TNSN91049A1 - Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique - Google Patents

Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique

Info

Publication number
TNSN91049A1
TNSN91049A1 TNTNSN91049A TNSN91049A TNSN91049A1 TN SN91049 A1 TNSN91049 A1 TN SN91049A1 TN TNSN91049 A TNTNSN91049 A TN TNSN91049A TN SN91049 A TNSN91049 A TN SN91049A TN SN91049 A1 TNSN91049 A1 TN SN91049A1
Authority
TN
Tunisia
Prior art keywords
carbon atoms
processes
preparation
pharmaceutical use
atoms
Prior art date
Application number
TNTNSN91049A
Other languages
English (en)
Inventor
Elof Brandstrom Arne
Lennart Lindberg Per
Elisabeth Sunden Gunnel
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of TNSN91049A1 publication Critical patent/TNSN91049A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

LES COMPOSES NOUVEAU AYANT LA FORMULE I OU R1 ET R2, QUI SONT DIFFERENTS, SONT CHACUN H, ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU - C(O)-R6 ; PARMI R1 ET R2 L'UN EST TOUJOURS SELECTIONNE A PARTIR DU GROUPE -C (O)-R6 ; DANS LEQUEL R6 EST ALKYLE CONTENANT 1 A 4 ATOMES DE CARBONE OU ALKOXY CONTENANT 1 A 4 ATOMES DE CARBONE, R3 EST LE GROUPE - CH2OCOOR7, OU R7 EST ALKYLE CONTENANT 1 A 6 ATOMES DE CARBONE OU BENZYLE ; R4 ET R5 SONT LES MEMES OU DIFFERENTS ET PEUVENT ETRE OCH3. FORMENT ENSEMBLE AVEC LES ATOMES D'OXYGENE ADJACENTS FIXES AU NOYAU PYRIDINE ET AVEC LES ATOMES DE CARBONE DU NOYAU PYRIDINE UN NOYAU, DANS LEQUEL LA PARTIE CONSTITUEE PAR R4 ET R5 EST -CH2CH2-CH2, -CH2CH2- OU - CH2-, AINSI QUE DES COMPOSITIONS PHARMACEUTIQUES CONTENANT LES DITS COMPOSES COMME INGREDIENTS ACTIFS, ET L'EMPLOI DE CES COMPOSES EN MEDECINE
TNTNSN91049A 1990-06-20 1991-06-19 Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique TNSN91049A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (1)

Publication Number Publication Date
TNSN91049A1 true TNSN91049A1 (fr) 1992-10-25

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN91049A TNSN91049A1 (fr) 1990-06-20 1991-06-19 Benzimidazoles substitues, procedes en vue de leur preparation, et leur emploi pharmaceutique

Country Status (26)

Country Link
EP (1) EP0535081A1 (fr)
JP (1) JPH05507713A (fr)
CN (1) CN1058212A (fr)
AP (1) AP215A (fr)
AU (1) AU649453B2 (fr)
CA (1) CA2083714A1 (fr)
CZ (1) CZ279772B6 (fr)
FI (1) FI925766A0 (fr)
HU (1) HUT62881A (fr)
IE (1) IE912025A1 (fr)
IL (1) IL98470A0 (fr)
IS (1) IS3721A7 (fr)
LT (2) LT3952B (fr)
LV (1) LV10953A (fr)
MA (1) MA22199A1 (fr)
NO (1) NO924775D0 (fr)
NZ (1) NZ238546A (fr)
OA (1) OA09682A (fr)
PT (1) PT98035A (fr)
RO (1) RO110493B1 (fr)
SE (1) SE9002206D0 (fr)
TN (1) TNSN91049A1 (fr)
TW (1) TW216418B (fr)
WO (1) WO1991019711A1 (fr)
YU (1) YU104191A (fr)
ZA (2) ZA914296B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
BR0017140A (pt) 2000-02-24 2004-05-25 Kopran Res Lab Ltd Derivados de benzimidazol anti-úlcera estáveis ácidos para administração oral
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
AU2003246792B2 (en) 2002-04-09 2008-08-28 Flamel Ireland Limited Oral suspension of active principle microcapsules
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
NZ546148A (en) 2003-09-26 2009-05-31 Alza Corp Drug coating providing high drug loading and methods for providing the same
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
WO2007122686A1 (fr) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. Composes benzimidazole
DK2046334T3 (da) 2006-07-25 2014-08-25 Vecta Ltd Sammensætninger og fremgangsmåder til at hæmme mavesyresekretion ved at anvende derivater af små dicarboxylsyrer i kombination med PPI
JP5492417B2 (ja) * 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
MX2011002515A (es) 2008-09-09 2011-04-07 Astrazeneca Ab Metodo de administracion de una composicion farmaceutica a un paciente que lo necesita.
MX2011013467A (es) 2009-06-25 2012-02-13 Astrazeneca Ab Metodo para tratar un paciente que corre el riesgo de desarollar una ulcera asociada a antiinflamatorio no esteroide (aine).
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
MX2014007935A (es) 2011-12-28 2014-11-14 Pozen Inc Composiciones y metodos mejorados para el suministro de omeprazol y de acido acetilsalicilico.
TWI659022B (zh) * 2016-09-14 2019-05-11 國立臺灣大學 作為d-胺基酸氧化酶(daao)抑制劑之新穎經取代苯并咪唑衍生物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
HU886738D0 (en) * 1987-10-30 1990-02-28 Haessle Ab Process for the preparation of pharmaceutical compositions against osteoporosis containing 2-pyridinyl-methyl-(sulfinyl or thio)-benzimidazoles
AU2817989A (en) * 1987-12-11 1989-07-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel benzimidazole derivatives
EP0415990A1 (fr) * 1988-05-25 1991-03-13 Byk Gulden Lomberg Chemische Fabrik GmbH Nouveaux composes fluores d'alkoxyde

Also Published As

Publication number Publication date
OA09682A (en) 1993-05-15
IE912025A1 (en) 1992-01-01
MA22199A1 (fr) 1992-04-01
IL98470A0 (en) 1992-07-15
AU649453B2 (en) 1994-05-26
PT98035A (pt) 1992-03-31
HUT62881A (en) 1993-06-28
LV10953A (lv) 1995-12-20
AP215A (en) 1992-09-02
AU8009791A (en) 1992-01-07
ZA914296B (en) 1992-03-25
LTIP1713A (en) 1995-08-25
AP9100285A0 (en) 1991-07-31
LT3977B (en) 1996-06-25
IS3721A7 (is) 1991-12-21
ZA914297B (en) 1992-03-25
YU104191A (sh) 1994-01-20
CS189491A3 (en) 1992-04-15
NO924775L (no) 1992-12-10
SE9002206D0 (sv) 1990-06-20
CA2083714A1 (fr) 1991-12-21
JPH05507713A (ja) 1993-11-04
LTIP1712A (en) 1995-08-25
CN1058212A (zh) 1992-01-29
NZ238546A (en) 1994-03-25
FI925766A (fi) 1992-12-18
RO110493B1 (ro) 1996-01-30
TW216418B (fr) 1993-11-21
LT3952B (en) 1996-05-27
HU9204033D0 (en) 1993-03-29
CZ279772B6 (cs) 1995-06-14
NO924775D0 (no) 1992-12-10
WO1991019711A1 (fr) 1991-12-26
EP0535081A1 (fr) 1993-04-07
FI925766A0 (fi) 1992-12-18

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