RO81079B - Procedeu pentru prepararea unei tetradeca peptide - Google Patents

Procedeu pentru prepararea unei tetradeca peptide

Info

Publication number
RO81079B
RO81079B RO102194A RO10219478A RO81079B RO 81079 B RO81079 B RO 81079B RO 102194 A RO102194 A RO 102194A RO 10219478 A RO10219478 A RO 10219478A RO 81079 B RO81079 B RO 81079B
Authority
RO
Romania
Prior art keywords
hydrogen
group
protecting group
amino
formula
Prior art date
Application number
RO102194A
Other languages
English (en)
Other versions
RO81079A (ro
Inventor
James Edwin Shielda
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of RO81079B publication Critical patent/RO81079B/ro
Publication of RO81079A publication Critical patent/RO81079A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C07K14/6555—Somatostatins at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/16—Somatostatin; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unei tetradecapeptide, utilizat ca intermediar în sinteza unor analogi valorosi ai somatostatinei, cu formula generala I: (vezi formula) în care aminoacizii catenei etradecapeptidice reprezentati prin prescurtarile uzuale sunt Val-valin, Gli-glicina (glicocol), Cis-cisteina, Lis-lisina, Asp-asparagina, Fen-fenilanina, Tri-triptofan, Tre-treonina si Ser-serina, prin tratarea unui compus cu formula generala II: (vezi formula) în care R reprezinta hidrogen sau o grupa alfa-amino-protectoare, R1 reprezinta hidrogen sau o grupa epsilon-amino-protectoare, R3 si R4 reprezinta fiecare hidrogen sau o grupa protectoare pentru hidroxidul alcoolic, R5 reprezinta hidrogen sau o grupa formil si X reprezinta o grupa hiroxi cînd R...R5 reprezinta hidrogen sau o grupa cu formula : (vezi formula) în care R6 reprezinta un rest de polistiren, cînd R...R5 sunt diferiti de hidrogen, cu acid fluorhidric la temperatura de circa 0 degree C, apoi produsul de reactie este separat din amestecul de reactie în mod cunoscut.
RO78102194A 1977-04-21 1978-04-18 Procedeu pentru prepararea unei tetra decapeptide RO81079A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/789,472 US4100117A (en) 1977-04-21 1977-04-21 Somatostatin analogs and intermediates thereto

Publications (2)

Publication Number Publication Date
RO81079B true RO81079B (ro) 1983-05-30
RO81079A RO81079A (ro) 1983-06-01

Family

ID=25147748

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7893835A RO76054A (ro) 1977-04-21 1978-04-18 Procedeu pentru prepararea unor tetradecapeptide
RO78102194A RO81079A (ro) 1977-04-21 1978-04-18 Procedeu pentru prepararea unei tetra decapeptide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO7893835A RO76054A (ro) 1977-04-21 1978-04-18 Procedeu pentru prepararea unor tetradecapeptide

Country Status (31)

Country Link
US (1) US4100117A (ro)
JP (1) JPS53132588A (ro)
AR (1) AR221699A1 (ro)
AT (1) AT361142B (ro)
AU (1) AU519275B2 (ro)
BE (1) BE866117A (ro)
BG (1) BG28703A3 (ro)
CA (2) CA1102315A (ro)
CH (1) CH634039A5 (ro)
CS (1) CS202096B2 (ro)
DD (1) DD135900A5 (ro)
DE (1) DE2816854A1 (ro)
DK (1) DK174278A (ro)
ES (2) ES469005A1 (ro)
FI (1) FI64576C (ro)
FR (1) FR2387941A1 (ro)
GB (1) GB1596328A (ro)
GR (1) GR68945B (ro)
HU (1) HU177435B (ro)
IE (1) IE46868B1 (ro)
IL (1) IL54533A (ro)
IT (1) IT1094462B (ro)
NL (1) NL7804218A (ro)
NZ (1) NZ187009A (ro)
PL (2) PL115827B1 (ro)
PT (1) PT67913B (ro)
RO (2) RO76054A (ro)
SE (1) SE7804397L (ro)
SU (2) SU730295A3 (ro)
YU (1) YU91578A (ro)
ZA (1) ZA782247B (ro)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4202802A (en) * 1978-10-02 1980-05-13 Eli Lilly And Company Peptides related to somatostatin
US4199501A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4199500A (en) * 1978-11-20 1980-04-22 Eli Lilly And Company Peptides related to somatostatin
US4428942A (en) 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
GB8423431D0 (en) * 1984-09-17 1984-10-24 Sandoz Ltd Organic compounds
SE8702550D0 (sv) * 1987-06-18 1987-06-18 Anders Grubb Cysteinproteashemmare
NZ240214A (en) 1990-10-16 1993-02-25 Takeda Chemical Industries Ltd Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
ES2110573T3 (es) 1992-08-07 1998-02-16 Takeda Chemical Industries Ltd Produccion de microcapsulas de farmacos solubles en agua.
CA2143044C (en) * 1994-02-21 2005-04-12 Yasutaka Igari Matrix for sustained-release preparation
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
US5908400A (en) * 1996-06-20 1999-06-01 Hisamitsu Pharmaceutical Co., Inc. Device structure for iontophoresis
US7169889B1 (en) 1999-06-19 2007-01-30 Biocon Limited Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
WO2002043709A1 (fr) 2000-12-01 2002-06-06 Takeda Chemical Industries, Ltd. Procede de production d'une preparation contenant une substance bioactive
US7060675B2 (en) * 2001-02-15 2006-06-13 Nobex Corporation Methods of treating diabetes mellitus
US6867183B2 (en) * 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6713452B2 (en) * 2001-06-04 2004-03-30 Nobex Corporation Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) * 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US7713932B2 (en) * 2001-06-04 2010-05-11 Biocon Limited Calcitonin drug-oligomer conjugates, and uses thereof
US6828305B2 (en) * 2001-06-04 2004-12-07 Nobex Corporation Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7312192B2 (en) * 2001-09-07 2007-12-25 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en) 2001-09-07 2007-03-27 Biocon Limited Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7166571B2 (en) * 2001-09-07 2007-01-23 Biocon Limited Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) 2001-09-07 2005-07-05 Nobex Corporation Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
AU2003236521A1 (en) * 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
RU2527893C2 (ru) * 2004-07-19 2014-09-10 Биокон Лимитед Инсулин-олигомерные конъюгаты, их препараты и применения
BRPI0818004B8 (pt) 2007-10-16 2021-05-25 Biocon Ltd composição farmacêutica sólida administrável por via oral e o processo da mesma.
EP2873422A4 (en) 2012-07-10 2015-12-30 Takeda Pharmaceutical PHARMACEUTICAL PREPARATION FOR INJECTION

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2608336A1 (de) * 1975-03-11 1976-09-30 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US4372884A (en) * 1975-08-06 1983-02-08 The Salk Institute For Biological Studies Pharmaceutically active peptides

Also Published As

Publication number Publication date
FI64576B (fi) 1983-08-31
PT67913B (en) 1979-11-14
SU904519A3 (ru) 1982-02-07
RO76054A (ro) 1981-08-17
ES469005A1 (es) 1979-09-01
FR2387941B1 (ro) 1983-06-10
GB1596328A (en) 1981-08-26
IE780765L (en) 1978-10-21
BE866117A (fr) 1978-10-19
PT67913A (en) 1978-05-01
AU519275B2 (en) 1981-11-19
HU177435B (en) 1981-10-28
AR221699A1 (es) 1981-03-13
DD135900A5 (de) 1979-06-06
FI64576C (fi) 1983-12-12
AT361142B (de) 1981-02-25
IT7822552A0 (it) 1978-04-20
US4100117A (en) 1978-07-11
AU3525378A (en) 1979-10-25
DE2816854A1 (de) 1978-11-02
CS202096B2 (en) 1980-12-31
SE7804397L (sv) 1978-10-22
IL54533A (en) 1982-11-30
ZA782247B (en) 1979-12-27
GR68945B (ro) 1982-03-29
SU730295A3 (ru) 1980-04-25
ES476901A1 (es) 1979-10-16
CA1102315A (en) 1981-06-02
IL54533A0 (en) 1978-07-31
CH634039A5 (de) 1983-01-14
IT1094462B (it) 1985-08-02
NZ187009A (en) 1981-04-24
BG28703A3 (bg) 1980-06-16
RO81079A (ro) 1983-06-01
FI781184A7 (fi) 1978-10-22
PL115827B1 (en) 1981-05-30
IE46868B1 (en) 1983-10-19
ATA282878A (de) 1980-07-15
PL206280A1 (ro) 1980-01-02
CA1113928A (en) 1981-12-08
DK174278A (da) 1978-10-22
YU91578A (en) 1983-01-21
JPS53132588A (en) 1978-11-18
NL7804218A (nl) 1978-10-24
FR2387941A1 (fr) 1978-11-17
PL114533B1 (en) 1981-02-28

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