CA2083714A1 - Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique - Google Patents
Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutiqueInfo
- Publication number
- CA2083714A1 CA2083714A1 CA002083714A CA2083714A CA2083714A1 CA 2083714 A1 CA2083714 A1 CA 2083714A1 CA 002083714 A CA002083714 A CA 002083714A CA 2083714 A CA2083714 A CA 2083714A CA 2083714 A1 CA2083714 A1 CA 2083714A1
- Authority
- CA
- Canada
- Prior art keywords
- methyl
- compound
- formula
- benzimidazole
- pyridinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9002206A SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds |
SE9002206-2 | 1990-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2083714A1 true CA2083714A1 (fr) | 1991-12-21 |
Family
ID=20379831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002083714A Abandoned CA2083714A1 (fr) | 1990-06-20 | 1991-06-11 | Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0535081A1 (fr) |
JP (1) | JPH05507713A (fr) |
CN (1) | CN1058212A (fr) |
AP (1) | AP215A (fr) |
AU (1) | AU649453B2 (fr) |
BG (1) | BG97200A (fr) |
CA (1) | CA2083714A1 (fr) |
CZ (1) | CZ279772B6 (fr) |
FI (1) | FI925766A0 (fr) |
HU (1) | HUT62881A (fr) |
IE (1) | IE912025A1 (fr) |
IL (1) | IL98470A0 (fr) |
IS (1) | IS3721A7 (fr) |
LT (2) | LT3977B (fr) |
LV (1) | LV10953A (fr) |
MA (1) | MA22199A1 (fr) |
NO (1) | NO924775L (fr) |
NZ (1) | NZ238546A (fr) |
OA (1) | OA09682A (fr) |
PT (1) | PT98035A (fr) |
RO (1) | RO110493B1 (fr) |
SE (1) | SE9002206D0 (fr) |
TN (1) | TNSN91049A1 (fr) |
TW (1) | TW216418B (fr) |
WO (1) | WO1991019711A1 (fr) |
YU (1) | YU104191A (fr) |
ZA (2) | ZA914297B (fr) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
SE9103776D0 (sv) * | 1991-12-19 | 1991-12-19 | Astra Ab | New compounds |
IS4232A (is) * | 1993-12-06 | 1995-06-07 | Astra Aktiebolag | Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun |
SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
SE9500478D0 (sv) * | 1995-02-09 | 1995-02-09 | Astra Ab | New pharmaceutical formulation and process |
SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
DK1257269T3 (da) | 2000-02-24 | 2005-03-14 | Kopran Res Lab Ltd | Syrestabile benzimidazolderivater til oral indgivelse mod ulcus |
SE0101379D0 (sv) | 2001-04-18 | 2001-04-18 | Diabact Ab | Komposition som hämmar utsöndring av magsyra |
US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
SE0203065D0 (sv) | 2002-10-16 | 2002-10-16 | Diabact Ab | Gastric acid secretion inhibiting composition |
ATE544447T1 (de) | 2003-09-26 | 2012-02-15 | Alza Corp | Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung |
TW200606163A (en) | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US20070015782A1 (en) * | 2005-04-15 | 2007-01-18 | Eisai Co., Ltd. | Benzimidazole compound |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
WO2007122686A1 (fr) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | Composes benzimidazole |
RU2467747C2 (ru) | 2006-07-25 | 2012-11-27 | Векта Лтд. | Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi |
EP2065379A4 (fr) * | 2006-10-13 | 2011-01-19 | Eisai R&D Man Co Ltd | Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique |
CA2736547C (fr) | 2008-09-09 | 2016-11-01 | Pozen Inc. | Procede d'administration d'une composition pharmaceutique a un patient en ayant besoin |
AU2010263304A1 (en) | 2009-06-25 | 2012-02-02 | Astrazeneca Ab | Method for treating a patient at risk for developing an NSAID-associated ulcer |
WO2011080500A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080502A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080501A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
EP2601947A1 (fr) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori |
MX2014007935A (es) | 2011-12-28 | 2014-11-14 | Pozen Inc | Composiciones y metodos mejorados para el suministro de omeprazol y de acido acetilsalicilico. |
KR102409502B1 (ko) * | 2016-09-14 | 2022-06-16 | 위펑 제인 쳉 | D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE418966B (sv) | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
