AT359506B - Verfahren zur herstellung von neuen, hetero- cyclischen pyrimido(1,2-a)-verbindungen und deren optisch aktiven isomeren - Google Patents

Verfahren zur herstellung von neuen, hetero- cyclischen pyrimido(1,2-a)-verbindungen und deren optisch aktiven isomeren

Info

Publication number
AT359506B
AT359506B AT873576A AT873576A AT359506B AT 359506 B AT359506 B AT 359506B AT 873576 A AT873576 A AT 873576A AT 873576 A AT873576 A AT 873576A AT 359506 B AT359506 B AT 359506B
Authority
AT
Austria
Prior art keywords
pyrimido
heterocyclic
compounds
optically active
active isomers
Prior art date
Application number
AT873576A
Other languages
English (en)
Other versions
ATA873576A (de
Inventor
Zoltan Dipl-Ing Chem Meszaros
Jozsef Dr Knoll
Peter Dr Szentmiklosi
Istvan Dipl-Ing Chem D Hermecz
Agnes Dipl-Ing Chem Horvath
Sandor Dr Virag
Arpadne Vasvari
Agoston Dr David
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Priority to AT418079A priority Critical patent/AT362382B/de
Publication of ATA873576A publication Critical patent/ATA873576A/de
Application granted granted Critical
Publication of AT359506B publication Critical patent/AT359506B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT873576A 1975-11-27 1976-11-25 Verfahren zur herstellung von neuen, hetero- cyclischen pyrimido(1,2-a)-verbindungen und deren optisch aktiven isomeren AT359506B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT418079A AT362382B (de) 1975-11-27 1979-06-12 Verfahren zur herstellung von neuen pyrimido (1,2-a)heterocyclen sowie ihren optisch aktiven isomeren

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU75CI1623A HU173438B (hu) 1975-11-27 1975-11-27 Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Publications (2)

Publication Number Publication Date
ATA873576A ATA873576A (de) 1980-04-15
AT359506B true AT359506B (de) 1980-11-10

Family

ID=10994587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT873576A AT359506B (de) 1975-11-27 1976-11-25 Verfahren zur herstellung von neuen, hetero- cyclischen pyrimido(1,2-a)-verbindungen und deren optisch aktiven isomeren

Country Status (28)

Country Link
US (2) US4460771A (de)
JP (1) JPS5914033B2 (de)
AT (1) AT359506B (de)
AU (1) AU512256B2 (de)
BE (1) BE848868A (de)
BG (1) BG31226A4 (de)
CA (1) CA1088531A (de)
CH (2) CH630378A5 (de)
CS (1) CS203135B2 (de)
DD (1) DD130431A5 (de)
DE (1) DE2653257A1 (de)
DK (1) DK153150C (de)
EG (1) EG12495A (de)
ES (1) ES453690A1 (de)
FI (1) FI62085C (de)
FR (1) FR2332755A1 (de)
GB (1) GB1531963A (de)
GR (1) GR61820B (de)
HU (1) HU173438B (de)
IL (1) IL50930A (de)
IN (1) IN148945B (de)
MX (1) MX5178E (de)
NL (1) NL188948C (de)
PL (1) PL109657B1 (de)
RO (2) RO79705A (de)
SE (1) SE433353B (de)
SU (2) SU664565A3 (de)
YU (2) YU289076A (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU180701B (en) * 1977-12-29 1983-04-29 Chinoin Gyogyszer Es Vegyeszet Process for preparing pyrido-/1,2-a/pyrimidines containing a carboxylic or ester group on the pirimidimering
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents
US4342870A (en) * 1980-03-28 1982-08-03 Janssen Pharmaceutica N.V. Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives
HU183408B (en) * 1981-04-28 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing oral ratard pharmaceutical compositions
HU186607B (en) * 1982-03-31 1985-08-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing pharmaceutical composition with synergetic antiinflammatory activity
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4772475A (en) * 1985-03-08 1988-09-20 Yamanouchi Pharmaceutical Co., Ltd. Controlled-release multiple units pharmaceutical formulation
US5252572A (en) * 1988-02-03 1993-10-12 Chinoin Gyogyszer- Es Vegyeszeti Termekek Gyara Rt. Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
HU201551B (en) * 1988-02-03 1990-11-28 Chinoin Gyogyszer Es Vegyeszet Process for producing 4-oxo-4h-pyrido(1,2-a)pyrimidine-3-carboxylic acid amide derivatives and pharmaceutical compositions comprising same
MY125533A (en) 1999-12-06 2006-08-30 Bristol Myers Squibb Co Heterocyclic dihydropyrimidine compounds
EP1521583B1 (de) * 2002-07-09 2007-01-10 Actelion Pharmaceuticals Ltd. 7,8,9,10-tetrahydro-6h-azepino, 6,7,8,9-tetrahydro-pyrido und 2,3-dihydro-2h-pyrrolo (2,1-b)-chinazolinon-derivate
US7772232B2 (en) * 2004-04-15 2010-08-10 Bristol-Myers Squibb Company Quinazolinyl compounds as inhibitors of potassium channel function
GB2423928B (en) * 2004-11-16 2008-04-09 Efflux Technology Inc Methods and compositions for treating pain

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT302311B (de) * 1966-11-02 1972-09-15 Chinoin Gyogyszer Es Vegyeszet Verfahren zur herstellung von homopyrimidazol-derivaten und deren saeureadditionssalzen und quaternaeren ammoniumsalzen
US3642797A (en) * 1968-06-10 1972-02-15 Sterling Drug Inc 4h-pyrido(1 2-a)pyrimidin-4-ones
HU168014B (de) * 1973-03-30 1976-02-28
US4209622A (en) * 1973-03-30 1980-06-24 Chinoin Gygyszer es Vegyeszeti Termekek Gyara Rt. 3-(Ethoxycarbonyl-methyl)-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine
HU168541B (de) * 1973-11-24 1976-05-28
US4022897A (en) * 1974-03-04 1977-05-10 E. R. Squibb & Sons, Inc. CNS active compounds
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
US4066766A (en) * 1975-03-03 1978-01-03 Pfizer Inc. 1-Oxo-6-substituted pyrimido [1,2-a]quinoline-2-carboxylic acids and derivatives thereof and their use as antiallergy agents
HU174693B (hu) * 1976-02-12 1980-03-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija kondensirovannykh proizvodnykh pirimidina
US4122274A (en) * 1977-05-25 1978-10-24 Bristol-Myers Company 3-Tetrazolo-5,6,7,8-substituted-pyrido[1,2-a]pyrimidin-4-ones
US4192944A (en) * 1978-04-03 1980-03-11 Bristol-Myers Company Optionally substituted 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-N-(1H-tetrazol-4-yl)carboxamides and their use as antiallergy agents

Also Published As

Publication number Publication date
GR61820B (en) 1979-01-22
ATA873576A (de) 1980-04-15
YU147583A (en) 1986-06-30
NL7613140A (nl) 1977-06-01
CH630378A5 (de) 1982-06-15
BE848868A (fr) 1977-03-16
AU1975976A (en) 1978-05-25
BG31226A4 (en) 1981-11-16
MX5178E (es) 1983-04-20
JPS5268198A (en) 1977-06-06
CH630379A5 (de) 1982-06-15
SU664565A3 (ru) 1979-05-25
JPS5914033B2 (ja) 1984-04-02
FR2332755B1 (de) 1978-12-22
IN148945B (de) 1981-07-25
CS203135B2 (en) 1981-02-27
ES453690A1 (es) 1977-12-01
GB1531963A (en) 1978-11-15
NL188948C (nl) 1992-11-16
CA1088531A (en) 1980-10-28
RO79705A (ro) 1982-08-17
DK153150C (da) 1988-10-24
IL50930A (en) 1981-06-29
AU512256B2 (en) 1980-10-02
SE7613140L (sv) 1977-05-28
DD130431A5 (de) 1978-03-29
YU289076A (en) 1983-12-31
DE2653257C2 (de) 1989-04-20
SU698532A3 (ru) 1979-11-15
DE2653257A1 (de) 1977-06-02
PL109657B1 (en) 1980-06-30
HU173438B (hu) 1979-05-28
US4472398A (en) 1984-09-18
FI62085C (fi) 1982-11-10
FI763401A (de) 1977-05-28
FI62085B (fi) 1982-07-30
SE433353B (sv) 1984-05-21
FR2332755A1 (fr) 1977-06-24
NL188948B (nl) 1992-06-16
IL50930A0 (en) 1977-01-31
DK534076A (da) 1977-05-28
EG12495A (en) 1980-12-31
US4460771A (en) 1984-07-17
RO73522A (ro) 1981-11-04
DK153150B (da) 1988-06-20

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