21 The Green Cross Corporation Novel aminophenol derivatives and pharmaceutical compositions thereof
EP1214937A2 (fr) * 1992-08-03 2002-06-19 Sepracor Inc. Le carboxylate de la terfénadine et le traitement de l'irritation de la peau
GB2284351A (en) * 1992-08-03 1995-06-07 Sepracor Inc Terfenadine metabolites and their optically pure isomers for treating allergic disorders
EP1688142A1 (fr) * 1992-08-03 2006-08-09 Sepracor Inc. Le carboxylate de la terfénadine et le traitement de l'irritation de la peau
GB2284351B (en) * 1992-08-03 1996-11-27 Sepracor Inc Terfenadine metabolites and their optically pure isomers for treating allergic disorders
EP0815860A2 (fr) * 1992-08-03 1998-01-07 Sepracor, Inc. Le carboxylate de la terfénadine et le traitement des troubles allergiques
EP0815860A3 (fr) * 1992-08-03 1998-01-14 Sepracor, Inc. Le carboxylate de la terfénadine et le traitement des troubles allergiques
EP1214937A3 (fr) * 1992-08-03 2002-10-30 Sepracor Inc. Le carboxylate de la terfénadine et le traitement de l'irritation de la peau
WO1994003170A1 (fr) * 1992-08-03 1994-02-17 Sepracor Inc. Metabolites de terfenadine et leurs isomeres optiquement purs utilises dans le traitement des affections allergiques
WO1995010278A1 (fr) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Traitement des troubles allergiques par le carboxylate de terfenadine
US5932247A (en) * 1995-02-28 1999-08-03 Hoechst Marion Roussel, Inc. Pharmaceutical composition for piperidinoalkanol compounds
US6113942A (en) * 1995-02-28 2000-09-05 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
US5738872A (en) * 1995-02-28 1998-04-14 Hoechst Marion Roussel, Inc. Pharmaceutical composition for piperidinoalkanol compounds
WO1996026726A1 (fr) * 1995-02-28 1996-09-06 Hoechst Marion Roussel, Inc. Composition pharmaceutique pour composes de piperidinoalcanol
US8129408B2 (en) 1995-02-28 2012-03-06 Aventisub Ii Inc. Pharmaceutical composition for piperidinoalkanol compounds
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6509353B1 (en) 1998-04-14 2003-01-21 Sepracor Inc. Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US8404715B2 (en) 1998-04-14 2013-03-26 Sunovion Pharmaceuticals Inc. Methods and compositions using racemic, (R)-, and (S)-fexofenadine in combination with leukotriene inhibitors
EP2371817A1 (fr) * 2010-04-01 2011-10-05 Arevipharma GmbH Procédé pour la préparation de 1-[4-(1,1-diméthyléthyl)phényl]-4-[4-(diphénylméthoxy)-1-pipéridinyl]-1-butanone et de sels d'addition acides correspondant
WO2011121099A3 (fr) * 2010-04-01 2012-03-08 Arevipharma Gmbh Procédé pour la préparation de la 1-[4-(1,1-diméthyléthyl)phényl]-4-[4-(diphénylméthoxy)-1-pipéridinyl]-1-butanone et de sels d'addition acide de celle-ci

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CH643245A5 (de) 1984-05-30
IL59158A (en) 1984-04-30
SE448726B (sv) 1987-03-16
NL190580B (nl) 1993-12-01
BE882703A (fr) 1980-07-31
FR2453854B1 (fr) 1983-06-24
JPS55141469A (en) 1980-11-05
IT8048245A0 (it) 1980-03-24
IT1143960B (it) 1986-10-29
SE8002634L (sv) 1980-10-11
ZA80332B (en) 1981-01-28
ES489934A0 (es) 1981-03-16
ATA144880A (de) 1984-03-15
AU5501680A (en) 1980-10-16
IL59158A0 (en) 1980-05-30
DK153709C (da) 1988-12-27
NL190580C (nl) 1994-05-02
NO154521B (no) 1986-06-30
NO801014L (no) 1980-10-13
NO1998017I1 (no) 1998-05-29
NL8000754A (nl) 1980-10-14
NL980013I2 (nl) 1998-10-01
DE3007498C2 (fr) 1989-09-07
AT376208B (de) 1984-10-25
NZ192653A (en) 1982-03-16
JPH0132823B2 (fr) 1989-07-10
DE3007498A1 (de) 1980-10-23
PH17023A (en) 1984-05-11
US4254129A (en) 1981-03-03
DK153709B (da) 1988-08-22
AU531146B2 (en) 1983-08-11
DK132980A (da) 1980-10-11
ES8103735A1 (es) 1981-03-16
NO154521C (no) 1986-10-08
NL980013I1 (nl) 1998-06-02
CA1123438A (fr) 1982-05-11

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