ES477784A1 - Procedimiento para la preparacion de nuevas 2-fenilimino-imidazolidinas sustituidas. - Google Patents
Procedimiento para la preparacion de nuevas 2-fenilimino-imidazolidinas sustituidas.Info
- Publication number
- ES477784A1 ES477784A1 ES477784A ES477784A ES477784A1 ES 477784 A1 ES477784 A1 ES 477784A1 ES 477784 A ES477784 A ES 477784A ES 477784 A ES477784 A ES 477784A ES 477784 A1 ES477784 A1 ES 477784A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- dihydroxy
- heart rate
- bromo
- dibromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.Procedimiento para la preparación de nuevas 2-fenilimino-imidazolidinas sustituidas de la fórmula general ** (fórmula 01) ** donde R significa un radical 2- bromo-4,5-dihidoxifenilo, 3-cloro-4-hidroxifenilo, 4-bromo- 2,5-dihifroxifenilo, 3,5- dihidroxifenilo, 5-cloro-2,4- dihifroxifenilo, 3-hidroxi-4-metrilfenilo, 2,6-dibromo-4-hidroximetilfenilo, 3,5-dibromo-4- aminofenilo, 3-metilmercaptofenilo, 3,4,5, trihidroxifenilo o 3-bromos-4-fluorofenilo, así como de sus sales por adición de ácido, caracterizado porque se hace reaccionar un compuesto de la fórmula general ** (formula 02 )** donde R posee el significado mencionado anteriormente y R1 significa un átomo de hidrógeno o un grupo alcohilo con hasta 4 átomos de carbono, o sus sales por adición de ácido, con etilendiamina o sus sales por adición del ácido, y por que se transforma eventualmente en una sal por adición de ácido el compuesto obtenido de la fórmula I.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19782806775 DE2806775A1 (de) | 1978-02-17 | 1978-02-17 | Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES477784A1 true ES477784A1 (es) | 1980-04-01 |
Family
ID=6032231
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES477784A Expired ES477784A1 (es) | 1978-02-17 | 1979-02-16 | Procedimiento para la preparacion de nuevas 2-fenilimino-imidazolidinas sustituidas. |
| ES485043A Expired ES485043A1 (es) | 1978-02-17 | 1979-10-16 | Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485043A Expired ES485043A1 (es) | 1978-02-17 | 1979-10-16 | Procedimiento para la preparacion de nuevas 2-fenilimino- imidazolidinas sustituidas |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US4250186A (es) |
| JP (1) | JPS54122273A (es) |
| AT (1) | AT370093B (es) |
| AU (1) | AU519356B2 (es) |
| BE (1) | BE874252A (es) |
| CA (1) | CA1115717A (es) |
| CH (1) | CH640230A5 (es) |
| CS (2) | CS207773B2 (es) |
| DD (1) | DD142048A5 (es) |
| DE (1) | DE2806775A1 (es) |
| DK (1) | DK69479A (es) |
| ES (2) | ES477784A1 (es) |
| FI (1) | FI69301C (es) |
| FR (1) | FR2417502A1 (es) |
| GB (1) | GB2014575B (es) |
| GR (2) | GR67626B (es) |
| HU (1) | HU180430B (es) |
| IE (1) | IE48073B1 (es) |
| IL (1) | IL56678A (es) |
| IT (1) | IT1113469B (es) |
| LU (1) | LU80924A1 (es) |
| NL (1) | NL7901241A (es) |
| NO (1) | NO151239C (es) |
| NZ (1) | NZ189684A (es) |
| PH (1) | PH16188A (es) |
| PL (2) | PL116527B1 (es) |
| PT (1) | PT69239A (es) |
| RO (2) | RO81504B (es) |
| SE (1) | SE7901405L (es) |
| SU (2) | SU812175A3 (es) |
| YU (1) | YU36779A (es) |
| ZA (1) | ZA79709B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2854659A1 (de) * | 1978-12-18 | 1980-07-10 | Boehringer Sohn Ingelheim | Neue 3,4-disubstituierte 2-phenylimino-imidazolidine, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu deren herstellung |
| EP0043659B1 (en) * | 1980-07-09 | 1985-02-06 | Beecham Group Plc | Clonidine derivatives useful in the treatment of diarrhoea |
| EP0070084A3 (en) * | 1981-04-24 | 1983-02-16 | Beecham Group Plc | Imidazoline derivatives |
| CA1201066A (en) * | 1981-11-20 | 1986-02-25 | Alcon Laboratories, Inc. | N-¬3,5-dichloro-4-(2-imidazolidinylideneamino)- phenyl|-acetamide solutions for lowering intraocular pressure |
| US4517199A (en) * | 1981-11-20 | 1985-05-14 | Alcon Laboratories, Inc. | Method for lowering intraocular pressure using phenylimino-imidazoles |
| US4461904A (en) * | 1981-11-20 | 1984-07-24 | Alcon Laboratories, Inc. | 2-(Trisubstituted phenylimino)-imidazolines |
| US4644007A (en) * | 1981-11-20 | 1987-02-17 | Alcon Laboratories, Inc. | 3-chloro-4-(4,5-dihydro-1H-imidazo-2-yl)-amino-5-alkylbenzoic acids, esters, salts, compositions and methods |
| US4515800A (en) * | 1981-11-20 | 1985-05-07 | Icilio Cavero | Method of lowering intraocular pressure using phenylimino-imidazoles |
