WO1991019711A1 - Benzimidazoles substitues, procede de preparation et utilisation pharmaceutique de ceux-ci - Google Patents
Benzimidazoles substitues, procede de preparation et utilisation pharmaceutique de ceux-ci Download PDFInfo
- Publication number
- WO1991019711A1 WO1991019711A1 PCT/SE1991/000415 SE9100415W WO9119711A1 WO 1991019711 A1 WO1991019711 A1 WO 1991019711A1 SE 9100415 W SE9100415 W SE 9100415W WO 9119711 A1 WO9119711 A1 WO 9119711A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- methyl
- compound
- formula
- pyridinyl
- dimethoxy
- Prior art date
Links
- 0 Cc1nc2cc(*=O)c(*)cc2[n]1C Chemical compound Cc1nc2cc(*=O)c(*)cc2[n]1C 0.000 description 2
- ODCKFUPHXJWCAL-UHFFFAOYSA-N CCN1C2=CC(C)=C(C)CC2N(C)C1 Chemical compound CCN1C2=CC(C)=C(C)CC2N(C)C1 ODCKFUPHXJWCAL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU80097/91A AU649453B2 (en) | 1990-06-20 | 1991-06-11 | Substituted benzimidazoles, process for their preparation and their pharmaceutical use |
JP91511435A JPH05507713A (ja) | 1990-06-20 | 1991-06-11 | 置換ベンズイミダゾール、その製造方法およびその薬学的使用 |
RO92-01581A RO110493B1 (ro) | 1990-06-20 | 1991-06-11 | Derivati de benzimidazol si procedee pentru prepararea acestora |
NO92924775A NO924775L (no) | 1990-06-20 | 1992-12-10 | Substituerte benzimidazoler, fremgangsmaate for deres fremstilling og deres farmasoeytiske anvendelse |
FI925766A FI925766A0 (fi) | 1990-06-20 | 1992-12-18 | Substituerade bensimidazoler, foerfarande foer deras framstaellning och deras farmaceutiska anvaendning |
BG097200A BG97200A (bg) | 1990-06-20 | 1992-12-18 | Заместени бензимидазоли,метод за получаването им и тяхното фармацевтично приложение |
LV931045A LV10953A (lv) | 1990-06-20 | 1993-08-27 | Aizvietotie benzimidazoli to iegusanas panemiens pielietojums farmaceitiska kompozicija |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9002206A SE9002206D0 (sv) | 1990-06-20 | 1990-06-20 | New compounds |
SE9002206-2 | 1990-06-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991019711A1 true WO1991019711A1 (fr) | 1991-12-26 |
Family
ID=20379831
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1991/000415 WO1991019711A1 (fr) | 1990-06-20 | 1991-06-11 | Benzimidazoles substitues, procede de preparation et utilisation pharmaceutique de ceux-ci |
Country Status (27)
Country | Link |
---|---|
EP (1) | EP0535081A1 (fr) |
JP (1) | JPH05507713A (fr) |
CN (1) | CN1058212A (fr) |
AP (1) | AP215A (fr) |
AU (1) | AU649453B2 (fr) |
BG (1) | BG97200A (fr) |
CA (1) | CA2083714A1 (fr) |
CZ (1) | CZ279772B6 (fr) |
FI (1) | FI925766A0 (fr) |
HU (1) | HUT62881A (fr) |
IE (1) | IE912025A1 (fr) |
IL (1) | IL98470A0 (fr) |
IS (1) | IS3721A7 (fr) |
LT (2) | LT3952B (fr) |
LV (1) | LV10953A (fr) |
MA (1) | MA22199A1 (fr) |
NO (1) | NO924775L (fr) |
NZ (1) | NZ238546A (fr) |
OA (1) | OA09682A (fr) |
PT (1) | PT98035A (fr) |
RO (1) | RO110493B1 (fr) |
SE (1) | SE9002206D0 (fr) |
TN (1) | TNSN91049A1 (fr) |
TW (1) | TW216418B (fr) |
WO (1) | WO1991019711A1 (fr) |
YU (1) | YU104191A (fr) |
ZA (2) | ZA914297B (fr) |
Cited By (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995015962A1 (fr) * | 1993-12-06 | 1995-06-15 | Astra Aktiebolag | Benzimidazole subtitue, ses procedes de preparation et son utilisation pharmaceutique |
AU665043B2 (en) * | 1991-12-19 | 1995-12-14 | Astra Aktiebolag | Substituted benzimidazoles, process for their preparation as well as their use |
US6013281A (en) * | 1995-02-09 | 2000-01-11 | Astra Aktiebolag | Method of making a pharmaceutical dosage form comprising a proton pump inhibitor |
US6136344A (en) * | 1995-02-06 | 2000-10-24 | Astra Aktiebolag | Oral pharmaceutical dosage form |
US6617338B2 (en) | 2000-02-24 | 2003-09-09 | Kopran Research Laboratories Limited | Orally administrable acid stable antiulcer benzimidazole derivatives |
WO2004035090A1 (fr) | 2002-10-16 | 2004-04-29 | Orexo Ab | Composition inhibant la secretion d'acide gastrique |
WO2008012621A2 (fr) | 2006-07-25 | 2008-01-31 | Vecta, Ltd. | Compositions et procédés d'inhibition de sécrétion d'acide gastrique utilisant des dérivés de petits acides dicarboxyliques combinés á un ipp |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US7815940B2 (en) | 2001-04-18 | 2010-10-19 | Orexo Ab | Gastric acid secretion inhibiting composition |
EP2275139A1 (fr) | 1996-01-08 | 2011-01-19 | AstraZeneca AB | Formes galéniques pharmaceutiques orales comprenant un inhibiteur de pompe à protons et un anti-inflammatoire non stéroidien |
WO2011080500A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080502A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080501A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US8226979B2 (en) | 2003-09-26 | 2012-07-24 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
EP2601938A1 (fr) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Compositions pharmqaceutiques pour le traitement de maladies associées à Hélicobacter pylori |
KR101285696B1 (ko) * | 2005-04-15 | 2013-07-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 벤즈이미다졸 화합물 |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US8852636B2 (en) | 2001-06-01 | 2014-10-07 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US8945621B2 (en) | 2009-06-25 | 2015-02-03 | Pozen Inc. | Method for treating a patient at risk for developing an NSAID-associated ulcer |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
US9220698B2 (en) | 2008-09-09 | 2015-12-29 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
US9539214B2 (en) | 2011-12-28 | 2017-01-10 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
US9814684B2 (en) | 2002-04-09 | 2017-11-14 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
AU2021200290B2 (en) * | 2016-09-14 | 2023-09-14 | National Health Research Institutes | Novel substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9002043D0 (sv) * | 1990-06-07 | 1990-06-07 | Astra Ab | Improved method for synthesis |
TW200606163A (en) | 2004-04-22 | 2006-02-16 | Eisai Co Ltd | Imidazopyridine compound |
WO2007122686A1 (fr) * | 2006-04-14 | 2007-11-01 | Eisai R & D Management Co., Ltd. | Composes benzimidazole |
JP5492417B2 (ja) * | 2006-10-13 | 2014-05-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 胃酸分泌抑制作用を有するベンズイミダゾール化合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0176308A2 (fr) * | 1984-09-24 | 1986-04-02 | The Upjohn Company | 2-(Pyridylalkylènesulfinyle)-benzimidazoles |
EP0221041A2 (fr) * | 1985-10-29 | 1987-05-06 | Aktiebolaget Hässle | Dérivés de benzimidazole, leur préparation et leur application comme médicaments |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE418966B (sv) | 1974-02-18 | 1981-07-06 | Haessle Ab | Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan |
SE416649B (sv) | 1974-05-16 | 1981-01-26 | Haessle Ab | Forfarande for framstellning av foreningar som paverkar magsyrasekretionen |
IN148930B (fr) | 1977-09-19 | 1981-07-25 | Hoffmann La Roche | |
SE7804231L (sv) | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
US4359465A (en) | 1980-07-28 | 1982-11-16 | The Upjohn Company | Methods for treating gastrointestinal inflammation |
CH644116A5 (de) | 1980-08-21 | 1984-07-13 | Hoffmann La Roche | Imidazolderivate. |
SE8300736D0 (sv) | 1983-02-11 | 1983-02-11 | Haessle Ab | Novel pharmacologically active compounds |
SE8301182D0 (sv) | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
IL75400A (en) * | 1984-06-16 | 1988-10-31 | Byk Gulden Lomberg Chem Fab | Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same |
IL76839A (en) * | 1984-10-31 | 1988-08-31 | Byk Gulden Lomberg Chem Fab | Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same |
US4738975A (en) | 1985-07-02 | 1988-04-19 | Takeda Chemical Industries, Ltd. | Pyridine derivatives, and use as anti-ulcer agents |
NZ222495A (en) | 1986-11-21 | 1991-04-26 | Haessle Ab | Benzimidazole derivatives and pharmaceutical compositions |
DE3722810A1 (de) * | 1987-07-10 | 1989-01-19 | Hoechst Ag | Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung |
JPH02501930A (ja) * | 1987-10-30 | 1990-06-28 | アクチエボラゲツト・ヘツスレ | 薬学的化合物のための新規な用途 |
AU2817989A (en) * | 1987-12-11 | 1989-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel benzimidazole derivatives |
WO1989011479A1 (fr) * | 1988-05-25 | 1989-11-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Nouveaux composes fluores d'alkoxyde |
-
1990
- 1990-06-20 SE SE9002206A patent/SE9002206D0/xx unknown
-
1991
- 1991-06-05 ZA ZA914297A patent/ZA914297B/xx unknown
- 1991-06-05 ZA ZA914296A patent/ZA914296B/xx unknown
- 1991-06-11 CA CA002083714A patent/CA2083714A1/fr not_active Abandoned
- 1991-06-11 EP EP91911659A patent/EP0535081A1/fr not_active Withdrawn
- 1991-06-11 HU HU924033A patent/HUT62881A/hu unknown
- 1991-06-11 RO RO92-01581A patent/RO110493B1/ro unknown
- 1991-06-11 AU AU80097/91A patent/AU649453B2/en not_active Ceased
- 1991-06-11 JP JP91511435A patent/JPH05507713A/ja active Pending
- 1991-06-11 WO PCT/SE1991/000415 patent/WO1991019711A1/fr not_active Application Discontinuation
- 1991-06-12 IL IL98470A patent/IL98470A0/xx unknown
- 1991-06-12 TW TW080104582A patent/TW216418B/zh active
- 1991-06-12 YU YU104191A patent/YU104191A/sh unknown
- 1991-06-14 IE IE202591A patent/IE912025A1/en unknown
- 1991-06-14 NZ NZ238546A patent/NZ238546A/en unknown
- 1991-06-18 MA MA22462A patent/MA22199A1/fr unknown
- 1991-06-19 TN TNTNSN91049A patent/TNSN91049A1/fr unknown
- 1991-06-19 AP APAP/P/1991/000285A patent/AP215A/en active
- 1991-06-19 PT PT98035A patent/PT98035A/pt not_active Application Discontinuation
- 1991-06-20 CZ CS911894A patent/CZ279772B6/cs unknown
- 1991-06-20 IS IS3721A patent/IS3721A7/is unknown
- 1991-06-20 CN CN91105024A patent/CN1058212A/zh active Pending
-
1992
- 1992-11-27 OA OA60306A patent/OA09682A/en unknown
- 1992-12-10 NO NO92924775A patent/NO924775L/no unknown
- 1992-12-18 FI FI925766A patent/FI925766A0/fi not_active Application Discontinuation
- 1992-12-18 BG BG097200A patent/BG97200A/bg unknown
-
1993
- 1993-08-27 LV LV931045A patent/LV10953A/xx unknown
- 1993-12-30 LT LTIP1712A patent/LT3952B/lt not_active IP Right Cessation
- 1993-12-30 LT LTIP1713A patent/LT3977B/lt not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0176308A2 (fr) * | 1984-09-24 | 1986-04-02 | The Upjohn Company | 2-(Pyridylalkylènesulfinyle)-benzimidazoles |
EP0221041A2 (fr) * | 1985-10-29 | 1987-05-06 | Aktiebolaget Hässle | Dérivés de benzimidazole, leur préparation et leur application comme médicaments |
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU665043B2 (en) * | 1991-12-19 | 1995-12-14 | Astra Aktiebolag | Substituted benzimidazoles, process for their preparation as well as their use |
WO1995015962A1 (fr) * | 1993-12-06 | 1995-06-15 | Astra Aktiebolag | Benzimidazole subtitue, ses procedes de preparation et son utilisation pharmaceutique |
US6136344A (en) * | 1995-02-06 | 2000-10-24 | Astra Aktiebolag | Oral pharmaceutical dosage form |
US6013281A (en) * | 1995-02-09 | 2000-01-11 | Astra Aktiebolag | Method of making a pharmaceutical dosage form comprising a proton pump inhibitor |
EP2275139A1 (fr) | 1996-01-08 | 2011-01-19 | AstraZeneca AB | Formes galéniques pharmaceutiques orales comprenant un inhibiteur de pompe à protons et un anti-inflammatoire non stéroidien |
US6617338B2 (en) | 2000-02-24 | 2003-09-09 | Kopran Research Laboratories Limited | Orally administrable acid stable antiulcer benzimidazole derivatives |
US7815940B2 (en) | 2001-04-18 | 2010-10-19 | Orexo Ab | Gastric acid secretion inhibiting composition |
EP2253309A2 (fr) | 2001-04-18 | 2010-11-24 | Orexo AB | Composition inhibant la secretion d'acides gastriques |
US9364439B2 (en) | 2001-06-01 | 2016-06-14 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US9198888B2 (en) | 2001-06-01 | 2015-12-01 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US8858996B2 (en) | 2001-06-01 | 2014-10-14 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDS |
US8865190B2 (en) | 2001-06-01 | 2014-10-21 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US9161920B2 (en) | 2001-06-01 | 2015-10-20 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US8852636B2 (en) | 2001-06-01 | 2014-10-07 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US9345695B2 (en) | 2001-06-01 | 2016-05-24 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US9707181B2 (en) | 2001-06-01 | 2017-07-18 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
US9814684B2 (en) | 2002-04-09 | 2017-11-14 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
US10004693B2 (en) | 2002-04-09 | 2018-06-26 | Flamel Ireland Limited | Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s) |
WO2004035090A1 (fr) | 2002-10-16 | 2004-04-29 | Orexo Ab | Composition inhibant la secretion d'acide gastrique |
EP2258341A2 (fr) | 2002-10-16 | 2010-12-08 | Orexo AB | Composition d'inhibition de sécrétion d'acide gastrique |
US7771747B2 (en) | 2002-10-16 | 2010-08-10 | Orexo Ab | Gastric acid secretion inhibiting composition |
US7785626B2 (en) | 2002-10-16 | 2010-08-31 | Orexo Ab | Gastric acid secretion inhibiting composition |
US8226979B2 (en) | 2003-09-26 | 2012-07-24 | Alza Corporation | Drug coating providing high drug loading and methods for providing the same |
US8246986B2 (en) | 2003-09-26 | 2012-08-21 | Alza Corporation | Drug coating providing high drug loading |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
KR101285696B1 (ko) * | 2005-04-15 | 2013-07-12 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 벤즈이미다졸 화합물 |
NO339502B1 (no) * | 2005-04-15 | 2016-12-19 | Eisai R&D Man Co Ltd | Benzimidazolforbindelser |
US9040564B2 (en) | 2005-04-28 | 2015-05-26 | Eisai R&D Management Co., Ltd. | Stabilized composition |
US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US9132082B2 (en) | 2005-05-11 | 2015-09-15 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US9370481B2 (en) | 2005-05-11 | 2016-06-21 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
US9278080B2 (en) | 2005-05-11 | 2016-03-08 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US9233092B2 (en) | 2006-07-25 | 2016-01-12 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI |
WO2008012621A2 (fr) | 2006-07-25 | 2008-01-31 | Vecta, Ltd. | Compositions et procédés d'inhibition de sécrétion d'acide gastrique utilisant des dérivés de petits acides dicarboxyliques combinés á un ipp |
US9801824B2 (en) | 2008-09-09 | 2017-10-31 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
US9220698B2 (en) | 2008-09-09 | 2015-12-29 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
US9393208B2 (en) | 2008-09-09 | 2016-07-19 | Pozen Inc. | Method for delivering a pharmaceutical composition to patient in need thereof |
US8945621B2 (en) | 2009-06-25 | 2015-02-03 | Pozen Inc. | Method for treating a patient at risk for developing an NSAID-associated ulcer |
WO2011080500A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080502A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
WO2011080501A2 (fr) | 2009-12-29 | 2011-07-07 | Orexo Ab | Nouvelle forme pharmaceutique destinée au traitement de troubles liés à l'acide gastrique |
EP2601947A1 (fr) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Combinaison à dose fixe pour le traitement de maladies associées à Hélicobacter pylori |
EP2601938A1 (fr) | 2011-12-05 | 2013-06-12 | Abo Bakr Mohammed Ali Al-Mehdar | Compositions pharmqaceutiques pour le traitement de maladies associées à Hélicobacter pylori |
US9539214B2 (en) | 2011-12-28 | 2017-01-10 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
US9987231B2 (en) | 2011-12-28 | 2018-06-05 | Pozen Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
US10603283B2 (en) | 2011-12-28 | 2020-03-31 | Genus Lifesciences, Inc. | Compositions and methods for delivery of omeprazole plus acetylsalicylic acid |
AU2021200290B2 (en) * | 2016-09-14 | 2023-09-14 | National Health Research Institutes | Novel substituted benzimidazole derivatives as D-amino acid oxidase (DAAO) inhibitors |
Also Published As
Publication number | Publication date |
---|---|
SE9002206D0 (sv) | 1990-06-20 |
HUT62881A (en) | 1993-06-28 |
EP0535081A1 (fr) | 1993-04-07 |
LV10953A (lv) | 1995-12-20 |
IS3721A7 (is) | 1991-12-21 |
YU104191A (sh) | 1994-01-20 |
FI925766A (fi) | 1992-12-18 |
AP9100285A0 (en) | 1991-07-31 |
LT3977B (en) | 1996-06-25 |
CA2083714A1 (fr) | 1991-12-21 |
TW216418B (fr) | 1993-11-21 |
ZA914296B (en) | 1992-03-25 |
HU9204033D0 (en) | 1993-03-29 |
PT98035A (pt) | 1992-03-31 |
CZ279772B6 (cs) | 1995-06-14 |
BG97200A (bg) | 1993-12-24 |
OA09682A (en) | 1993-05-15 |
AU8009791A (en) | 1992-01-07 |
LT3952B (en) | 1996-05-27 |
AP215A (en) | 1992-09-02 |
RO110493B1 (ro) | 1996-01-30 |
NZ238546A (en) | 1994-03-25 |
LTIP1713A (en) | 1995-08-25 |
CS189491A3 (en) | 1992-04-15 |
IE912025A1 (en) | 1992-01-01 |
MA22199A1 (fr) | 1992-04-01 |
LTIP1712A (en) | 1995-08-25 |
TNSN91049A1 (fr) | 1992-10-25 |
FI925766A0 (fi) | 1992-12-18 |
ZA914297B (en) | 1992-03-25 |
AU649453B2 (en) | 1994-05-26 |
CN1058212A (zh) | 1992-01-29 |
NO924775D0 (no) | 1992-12-10 |
NO924775L (no) | 1992-12-10 |
IL98470A0 (en) | 1992-07-15 |
JPH05507713A (ja) | 1993-11-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AP215A (en) | Substituted benzimidazoles, process for their preparation and their pharmaceutical use. | |
EP0593463B1 (fr) | Derives de dialcoxy-pyridinyle-benzimidazole, procede de preparation et utilisation pharmaceutique de ces derives | |
EP0449940B1 (fr) | Nouveau compose therapeutiquement actif et son procede de preparation | |
US4965269A (en) | Therapeutically active chloro substituted benzimidazoles | |
EP0451188B1 (fr) | Benzimidazole therapeutiquement actif a substitution et son procede de preparation | |
EP0449935B1 (fr) | Compose a effet inhibiteur d'acide gastrique et son procede de preparation | |
WO1987005021A1 (fr) | Benzimidazoles et utilisation pharmaceutique desdits benzimidazoles | |
WO1995015962A1 (fr) | Benzimidazole subtitue, ses procedes de preparation et son utilisation pharmaceutique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AT AU BB BG BR CA CH DE DK ES FI GB HU JP KP KR LK LU MC MG MW NL NO PL RO SD SE SU |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE BF BJ CF CG CH CI CM DE DK ES FR GA GB GN GR IT LU ML MR NL SE SN TD TG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1991911659 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2083714 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 925766 Country of ref document: FI Ref document number: 92-01581 Country of ref document: RO |
|
WWP | Wipo information: published in national office |
Ref document number: 1991911659 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1991911659 Country of ref document: EP |