FR2387941A1 - Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament - Google Patents

Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament

Info

Publication number
FR2387941A1
FR2387941A1 FR7811580A FR7811580A FR2387941A1 FR 2387941 A1 FR2387941 A1 FR 2387941A1 FR 7811580 A FR7811580 A FR 7811580A FR 7811580 A FR7811580 A FR 7811580A FR 2387941 A1 FR2387941 A1 FR 2387941A1
Authority
FR
France
Prior art keywords
somatostatin
phé
intermediaries
approved
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7811580A
Other languages
English (en)
Other versions
FR2387941B1 (fr
Inventor
James Edwin Shields
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of FR2387941A1 publication Critical patent/FR2387941A1/fr
Application granted granted Critical
Publication of FR2387941B1 publication Critical patent/FR2387941B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Abstract

L'invention concerne un composé de formule : H-D-Val-Gly-L-Cys-L-Lys-L-Asn -L-Phé-L- Phé- L-Trp -L-Lys-L-Thr-L-Phé-L- Thr-L-Sér-L-Cys-OH, et ses sels d'addition d'acide non toxiques pharmaceutiquement acceptables. On prepare ce composé en oxydant le tétradécapeptide à chaîne droite correspondant, que l'on synthétise par addition successive d'amino-acides. Le composé obtenu a un effet thérapeutique du type de celui de la somatostatine.
FR7811580A 1977-04-21 1978-04-19 Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament Granted FR2387941A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/789,472 US4100117A (en) 1977-04-21 1977-04-21 Somatostatin analogs and intermediates thereto

Publications (2)

Publication Number Publication Date
FR2387941A1 true FR2387941A1 (fr) 1978-11-17
FR2387941B1 FR2387941B1 (fr) 1983-06-10

Family

ID=25147748

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7811580A Granted FR2387941A1 (fr) 1977-04-21 1978-04-19 Homologue de la somatostatine, ses intermediaires de preparation, et son utilisation comme medicament

Country Status (31)

Country Link
US (1) US4100117A (fr)
JP (1) JPS53132588A (fr)
AR (1) AR221699A1 (fr)
AT (1) AT361142B (fr)
AU (1) AU519275B2 (fr)
BE (1) BE866117A (fr)
BG (1) BG28703A3 (fr)
CA (2) CA1102315A (fr)
CH (1) CH634039A5 (fr)
CS (1) CS202096B2 (fr)
DD (1) DD135900A5 (fr)
DE (1) DE2816854A1 (fr)
DK (1) DK174278A (fr)
ES (2) ES469005A1 (fr)
FI (1) FI64576C (fr)
FR (1) FR2387941A1 (fr)
GB (1) GB1596328A (fr)
GR (1) GR68945B (fr)
HU (1) HU177435B (fr)
IE (1) IE46868B1 (fr)
IL (1) IL54533A (fr)
IT (1) IT1094462B (fr)
NL (1) NL7804218A (fr)
NZ (1) NZ187009A (fr)
PL (2) PL114533B1 (fr)
PT (1) PT67913B (fr)
RO (2) RO76054A (fr)
SE (1) SE7804397L (fr)
SU (2) SU730295A3 (fr)
YU (1) YU91578A (fr)
ZA (1) ZA782247B (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202802A (en) * 1978-10-02 1980-05-13 Eli Lilly And Company Peptides related to somatostatin
US4199501A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4199500A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4428942A (en) 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
SE8702550D0 (sv) * 1987-06-18 1987-06-18 Anders Grubb Cysteinproteashemmare
NO302481B1 (no) 1990-10-16 1998-03-09 Takeda Chemical Industries Ltd Polymer for et preparat med forlenget frigjöring, samt preparat med forlenget frigjöring
ATE161716T1 (de) 1992-08-07 1998-01-15 Takeda Chemical Industries Ltd Herstellung von mikrokapseln, die wasserlösliche arzneimittel enthalten
EP0668073B1 (fr) * 1994-02-21 1999-04-14 Takeda Chemical Industries, Ltd. Matrice en polyester pour une préparation pharmaceutique à libération prolongée
US6117455A (en) * 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
CA2192782C (fr) 1995-12-15 2008-10-14 Nobuyuki Takechi Production de microsphere
EP0813887A3 (fr) * 1996-06-20 1999-11-03 Hisamitsu Pharmaceutical Co. Inc. Appareil d'ionophorèse
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
EP1346722B1 (fr) 2000-12-01 2008-12-10 Takeda Pharmaceutical Company Limited Procede de production d'une preparation contenant une substance bioactive
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
WO2003105768A2 (fr) * 2002-06-13 2003-12-24 Nobex Corporation Methodes de reduction du nombre et de la gravite des episodes hypoglycemiques dans le traitement du diabete sucre
BRPI0513508B1 (pt) * 2004-07-19 2021-06-01 Biocon Limited Conjugados de insulina-oligômero, formulações e usos desses
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
EP2873422A4 (fr) 2012-07-10 2015-12-30 Takeda Pharmaceutical Préparation pharmaceutique pour l'injection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2303560A1 (fr) * 1975-03-11 1976-10-08 Sandoz Sa Nouveaux polypeptides, leur preparation et leur application comme medicaments
FR2320108A1 (fr) * 1975-08-06 1977-03-04 Salk Inst For Biological Studi Polypeptides derives de la somatostatine

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2303560A1 (fr) * 1975-03-11 1976-10-08 Sandoz Sa Nouveaux polypeptides, leur preparation et leur application comme medicaments
FR2320108A1 (fr) * 1975-08-06 1977-03-04 Salk Inst For Biological Studi Polypeptides derives de la somatostatine

Also Published As

Publication number Publication date
FI64576C (fi) 1983-12-12
CH634039A5 (de) 1983-01-14
ATA282878A (de) 1980-07-15
IL54533A (en) 1982-11-30
SU730295A3 (ru) 1980-04-25
PL206280A1 (fr) 1980-01-02
GR68945B (fr) 1982-03-29
SE7804397L (sv) 1978-10-22
AR221699A1 (es) 1981-03-13
IL54533A0 (en) 1978-07-31
IT7822552A0 (it) 1978-04-20
ZA782247B (en) 1979-12-27
BE866117A (fr) 1978-10-19
DK174278A (da) 1978-10-22
FR2387941B1 (fr) 1983-06-10
FI64576B (fi) 1983-08-31
CA1113928A (fr) 1981-12-08
JPS53132588A (en) 1978-11-18
FI781184A (fi) 1978-10-22
PL115827B1 (en) 1981-05-30
AU3525378A (en) 1979-10-25
YU91578A (en) 1983-01-21
BG28703A3 (en) 1980-06-16
IT1094462B (it) 1985-08-02
CS202096B2 (en) 1980-12-31
PT67913B (en) 1979-11-14
US4100117A (en) 1978-07-11
PT67913A (en) 1978-05-01
PL114533B1 (en) 1981-02-28
HU177435B (en) 1981-10-28
NL7804218A (nl) 1978-10-24
SU904519A3 (ru) 1982-02-07
IE780765L (en) 1978-10-21
RO81079A (fr) 1983-06-01
RO76054A (fr) 1981-08-17
GB1596328A (en) 1981-08-26
DD135900A5 (de) 1979-06-06
IE46868B1 (en) 1983-10-19
ES476901A1 (es) 1979-10-16
AU519275B2 (en) 1981-11-19
AT361142B (de) 1981-02-25
CA1102315A (fr) 1981-06-02
ES469005A1 (es) 1979-09-01
DE2816854A1 (de) 1978-11-02
RO81079B (ro) 1983-05-30
NZ187009A (en) 1981-04-24

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