AT363489B - Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren - Google Patents
Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomerenInfo
- Publication number
- AT363489B AT363489B AT0198680A AT198680A AT363489B AT 363489 B AT363489 B AT 363489B AT 0198680 A AT0198680 A AT 0198680A AT 198680 A AT198680 A AT 198680A AT 363489 B AT363489 B AT 363489B
- Authority
- AT
- Austria
- Prior art keywords
- dihydropyridazone
- acylaminophenyl
- enantiomers
- producing new
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19772727481 DE2727481A1 (de) | 1977-06-18 | 1977-06-18 | Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel |
AT441178A AT361494B (de) | 1977-06-18 | 1978-06-16 | Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren |
Publications (2)
Publication Number | Publication Date |
---|---|
ATA198680A ATA198680A (de) | 1981-01-15 |
AT363489B true AT363489B (de) | 1981-08-10 |
Family
ID=6011790
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT441178A AT361494B (de) | 1977-06-18 | 1978-06-16 | Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren |
AT0198680A AT363489B (de) | 1977-06-18 | 1980-04-11 | Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT441178A AT361494B (de) | 1977-06-18 | 1978-06-16 | Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren |
Country Status (7)
Country | Link |
---|---|
US (1) | US4376771A (de) |
EP (1) | EP0000113B1 (de) |
JP (1) | JPS549289A (de) |
AT (2) | AT361494B (de) |
CA (1) | CA1108614A (de) |
DE (2) | DE2727481A1 (de) |
ZA (1) | ZA783464B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2854191A1 (de) * | 1978-12-15 | 1980-07-03 | Basf Ag | Dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel |
DE2854475A1 (de) * | 1978-12-16 | 1980-07-03 | Basf Ag | Neue 3,4-diaza-bicyclo eckige klammer auf 4.1.0 eckige klammer zu hepten-(2)- one-(5), verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel |
GR81309B (de) | 1980-06-13 | 1984-12-11 | Basf Ag | |
DE3022176A1 (de) | 1980-06-13 | 1982-01-07 | Basf Ag, 6700 Ludwigshafen | Neue dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel |
DE3124699A1 (de) * | 1981-06-24 | 1983-01-13 | Basf Ag, 6700 Ludwigshafen | Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
EP0107735B1 (de) * | 1981-10-20 | 1988-10-19 | Mitsui Toatsu Kagaku Kabushiki Kaisha | Neue pyridazinon-abkömmlinge |
DE3209159A1 (de) * | 1982-03-13 | 1983-09-15 | Basf Ag, 6700 Ludwigshafen | Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung |
DE3212304A1 (de) * | 1982-04-02 | 1983-10-06 | Nattermann A & Cie | Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
DE3328286A1 (de) * | 1982-08-07 | 1984-02-09 | Basf Ag, 6700 Ludwigshafen | Neue anilide, verfahren zu ihrer herstellung und ihre verwendung |
DE3302021A1 (de) * | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung |
JPH02119064A (ja) * | 1988-10-28 | 1990-05-07 | Matsushita Electric Ind Co Ltd | 密閉形鉛蓄電池 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EP2218442A1 (de) | 2005-11-09 | 2010-08-18 | CombinatoRx, Inc. | Verfahren, Zusammensetzungen und Kits zur Behandlung von ophthalmologischen Erkrankungen |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
WO2010009319A2 (en) | 2008-07-16 | 2010-01-21 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9580471B2 (en) | 2011-03-01 | 2017-02-28 | Synergy Pharmaceuticals, Inc. | Process of preparing guanylate cyclase C agonists |
WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonisten der guanylatcyclase und deren verwendungen |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
JP6694385B2 (ja) | 2013-08-09 | 2020-05-13 | アーデリクス,インコーポレーテッド | リン酸塩輸送阻害のための化合物及び方法 |
WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670043C3 (de) * | 1966-01-07 | 1975-05-22 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von 3-(Aminophenyl)-pyridazon-(6)-derivaten |
IL37788A0 (en) * | 1970-10-09 | 1971-12-29 | American Cyanamid Co | New pyridazinone compounds,their preparation and pharmaceutical compositions containing them |
US3689652A (en) * | 1970-10-09 | 1972-09-05 | William Vincent Curran | Method of lowering blood pressure in mammals |
US3822260A (en) * | 1970-10-09 | 1974-07-02 | American Cyanamid Co | 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones |
US3975388A (en) * | 1971-02-22 | 1976-08-17 | Bdh Pharmaceuticals Limited | Pyridazinones |
DE2123246C2 (de) * | 1971-05-11 | 1982-11-25 | Basf Ag, 6700 Ludwigshafen | 6-[p-(β-Phenyläthylaminoacetylamino)-phenyl]-4,5-dihydropyridazon-(3) |
