TNSN91049A1 - Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique - Google Patents

Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique

Info

Publication number
TNSN91049A1
TNSN91049A1 TNTNSN91049A TNSN91049A TNSN91049A1 TN SN91049 A1 TNSN91049 A1 TN SN91049A1 TN TNSN91049 A TNTNSN91049 A TN TNSN91049A TN SN91049 A TNSN91049 A TN SN91049A TN SN91049 A1 TNSN91049 A1 TN SN91049A1
Authority
TN
Tunisia
Prior art keywords
carbon atoms
processes
preparation
pharmaceutical use
atoms
Prior art date
Application number
TNTNSN91049A
Other languages
English (en)
Inventor
Elof Brandstrom Arne
Lennart Lindberg Per
Elisabeth Sunden Gunnel
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of TNSN91049A1 publication Critical patent/TNSN91049A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

LES COMPOSES NOUVEAU AYANT LA FORMULE I OU R1 ET R2, QUI SONT DIFFERENTS, SONT CHACUN H, ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU - C(O)-R6 ; PARMI R1 ET R2 L'UN EST TOUJOURS SELECTIONNE A PARTIR DU GROUPE -C (O)-R6 ; DANS LEQUEL R6 EST ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU ALKOXY CONTENANT 1 A 4 ATOMES DE CARBONE, R3 EST LE GROUPE - CH2OCOOR7, OU R7 EST ALKYLE CONTENANT 1 A 6 ATOMES DE CARBONE OU BENZYLE ; R4 ET R5 SONT LES MEMES OU DIFFERENTS ET PEUVENT ETRE OCH3. FORMENT ENSEMBLE AVEC LES ATOMES D'OXYGENE ADJACENTS FIXES AU NOYAU PYRIDINE ET AVEC LES ATOMES DE CARBONE DU NOYAU PYRIDINE UN NOYAU, DANS LEQUEL LA PARTIE CONSTITUEE PAR R4 ET R5 EST -CH2CH2-CH2, -CH2CH2- OU - CH2-, AINSI QUE DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LES DITS COMPOSES COMME INGREDIENTS ACTIFS, ET L'EMPLOI DE CES COMPOSES EN MEDECINE
TNTNSN91049A 1990-06-20 1991-06-19 Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique TNSN91049A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (1)

Publication Number Publication Date
TNSN91049A1 true TNSN91049A1 (fr) 1992-10-25

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN91049A TNSN91049A1 (fr) 1990-06-20 1991-06-19 Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique

Country Status (27)

Country Link
EP (1) EP0535081A1 (fr)
JP (1) JPH05507713A (fr)
CN (1) CN1058212A (fr)
AP (1) AP215A (fr)
AU (1) AU649453B2 (fr)
BG (1) BG97200A (fr)
CA (1) CA2083714A1 (fr)
CZ (1) CZ279772B6 (fr)
FI (1) FI925766A (fr)
HU (1) HUT62881A (fr)
IE (1) IE912025A1 (fr)
IL (1) IL98470A0 (fr)
IS (1) IS3721A7 (fr)
LT (2) LT3977B (fr)
LV (1) LV10953A (fr)
MA (1) MA22199A1 (fr)
NO (1) NO924775D0 (fr)
NZ (1) NZ238546A (fr)
OA (1) OA09682A (fr)
PT (1) PT98035A (fr)
RO (1) RO110493B1 (fr)
SE (1) SE9002206D0 (fr)
TN (1) TNSN91049A1 (fr)
TW (1) TW216418B (fr)
WO (1) WO1991019711A1 (fr)
YU (1) YU104191A (fr)
ZA (2) ZA914297B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
CA2400953A1 (fr) 2000-02-24 2001-08-30 Kopran Research Laboratories Limited Derives de benzimidazole antiulcereux a acidite stable administrables oralement
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
CA2480826C (fr) 2002-04-09 2012-02-07 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
EP1708684A2 (fr) 2003-09-26 2006-10-11 Alza Corporation Enrobage de medicaments a charge medicamenteuse elevee et procedes de fabrication
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (fr) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. Composes benzimidazole
CA2658804A1 (fr) 2006-07-25 2008-01-31 Vecta Ltd. Compositions et procedes d'inhibition de secretion d'acide gastrique utilisant des derives de petits acides dicarboxyliques combines a un ipp
EP2065379A4 (fr) * 2006-10-13 2011-01-19 Eisai R&D Man Co Ltd Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique
CA2736547C (fr) 2008-09-09 2016-11-01 Pozen Inc. Procede d'administration d'une composition pharmaceutique a un patient en ayant besoin
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2519229A2 (fr) 2009-12-29 2012-11-07 Novartis AG Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
UA115139C2 (uk) 2011-12-28 2017-09-25 Поузен Інк. Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту
CA3036250C (fr) * 2016-09-14 2023-09-26 Yufeng Jane Tseng Nouveaux derives de benzimidazole substitues utilises en tant qu'inhibiteurs de la d-amino-acide oxydase (daao)

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ222495A (en) 1986-11-21 1991-04-26 Haessle Ab Benzimidazole derivatives and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
WO1989003829A1 (fr) * 1987-10-30 1989-05-05 Aktiebolaget Hässle Omeprazole permettant le traitement de maladies relatives a la perte osseuse
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
AU3690289A (en) * 1988-05-25 1989-12-12 Byk Gulden Lomberg Chemische Fabrik Gmbh New fluoralkoxy compounds

Also Published As

Publication number Publication date
AP9100285A0 (en) 1991-07-31
LT3952B (en) 1996-05-27
CN1058212A (zh) 1992-01-29
MA22199A1 (fr) 1992-04-01
PT98035A (pt) 1992-03-31
FI925766A0 (fi) 1992-12-18
RO110493B1 (ro) 1996-01-30
SE9002206D0 (sv) 1990-06-20
IE912025A1 (en) 1992-01-01
AU649453B2 (en) 1994-05-26
LTIP1713A (en) 1995-08-25
BG97200A (bg) 1993-12-24
LT3977B (en) 1996-06-25
CZ279772B6 (cs) 1995-06-14
HU9204033D0 (en) 1993-03-29
CS189491A3 (en) 1992-04-15
AP215A (en) 1992-09-02
OA09682A (en) 1993-05-15
NZ238546A (en) 1994-03-25
WO1991019711A1 (fr) 1991-12-26
IS3721A7 (is) 1991-12-21
NO924775L (no) 1992-12-10
ZA914297B (en) 1992-03-25
NO924775D0 (no) 1992-12-10
HUT62881A (en) 1993-06-28
ZA914296B (en) 1992-03-25
IL98470A0 (en) 1992-07-15
EP0535081A1 (fr) 1993-04-07
TW216418B (fr) 1993-11-21
YU104191A (sh) 1994-01-20
JPH05507713A (ja) 1993-11-04
FI925766A (fi) 1992-12-18
LV10953A (lv) 1995-12-20
LTIP1712A (en) 1995-08-25
CA2083714A1 (fr) 1991-12-21
AU8009791A (en) 1992-01-07

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