CA2083714A1 - Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique - Google Patents

Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique

Info

Publication number
CA2083714A1
CA2083714A1 CA002083714A CA2083714A CA2083714A1 CA 2083714 A1 CA2083714 A1 CA 2083714A1 CA 002083714 A CA002083714 A CA 002083714A CA 2083714 A CA2083714 A CA 2083714A CA 2083714 A1 CA2083714 A1 CA 2083714A1
Authority
CA
Canada
Prior art keywords
methyl
compound
formula
benzimidazole
pyridinyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002083714A
Other languages
English (en)
Inventor
Arne Elof Brandstrom
Per Lennart Lindberg
Gunnel Elisabeth Sunden
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2083714A1 publication Critical patent/CA2083714A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA002083714A 1990-06-20 1991-06-11 Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique Abandoned CA2083714A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds
SE9002206-2 1990-06-20

Publications (1)

Publication Number Publication Date
CA2083714A1 true CA2083714A1 (fr) 1991-12-21

Family

ID=20379831

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002083714A Abandoned CA2083714A1 (fr) 1990-06-20 1991-06-11 Benzimidazoles substituees, leur procede de preparation et leur utilisation pharmaceutique

Country Status (27)

Country Link
EP (1) EP0535081A1 (fr)
JP (1) JPH05507713A (fr)
CN (1) CN1058212A (fr)
AP (1) AP215A (fr)
AU (1) AU649453B2 (fr)
BG (1) BG97200A (fr)
CA (1) CA2083714A1 (fr)
CZ (1) CZ279772B6 (fr)
FI (1) FI925766A0 (fr)
HU (1) HUT62881A (fr)
IE (1) IE912025A1 (fr)
IL (1) IL98470A0 (fr)
IS (1) IS3721A7 (fr)
LT (2) LT3977B (fr)
LV (1) LV10953A (fr)
MA (1) MA22199A1 (fr)
NO (1) NO924775L (fr)
NZ (1) NZ238546A (fr)
OA (1) OA09682A (fr)
PT (1) PT98035A (fr)
RO (1) RO110493B1 (fr)
SE (1) SE9002206D0 (fr)
TN (1) TNSN91049A1 (fr)
TW (1) TW216418B (fr)
WO (1) WO1991019711A1 (fr)
YU (1) YU104191A (fr)
ZA (2) ZA914297B (fr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9002043D0 (sv) * 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
SE9103776D0 (sv) * 1991-12-19 1991-12-19 Astra Ab New compounds
IS4232A (is) * 1993-12-06 1995-06-07 Astra Aktiebolag Súbstitúerað bensimidasól, aðferðir við framleiðslu þess og lyfjafræðileg notkun
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
SE9600070D0 (sv) 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DK1257269T3 (da) 2000-02-24 2005-03-14 Kopran Res Lab Ltd Syrestabile benzimidazolderivater til oral indgivelse mod ulcus
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
CA2480826C (fr) 2002-04-09 2012-02-07 Flamel Technologies Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s)
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
ATE544447T1 (de) 2003-09-26 2012-02-15 Alza Corp Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung
TW200606163A (en) 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
WO2007122686A1 (fr) * 2006-04-14 2007-11-01 Eisai R & D Management Co., Ltd. Composes benzimidazole
RU2467747C2 (ru) 2006-07-25 2012-11-27 Векта Лтд. Композиции и способы для ингибирования секреции желудочной кислоты с использованием производных малых дикарбоновых кислот в сочетании с ppi
EP2065379A4 (fr) * 2006-10-13 2011-01-19 Eisai R&D Man Co Ltd Benzimidazole présentant une activité inhibitrice de la sécrétion d'acide gastrique
CA2736547C (fr) 2008-09-09 2016-11-01 Pozen Inc. Procede d'administration d'une composition pharmaceutique a un patient en ayant besoin
AU2010263304A1 (en) 2009-06-25 2012-02-02 Astrazeneca Ab Method for treating a patient at risk for developing an NSAID-associated ulcer
WO2011080500A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080502A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
WO2011080501A2 (fr) 2009-12-29 2011-07-07 Orexo Ab Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique
EP2601947A1 (fr) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori
MX2014007935A (es) 2011-12-28 2014-11-14 Pozen Inc Composiciones y metodos mejorados para el suministro de omeprazol y de acido acetilsalicilico.
KR102409502B1 (ko) * 2016-09-14 2022-06-16 위펑 제인 쳉 D-아미노산 옥시다제 (daao) 저해제로서 신규한 치환된 벤즈이미다졸 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE418966B (sv) 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (fr) 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
SE8300736D0 (sv) 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
SE8301182D0 (sv) 1983-03-04 1983-03-04 Haessle Ab Novel compounds
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
US4738975A (en) 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
NZ234564A (en) 1986-11-21 1991-04-26 Haessle Ab 1-substituted benzimidazoles and pharmaceutical compositions
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
WO1989003830A1 (fr) * 1987-10-30 1989-05-05 Aktiebolaget Hässle 2-pyridinylmethyle (sulfinyle ou thio)benzimidazoles permettant le traitement de maladies relatives aux pertes osseuses
ZA889194B (en) * 1987-12-11 1989-08-30 Byk Gulden Lomberg Chemisch Fa Novel benzimidazole derivatives
JPH03504497A (ja) * 1988-05-25 1991-10-03 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 新規フルオルアルコキシ化合物

Also Published As

Publication number Publication date
ZA914296B (en) 1992-03-25
IE912025A1 (en) 1992-01-01
YU104191A (sh) 1994-01-20
AP215A (en) 1992-09-02
NZ238546A (en) 1994-03-25
TW216418B (fr) 1993-11-21
PT98035A (pt) 1992-03-31
CN1058212A (zh) 1992-01-29
LTIP1713A (en) 1995-08-25
OA09682A (en) 1993-05-15
CS189491A3 (en) 1992-04-15
BG97200A (bg) 1993-12-24
IL98470A0 (en) 1992-07-15
FI925766A (fi) 1992-12-18
LT3977B (en) 1996-06-25
HU9204033D0 (en) 1993-03-29
LTIP1712A (en) 1995-08-25
JPH05507713A (ja) 1993-11-04
MA22199A1 (fr) 1992-04-01
AU8009791A (en) 1992-01-07
CZ279772B6 (cs) 1995-06-14
RO110493B1 (ro) 1996-01-30
WO1991019711A1 (fr) 1991-12-26
NO924775D0 (no) 1992-12-10
LT3952B (en) 1996-05-27
EP0535081A1 (fr) 1993-04-07
HUT62881A (en) 1993-06-28
NO924775L (no) 1992-12-10
ZA914297B (en) 1992-03-25
TNSN91049A1 (fr) 1992-10-25
AU649453B2 (en) 1994-05-26
AP9100285A0 (en) 1991-07-31
LV10953A (lv) 1995-12-20
IS3721A7 (is) 1991-12-21
FI925766A0 (fi) 1992-12-18
SE9002206D0 (sv) 1990-06-20

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Legal Events

Date Code Title Description
FZDE Discontinued