ATA873678A - Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate sowie von deren salzen, solvaten, optisch aktiven antipoden, geometrischen und stereoisomeren und tautomeren - Google Patents

Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate sowie von deren salzen, solvaten, optisch aktiven antipoden, geometrischen und stereoisomeren und tautomeren

Info

Publication number
ATA873678A
ATA873678A AT0873678A AT873678A ATA873678A AT A873678 A ATA873678 A AT A873678A AT 0873678 A AT0873678 A AT 0873678A AT 873678 A AT873678 A AT 873678A AT A873678 A ATA873678 A AT A873678A
Authority
AT
Austria
Prior art keywords
tautomers
solvates
stereoisomers
geometric
salts
Prior art date
Application number
AT0873678A
Other languages
English (en)
Other versions
AT375936B (de
Inventor
Istvan Dipl Ing Chem D Hermecz
Zoltan Dipl Ing Chem Meszaros
Tibor Dipl Ing Chem Breining
Sandor Dr Virag
Lelle Dr Vasvari
Agnes Dipl Ing Chem Horvath
Gabor Dr Nagy
Attila Dipl Ing Chem Dr Mandi
Tamas Dipl Ing Chem Dr Szuecs
Istvan Dipl Ing Chem Dr Bitter
Gyula Dr Sebestyen
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to AT58982A priority Critical patent/AT376981B/de
Priority to AT58882A priority patent/AT376980B/de
Publication of ATA873678A publication Critical patent/ATA873678A/de
Application granted granted Critical
Publication of AT375936B publication Critical patent/AT375936B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT0873678A 1977-12-29 1978-12-07 Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate sowie von deren salzen, solvaten, optisch aktiven antipoden, geometrischen und stereoisomeren und tautomeren AT375936B (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT58982A AT376981B (de) 1977-12-29 1982-02-16 Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate, von deren pharmazeutisch akzeptablen salzen sowie deren solvaten, stereoisomeren und tautomeren
AT58882A AT376980B (de) 1977-12-29 1982-02-16 Verfahren zur herstellung neuer pyrido(1,2-a)pyrimidin-derivate, von deren pharmazeutisch akzeptablen salzen sowie deren solvaten, stereoisomeren und tautomeren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1794A HU178496B (en) 1977-12-29 1977-12-29 Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Publications (2)

Publication Number Publication Date
ATA873678A true ATA873678A (de) 1984-02-15
AT375936B AT375936B (de) 1984-09-25

Family

ID=10994683

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0873678A AT375936B (de) 1977-12-29 1978-12-07 Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate sowie von deren salzen, solvaten, optisch aktiven antipoden, geometrischen und stereoisomeren und tautomeren

Country Status (29)

Country Link
US (2) US4234586A (de)
JP (1) JPS5495598A (de)
AR (3) AR222985A1 (de)
AT (1) AT375936B (de)
AU (1) AU520428B2 (de)
BE (1) BE873194A (de)
CA (1) CA1130284A (de)
CH (1) CH642078A5 (de)
CS (1) CS244654B2 (de)
DD (1) DD139854A5 (de)
DE (1) DE2854115A1 (de)
DK (1) DK157022C (de)
ES (7) ES476442A1 (de)
FI (1) FI66614C (de)
FR (1) FR2413389A1 (de)
GB (1) GB2011898B (de)
GR (1) GR68357B (de)
HU (1) HU178496B (de)
IL (1) IL56078A (de)
IT (1) IT1203210B (de)
LU (1) LU80601A1 (de)
NL (1) NL7812547A (de)
NO (1) NO151287C (de)
PL (5) PL119641B1 (de)
PT (1) PT68935A (de)
SE (1) SE438675B (de)
SU (2) SU999972A3 (de)
YU (3) YU42093B (de)
ZA (1) ZA787385B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity
HU179443B (en) * 1979-05-11 1982-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing substituted geminal dihalogeno-derivatives of pyrido-square bracket-1,2-a-square closed-pyrimidines,pyrrolo-square bracket-1,2-a-square bracket closed-pyrimidines and pyrimido-square bracket-1,2,-a-square bracket closed-asepines
HU178452B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 9-substituted amino-4-oxo-6,7-dihydro-4h-pyrido/1,2-a/pyrimidine derivatives
US4482557A (en) * 1979-05-11 1984-11-13 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 3-Substituted-2-oxo-tetrahydro-pyrrol[1,2-a]pyrimidines having digitalis-like activity
HU176942B (hu) * 1979-05-11 1981-06-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija 2,3- i 3,4-dvuzamehhjonnykh tetragidro-pirrolo!1,2-a!-pirimidinov
HU178453B (en) * 1979-05-11 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 9-hydrazino-4-oxo-6,7,8,9-tetrahydro-4h-p-pyrido-square bracket-1,2-a-square bracket closed-pyrimidine derivatives
HU183173B (en) * 1980-06-24 1984-04-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 6-hydrazono-pyrido-aracket-2,1-b-bracket closed-quinazolin-11-ones
AT381093B (de) * 1980-06-24 1986-08-25 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung neuer 6-hydrazono-pyrido(2,1-b)chinazolin-11-on-deriv te, von deren salzen sowie von deren stereomeren
HU183408B (en) 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
US4395549A (en) * 1981-10-02 1983-07-26 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. 6-Hydrazono-pyrido[2,1-b] quinazoline-11 ones
US5344933A (en) * 1991-09-11 1994-09-06 Fuji Photo Film Co., Ltd. Pyrrole ring-or condensed pyrrole ring-containing azomethine dye
EP1790649A1 (de) * 2005-11-21 2007-05-30 Sanofi-Aventis Substituierte bicyclische Pyrimidone Derivaten
EP2138495A1 (de) 2008-06-26 2009-12-30 sanofi-aventis Substituierte Pyrimido[2,1-a]isochinolin-4-on-Derivate
EP2138492A1 (de) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Pyrimidin-4-one-Derivate
EP2138493A1 (de) 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Pyrimidon-Derivate
EP2138498A1 (de) 2008-06-26 2009-12-30 sanofi-aventis Substituierte trizyklische Derivate gegen neurodegenerative Erkrankungen
EP2138494A1 (de) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituierte Alkylpyrimidin-4-one-Derivate
EP2138488A1 (de) 2008-06-26 2009-12-30 sanofi-aventis 4-(Pyridin-4-yl)-1H-[1,3,5]Triazin-2-one-Verbindungen als GSK3-beta Hemmer zur Behandlung neurodegenerative Erkrankungen
EP2138485A1 (de) 2008-06-26 2009-12-30 sanofi-aventis Substituierte N-Oxid-Pyrazin-Derivate