IN148930B (fr) | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
SE8301182D0 (sv) | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
AU568441B2 (en) * | 1984-09-24 | 1987-12-24 | Upjohn Company, The | 2-(pyridylalkenesulfinyl) benzimidazole derivatives |
IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
US4738975A (en) | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
SE8505112D0 (sv) * | 1985-10-29 | 1985-10-29 | Haessle Ab | Novel pharmacological compounds |
NZ234564A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | 1-substituted benzimidazoles and pharmaceutical compositions |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
WO1989003830A1 (fr) * | 1987-10-30 | 1989-05-05 | Aktiebolaget Hässle | 2-pyridinylmethyle (sulfinyle ou thio)benzimidazoles permettant le traitement de maladies relatives aux pertes osseuses |
ZA889194B (en) * | 1987-12-11 | 1989-08-30 | Byk Gulden Lomberg Chemisch Fa | Novel benzimidazole derivatives |
JPH03504497A (ja) * | 1988-05-25 | 1991-10-03 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規フルオルアルコキシ化合物 |
-
1990
- 1990-06-20 SE SE9002206A patent/SE9002206D0/xx unknown
-
1991
- 1991-06-05 ZA ZA914297A patent/ZA914297B/xx unknown
- 1991-06-05 ZA ZA914296A patent/ZA914296B/xx unknown
- 1991-06-11 RO RO92-01581A patent/RO110493B1/ro unknown
- 1991-06-11 HU HU924033A patent/HUT62881A/hu unknown
- 1991-06-11 JP JP91511435A patent/JPH05507713A/ja active Pending
- 1991-06-11 AU AU80097/91A patent/AU649453B2/en not_active Ceased
- 1991-06-11 WO PCT/SE1991/000415 patent/WO1991019711A1/fr not_active Application Discontinuation
- 1991-06-11 EP EP91911659A patent/EP0535081A1/fr not_active Withdrawn
- 1991-06-11 CA CA002083714A patent/CA2083714A1/fr not_active Abandoned
- 1991-06-12 YU YU104191A patent/YU104191A/sh unknown
- 1991-06-12 TW TW080104582A patent/TW216418B/zh active
- 1991-06-12 IL IL98470A patent/IL98470A0/xx unknown
- 1991-06-14 NZ NZ238546A patent/NZ238546A/en unknown
- 1991-06-14 IE IE202591A patent/IE912025A1/en unknown
- 1991-06-18 MA MA22462A patent/MA22199A1/fr unknown
- 1991-06-19 PT PT98035A patent/PT98035A/pt not_active Application Discontinuation
- 1991-06-19 TN TNTNSN91049A patent/TNSN91049A1/fr unknown
- 1991-06-19 AP APAP/P/1991/000285A patent/AP215A/en active
- 1991-06-20 IS IS3721A patent/IS3721A7/is unknown
- 1991-06-20 CN CN91105024A patent/CN1058212A/zh active Pending
- 1991-06-20 CZ CS911894A patent/CZ279772B6/cs unknown
-
1992
- 1992-11-27 OA OA60306A patent/OA09682A/en unknown
- 1992-12-10 NO NO92924775A patent/NO924775L/no unknown
- 1992-12-18 FI FI925766A patent/FI925766A0/fi not_active Application Discontinuation
- 1992-12-18 BG BG097200A patent/BG97200A/bg unknown
-
1993
- 1993-08-27 LV LV931045A patent/LV10953A/xx unknown
- 1993-12-30 LT LTIP1713A patent/LT3977B/lt not_active IP Right Cessation
- 1993-12-30 LT LTIP1712A patent/LT3952B/lt not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA914296B (en) | 1992-03-25 |
IE912025A1 (en) | 1992-01-01 |
YU104191A (sh) | 1994-01-20 |
AP215A (en) | 1992-09-02 |
NZ238546A (en) | 1994-03-25 |
TW216418B (fr) | 1993-11-21 |
PT98035A (pt) | 1992-03-31 |
CN1058212A (zh) | 1992-01-29 |
LTIP1713A (en) | 1995-08-25 |
OA09682A (en) | 1993-05-15 |
CS189491A3 (en) | 1992-04-15 |
BG97200A (bg) | 1993-12-24 |
IL98470A0 (en) | 1992-07-15 |
FI925766A (fi) | 1992-12-18 |
LT3977B (en) | 1996-06-25 |
HU9204033D0 (en) | 1993-03-29 |
LTIP1712A (en) | 1995-08-25 |
JPH05507713A (ja) | 1993-11-04 |
MA22199A1 (fr) | 1992-04-01 |
AU8009791A (en) | 1992-01-07 |
CZ279772B6 (cs) | 1995-06-14 |
RO110493B1 (ro) | 1996-01-30 |
WO1991019711A1 (fr) | 1991-12-26 |
NO924775D0 (no) | 1992-12-10 |
LT3952B (en) | 1996-05-27 |
EP0535081A1 (fr) | 1993-04-07 |
HUT62881A (en) | 1993-06-28 |
NO924775L (no) | 1992-12-10 |
ZA914297B (en) | 1992-03-25 |
TNSN91049A1 (fr) | 1992-10-25 |
AU649453B2 (en) | 1994-05-26 |
AP9100285A0 (en) | 1991-07-31 |
LV10953A (lv) | 1995-12-20 |
IS3721A7 (is) | 1991-12-21 |
FI925766A0 (fi) | 1992-12-18 |
SE9002206D0 (sv) | 1990-06-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |