IT8048245A0 - Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la loro preparazione - Google Patents

Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la loro preparazione

Info

Publication number
IT8048245A0
IT8048245A0 IT8048245A IT4824580A IT8048245A0 IT 8048245 A0 IT8048245 A0 IT 8048245A0 IT 8048245 A IT8048245 A IT 8048245A IT 4824580 A IT4824580 A IT 4824580A IT 8048245 A0 IT8048245 A0 IT 8048245A0
Authority
IT
Italy
Prior art keywords
bronchodilatator
histaminic
allergy
activity
procedure
Prior art date
Application number
IT8048245A
Other languages
English (en)
Other versions
IT1143960B (it
Inventor
Albert A Carr
Joseph E Dolfini
George J Wright
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21845568&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT8048245(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of IT8048245A0 publication Critical patent/IT8048245A0/it
Application granted granted Critical
Publication of IT1143960B publication Critical patent/IT1143960B/it

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT48245/80A 1979-04-10 1980-03-24 Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la preparazione IT1143960B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/028,813 US4254129A (en) 1979-04-10 1979-04-10 Piperidine derivatives

Publications (2)

Publication Number Publication Date
IT8048245A0 true IT8048245A0 (it) 1980-03-24
IT1143960B IT1143960B (it) 1986-10-29

Family

ID=21845568

Family Applications (1)

Application Number Title Priority Date Filing Date
IT48245/80A IT1143960B (it) 1979-04-10 1980-03-24 Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la preparazione

Country Status (19)

Country Link
US (1) US4254129A (it)
JP (1) JPS55141469A (it)
AT (1) AT376208B (it)
AU (1) AU531146B2 (it)
BE (1) BE882703A (it)
CA (1) CA1123438A (it)
CH (1) CH643245A5 (it)
DE (1) DE3007498A1 (it)
DK (1) DK153709C (it)
ES (1) ES8103735A1 (it)
FR (1) FR2453854A1 (it)
IL (1) IL59158A (it)
IT (1) IT1143960B (it)
NL (2) NL190580C (it)
NO (2) NO154521C (it)
NZ (1) NZ192653A (it)
PH (1) PH17023A (it)
SE (1) SE448726B (it)
ZA (1) ZA80332B (it)

Families Citing this family (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1053570C (zh) 1987-10-07 2000-06-21 默尔多药物公司 哌啶子基链烷醇的药用组合物-减充血剂复方的制备方法
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
US4908372A (en) * 1988-10-13 1990-03-13 Merrell Dow Pharmaceuticals Inc. Antihistaminic piperidinyl benzimidazoles
ZA90341B (en) * 1989-01-23 1990-10-31 Merrell Dow Pharma Liquid pharmaceutical composition for piperidinoalkanol derivatives
DE3917241A1 (de) * 1989-05-26 1990-11-29 Schaper & Bruemmer Gmbh 4-(hydroxydiphenylmethyl)-1-piperidyl-phenylalkan-derivate
US5182097A (en) * 1991-02-14 1993-01-26 Virginia Commonwealth University Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
US5190029A (en) * 1991-02-14 1993-03-02 Virginia Commonwealth University Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content
TW198008B (it) * 1991-04-08 1993-01-11 Green Cross Corp
HU211019B (en) * 1991-12-02 1995-09-28 Richter Gedeon Vegyeszet Process for producing new 1,2,3,6-tetrahydropyridine and piperidine derivatives substituted with n-(hydroxylalkyl) group and compositions comprising such compounds
PT626968E (pt) * 1992-02-13 2002-03-28 Merrell Pharma Inc Derivados de piperidinilo tiaciclicos
US5631375A (en) * 1992-04-10 1997-05-20 Merrell Pharmaceuticals, Inc. Process for piperidine derivatives
DK0635004T3 (da) * 1992-04-10 2002-11-11 Merrell Pharma Inc 4-Diphenylmethylpiperidinderivater og fremgangsmåde til fremstilling deraf
DE69320952T2 (de) * 1992-05-11 1999-05-27 Merrell Pharma Inc Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
ES2284740T3 (es) * 1992-08-03 2007-11-16 Sepracor Inc. Carboxilato de terfenadina y el tratamiento de la irritacion cutanea.
US5654433A (en) * 1993-01-26 1997-08-05 Merrell Pharmaceuticals Inc. Process for piperidine derivatives
ATE174589T1 (de) * 1993-06-24 1999-01-15 Albany Molecular Res Inc Verfahren zur herstellung von piperidinderivaten
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
CA2362337C (en) 1993-06-25 2005-08-02 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
CA2173467A1 (en) * 1993-10-25 1995-05-04 Keith D. Ertel A stable pharmaceutical composition of terfenadine and ibuprofen
WO1995031436A1 (en) * 1994-05-16 1995-11-23 Merrell Pharmaceuticals Inc. PROCESS AND DIASTEREOMERIC SALTS USEFUL FOR THE OPTICAL RESOLUTION OF RACEMIC α-[4-(1,1-DIMETHYLETHYL)PHENYL]-4-(HYDROXYDIPHENYLMETHYL)-1-PIPERIDINEBUTANOL AND DERIVATIVE COMPOUNDS
MX9605613A (es) * 1994-05-18 1998-05-31 Hoechst Marion Roussel Inc Procedimiento para preparar formas anhidras e hidratadas de derivados de piperidina antihistaminica, polimorfos y pseudomorfos de los mismos.
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
CN101497581B (zh) * 1994-05-18 2012-07-11 安万特萨博Ⅱ有限公司 抗组胺哌啶衍生物,其多晶形物和假同晶物的无水和水合物形式的制备方法
MX9701305A (es) 1994-08-25 1998-05-31 Merrell Pharma Inc Piperidinas sustituidas novedosas utiles para el tratamiento de enfermedades alergicas.
EP0812195B1 (en) * 1995-02-28 2002-10-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol compounds
CN1183769A (zh) * 1995-05-08 1998-06-03 赫彻斯特马里恩鲁斯公司 α-(取代的烷基苯基)-4-(羟基二苯基甲基)-1-哌啶丁醇衍生物,其制备和其用作抗组胺剂、抗变应性剂和支气管扩张药的用途
US5574045A (en) * 1995-06-06 1996-11-12 Hoechst Marion Roussel, Inc. Oral pharmaceutical composition of piperidinoalkanol compounds in solution form
US5906747A (en) * 1995-11-13 1999-05-25 Biosepra Inc. Separation of molecules from dilute solutions using composite chromatography media having high dynamic sorptive capacity at high flow rates
US6211199B1 (en) 1995-11-17 2001-04-03 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl-amino)piperidines useful for the treatment of allergic diseases
US6423704B2 (en) 1995-12-20 2002-07-23 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic diseases
US6194406B1 (en) 1995-12-20 2001-02-27 Aventis Pharmaceuticals Inc. Substituted 4-(1H-benzimidazol-2-yl)[1,4]diazepanes useful for the treatment of allergic disease
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5925761A (en) * 1997-02-04 1999-07-20 Sepracor Inc. Synthesis of terfenadine and derivatives
EP0864653B1 (de) * 1997-03-11 2004-03-03 Aventis Pharmaceuticals Inc. Verfahren zur Herstellung von 4-(4-(4-(Hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alpha,alpha-dimenthylphenylessigsäure und phosphorylierter Derivate