US3812256A (en) * | 1971-06-08 | 1974-05-21 | American Cyanamid Co | Novel method for lowering blood pressure in mammals |
US3746712A (en) * | 1971-06-08 | 1973-07-17 | A Ross | 6-(substituted-phenyl)-5-methyl-4,5-dihydro-3(2h)-pyridazinones |
BE790106A (fr) * | 1971-10-14 | 1973-04-13 | Basf Ag | Dihydropyridazones, leur preparation et leurs utilisations therapeutiques |
US3824271A (en) * | 1972-07-20 | 1974-07-16 | American Cyanamid Co | 3-alkyl-3-(benzoyl)propionitriles |
DE2304977A1 (de) * | 1973-02-01 | 1974-08-08 | Basf Ag | Neue dihydropyridazinone |
US4112095A (en) * | 1976-10-07 | 1978-09-05 | American Cyanamid Company | 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents |
-
1977
- 1977-06-18 DE DE19772727481 patent/DE2727481A1/de not_active Withdrawn
-
1978
- 1978-06-01 DE DE7878100001T patent/DE2861089D1/de not_active Expired
- 1978-06-01 EP EP78100001A patent/EP0000113B1/de not_active Expired
- 1978-06-16 ZA ZA00783464A patent/ZA783464B/xx unknown
- 1978-06-16 CA CA305,625A patent/CA1108614A/en not_active Expired
- 1978-06-16 AT AT441178A patent/AT361494B/de not_active IP Right Cessation
- 1978-06-16 JP JP7226978A patent/JPS549289A/ja active Granted
-
1980
- 1980-04-11 AT AT0198680A patent/AT363489B/de not_active IP Right Cessation
-
1981
- 1981-01-14 US US06/224,939 patent/US4376771A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ZA783464B (en) | 1979-07-25 |
AT361494B (de) | 1981-03-10 |
JPS6231708B2 (de) | 1987-07-09 |
EP0000113B1 (de) | 1981-09-16 |
EP0000113A1 (de) | 1979-01-10 |
ATA198680A (de) | 1981-01-15 |
ATA441178A (de) | 1980-08-15 |
CA1108614A (en) | 1981-09-08 |
DE2861089D1 (en) | 1981-12-03 |
US4376771A (en) | 1983-03-15 |
DE2727481A1 (de) | 1979-01-11 |
JPS549289A (en) | 1979-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AT363489B (de) | Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren | |
AT365187B (de) | Verfahren zur herstellung neuer 3-(1h-tetrazol-5yl)-hh-pyrido(1,2-a)-pyrimidin-4-one und von derensalzen | |
AT365589B (de) | Verfahren zur herstellung neuer 4-hydroxy-2h-1,2benzothiazin-3-carboxamid-1,1-dioxide und deren salze | |
AT363952B (de) | Verfahren zur herstellung von neuen triazinverbindungen und deren salzen | |
AT363491B (de) | Verfahren zur herstellung von neuen 1,3,8trisubstituierten xanthinen und deren salzen | |
AT363469B (de) | Verfahren zur herstellung von 3,4,5,6-tetrahydro-2h-1-benzoxocinen und 6a,10a-cis-hexahydrodibenzo(b,d)pyran-9-onen | |
AT376220B (de) | Verfahren zur herstellung neuer 1,4-dihydropyridinderivate | |
AT351508B (de) | Verfahren zur herstellung von 2,5-dichlorphenol | |
AT376971B (de) | Verfahren zur herstellung neuer substituierter 2-mercaptoimidazole und von deren salzen | |
ATA338078A (de) | Verfahren zur herstellung von 5(6)-thiobenzimidazol-derivaten sowie von deren salzen en und deren salzen | |
AT363619B (de) | Verfahren zur herstellung von 2,6-diaminonebularinen und ihren salzen | |
AT375369B (de) | Verfahren zur herstellung neuer 1,2,4-oxadiazolin-5-on-derivate sowie von deren salzen | |
AT381494B (de) | Verfahren zur herstellung neuer 2,3,4-trinor-1,5inter-m-phenylen-prostacyclin-derivaten und von deren salzen | |
AT352139B (de) | Verfahren zur herstellung von neuen 2,9- dioxatricyclo-(4,3,1,03,7)decanen und deren salzen | |
AT359070B (de) | Verfahren zur herstellung von neuen 2,4-diamino -5-benzylpyrimidinen und deren salzen | |
AT375069B (de) | Verfahren zur herstellung der (2,2-dimethyl-1,2dihydro-chinolin-4-yl)-methyl-sulfon-s[ure und von deren salzen | |
AT361002B (de) | Verfahren zur herstellung von neuen 2,9- dioxatricyclo(4,3,1,03,7)decanen und deren salzen | |
AT373247B (de) | Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salzen | |
AT374800B (de) | Verfahren zur herstellung neuer guanidinothiazole und von deren salzen | |
AT375653B (de) | Verfahren zur herstellung von 2-oxodihydrobenzo(d)(1,3)-oxazinen | |
ATA93082A (de) | Verfahren zur herstellung von 6-(d(-)-alphaus810330248754 | |
ATA415383A (de) | Verfahren zur herstellung neuer 2-hydroxymethyl-3,4,5-trihydroxypiperidinderiva e | |
ATA328383A (de) | Verfahren zur herstellung neuer 1,2,4-qxadiazolin -5-on-derivaten sowie von deren salzen | |
ATA62282A (de) | Verfahren zur herstellung neuer amino-2,1,3-benzo-thiadiazol- und -benzoxadiazolderivate | |
ATA533181A (de) | Verfahren zur herstellung neuer 2-hydroxymethyl -3,4,5-trihydroxypiperidinderivate |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
ELJ | Ceased due to non-payment of the annual fee | ||
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |