ES2121084T3 - Utilizacion de derivados de terfenadina como antihistaminicos en un paciente que padece de trastornos hepaticos. - Google Patents
Utilizacion de derivados de terfenadina como antihistaminicos en un paciente que padece de trastornos hepaticos.Info
- Publication number
- ES2121084T3 ES2121084T3 ES93909249T ES93909249T ES2121084T3 ES 2121084 T3 ES2121084 T3 ES 2121084T3 ES 93909249 T ES93909249 T ES 93909249T ES 93909249 T ES93909249 T ES 93909249T ES 2121084 T3 ES2121084 T3 ES 2121084T3
- Authority
- ES
- Spain
- Prior art keywords
- patient
- hydrogen
- antihistaminics
- hepatic disorders
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immunology (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN METODO PARA PROPORCIONAR UN EFECTO ANTIHISTAMINICO EN UN PACIENTE DAÑADO HEPATICAMENTE QUE LO NECESITE, Y QUE CONSISTE EN ADMINISTRAR A DICHO PACIENTE UNA CANTIDAD ANTIHISTAMINICA EFECTIVA DE UN COMPUESTO DE LA FORMULA (I) EN LA QUE R1 ES HIDROGENO O HIDROXI; R2 ES HIDROGENO; O R1 Y R2 JUNTOS FORMAN UN SEGUNDO ENLACE ENTRE LOS ATOMOS DE CARBONO QUE LLEVAN R1 Y R2; N ES UN ENTRE DE 1 A 5; R3 ES -COOH O -COOALKILO EN DONDE LA UNIDAD DE ALKILO TIENE DE 1 A 6 ATOMOS DE CARBONO Y ES DE CADENA RECTA O RAMIFICADA; CADA A Y B ES HIDROGENO O HIDROXI SIEMPRE Y CUANDO AL MENOS UNO DE ENTRE A Y B SEA HIDROGENO; O UNA SAL FARMACEUTICAMENTE ACEPTABLE E ISOMEROS INDIVIDUALES DEL MISMO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88080192A | 1992-05-11 | 1992-05-11 | |
US92289092A | 1992-07-31 | 1992-07-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2121084T3 true ES2121084T3 (es) | 2002-02-16 |
Family
ID=27128589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93909249T Expired - Lifetime ES2121084T3 (es) | 1992-05-11 | 1993-04-06 | Utilizacion de derivados de terfenadina como antihistaminicos en un paciente que padece de trastornos hepaticos. |
Country Status (16)
Country | Link |
---|---|
US (7) | US6037353A (es) |
EP (1) | EP0639976B1 (es) |
JP (1) | JPH07506828A (es) |
KR (1) | KR950701525A (es) |
AT (1) | ATE194913T1 (es) |
AU (1) | AU679910B2 (es) |
CA (1) | CA2134211C (es) |
CL (1) | CL2004000304A1 (es) |
DE (1) | DE69320952T2 (es) |
DK (1) | DK0639976T3 (es) |
ES (1) | ES2121084T3 (es) |
HU (1) | HU223774B1 (es) |
MX (1) | MX9302704A (es) |
NO (1) | NO307688B1 (es) |
NZ (1) | NZ251834A (es) |
WO (1) | WO1993023047A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU223774B1 (hu) * | 1992-05-11 | 2005-01-28 | Merrell Dow Pharmaceuticals Inc. | Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására |
DE69334008T2 (de) † | 1992-08-03 | 2006-10-19 | Sepracor Inc., Marlborough | Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen |
IT1271417B (it) * | 1993-10-15 | 1997-05-28 | Erregierre Ind Chim | Composti ad attivita' antiistaminica procedimento per la loro preperazione e composizioni farmaceutiche che li contengono. |
WO1995010278A1 (en) * | 1993-10-15 | 1995-04-20 | Hoechst Marion Roussel, Inc. | Treatment of allergic disorders with terfenadine carboxylate |
CA2189007C (en) | 1994-05-18 | 2004-03-02 | Daniel R. Henton | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof |
US20030045722A1 (en) * | 1994-05-18 | 2003-03-06 | Henton Daniel R. | Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof |
MX9706449A (es) | 1995-02-28 | 1997-11-29 | Hoechst Marion Roussel Inc | Composicion farmaceutica para compuestos de piperidinalcanol. |
WO1999009957A1 (en) * | 1997-08-26 | 1999-03-04 | Hoechst Marion Roussel, Inc. | Pharmaceutical composition for combination of piperidinoalkanol-decongestant |
US6194431B1 (en) | 1998-04-14 | 2001-02-27 | Paul D. Rubin | Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors |
US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
US20020177608A1 (en) * | 2001-04-09 | 2002-11-28 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
JP4625637B2 (ja) | 2002-02-22 | 2011-02-02 | シャイア エルエルシー | 活性物質送達系及び活性物質を保護し投与する方法 |
DE03757471T1 (de) * | 2002-06-10 | 2005-09-01 | Teva Pharmaceutical Industries Ltd. | Polymorphe form xvi von fexofenadin-hydrochlorid |
EP1393728A1 (en) * | 2002-08-30 | 2004-03-03 | Vrije Universiteit | Inverse agonists acting at virus-encoded G protein-coupled receptors |
US20050065183A1 (en) * | 2003-07-31 | 2005-03-24 | Indranil Nandi | Fexofenadine composition and process for preparing |
CA2560882A1 (en) * | 2004-04-26 | 2005-11-03 | Teva Pharmaceutical Industries Ltd. | Crystalline forms of fexofenadine hydrochloride and processes for their preparation |
JP2008514641A (ja) * | 2004-09-28 | 2008-05-08 | テバ ファーマシューティカル インダストリーズ リミティド | 結晶形フェキソフェナジン、およびその調製方法 |
US20090076080A1 (en) * | 2007-09-19 | 2009-03-19 | Protia, Llc | Deuterium-enriched fexofenadine |
KR20110017365A (ko) * | 2008-05-30 | 2011-02-21 | 페어필드 클리니컬 트라이얼즈 엘엘씨 | 피부 염증 및 변색을 위한 방법 및 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
US4285958A (en) * | 1979-04-10 | 1981-08-25 | Richardson-Merrell Inc. | 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof |
AR240018A1 (es) * | 1987-10-07 | 1990-01-31 | Merrell Pharma Inc | Procedimiento para preparar una composicion que comprende derivados de piperidinoalcanol. |
US4929605A (en) * | 1987-10-07 | 1990-05-29 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical composition for piperidinoalkanol derivatives |
HU223774B1 (hu) * | 1992-05-11 | 2005-01-28 | Merrell Dow Pharmaceuticals Inc. | Terfenadinszármazékok alkalmazása antihisztamin hatású gyógyszerkészítmények előállítására |
DE69334008T2 (de) * | 1992-08-03 | 2006-10-19 | Sepracor Inc., Marlborough | Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen |
-
1993
- 1993-04-06 HU HU9403234A patent/HU223774B1/hu active IP Right Grant
- 1993-04-06 AU AU39734/93A patent/AU679910B2/en not_active Expired
- 1993-04-06 AT AT93909249T patent/ATE194913T1/de active
- 1993-04-06 DE DE69320952T patent/DE69320952T2/de not_active Expired - Lifetime
- 1993-04-06 KR KR1019940704016A patent/KR950701525A/ko active Search and Examination
- 1993-04-06 NZ NZ251834A patent/NZ251834A/en not_active IP Right Cessation
- 1993-04-06 DK DK93909249T patent/DK0639976T3/da active
- 1993-04-06 EP EP93909249A patent/EP0639976B1/en not_active Expired - Lifetime
- 1993-04-06 JP JP5520211A patent/JPH07506828A/ja active Pending
