FR2439187A1 - Derives de 1-piperazine-carboxamides et -carbothioamides substitues, procede de preparation et compositions pharmaceutiques les contenant - Google Patents

Derives de 1-piperazine-carboxamides et -carbothioamides substitues, procede de preparation et compositions pharmaceutiques les contenant

Info

Publication number
FR2439187A1
FR2439187A1 FR7925953A FR7925953A FR2439187A1 FR 2439187 A1 FR2439187 A1 FR 2439187A1 FR 7925953 A FR7925953 A FR 7925953A FR 7925953 A FR7925953 A FR 7925953A FR 2439187 A1 FR2439187 A1 FR 2439187A1
Authority
FR
France
Prior art keywords
carbothioamides
carboxamides
piperazine
derivatives
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7925953A
Other languages
English (en)
Other versions
FR2439187B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia Animal Health Inc
Original Assignee
Ferrosan AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan AB filed Critical Ferrosan AB
Publication of FR2439187A1 publication Critical patent/FR2439187A1/fr
Application granted granted Critical
Publication of FR2439187B1 publication Critical patent/FR2439187B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/194—Radicals derived from thio- or thiono carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/52—Transportable laboratories; Field kits

Abstract

SUBSTANCES ANTIPSYCHOTIQUES A LARGE SPECTRE D'ACTIVITE. IL S'AGIT DE SUBSTANCES AYANT POUR FORMULE GENERALE: (CF DESSIN DANS BOPI) OU X EST OXYGENE OU SOUFRE, ET LES AUTRES SUBSTITUANTS SONT SPECIFIES, AINSI QUE LES SELS D'ADDITION DE TELLES SUBSTANCES AVEC DES ACIDES PHARMACEUTIQUEMENT ACCEPTABLES. ADMINISTRES A DES ETRES HUMAINS ET A DES ANIMAUX ATTEINTS DE DESORDRES MENTAUX ET PSYCHOSOMATIQUES, CES POINTS NE PROVOQUENT QUE PEU D'EFFETS SECONDAIRES GENANTS, SONT PEU TOXIQUES, ET SONT AUSSI DES ANALGESIQUES ET ANTI-INFLAMMATOIRES.
FR7925953A 1978-10-20 1979-10-18 Derives de 1-piperazine-carboxamides et -carbothioamides substitues, procede de preparation et compositions pharmaceutiques les contenant Granted FR2439187A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7810971 1978-10-20

Publications (2)

Publication Number Publication Date
FR2439187A1 true FR2439187A1 (fr) 1980-05-16
FR2439187B1 FR2439187B1 (fr) 1983-03-18

Family

ID=20336152

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7925953A Granted FR2439187A1 (fr) 1978-10-20 1979-10-18 Derives de 1-piperazine-carboxamides et -carbothioamides substitues, procede de preparation et compositions pharmaceutiques les contenant

Country Status (21)

Country Link
US (3) US4308387A (fr)
JP (1) JPS5557572A (fr)
AT (1) AT376666B (fr)
AU (1) AU529260B2 (fr)
BE (1) BE879528A (fr)
CA (1) CA1130807A (fr)
CH (1) CH643247A5 (fr)
DE (1) DE2941880A1 (fr)
DK (1) DK149057C (fr)
ES (1) ES485188A1 (fr)
FI (1) FI73986C (fr)
FR (1) FR2439187A1 (fr)
GB (1) GB2037745B (fr)
HK (1) HK57184A (fr)
IT (1) IT1207269B (fr)
LU (1) LU81807A1 (fr)
NL (2) NL190160C (fr)
NO (1) NO154582C (fr)
NZ (1) NZ191867A (fr)
SE (1) SE448730B (fr)
SG (1) SG7384G (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE791501A (fr) * 1971-11-19 1973-05-17 Albert Ag Chem Werke Diamines cycliques n,n'-disubstituees et leur procede de preparation
JPS57500828A (fr) * 1980-06-16 1982-05-13
ATE28327T1 (de) * 1981-12-02 1987-08-15 Ferrosan Ab 1-piperazinocarboxylate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4543352A (en) * 1983-04-29 1985-09-24 William H. Rorer, Inc. Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
AT387572B (de) * 1983-05-20 1989-02-10 Ferrosan Ab Verfahren zur herstellung von neuen 4-(4,4-bis-(p-fluorphenyl)-butyl)-1-carbophenox -piperazinen und von 1-piperazincarboxamiden
ES8502099A1 (es) * 1983-08-02 1984-12-16 Espanola Farma Therapeut Procedimiento de obtencion de nuevos compuestos derivados de la difenil-metilen-etilamina.
SE8304361D0 (sv) * 1983-08-10 1983-08-10 Ferrosan Ab Novel 1-acylpiperazine derivatives novel 1-acylpiperazine derivatives
FR2558162B1 (fr) * 1984-01-17 1986-04-25 Adir Nouveaux derives de la xanthine, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
SE8500573D0 (sv) * 1985-02-08 1985-02-08 Ferrosan Ab Novel piperazinecarboxamides having a phenoxyalkyl or thiophenoxyalkyl side chain
US4960776A (en) * 1987-01-28 1990-10-02 A. H. Robins Company, Inc. 4-aryl-N-(alkylaminoalkyl, heterocyclicamino and heterocyclicamino)alkyl)-1-piperazinecarboxamides
WO1990013539A1 (fr) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. Nouveaux derives de piperazine a substitution n et medicament de traitement des troubles fonctionnels du cerveau
SE9100860D0 (sv) * 1991-03-22 1991-03-22 Kabi Pharmacia Ab New use
SE9201239D0 (sv) * 1992-04-21 1992-04-21 Kabi Pharmacia Ab Agents for treating substance abuse disorders
DE4219973A1 (de) * 1992-06-19 1993-12-23 Basf Ag N-substituierte Azabicycloheptan-Derivate, ihre Herstellung und Verwendung
SE9202266D0 (sv) * 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel piperazine carboxamides
DE4307181C1 (de) * 1993-03-08 1994-11-10 Dresden Arzneimittel Verfahren zur Herstellung von 5H-Dibenz/b,f/azepin-5-carboxamid
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
JP3274579B2 (ja) * 1995-01-12 2002-04-15 住友製薬株式会社 脳血管障害に伴う精神症候治療剤
DE29815747U1 (de) 1998-09-02 2000-01-05 Ramsauer Dieter Anschraubscharnier mit Raststellung
GB9923748D0 (en) * 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
GB0108594D0 (en) * 2001-04-05 2001-05-23 Glaxo Group Ltd Chemical compounds
US7842307B2 (en) 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
US7157103B2 (en) 2001-08-06 2007-01-02 Euro-Celtique S.A. Pharmaceutical formulation containing irritant
US7141250B2 (en) * 2001-08-06 2006-11-28 Euro-Celtique S.A. Pharmaceutical formulation containing bittering agent
US7332182B2 (en) 2001-08-06 2008-02-19 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant
US20030044458A1 (en) * 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
GB0203020D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
AU2003244455A1 (en) * 2002-02-08 2003-09-02 Glaxo Group Limited Piperidylcarboxamide derivatives and their use in the treatment of tachykinim-mediated diseases
GB0203022D0 (en) * 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
EP1765292B1 (fr) 2004-06-12 2017-10-04 Collegium Pharmaceutical, Inc. Formulations de prévention des abus
JP4823673B2 (ja) * 2005-12-15 2011-11-24 タカラベルモント株式会社 ショックレス弁を接続した油圧回路
JP2010169206A (ja) * 2009-01-23 2010-08-05 Finesinter Co Ltd ノンリークショックレス電磁比例制御弁
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
AP3815A (en) 2010-12-22 2016-09-30 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
BR112013015939A2 (pt) 2010-12-23 2020-08-04 Purdue Pharma L.P. formas farmacêuticas orais sólidas resistentes à adulteração
JP6208261B2 (ja) 2013-02-05 2017-10-04 パーデュー、ファーマ、リミテッド、パートナーシップＰｕｒｄｕｅ Ｐｈａｒｍａ Ｌ．Ｐ． タンパリング抵抗性医薬製剤
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
WO2017222575A1 (fr) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Procédé de préparation de formulations orales dissuasives d'abus plus stables

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS518283A (en) * 1974-07-09 1976-01-23 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
FR2367067A1 (fr) * 1976-10-07 1978-05-05 Kyorin Seiyaku Kk Nouveaux derives de la piperazine et medicaments contenant ces substances

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
NL137318C (fr) * 1964-06-09

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS518283A (en) * 1974-07-09 1976-01-23 Kyorin Seiyaku Kk 11 * 33 fuenirupuropiru * 44 karubamoirupiperajinjudotaino seizoho
FR2367067A1 (fr) * 1976-10-07 1978-05-05 Kyorin Seiyaku Kk Nouveaux derives de la piperazine et medicaments contenant ces substances

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CA1976 *
EXBK/57 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2673182A1 (fr) * 1991-02-22 1992-08-28 Univ Caen Piperazines n,n'-disubstituees, leur procede de preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
US4385057A (en) 1983-05-24
FI73986B (fi) 1987-08-31
NL190160C (nl) 1993-11-16
CA1130807A (fr) 1982-08-31
US4447433A (en) 1984-05-08
IT1207269B (it) 1989-05-17
AU529260B2 (en) 1983-06-02
FI793238A (fi) 1980-04-21
DE2941880C2 (fr) 1989-04-20
SE448730B (sv) 1987-03-16
IT7926603A0 (it) 1979-10-18
LU81807A1 (de) 1980-01-25
CH643247A5 (de) 1984-05-30
SE7908701L (sv) 1980-04-21
US4308387A (en) 1981-12-29
NO793315L (no) 1980-04-22
HK57184A (en) 1984-08-03
NO154582C (no) 1986-11-05
BE879528A (fr) 1980-04-21
AT376666B (de) 1984-12-27
SG7384G (en) 1985-02-08
ES485188A1 (es) 1980-05-16
DE2941880A1 (de) 1980-04-30
FR2439187B1 (fr) 1983-03-18
FI73986C (fi) 1987-12-10
JPS6326756B2 (fr) 1988-05-31
DK149057C (da) 1986-06-02
AU5198479A (en) 1980-06-19
NL7907741A (nl) 1980-04-22
DK149057B (da) 1986-01-06
NZ191867A (en) 1983-06-14
DK442779A (da) 1980-04-21
NO154582B (no) 1986-07-28
NL190160B (nl) 1993-06-16
GB2037745A (en) 1980-07-16
GB2037745B (en) 1982-11-24
ATA683479A (de) 1984-05-15
NL940004I1 (nl) 1994-05-02
JPS5557572A (en) 1980-04-28

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