US6451815B1 (en) 1997-08-14 2002-09-17 Aventis Pharmaceuticals Inc. Method of enhancing bioavailability of fexofenadine and its derivatives
NZ501248A (en) * 1997-08-26 2001-06-29 Aventis Pharma Inc Pharmaceutical composition for combination of piperidinoalkanol-decongestant
ES2200260T3 (es) * 1997-12-17 2004-03-01 Aventis Pharma Deutschland Gmbh Procedimiento para la alquilacion de derivados de alquil-o bencilciano en presencia de trialquilaminas o trialquifosfinas.
EP1041990B1 (en) * 1997-12-23 2006-06-28 Schering Corporation Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
BR9911794A (pt) * 1998-07-02 2001-03-27 Aventis Pharma Inc Derivados anti-histamìnicos de piperidina e intermediários para a preparação dos mesmos
US6930197B2 (en) 1998-07-02 2005-08-16 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
AU2007200674C1 (en) * 1998-07-02 2011-02-24 Aventisub Llc Novel antihistaminic piperidine derivatives and intermediates for the preparation thereof
GB9822170D0 (en) * 1998-10-13 1998-12-02 Danbioyst Uk Ltd Novel formulations of fexofenadine
IN191492B (it) * 1999-05-25 2003-12-06 Ranbaxy Lab Ltd
US6613906B1 (en) * 2000-06-06 2003-09-02 Geneva Pharmaceuticals, Inc. Crystal modification
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
CH695216A5 (de) * 2001-02-23 2006-01-31 Cilag Ag Verfahren zur Herstellung eines nicht hydratisierten Salzes eines Piperidinderivats und eine so erhältliche neue kristalline Form eines solchen Salzes.
CA2444456A1 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
MXPA03011728A (es) 2001-06-18 2004-07-08 Reddyaes Lab Ltd Formas cristalinas novedosas del acido 4-[4-[4- (hidroxidifenilmetil) -1-piperidinil] -1-hidroxibutil] -alfa, alfa -dimetilbencen acetico y su clorohidrato.
US7700779B2 (en) * 2001-06-18 2010-04-20 Dr. Reddy's Laboratories Limited Crystalline forms of fexofenadine and its hydrochloride
US20030158227A1 (en) * 2001-11-08 2003-08-21 Barnaba Krochmal Polymorphs of fexofenadine base
AU2002357701A1 (en) * 2001-11-08 2003-05-19 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine base
US6723348B2 (en) * 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
EP2266590A3 (en) 2002-02-22 2011-04-20 Shire LLC Active agent delivery sytems and methods for protecting and administering active agents
WO2003104197A1 (en) * 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
CN1741981A (zh) * 2002-12-16 2006-03-01 兰贝克赛实验室有限公司 非索那汀的制备方法
US20070106078A1 (en) * 2003-01-31 2007-05-10 Sharma Mukesh K Process for the preparation of fexofenadine
US20050026890A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an antihistamine for treatment of asthma or chronic obstructive pulmonary disease
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
GB0319935D0 (en) * 2003-08-26 2003-09-24 Cipla Ltd Polymorphs
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
EP1628959A2 (en) * 2004-04-26 2006-03-01 Teva Pharmaceutical Industries Ltd Crystalline forms of fexofenadine hydrochloride and processes for their preparation
WO2006008567A1 (en) * 2004-06-18 2006-01-26 Wockhardt Limited Pharmaceutical compositions for piperidinoalkanol compounds
ITMI20041568A1 (it) * 2004-07-30 2004-10-30 Dipharma Spa "polimorfi di fexofenadina base"
US7498443B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of carebastine
US7498345B2 (en) * 2004-09-17 2009-03-03 Albany Molecular Research, Inc. Process for production of piperidine derivatives
EP1685106A2 (en) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadine crystal form and processes for its preparation thereof
US20070020330A1 (en) * 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
DK2522365T3 (en) 2004-11-24 2017-02-06 Meda Pharmaceuticals Inc Compositions comprising azelastine and methods for its use
JP2008120684A (ja) * 2005-03-07 2008-05-29 Kumamoto Univ 抗アレルギー薬
JP5133244B2 (ja) * 2005-08-05 2013-01-30 ルピン・リミテッド フェキソフェナジンの経口用医薬懸濁組成物
US20080292584A1 (en) * 2005-10-14 2008-11-27 Mutual Pharmaceutical Company, Inc. Metaxalone products, method of manufacture, and method of use
US20070088065A1 (en) * 2005-10-14 2007-04-19 Jie Du Metaxalone products, method of manufacture, and method of use
WO2007049303A2 (en) * 2005-10-28 2007-05-03 Ind-Swift Laboratories Limited An improved process for the preparation of highly pure fexofenadine