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2786056A (en) * 1954-05-03 1957-03-19 Merck & Co Inc Acylamido-hydroxy pteridines and preparation thereof
US2894031A (en) * 1958-09-16 1959-07-07 Grace W R & Co Process for cyclohexanone hydrazone hydrate
US3140315A (en) * 1959-02-18 1964-07-07 Bayer Ag Alkyl-substituted hydrazines and hydrazones and process for preparation thereof
FR1255365A (fr) * 1959-12-22 1961-03-10 Cfmc Nouveaux colorants basiques, leur procédé de préparation et leurs applications
US3141043A (en) * 1961-03-24 1964-07-14 Purdue Research Foundation Cyclopentadienylimines, process for their production and condensation products thereof
CH441366A (de) * 1961-06-09 1967-08-15 Hoffmann La Roche Verfahren zur Herstellung von substituierten Hydrazinverbindungen
US3417082A (en) * 1965-08-16 1968-12-17 Polaroid Corp Novel chemical compounds and syntheses
AT302311B (de) * 1966-11-02 1972-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung von homopyrimidazol-derivaten und deren saeureadditionssalzen und quaternaeren ammoniumsalzen
HU168014B (de) * 1973-03-30 1976-02-28
US4024132A (en) * 1973-09-07 1977-05-17 Ciba-Geigy Corporation Azomethine pigments
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
HU178496B (en) * 1977-12-29 1982-05-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing 6,7,8,9-tetrahydro-4h-pyrido/1,2-a/pyrimidine derivatives with antiallergic activity

Also Published As

Publication number Publication date
IT7869933A0 (it) 1978-12-22
AT375936B (de) 1984-09-25
PL122965B1 (en) 1982-09-30
FI784013A (fi) 1979-06-30
IT1203210B (it) 1989-02-15
FI66614B (fi) 1984-07-31
PL212212A1 (de) 1980-02-25
NL7812547A (nl) 1979-07-03
FI66614C (fi) 1984-11-12
FR2413389B1 (de) 1982-03-26
FR2413389A1 (fr) 1979-07-27
NO784393L (no) 1979-07-02
DD139854A5 (de) 1980-01-23
BE873194A (fr) 1979-04-17
SU999972A3 (ru) 1983-02-23
YU279582A (en) 1983-10-31
YU42062B (en) 1988-04-30
YU41538B (en) 1987-08-31
CS909178A2 (en) 1985-08-15
YU296478A (en) 1983-10-31
GR68357B (de) 1981-12-23
DE2854115A1 (de) 1979-07-12
HU178496B (en) 1982-05-28
AR227882A1 (es) 1982-12-30
CA1130284A (en) 1982-08-24
PL125321B1 (en) 1983-04-30
SU978730A3 (ru) 1982-11-30
US4461769A (en) 1984-07-24
IL56078A (en) 1982-11-30
GB2011898B (en) 1982-04-28
CS244654B2 (en) 1986-08-14
GB2011898A (en) 1979-07-18
JPH0146514B2 (de) 1989-10-09
AR222985A1 (es) 1981-07-15
ES481744A1 (es) 1980-06-16
IL56078A0 (en) 1979-01-31
US4234586A (en) 1980-11-18
DK157022B (da) 1989-10-30
ES481749A1 (es) 1980-07-01
PL119641B1 (en) 1982-01-30
DK157022C (da) 1990-04-02
ES481745A1 (es) 1980-07-01
PT68935A (en) 1979-01-01
NO151287C (no) 1985-03-13
AR228949A1 (es) 1983-05-13
AU520428B2 (en) 1982-01-28
DK585578A (da) 1979-06-30
YU279682A (en) 1983-10-31
DE2854115C2 (de) 1988-07-28
LU80601A1 (de) 1979-03-22
ZA787385B (en) 1980-02-27
JPS5495598A (en) 1979-07-28
CH642078A5 (de) 1984-03-30
PL119520B1 (en) 1982-01-30
SE7813226L (sv) 1979-06-30
ES476442A1 (es) 1979-11-16
NO151287B (no) 1984-12-03
YU42093B (en) 1988-04-30
AU4262778A (en) 1979-07-05
ES481748A1 (es) 1980-07-01
PL119501B1 (en) 1982-01-30
SE438675B (sv) 1985-04-29
ES481746A1 (es) 1980-07-01
ES481747A1 (es) 1980-07-01

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