ES2180034T3 - Derivados de feniletanolaminotetralincarboxilato disustituidos en las posiciones 3 y 4. - Google Patents

Derivados de feniletanolaminotetralincarboxilato disustituidos en las posiciones 3 y 4.

Info

Publication number
ES2180034T3
ES2180034T3 ES97914541T ES97914541T ES2180034T3 ES 2180034 T3 ES2180034 T3 ES 2180034T3 ES 97914541 T ES97914541 T ES 97914541T ES 97914541 T ES97914541 T ES 97914541T ES 2180034 T3 ES2180034 T3 ES 2180034T3
Authority
ES
Spain
Prior art keywords
carbon atom
group
integer
general formula
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97914541T
Other languages
English (en)
Inventor
Makio Kitazawa
Kosuke Okazaki
Tetsuro Tamai
Masaru Saito
Nobuyuki Tanaka
Hiroaki Kobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2180034T3 publication Critical patent/ES2180034T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A LOS DERIVADOS DEL ACIDO 3,4 FENILETANOLAMINOTETRALINCARBOXILICO DISUBSTITUIDO REPRESENTADOS POR LA FORMULA GENERAL: [EN LA QUE Q REPRESENTA UN GRUPO VINILENO O UN GRUPO REPRESENTADO POR LA FORMULA GENERAL: (EN DONDE A REPRESENTA UN ATOMO DE OXIGENO O UN GRUPO METILENO; Y M ES UN ENTERO DEL 1 AL 6); R REPRESENTA UN ATOMO DE HIDROGENO O UN GRUPO ALQUILO INFERIOR; N ES UN ENTERO DE 1 O 2; EL ATOMO DE CARBONO MARCADO CON * REPRESENTA UN ATOMO DE CARBONO EN LA CONFIGURACION R, LA CONFIGURACION S O UNA MEZCLA DERIVADA; Y EL ATOMO DE CARBONO MARCADO CON (S) REPRESENTA UN ATOMO DE CARBONO EN CONFIGURACION S] Y SALES DERIVADAS FARMACEUTICAMENTE ACEPTABLES, QUE TIENEN UN EFECTO ESTIMULANTE DEL RECEPTOR ADRENERGICO SELECTIVO BE 2 , CON ALIVIO DE OPRESIONES EN EL COR AZON TALES COMO TAQUICARDIA Y SON UTILES COMO AGENTES PARA LA PREVENCION DE AMENAZA DE ABORTO Y PARTO PREMATURO, UN BRONCODILATADOR Y UN AGENTE PARA LA REMISION DEL DOLOR Y PARA PROMOVER LA ELIMINACION DEPIEDRAS EN UROLITIASIS.
ES97914541T 1996-03-27 1997-03-26 Derivados de feniletanolaminotetralincarboxilato disustituidos en las posiciones 3 y 4. Expired - Lifetime ES2180034T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11107796A JP3708624B2 (ja) 1996-03-27 1996-03-27 ３，４−ジ置換フェニルエタノールアミノテトラリンカルボン酸誘導体

Publications (1)

Publication Number Publication Date
ES2180034T3 true ES2180034T3 (es) 2003-02-01

Family

ID=14551809

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97914541T Expired - Lifetime ES2180034T3 (es) 1996-03-27 1997-03-26 Derivados de feniletanolaminotetralincarboxilato disustituidos en las posiciones 3 y 4.

Country Status (10)

Country Link
US (1) US6136852A (es)
EP (1) EP0894787B1 (es)
JP (1) JP3708624B2 (es)
AT (1) ATE219046T1 (es)
AU (1) AU2176197A (es)
DE (1) DE69713319T2 (es)
DK (1) DK0894787T3 (es)
ES (1) ES2180034T3 (es)
PT (1) PT894787E (es)
WO (1) WO1997035835A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999009001A1 (fr) * 1997-08-19 1999-02-25 Kissei Pharmaceutical Co., Ltd. Derives de phenylethanolaminotetraline et bronchodilatateurs
US6469031B1 (en) 1998-12-18 2002-10-22 Bayer Corporation Carboxyl substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
US6051586A (en) * 1997-12-19 2000-04-18 Bayer Corporation Sulfonamide substituted chroman derivatives useful as beta 3 adrenoreceptor agonists
GB9913083D0 (en) 1999-06-04 1999-08-04 Novartis Ag Organic compounds
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es) 2001-04-23 2004-07-21 Bayer Corp Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
JP2005526696A (ja) 2001-09-14 2005-09-08 バイエル・フアーマシユーチカルズ・コーポレーシヨン ベータ−３アドレナリン受容体アゴニストとして有用なベンゾフランおよびジヒドロベンゾフラン誘導体
WO2011062984A1 (en) 2009-11-18 2011-05-26 Medicinova, Inc. Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom
EP2544534A4 (en) * 2010-03-08 2015-05-13 Medicinova Inc COMPOSITIONS, METHODS AND DEVICES USED IN THE TREATMENT OF DYSMENORRHEA
KR20130040862A (ko) * 2010-04-08 2013-04-24 메디시노바, 인크. 과민성 대장 증후군의 치료를 위한 방법 및 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2643076B1 (fr) * 1989-02-14 1991-06-21 Midy Spa Carboxyalkyl-ethers de la 2-amino-7-hydroxytetraline
IT1230931B (it) * 1989-06-27 1991-11-08 Chiesi Farma Spa Derivati di 2 ammino 1,2,3,4 tetraidronaftalene ad attivita' cardiovascolare, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
EP0499755A1 (fr) * 1991-02-18 1992-08-26 MIDY S.p.A. Nouvelles phényléthanolaminotétralines, procédé pour leur préparation, intermédiaires dans ce procédé et compositions pharmaceutiques les contenant
GB9107827D0 (en) * 1991-04-12 1991-05-29 Fujisawa Pharmaceutical Co New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same

Also Published As

Publication number Publication date
EP0894787A1 (en) 1999-02-03
DE69713319T2 (de) 2002-10-31
JP3708624B2 (ja) 2005-10-19
ATE219046T1 (de) 2002-06-15
PT894787E (pt) 2002-11-29
JPH09255637A (ja) 1997-09-30
EP0894787A4 (en) 2000-09-20
DK0894787T3 (da) 2002-09-30
AU2176197A (en) 1997-10-17
EP0894787B1 (en) 2002-06-12
WO1997035835A1 (fr) 1997-10-02
DE69713319D1 (de) 2002-07-18
US6136852A (en) 2000-10-24

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