- 1993-04-06 CA CA002134211A patent/CA2134211C/en not_active Expired - Lifetime
- 1993-04-06 WO PCT/US1993/003151 patent/WO1993023047A1/en active IP Right Grant
- 1993-04-06 ES ES93909249T patent/ES2121084T3/es not_active Expired - Lifetime
- 1993-05-07 MX MX9302704A patent/MX9302704A/es unknown
-
1994
- 1994-11-10 NO NO944287A patent/NO307688B1/no not_active IP Right Cessation
-
1995
- 1995-03-02 US US08/397,542 patent/US6037353A/en not_active Expired - Lifetime
-
2000
- 2000-01-12 US US09/481,404 patent/US6187791B1/en not_active Expired - Fee Related
- 2000-02-11 US US09/502,331 patent/US20030055083A1/en not_active Abandoned
- 2000-09-15 US US09/663,343 patent/US6399632B1/en not_active Expired - Fee Related
-
2003
- 2003-02-25 US US10/372,307 patent/US20030130315A1/en not_active Abandoned
-
2004
- 2004-02-19 CL CL200400304A patent/CL2004000304A1/es unknown
-
2006
- 2006-05-15 US US11/433,433 patent/US20060205782A1/en not_active Abandoned
-
2009
- 2009-07-01 US US12/496,153 patent/US20100168166A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ251834A (en) | 1997-07-27 |
US6037353A (en) | 2000-03-14 |
DE69320952T2 (de) | 1999-05-27 |
MX9302704A (es) | 1994-06-30 |
CL2004000304A1 (es) | 2005-05-27 |
NO944287D0 (no) | 1994-11-10 |
EP0639976B1 (en) | 2000-07-26 |
HUT71402A (en) | 1995-11-28 |
DE69320952D1 (de) | 1998-10-15 |
EP0639976A1 (en) | 1995-03-01 |
US6187791B1 (en) | 2001-02-13 |
NO944287L (no) | 1994-11-10 |
US20100168166A1 (en) | 2010-07-01 |
AU679910B2 (en) | 1997-07-17 |
HU223774B1 (hu) | 2005-01-28 |
NO307688B1 (no) | 2000-05-15 |
US20030130315A1 (en) | 2003-07-10 |
DK0639976T3 (da) | 1999-02-15 |
US20030055083A1 (en) | 2003-03-20 |
ATE194913T1 (de) | 2000-08-15 |
KR950701525A (ko) | 1995-04-28 |
US20060205782A1 (en) | 2006-09-14 |
US6399632B1 (en) | 2002-06-04 |
CA2134211C (en) | 1999-06-29 |
AU3973493A (en) | 1993-12-13 |
CA2134211A1 (en) | 1993-11-25 |
WO1993023047A1 (en) | 1993-11-25 |
JPH07506828A (ja) | 1995-07-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2121084T3 (es) | Utilizacion de derivados de terfenadina como antihistaminicos en un paciente que padece de trastornos hepaticos. | |
HK1032226A1 (en) | Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/eiphenylmethoxy piperidine derivatives. | |
ES2126068T3 (es) | Derivados de estilbeno citotoxicos y composicion farmaceutica que los contiene. | |
ES2091057T3 (es) | Composicion medicinal que mejora el metabolismo de los lipidos. | |
DE69315827D1 (de) | Neue acylierte phospholipid-arzneimittel | |
ES2055235T3 (es) | Composicion anti-inflamatoria y/o antialergica que comprende derivados de glutation. | |
ATE172959T1 (de) | Acylphenylglycin-derivat und dieses als aktivbestandteil enthaltendes vorbeugungs -und heilmittel gegen durch erhöhte collagenaseaktivität verursachte krankheiten | |
ES2058315T3 (es) | Compuestos eficaces contra insuficiencia cerebral. | |
HN1999000026A (es) | Biciclo (2.2.1) heptanos y compuestos relacionados. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 639976 Country of ref document: ES |
|
FG2A | Definitive protection |
Ref document number: 639976 Country of ref document: ES |