KR860008174A - 항정신질환성 벤지소티아졸 s-산화물의 제조방법 - Google Patents

항정신질환성 벤지소티아졸 s-산화물의 제조방법 Download PDF

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Publication number
KR860008174A
KR860008174A KR1019860002515A KR860002515A KR860008174A KR 860008174 A KR860008174 A KR 860008174A KR 1019860002515 A KR1019860002515 A KR 1019860002515A KR 860002515 A KR860002515 A KR 860002515A KR 860008174 A KR860008174 A KR 860008174A
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KR
South Korea
Prior art keywords
preparing
benzisothiazole
antipsychotic
oxide
acid
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KR1019860002515A
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English (en)
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KR900000372B1 (ko
Inventor
피.예비치 요셉
예비치 요셉피.
주니어 월터 지.로벡크
주니어 월터지. 로벡크
Original Assignee
브리스톨-마이어즈 스퀴브 컴페니
아이삭 자아코브스키
브리스톨-마이어즈 컴페니
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Publication of KR860008174A publication Critical patent/KR860008174A/ko
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Publication of KR900000372B1 publication Critical patent/KR900000372B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

항정신질환성 벤지소티아졸 S-산화물의 제조방법.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 구조식(A)의 화합물을 약 5℃이하에서 무기산류의 혼합물과 반응시키고, 요구에 따라서 주최종생성물을 선택된 유기 또는 무기산과 반응시켜 제약상 허용되는 염을 제조함을 특징으로 하는 하기 구조식(Ⅰ)의 화합물 또는 제약상 허용되는 그 산부가염의 제조방법.
  2. 제1항에 있어서, 무기산의 혼합물이 염산 및 황산으로 구성됨을 특징으로 하는 방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002515A 1985-04-24 1986-04-02 항정신질환성 벤즈이소티아졸 s-산화물 및 그 제조방법 KR900000372B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US726,449 1985-04-24
US06/726,449 US4656173A (en) 1985-04-24 1985-04-24 Antipsychotic benzisothiazole S-oxide compound
US726449 1991-07-08

Publications (2)

Publication Number Publication Date
KR860008174A true KR860008174A (ko) 1986-11-12
KR900000372B1 KR900000372B1 (ko) 1990-01-25

Family

ID=24918649

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860002515A KR900000372B1 (ko) 1985-04-24 1986-04-02 항정신질환성 벤즈이소티아졸 s-산화물 및 그 제조방법

Country Status (26)

Country Link
US (1) US4656173A (ko)
JP (1) JPH0764842B2 (ko)
KR (1) KR900000372B1 (ko)
CN (1) CN1017528B (ko)
AT (1) AT394719B (ko)
AU (1) AU592787B2 (ko)
BE (1) BE904662A (ko)
CA (1) CA1247102A (ko)
CH (1) CH666034A5 (ko)
DE (1) DE3613739C2 (ko)
DK (1) DK187686A (ko)
EG (1) EG18002A (ko)
ES (1) ES8708228A1 (ko)
FI (1) FI84604C (ko)
FR (1) FR2581064B1 (ko)
GB (1) GB2174393B (ko)
GR (1) GR861063B (ko)
HU (1) HU195654B (ko)
IE (1) IE59182B1 (ko)
IT (1) IT1208600B (ko)
LU (1) LU86405A1 (ko)
MY (1) MY102041A (ko)
NL (1) NL8601043A (ko)
PT (1) PT82450B (ko)
SE (1) SE462163B (ko)
ZA (1) ZA861531B (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
EP0350145A3 (en) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Pyridylthiazolidine carboxamide derivatives and their intermediates and production of both
US5077295A (en) * 1988-09-16 1991-12-31 Pfizer Inc. Antipsychoic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)buytl bridged bicycle imides
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
CA2891122C (en) 2012-11-14 2021-07-20 The Johns Hopkins University Methods and compositions for treating schizophrenia

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
CH582699A5 (ko) * 1973-03-26 1976-12-15 Sandoz Ag
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
FI753625A (ko) * 1975-01-06 1976-07-07 Spofa Vereinigte Pharma Werke
JPS51144735A (en) * 1975-06-06 1976-12-13 Nippon Nohyaku Co Ltd A remedy for hepatic failure
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
ZA861531B (en) 1986-10-29
CA1247102A (en) 1988-12-20
BE904662A (fr) 1986-10-23
EG18002A (en) 1991-08-30
IT1208600B (it) 1989-07-10
ES8708228A1 (es) 1987-10-01
SE8601883D0 (sv) 1986-04-23
LU86405A1 (fr) 1986-11-05
ATA110486A (de) 1991-11-15
IE59182B1 (en) 1994-01-26
FI84604C (fi) 1991-12-27
FI861668A0 (fi) 1986-04-21
FI861668A (fi) 1986-10-25
PT82450B (pt) 1988-11-30
FR2581064B1 (fr) 1988-09-16
GB2174393A (en) 1986-11-05
FR2581064A1 (fr) 1986-10-31
US4656173A (en) 1987-04-07
KR900000372B1 (ko) 1990-01-25
NL8601043A (nl) 1986-11-17
CN86102742A (zh) 1987-02-04
JPH0764842B2 (ja) 1995-07-12
DE3613739C2 (de) 1993-12-09
AU5612186A (en) 1986-10-30
GB8609932D0 (en) 1986-05-29
ES554284A0 (es) 1987-10-01
AT394719B (de) 1992-06-10
IE861083L (en) 1986-10-24
SE462163B (sv) 1990-05-14
DE3613739A1 (de) 1986-11-20
JPS61251683A (ja) 1986-11-08
DK187686D0 (da) 1986-04-23
HUT42088A (en) 1987-06-29
PT82450A (en) 1986-05-01
CN1017528B (zh) 1992-07-22
CH666034A5 (de) 1988-06-30
GB2174393B (en) 1989-02-01
AU592787B2 (en) 1990-01-25
IT8620187A0 (it) 1986-04-23
MY102041A (en) 1992-02-29
DK187686A (da) 1986-10-25
GR861063B (en) 1986-09-01
SE8601883L (sv) 1986-10-25
FI84604B (fi) 1991-09-13
HU195654B (en) 1988-06-28

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