FR2424908A1 - Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant - Google Patents

Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant

Info

Publication number
FR2424908A1
FR2424908A1 FR7903536A FR7903536A FR2424908A1 FR 2424908 A1 FR2424908 A1 FR 2424908A1 FR 7903536 A FR7903536 A FR 7903536A FR 7903536 A FR7903536 A FR 7903536A FR 2424908 A1 FR2424908 A1 FR 2424908A1
Authority
FR
France
Prior art keywords
new
prostacycline
analogues
production process
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7903536A
Other languages
English (en)
Other versions
FR2424908B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of FR2424908A1 publication Critical patent/FR2424908A1/fr
Application granted granted Critical
Publication of FR2424908B1 publication Critical patent/FR2424908B1/fr
Granted legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/095—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of esters of organic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/60—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/08—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE DE NOUVEAUX ANALOGUES DE PROSTACYCLINE PGI DU TYPE 6A-CARBA, PAR EXEMPLE UN COMPOSE DE FORMULE: (CF DESSIN DANS BOPI) ELLE CONCERNE EN OUTRE UN PROCEDE DE PREPARATION DE CES COMPOSES ET DES COMPOSES INTERMEDIAIRES CORRESPONDANTS. LES NOUVEAUX ANALOGUES DE PROSTACYCLINE DE L'INVENTION SONT DOUES D'ACTIVITE PHARMACOLOGIQUE.
FR7903536A 1978-02-13 1979-02-12 Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant Granted FR2424908A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/877,253 US4705806A (en) 1978-02-13 1978-02-13 Prostacyclin analogs

Publications (2)

Publication Number Publication Date
FR2424908A1 true FR2424908A1 (fr) 1979-11-30
FR2424908B1 FR2424908B1 (fr) 1982-04-16

Family

ID=25369560

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7903536A Granted FR2424908A1 (fr) 1978-02-13 1979-02-12 Nouveaux analogues de prostacycline, leur procede de production et medicament les contenant

Country Status (14)

Country Link
US (1) US4705806A (fr)
JP (1) JPS5823869B2 (fr)
AU (1) AU536416B2 (fr)
BE (1) BE874135A (fr)
CH (2) CH639062A5 (fr)
DE (1) DE2904655A1 (fr)
FR (1) FR2424908A1 (fr)
GB (1) GB2014143B (fr)
IE (1) IE48178B1 (fr)
IL (2) IL56479A0 (fr)
IT (1) IT1113024B (fr)
NL (2) NL7901070A (fr)
SE (1) SE7901126L (fr)
ZA (1) ZA79176B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2466446A1 (fr) * 1978-01-26 1981-04-10 Erba Farmitalia Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2
US4608388A (en) * 1985-03-27 1986-08-26 Syntex (U.S.A.) Inc. Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties
US4678805A (en) * 1985-03-27 1987-07-07 Syntex (U.S.A.) Inc. Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4525586A (en) * 1980-02-28 1985-06-25 The Upjohn Company Composition and process
DE3048906A1 (de) * 1980-12-19 1982-07-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3104044A1 (de) * 1981-02-02 1982-08-26 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE3121155A1 (de) * 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3221193A1 (de) * 1982-05-28 1983-12-01 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3225287A1 (de) * 1982-07-02 1984-01-05 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3226550A1 (de) * 1982-07-13 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS5951276A (ja) * 1982-09-17 1984-03-24 Ono Pharmaceut Co Ltd ビシクロ〔３．３．０〕オクタン誘導体及びその製造方法
GB2156340A (en) * 1984-03-26 1985-10-09 Erba Farmitalia 1-Nor-2-hydroxymethyl-derivatives of carboprostacyclins and process for their preparation
JPS6188975U (fr) * 1984-11-16 1986-06-10
JPH0313502Y2 (fr) * 1985-06-28 1991-03-27
JPH0313492Y2 (fr) * 1985-07-22 1991-03-27
EP0293465B1 (fr) * 1986-11-28 1992-03-18 The Liposome Company, Inc. Composition a base de phospholipides
EP0634172A4 (fr) * 1993-02-03 1995-08-02 Teijin Ltd Composition de preparation dermatologique contenant de la prostacycline comme principe actif.
AU782869B2 (en) * 1999-08-05 2005-09-08 Teijin Limited Neuropathy improvers containing nitrogenous compounds as the active ingredient
BRPI0918134B1 (pt) * 2008-09-10 2019-02-12 Kaken Pharmaceutical Co., Ltd Derivado de prostaglandina i2

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1060007A (fr) * 1975-02-18 1979-08-07 Gilbert A. Youngdale Analogues de la 2a,2b-dihomo-16,16-dimethylprostaglandine
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
EXBK/69 *
EXBK/78 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2466446A1 (fr) * 1978-01-26 1981-04-10 Erba Farmitalia Bicyclo-alcanones, intermediaires de la preparation d'isosteres de type 9-desoxy-9a-methylene de pgi2
US4608388A (en) * 1985-03-27 1986-08-26 Syntex (U.S.A.) Inc. Novel [4,2,0]bicyclooctane derivatives with valuable therapeutic properties
US4678805A (en) * 1985-03-27 1987-07-07 Syntex (U.S.A.) Inc. Novel 8-(lower alkyl)bicyclo[4.2.0]octane derivatives with valuable therapeutic properties

Also Published As

Publication number Publication date
FR2424908B1 (fr) 1982-04-16
IL60491A0 (en) 1980-09-16
CH638483A5 (de) 1983-09-30
BE874135A (fr) 1979-08-13
AU536416B2 (en) 1984-05-10
IT7920138A0 (it) 1979-02-12
CH639062A5 (de) 1983-10-31
US4705806A (en) 1987-11-10
DE2904655A1 (de) 1979-08-23
IE790270L (en) 1979-08-13
JPS54117450A (en) 1979-09-12
NL8003579A (nl) 1980-09-30
GB2014143A (en) 1979-08-22
AU4360579A (en) 1979-08-23
GB2014143B (en) 1982-08-04
IT1113024B (it) 1986-01-20
JPS5823869B2 (ja) 1983-05-18
NL7901070A (nl) 1979-08-15
IL56479A0 (en) 1979-03-12
SE7901126L (sv) 1979-08-14
ZA79176B (en) 1979-12-27
IE48178B1 (en) 1984-10-17

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