KR870003078A - N-설파밀-3-(2-구아니디노-티아졸-4-일-메틸티오)프로피온아미딘의 제조방법 - Google Patents
N-설파밀-3-(2-구아니디노-티아졸-4-일-메틸티오)프로피온아미딘의 제조방법 Download PDFInfo
- Publication number
- KR870003078A KR870003078A KR1019860007508A KR860007508A KR870003078A KR 870003078 A KR870003078 A KR 870003078A KR 1019860007508 A KR1019860007508 A KR 1019860007508A KR 860007508 A KR860007508 A KR 860007508A KR 870003078 A KR870003078 A KR 870003078A
- Authority
- KR
- South Korea
- Prior art keywords
- guanidino
- sulfamil
- propionamidine
- thiazol
- methylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (6)
- 하기 구조식(Ⅱ)의 N-설파밀-3-할로-프로피온아미딘을 이용하여 S-알킬화시킴을 특징으로하여, 하기 구조식(Ⅲ)의 S-(2-구아니디노-티아졸-4-일-메틸)이소티오우레아디히드로부터 얻어지는 2-구아니디노-티아졸-4-일-메탄티올과 염기와의 직접적인 처리하의 S-알킬화에 의하여 하기 구조식(Ⅰ)로 표시하는 N-설파밀-3-(2-구아니디노-티아졸-4-일-메틸티오)프로피온아미딘)파모티딘)을 제조하는 방법.(식중 X는 할로겐원자를 나타낸다.)
- 제1항에 있어서 물고 탄소소 1내지 4인 알카놀의 알카리성 혼합물 중에서 알킬화하는 제조방법.
- 제1항 또는 2항에 있어서 염기로 스디움히드록사이드를 사용하는 것이 특징인 제조방법.
- 제3항에 있어서, 스디움히드록사이드를 40% 수용액으로 하는 제조방법.
- 제3항 또는 제4항에 있어서, 0∼50℃에서 반응물에 염기를 가하는 것이 특징인 제조방법.
- 제3항 또는 제4항에 있어서 반응 온도가 20∼30℃임이 특징인 제조방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU853424A HU194845B (en) | 1985-09-11 | 1985-09-11 | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
HU85-3424 | 1985-09-11 | ||
HU22513424-85 | 1985-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870003078A true KR870003078A (ko) | 1987-04-15 |
KR910000237B1 KR910000237B1 (ko) | 1991-01-23 |
Family
ID=10963968
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860007508A KR910000237B1 (ko) | 1985-09-11 | 1986-09-08 | N-설파밀-3-(2-구아니디노-티아졸-4-일-메틸티오)-프로피온아미딘의 제조방법 |
Country Status (22)
Country | Link |
---|---|
US (1) | US4835281A (ko) |
JP (1) | JPH0645609B2 (ko) |
KR (1) | KR910000237B1 (ko) |
CN (1) | CN1013674B (ko) |
AR (1) | AR240319A1 (ko) |
AT (1) | AT386824B (ko) |
AU (1) | AU587279B2 (ko) |
BE (1) | BE905409A (ko) |
CA (1) | CA1263120A (ko) |
DD (1) | DD249479A5 (ko) |
DK (1) | DK169920B1 (ko) |
ES (1) | ES2001677A6 (ko) |
FI (1) | FI86423C (ko) |
GB (1) | GB2180237B (ko) |
GE (1) | GEP19960471B (ko) |
GR (1) | GR862308B (ko) |
HU (1) | HU194845B (ko) |
NL (1) | NL8602225A (ko) |
NO (1) | NO163010C (ko) |
PT (1) | PT83348B (ko) |
SE (1) | SE8603797L (ko) |
SU (1) | SU1450743A3 (ko) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU194845B (en) * | 1985-09-11 | 1988-03-28 | Richter Gedeon Vegyeszet | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
HU196775B (en) * | 1986-08-05 | 1989-01-30 | Richter Gedeon Vegyeszet | Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances |
IL86330A0 (en) * | 1987-06-22 | 1988-11-15 | Marga Investigacion | Famotidine polymorphic forms and their preparation |
US5856500A (en) * | 1997-03-11 | 1999-01-05 | Albemarle Corporation | Synthesis of thiazole derivatives |
US5731442A (en) * | 1997-03-11 | 1998-03-24 | Albemarle Corporation | Synthesis of thiazole derivatives |
WO2000028988A1 (en) * | 1998-11-17 | 2000-05-25 | Nitromed, Inc. | Nitrosated and nitrosylated h2 receptor antagonist compounds, compositions and methods of use |
WO2009058997A2 (en) * | 2007-11-01 | 2009-05-07 | Biocept Inc. | Non-invasive isolation of fetal nucleic acid |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6056143B2 (ja) * | 1979-08-02 | 1985-12-09 | 山之内製薬株式会社 | アミジン誘導体ならびにその製造法 |
US4808589A (en) * | 1982-02-20 | 1989-02-28 | Smith Kline & French Laboratories Limited | Pyrimidone derivatives |
US4496737A (en) * | 1982-09-27 | 1985-01-29 | Merck & Co., Inc. | Process for preparing sulfamylamidine antisecretory agents |
ES8504157A1 (es) * | 1983-10-07 | 1985-04-01 | Inke Sa | Procedimiento para la obtencion de (-1amino-3-(((2-((diaminometileno) amino)-4-tiazolil)metil)tio)propilideno)sulfamida |
ES532239A0 (es) * | 1984-05-07 | 1985-08-01 | Inke Sa | Procedimiento para la obtencion de la 1-amino-3-2-diamino-metilen-amino-4-tiazolil-metil-tio-propiliden-sulfamida. |
ES536322A0 (es) * | 1984-09-27 | 1985-08-01 | Bioiberica | Procedimiento para la obtencion del n-aminosolfenil-3-(((2-guanidin-4-tiazonil)metil)tio) propionamidina |
ES536803A0 (es) * | 1984-10-17 | 1985-08-01 | Inke Sa | Procedimiento para la obtencion de la (1-amino-3(((2-((diamino-metilen) amino)-4-tiazolil)metil)tio)propiliden)sulfamida |
HU194845B (en) * | 1985-09-11 | 1988-03-28 | Richter Gedeon Vegyeszet | Process for production of n-sulphamil-3-/2-guanidintiazolil-4-methil-tio/-propion-amidin |
HU193608B (en) * | 1985-09-11 | 1987-11-30 | Richter Gedeon Vegyeszet | Process for production of new dervatives of n-sulphanol-propion-amidine |
JP3751649B2 (ja) * | 1994-12-01 | 2006-03-01 | 関西ペイント株式会社 | 自動車外板塗膜の一時保護方法 |
-
1985
- 1985-09-11 HU HU853424A patent/HU194845B/hu unknown
-
1986
- 1986-08-22 CA CA000516617A patent/CA1263120A/en not_active Expired
- 1986-09-03 NL NL8602225A patent/NL8602225A/nl not_active Application Discontinuation
- 1986-09-08 AR AR305176A patent/AR240319A1/es active
- 1986-09-08 KR KR1019860007508A patent/KR910000237B1/ko not_active IP Right Cessation
- 1986-09-09 SU SU864028107A patent/SU1450743A3/ru active
- 1986-09-09 GR GR862308A patent/GR862308B/el unknown
- 1986-09-09 DD DD86294264A patent/DD249479A5/de unknown
- 1986-09-10 AT AT0243486A patent/AT386824B/de not_active IP Right Cessation
- 1986-09-10 JP JP61211792A patent/JPH0645609B2/ja not_active Expired - Lifetime
- 1986-09-10 GB GB8621742A patent/GB2180237B/en not_active Expired
- 1986-09-10 SE SE8603797A patent/SE8603797L/xx not_active Application Discontinuation
- 1986-09-10 BE BE0/217144A patent/BE905409A/fr not_active IP Right Cessation
- 1986-09-10 DK DK434586A patent/DK169920B1/da not_active IP Right Cessation
- 1986-09-10 FI FI863657A patent/FI86423C/fi not_active IP Right Cessation
- 1986-09-10 AU AU62569/86A patent/AU587279B2/en not_active Expired
- 1986-09-10 PT PT83348A patent/PT83348B/pt unknown
- 1986-09-10 NO NO863616A patent/NO163010C/no not_active IP Right Cessation
- 1986-09-11 CN CN86105909A patent/CN1013674B/zh not_active Expired
- 1986-09-11 ES ES8601790A patent/ES2001677A6/es not_active Expired
-
1987
- 1987-07-23 US US07/077,095 patent/US4835281A/en not_active Expired - Lifetime
-
1993
- 1993-06-14 GE GEAP1993867A patent/GEP19960471B/en unknown
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