AU2006311577B2 (en) 2005-11-09 2013-02-07 Zalicus Inc. Methods, compositions, and kits for the treatment of medical conditions
DOP2006000274A (es) * 2005-12-14 2007-10-15 Sanofi Aventis Us Llc Formulación de suspensión de fexofenadina
CN100443470C (zh) * 2006-07-21 2008-12-17 杭州保灵有限公司 一种依巴斯汀的制备方法
ITMI20061492A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
ITMI20061491A1 (it) * 2006-07-27 2008-01-28 Archimica Srl Processo per la preparazione di fexofenadina.
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
BRPI0810621A2 (pt) 2007-04-13 2017-06-06 Southern Res Inst métodos de inibição ou redução da angiogênese, do crescimento ou metástase de tumor dependente da mesma e de tratamento de doença ou desordem associada a angiogênese.
ITMI20070987A1 (it) * 2007-05-16 2008-11-17 Dipharma Francis Srl Procedimento per la preparazione di composti chetonici
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
US20090306135A1 (en) 2008-03-24 2009-12-10 Mukesh Kumar Sharma Stable amorphous fexofenadine hydrochloride
WO2009158144A1 (en) * 2008-05-30 2009-12-30 Fairfield Clinical Trials Llc Method and composition for dermatoses
US20100092479A1 (en) * 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
CN101585805B (zh) * 2009-06-06 2011-07-06 浙江大学宁波理工学院 一种抗过敏药物非索非那定盐酸盐的制备方法
EP2289867A3 (en) 2009-08-19 2012-04-25 Jubilant Organosys Limited A process for producing 4-(4-halo-1-oxybutyl)-alpha,alpha-dimethylbenzene acetic acid or alkyl esters thereof
CN101671292B (zh) * 2009-10-10 2011-09-07 浙江大学宁波理工学院 盐酸非索非那定的合成方法
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
EP2371817A1 (en) * 2010-04-01 2011-10-05 Arevipharma GmbH Process for the preparation of 1-[4-(1,1-dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone and acid addition salts thereof
WO2011158262A1 (en) 2010-06-15 2011-12-22 Chemelectiva S.R.L. Polymorphic form of fexofenadine hydrochloride, intermediates and process for its preparation
SG194625A1 (en) 2011-05-23 2013-12-30 Sanofi Sa Process for the preparation of deuterated compounds containing n-alkyl groups
AR088204A1 (es) 2011-09-29 2014-05-14 Shionogi & Co Medicamentos para el tratamiento de la rinitis alergica que comprenden un antagonista de pgd2 y un antagonista de histamina
EP2578570A1 (en) 2011-10-07 2013-04-10 Almirall, S.A. Novel process for preparing 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1(r)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one via novel intermediates of synthesis.
EP2641900A1 (en) 2012-03-20 2013-09-25 Almirall, S.A. Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor.
CN102659667B (zh) * 2012-04-20 2013-08-14 浙江启明药业有限公司 一种非索非那定关键中间体的合成方法
CN103333100B (zh) * 2013-06-06 2016-04-06 池州东升药业有限公司 一种盐酸非索非那定的合成工艺
ITMI20131652A1 (it) 2013-10-07 2015-04-08 Dipharma Francis Srl Procedimento per la purificazione di derivati dell'acido 2-fenil-2-metil-propanoico
CN104557671B (zh) * 2013-10-10 2018-04-13 池州东升药业有限公司 一种非索非那定及中间体的合成方法
EP2949321A1 (en) 2014-05-26 2015-12-02 Sanovel Ilac Sanayi ve Ticaret A.S. Multilayer formulations of fexofenadine and montelukast
CN107428678B (zh) 2015-01-22 2021-01-01 赛诺菲-安万特德国有限公司 用于制备2-[4-(环丙烷羰基)苯基]-2-甲基-丙腈的方法
RS59874B1 (sr) 2015-10-22 2020-03-31 Sanofi Aventis Deutschland Proces za pripremu feksofenadina i njegovih intermedijara
GB202212656D0 (en) 2022-08-31 2022-10-12 Novumgen Ltd An orodispersible tablet of fecofenadine and it process of preparation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1242169A (en) * 1969-04-09 1971-08-11 Ucb Sa Piperidine derivatives
BE794596A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Piperidinoalcanone-oximes substituees et leur procede de preparation
US3965257A (en) * 1972-01-28 1976-06-22 Richardson-Merrell Inc. Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
BE794598A (fr) * 1972-01-28 1973-05-16 Richardson Merrell Inc Nouveaux derives olefiniques de piperidines substituees en 4 et leur procede de preparation
US3931197A (en) * 1974-02-08 1976-01-06 Richardson-Merrell Inc. Substituted piperidine derivatives
US3941795A (en) * 1974-02-08 1976-03-02 Richardson-Merrell Inc. α-ARYL-4-SUBSTITUTED PIPERIDINOALKANOL DERIVATIVES
US3946022A (en) * 1974-03-04 1976-03-23 Richardson-Merrell Inc. Piperidine derivatives
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
US3922276A (en) * 1974-12-11 1975-11-25 Robins Co Inc A H 1-Substituted-4-benzylidenepiperidines

