AT363489B - Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren - Google Patents

Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren

Info

Publication number
AT363489B
AT363489B AT0198680A AT198680A AT363489B AT 363489 B AT363489 B AT 363489B AT 0198680 A AT0198680 A AT 0198680A AT 198680 A AT198680 A AT 198680A AT 363489 B AT363489 B AT 363489B
Authority
AT
Austria
Prior art keywords
dihydropyridazone
acylaminophenyl
enantiomers
producing new
producing
Prior art date
Application number
AT0198680A
Other languages
English (en)
Other versions
ATA198680A (de
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of ATA198680A publication Critical patent/ATA198680A/de
Application granted granted Critical
Publication of AT363489B publication Critical patent/AT363489B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT0198680A 1977-06-18 1980-04-11 Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren AT363489B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19772727481 DE2727481A1 (de) 1977-06-18 1977-06-18 Dihydropyridazone und dihydropyridazone enthaltende therapeutische mittel
AT441178A AT361494B (de) 1977-06-18 1978-06-16 Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren

Publications (2)

Publication Number Publication Date
ATA198680A ATA198680A (de) 1981-01-15
AT363489B true AT363489B (de) 1981-08-10

Family

ID=6011790

Family Applications (2)

Application Number Title Priority Date Filing Date
AT441178A AT361494B (de) 1977-06-18 1978-06-16 Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren
AT0198680A AT363489B (de) 1977-06-18 1980-04-11 Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT441178A AT361494B (de) 1977-06-18 1978-06-16 Verfahren zur herstellung neuer 6-(p-acylamino- phenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren

Country Status (7)

Country Link
US (1) US4376771A (de)
EP (1) EP0000113B1 (de)
JP (1) JPS549289A (de)
AT (2) AT361494B (de)
CA (1) CA1108614A (de)
DE (2) DE2727481A1 (de)
ZA (1) ZA783464B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2854191A1 (de) * 1978-12-15 1980-07-03 Basf Ag Dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel
DE2854475A1 (de) 1978-12-16 1980-07-03 Basf Ag Neue 3,4-diaza-bicyclo eckige klammer auf 4.1.0 eckige klammer zu hepten-(2)- one-(5), verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel
DE3022176A1 (de) * 1980-06-13 1982-01-07 Basf Ag, 6700 Ludwigshafen Neue dihydropyridazinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende therapeutische mittel
GR81309B (de) 1980-06-13 1984-12-11 Basf Ag
DE3124699A1 (de) * 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen Neue 2-aryl-3,4-diaza-bicyclo(4.n.0.)alken-(2)-one-(5),verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0107735B1 (de) * 1981-10-20 1988-10-19 Mitsui Toatsu Kagaku Kabushiki Kaisha Neue pyridazinon-abkömmlinge
DE3209159A1 (de) * 1982-03-13 1983-09-15 Basf Ag, 6700 Ludwigshafen Neue 6-aryl-4,5-dihydro-3(2h)-pyridazinone, verfahren zu ihrer herstellung, diese verbindungen enthaltende therapeutische mittel und deren verwendung
DE3212304A1 (de) * 1982-04-02 1983-10-06 Nattermann A & Cie Imidazolylphenyl-tetrahydropyridazine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3328286A1 (de) * 1982-08-07 1984-02-09 Basf Ag, 6700 Ludwigshafen Neue anilide, verfahren zu ihrer herstellung und ihre verwendung
DE3302021A1 (de) * 1983-01-22 1984-07-26 Basf Ag, 6700 Ludwigshafen 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung
JPH02119064A (ja) * 1988-10-28 1990-05-07 Matsushita Electric Ind Co Ltd 密閉形鉛蓄電池
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US20070225217A1 (en) 2005-11-09 2007-09-27 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
WO2008151257A2 (en) 2007-06-04 2008-12-11 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN107090016A (zh) 2011-03-01 2017-08-25 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
WO2013106547A1 (en) 2012-01-10 2013-07-18 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
EP3972599B1 (de) 2019-05-21 2025-10-22 Ardelyx, Inc. Kombination zur senkung des serum-phosphatspiegels bei einem patienten

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670043C3 (de) * 1966-01-07 1975-05-22 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von 3-(Aminophenyl)-pyridazon-(6)-derivaten
US3822260A (en) * 1970-10-09 1974-07-02 American Cyanamid Co 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones
US3689652A (en) * 1970-10-09 1972-09-05 William Vincent Curran Method of lowering blood pressure in mammals
IL37788A0 (en) * 1970-10-09 1971-12-29 American Cyanamid Co New pyridazinone compounds,their preparation and pharmaceutical compositions containing them
US3975388A (en) * 1971-02-22 1976-08-17 Bdh Pharmaceuticals Limited Pyridazinones
DE2123246C2 (de) * 1971-05-11 1982-11-25 Basf Ag, 6700 Ludwigshafen 6-[p-(β-Phenyläthylaminoacetylamino)-phenyl]-4,5-dihydropyridazon-(3)
US3812256A (en) * 1971-06-08 1974-05-21 American Cyanamid Co Novel method for lowering blood pressure in mammals
US3746712A (en) * 1971-06-08 1973-07-17 A Ross 6-(substituted-phenyl)-5-methyl-4,5-dihydro-3(2h)-pyridazinones
BE790106A (fr) * 1971-10-14 1973-04-13 Basf Ag Dihydropyridazones, leur preparation et leurs utilisations therapeutiques
US3824271A (en) * 1972-07-20 1974-07-16 American Cyanamid Co 3-alkyl-3-(benzoyl)propionitriles
DE2304977A1 (de) * 1973-02-01 1974-08-08 Basf Ag Neue dihydropyridazinone
US4112095A (en) * 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents

Also Published As

Publication number Publication date
DE2861089D1 (en) 1981-12-03
ATA441178A (de) 1980-08-15
US4376771A (en) 1983-03-15
CA1108614A (en) 1981-09-08
JPS549289A (en) 1979-01-24
DE2727481A1 (de) 1979-01-11
EP0000113B1 (de) 1981-09-16
JPS6231708B2 (de) 1987-07-09
AT361494B (de) 1981-03-10
EP0000113A1 (de) 1979-01-10
ZA783464B (en) 1979-07-25
ATA198680A (de) 1981-01-15

Similar Documents

Publication Publication Date Title
AT363489B (de) Verfahren zur herstellung neuer 6-(p-acylaminophenyl)-4,5-dihydropyridazone-(3) und von deren enantiomeren
AT365187B (de) Verfahren zur herstellung neuer 3-(1h-tetrazol-5yl)-hh-pyrido(1,2-a)-pyrimidin-4-one und von derensalzen
AT363952B (de) Verfahren zur herstellung von neuen triazinverbindungen und deren salzen
AT363491B (de) Verfahren zur herstellung von neuen 1,3,8trisubstituierten xanthinen und deren salzen
AT363469B (de) Verfahren zur herstellung von 3,4,5,6-tetrahydro-2h-1-benzoxocinen und 6a,10a-cis-hexahydrodibenzo(b,d)pyran-9-onen
ATA338078A (de) Verfahren zur herstellung von 5(6)-thiobenzimidazol-derivaten sowie von deren salzen en und deren salzen
AT363619B (de) Verfahren zur herstellung von 2,6-diaminonebularinen und ihren salzen
AT375369B (de) Verfahren zur herstellung neuer 1,2,4-oxadiazolin-5-on-derivate sowie von deren salzen
AT381494B (de) Verfahren zur herstellung neuer 2,3,4-trinor-1,5inter-m-phenylen-prostacyclin-derivaten und von deren salzen
ATA363280A (de) Verfahren zur herstellung von 1,2,-dihydro-2oxo-5-(pyridinyl)nicotinonitrilen
AT352139B (de) Verfahren zur herstellung von neuen 2,9- dioxatricyclo-(4,3,1,03,7)decanen und deren salzen
AT359070B (de) Verfahren zur herstellung von neuen 2,4-diamino -5-benzylpyrimidinen und deren salzen
AT375069B (de) Verfahren zur herstellung der (2,2-dimethyl-1,2dihydro-chinolin-4-yl)-methyl-sulfon-s[ure und von deren salzen
AT361002B (de) Verfahren zur herstellung von neuen 2,9- dioxatricyclo(4,3,1,03,7)decanen und deren salzen
AT373247B (de) Verfahren zur herstellung neuer 1,2,4-oxadiazin -derivate sowie von deren salzen
AT361641B (de) Verfahren zur herstellung von a-nor-androsta- -3(5), 16-dien-2-on- und a-nor-androsta-3(5),6, 16-trien-2-on-derivaten
AT373872B (de) Verfahren zur herstellung von 2,2-dialkyl-4-methyl-5,5-dialkyl-3-formyl-3-pyr olinen
AT374800B (de) Verfahren zur herstellung neuer guanidinothiazole und von deren salzen
ATA93082A (de) Verfahren zur herstellung von 6-(d(-)-alphaus810330248754
ATA415383A (de) Verfahren zur herstellung neuer 2-hydroxymethyl-3,4,5-trihydroxypiperidinderiva e
ATA328383A (de) Verfahren zur herstellung neuer 1,2,4-qxadiazolin -5-on-derivaten sowie von deren salzen
ATA62282A (de) Verfahren zur herstellung neuer amino-2,1,3-benzo-thiadiazol- und -benzoxadiazolderivate
ATA533181A (de) Verfahren zur herstellung neuer 2-hydroxymethyl -3,4,5-trihydroxypiperidinderivate
ATA227183A (de) Verfahren zur herstellung neuer 2-hydroxymethyl -3,4,5-trihydroxypiperidinderivate
ATA73980A (de) Verfahren zur herstellung von neuen 2,9- -dioxatricyclo(4,3,1,03,7)decanen und deren salzen

Legal Events

Date Code Title Description
ELJ Ceased due to non-payment of the annual fee
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties