DE69320952T2 - Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten - Google Patents

Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten

Info

Publication number
DE69320952T2
DE69320952T2 DE69320952T DE69320952T DE69320952T2 DE 69320952 T2 DE69320952 T2 DE 69320952T2 DE 69320952 T DE69320952 T DE 69320952T DE 69320952 T DE69320952 T DE 69320952T DE 69320952 T2 DE69320952 T2 DE 69320952T2
Authority
DE
Germany
Prior art keywords
hydrogen
antihistaminics
liver disease
disease patients
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69320952T
Other languages
English (en)
Other versions
DE69320952D1 (de
Inventor
James Woodward
Richard Okerholm
Mark Eller
Bruce Mcnutt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27128589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69320952(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69320952D1 publication Critical patent/DE69320952D1/de
Application granted granted Critical
Publication of DE69320952T2 publication Critical patent/DE69320952T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69320952T 1992-05-11 1993-04-06 Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten Expired - Lifetime DE69320952T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88080192A 1992-05-11 1992-05-11
US92289092A 1992-07-31 1992-07-31
PCT/US1993/003151 WO1993023047A1 (en) 1992-05-11 1993-04-06 Use of terfenadine derivatives as antihistaminics in a hepatically impaired patient

Publications (2)

Publication Number Publication Date
DE69320952D1 DE69320952D1 (de) 1998-10-15
DE69320952T2 true DE69320952T2 (de) 1999-05-27

Family

ID=27128589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69320952T Expired - Lifetime DE69320952T2 (de) 1992-05-11 1993-04-06 Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten

Country Status (16)

Country Link
US (7) US6037353A (de)
EP (1) EP0639976B1 (de)
JP (1) JPH07506828A (de)
KR (1) KR950701525A (de)
AT (1) ATE194913T1 (de)
AU (1) AU679910B2 (de)
CA (1) CA2134211C (de)
CL (1) CL2004000304A1 (de)
DE (1) DE69320952T2 (de)
DK (1) DK0639976T3 (de)
ES (1) ES2121084T3 (de)
HU (1) HU223774B1 (de)
MX (1) MX9302704A (de)
NO (1) NO307688B1 (de)
NZ (1) NZ251834A (de)
WO (1) WO1993023047A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69320952T2 (de) * 1992-05-11 1999-05-27 Merrell Pharma Inc Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
WO1995010278A1 (en) * 1993-10-15 1995-04-20 Hoechst Marion Roussel, Inc. Treatment of allergic disorders with terfenadine carboxylate
IT1271417B (it) * 1993-10-15 1997-05-28 Erregierre Ind Chim Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono.
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
AU693892B2 (en) 1994-05-18 1998-07-09 Aventisub Ii Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof
DE69624559T2 (de) 1995-02-28 2003-07-10 Aventis Pharma Inc Arzneizubereitungen für piperidinalkanolderivate
KR100514264B1 (ko) * 1997-08-26 2005-09-15 아벤티스 파마슈티칼스 인크. 피페리디노알칸올-충혈완화제 조합용 제약 조성물
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US20030021849A1 (en) * 2001-04-09 2003-01-30 Ben-Zion Dolitzky Polymorphs of fexofenadine hydrochloride
CA2444456A1 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
WO2003104197A1 (en) * 2002-06-10 2003-12-18 Teva Pharmaceutical Industries Ltd. Polymorphic form xvi of fexofenadine hydrochloride
EP1393728A1 (de) * 2002-08-30 2004-03-03 Vrije Universiteit Auf Virus-kodierte G Protein-gekoppelte Rezeptoren wirkende inverse Agonisten
US20050065183A1 (en) * 2003-07-31 2005-03-24 Indranil Nandi Fexofenadine composition and process for preparing
MXPA06012281A (es) * 2004-04-26 2007-07-18 Teva Pharma Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion.
EP1685106A2 (de) * 2004-09-28 2006-08-02 Teva Pharmaceutical Industries, Inc. Fexofendadin-kristallform und verfahren zu deren herstellung
US20090076080A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched fexofenadine
AU2009251743A1 (en) * 2008-05-30 2009-12-03 Fairfield Clinical Trials, Llc Method and composition for skin inflammation and discoloration

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254129A (en) * 1979-04-10 1981-03-03 Richardson-Merrell Inc. Piperidine derivatives
US4285958A (en) * 1979-04-10 1981-08-25 Richardson-Merrell Inc. 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof
US4929605A (en) * 1987-10-07 1990-05-29 Merrell Dow Pharmaceuticals Inc. Pharmaceutical composition for piperidinoalkanol derivatives
AR240018A1 (es) * 1987-10-07 1990-01-31 Merrell Pharma Inc Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol.
DE69320952T2 (de) * 1992-05-11 1999-05-27 Merrell Pharma Inc Verwendung von terfenadin-derivaten als antihistaminika in leberkranken patienten
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica

Also Published As

Publication number Publication date
EP0639976B1 (de) 2000-07-26
NZ251834A (en) 1997-07-27
US20030055083A1 (en) 2003-03-20
US20100168166A1 (en) 2010-07-01
ES2121084T3 (es) 2002-02-16
NO944287D0 (no) 1994-11-10
MX9302704A (es) 1994-06-30
DE69320952D1 (de) 1998-10-15
US20060205782A1 (en) 2006-09-14
CA2134211C (en) 1999-06-29
DK0639976T3 (da) 1999-02-15
CA2134211A1 (en) 1993-11-25
CL2004000304A1 (es) 2005-05-27
NO944287L (no) 1994-11-10
AU3973493A (en) 1993-12-13
US6037353A (en) 2000-03-14
KR950701525A (ko) 1995-04-28
US6187791B1 (en) 2001-02-13
US6399632B1 (en) 2002-06-04
ATE194913T1 (de) 2000-08-15
HUT71402A (en) 1995-11-28
AU679910B2 (en) 1997-07-17
US20030130315A1 (en) 2003-07-10
EP0639976A1 (de) 1995-03-01
HU223774B1 (hu) 2005-01-28
WO1993023047A1 (en) 1993-11-25
NO307688B1 (no) 2000-05-15
JPH07506828A (ja) 1995-07-27

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Legal Events

Date Code Title Description
8370 Indication related to discontinuation of the patent is to be deleted
8380 Miscellaneous part iii

Free format text: IM HEFT 21/99, SEITE 6667, SP.2: DIE VEROEFFENTLICHUNG IST ZU STREICHEN

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US