Also Published As

Publication number Publication date
NO1998017I1 (no) 1998-05-29
AT376208B (de) 1984-10-25
FR2453854B1 (it) 1983-06-24
NL8000754A (nl) 1980-10-14
DK132980A (da) 1980-10-11
AU5501680A (en) 1980-10-16
NO154521C (no) 1986-10-08
DK153709B (da) 1988-08-22
NL190580C (nl) 1994-05-02
CA1123438A (en) 1982-05-11
DK153709C (da) 1988-12-27
IL59158A (en) 1984-04-30
US4254129A (en) 1981-03-03
ATA144880A (de) 1984-03-15
ES489934A0 (es) 1981-03-16
SE448726B (sv) 1987-03-16
IT1143960B (it) 1986-10-29
NO154521B (no) 1986-06-30
NL980013I1 (nl) 1998-06-02
BE882703A (fr) 1980-07-31
IL59158A0 (en) 1980-05-30
FR2453854A1 (fr) 1980-11-07
DE3007498C2 (it) 1989-09-07
AU531146B2 (en) 1983-08-11
JPH0132823B2 (it) 1989-07-10
ES8103735A1 (es) 1981-03-16
ZA80332B (en) 1981-01-28
NL190580B (nl) 1993-12-01
DE3007498A1 (de) 1980-10-23
PH17023A (en) 1984-05-11
NO801014L (no) 1980-10-13
NZ192653A (en) 1982-03-16
NL980013I2 (nl) 1998-10-01
SE8002634L (sv) 1980-10-11
JPS55141469A (en) 1980-11-05
CH643245A5 (de) 1984-05-30

Similar Documents

Publication Publication Date Title
IT8048245A0 (it) Nuovi derivati piperidinici dotati di attivita' anti-istaminica antiallergia e broncodilatatrice e procedimento per la loro preparazione
IT8047919A0 (it) Nuovi derivati piperidinici dotati di proprieta' antiistaminiche antiallergiche e broncodilatatrici e procedimento per la loro preparazione
IT1200092B (it) Derivati amminopropossi, loro preparazione e loro impiego come medicamenti
IT1148277B (it) Derivati encefalinici dotati di attivita' analgesica e tranquillante neurolettica e procedimento per la loro preparazione
IT1189208B (it) Derivati dell'indolo,loro preparazione e loro impiego come medicamenti
IT1229523B (it) Derivati isochinolinici, procedimento per la loro preparazione ed impiego
IT1219542B (it) Derivati pepticidi,loro preparazione e loro impiego come medicamenti
IT1164761B (it) Derivati amminci dotati di attivita' farmacologica e procedimento per la loro preparazione
MY8400079A (en) 2,3-dihydro-2,2-dimenthyl-benzofuran-7-yl derivatives and their use as insecticides
IT8747874A0 (it) La loro preparazione derivati tiodiossolanici ad attivita' moculitica e procedimento per
IT1185828B (it) Derivati del calcone e procedimento per la loro preparazione
IT8548298A0 (it) Nuovi derivati steroidei sostituiti in posizione 11-beta, procedimento per la loro preparazione e loro applicazione come medicamenti
IT1149026B (it) Derivati di spirotiazolidinil piperazina dotati di attivita' antipsicotica, e procedimento per la loro preparazione
IT1162395B (it) Derivati auronici dotati di attivita' farmacologica e procedimento per la loro preparazione
IT8249771A0 (it) Derivati di cicloesanone aventi attivita' diserbante, e procedimento per la loro preparazione
IT1143941B (it) Derivati alfa-alogenometilamminici dotati di attivita' farmacologica e procedimento per la loro preparazione
IT1147646B (it) Alcoli eterociclici,loro derivati funzionali,e procedimento per la loro preparazione
IT8021285A0 (it) Derivati dell'amminoisochinolina e procedimento per la loro preparazione.
IT1231756B (it) Composti eterociclici, loro preparazione e loro impiego come coloranti
IT1148145B (it) Derivati azaspiroalcandionici dotati di attivita'psicotropica e procedimento per la loro preparazione
IT1190721B (it) Derivati 3-azetidiniletil-1-fenil-2-imidazolidinici ad attivita' neurolettica,procedimento per la loro preparazione e loro impiego
IT1103860B (it) Derivati di piridina dotati di attivita'diserbante e procedimento per la loro produzione
IT8819545A0 (it) Derivati piperazinici eprocedimento per la loro preparazione.
IT1209900B (it) Derivati benzanilidici dotati di attivita' farmacologica e procedimento per la loro produzione
IT1211010B (it) Nuovi derivati dell'isossazolo eprocedimento per la loro preparazione.

Legal Events

Date Code Title Description
MEDD Supplementary protection certificate for pharmaceutical products: granted

Free format text: CCP 598, 19971120; MERRELL PHARMACEUTICAL INCORPORATIO N

TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19990331