| FR2521140A1 (fr) * | 1982-02-05 | 1983-08-12 | Synthelabo | Derives d'imidazolidine, leur preparation et leur application en therapeutique |
| GB2137191A (en) * | 1983-02-28 | 1984-10-03 | Sumitomo Chemical Co | Fungicidal N-phenylimidates |
| DE19514579A1 (de) * | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
| JP2003166617A (ja) | 2001-11-28 | 2003-06-13 | Honda Motor Co Ltd | トルクコンバータ付き内燃機関 |
| JP2007308392A (ja) * | 2006-05-16 | 2007-11-29 | Bayer Cropscience Ag | 殺虫性ベンズアミジン類 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2899426A (en) * | 1959-08-11 | Synthesis of l | ||
| US2938038A (en) * | 1960-05-24 | X-dihydroxyphenylamino | ||
| FR1211341A (fr) * | 1955-12-19 | 1960-03-15 | A Wander Dr | Procédé pour la préparation de 2-amino-imidazolines |
| US3595961A (en) * | 1965-10-01 | 1971-07-27 | Boehringer Sohn Ingelheim | Hypotensive compositions containing 2-(2' - halo-anilino) - 1,3 -diazacyclopentenes-(2) and methods of using the same |
| DE1670274A1 (de) * | 1966-10-31 | 1970-07-16 | Boehringer Sohn Ingelheim | Neues Verfahren zur Herstellung von 2-Arylamino-1,3-diazacycloalkenen-(2) |
| AT285599B (de) * | 1968-06-21 | 1970-11-10 | Boehringer Sohn Ingelheim | Verfahren zur Herstellung von neuen trisubstituierten 2-Arylaminoimidazolinen und ihren Salzen |
| DE2446758C3 (de) * | 1974-10-01 | 1979-01-04 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie |
| DE2523103C3 (de) * | 1975-05-24 | 1979-11-29 | C.H. Boehringer Sohn, 6507 Ingelheim | Substituierte 2-[N-Progargyl-N-(2-chlorphenyl)amino] -imidazoline-^), deren Säureadditionssalze, Verfahren zu ihrer Herstellung und deren Verwendung |
| DE2630060C2 (de) * | 1976-07-03 | 1984-04-19 | C.H. Boehringer Sohn, 6507 Ingelheim | 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung |
-
1978
- 1978-02-17 DE DE19782806775 patent/DE2806775A1/de not_active Withdrawn
-
1979
- 1979-02-09 SU SU792721602A patent/SU812175A3/ru active
- 1979-02-12 GR GR58340A patent/GR67626B/el unknown
- 1979-02-12 AT AT0101579A patent/AT370093B/de not_active IP Right Cessation
- 1979-02-13 RO RO103172A patent/RO81504B/ro unknown
- 1979-02-14 CH CH142879A patent/CH640230A5/de not_active IP Right Cessation
- 1979-02-15 YU YU00367/79A patent/YU36779A/xx unknown
- 1979-02-15 LU LU80924A patent/LU80924A1/de unknown
- 1979-02-15 HU HU79BO1764A patent/HU180430B/hu unknown
- 1979-02-15 IT IT48010/79A patent/IT1113469B/it active
- 1979-02-15 PT PT7969239A patent/PT69239A/pt unknown
- 1979-02-15 DD DD79211044A patent/DD142048A5/de unknown
- 1979-02-15 IL IL56678A patent/IL56678A/xx unknown
- 1979-02-15 FI FI790510A patent/FI69301C/fi not_active IP Right Cessation
- 1979-02-16 ZA ZA79709A patent/ZA79709B/xx unknown
- 1979-02-16 PL PL1979221508A patent/PL116527B1/pl unknown
- 1979-02-16 SE SE7901405A patent/SE7901405L/xx not_active Application Discontinuation
- 1979-02-16 AU AU44325/79A patent/AU519356B2/en not_active Ceased
- 1979-02-16 NO NO790523A patent/NO151239C/no unknown
- 1979-02-16 GB GB7905506A patent/GB2014575B/en not_active Expired
- 1979-02-16 ES ES477784A patent/ES477784A1/es not_active Expired
- 1979-02-16 DK DK69479A patent/DK69479A/da not_active Application Discontinuation
- 1979-02-16 PL PL1979213475A patent/PL115759B1/pl unknown
- 1979-02-16 US US06/012,650 patent/US4250186A/en not_active Expired - Lifetime
- 1979-02-16 NZ NZ189684A patent/NZ189684A/xx unknown
- 1979-02-16 JP JP1715679A patent/JPS54122273A/ja active Pending
- 1979-02-16 CA CA321,805A patent/CA1115717A/en not_active Expired
- 1979-02-16 IE IE311/79A patent/IE48073B1/en unknown
- 1979-02-16 FR FR7904052A patent/FR2417502A1/fr active Granted
- 1979-02-16 BE BE0/193531A patent/BE874252A/xx not_active IP Right Cessation
- 1979-02-16 NL NL7901241A patent/NL7901241A/xx not_active Application Discontinuation
- 1979-02-17 RO RO7996602A patent/RO76799A/ro unknown
- 1979-02-19 CS CS791092A patent/CS207773B2/cs unknown
- 1979-02-19 CS CS798500A patent/CS207774B2/cs unknown
- 1979-06-18 GR GR59371A patent/GR69232B/el unknown
- 1979-10-16 ES ES485043A patent/ES485043A1/es not_active Expired
-
1980
- 1980-01-30 SU SU802874805A patent/SU828964A3/ru active
- 1980-08-20 US US06/179,839 patent/US4293564A/en not_active Expired - Lifetime
- 1980-09-08 PH PH24546A patent/PH16188A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19971201 |