KR860009020A - 히드록시메틸세펨 화합물의 제조방법 - Google Patents

히드록시메틸세펨 화합물의 제조방법 Download PDF

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Publication number
KR860009020A
KR860009020A KR1019860004237A KR860004237A KR860009020A KR 860009020 A KR860009020 A KR 860009020A KR 1019860004237 A KR1019860004237 A KR 1019860004237A KR 860004237 A KR860004237 A KR 860004237A KR 860009020 A KR860009020 A KR 860009020A
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KR
South Korea
Prior art keywords
alkali metal
metal hydroxide
alkanol
hydroxymethylcefe
preparing
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KR1019860004237A
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English (en)
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KR930004013B1 (ko
Inventor
데루지 쓰지
데쓰오 오까다
Original Assignee
시오노기세이야꾸 가부시끼가이샤
요시또시 가즈오
시오노기세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 시오노기세이야꾸 가부시끼가이샤, 요시또시 가즈오, 시오노기세이야꾸 가부시끼 가이샤 filed Critical 시오노기세이야꾸 가부시끼가이샤
Publication of KR860009020A publication Critical patent/KR860009020A/ko
Application granted granted Critical
Publication of KR930004013B1 publication Critical patent/KR930004013B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/02—Preparation
    • C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

히드록시메틸세펨 화합물의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 임의로 7α-메톡시를 갖는 7β-아실아미노세팔로스포란산을 저급 알칸올내에서 수성알칼리 금속 수산화물로 처리함을 특징으로 하는 임의로 7α-메톡시를 갖는 7β-아실아미노-3-히드록시메틸-3-세펨-4-카르복실산 또는 그의 알칼리금속염의 제조방법.
  2. 제1항에 있어서, 아실기가 1~20탄소원자를 가짐을 특징으로 하는 방법.
  3. 제1항에 있어서, 알칼리 금속 수산화물이 수산화나트륨임을 특징으로 하는 방법.
  4. 제1항에 있어서, 1~8몰 당량의 알칼리 금속 수산화물을 사용함을 특징으로 하는 방법.
  5. 제1항에 있어서, 저급 알칸올이 C1~C5알칸올 임을 특징으로 하는 방법.
  6. 제5항에 있어서, 저급 알칸올이 메탄올임을 특징으로 하는 방법.
  7. 제5항에 있어서, 몰과 메탄올의 비율이 1:3~3:1임을 특징으로 하는 방법.
  8. 제1항에 있어서, 저급 알칸올 대 출발 세펨의 비율이 1:3~1:10(w/w)임을 특징으로 하는 방법.
  9. 제1항에 있어서, 처리를 40~0℃의 온도에서 5분~3시간 동안 실시함을 특징으로 하는 방법.
  10. 제1항에 있어서, 생성물을 중화시켜 대응 유리산을 수득함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860004237A 1985-05-30 1986-05-29 히드록시메틸세펨 화합물의 제조방법 KR930004013B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP118625 1985-05-30
JP11862585 1985-05-30

Publications (2)

Publication Number Publication Date
KR860009020A true KR860009020A (ko) 1986-12-19
KR930004013B1 KR930004013B1 (ko) 1993-05-19

Family

ID=14741161

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860004237A KR930004013B1 (ko) 1985-05-30 1986-05-29 히드록시메틸세펨 화합물의 제조방법

Country Status (7)

Country Link
EP (1) EP0204517A3 (ko)
JP (1) JPS6253992A (ko)
KR (1) KR930004013B1 (ko)
AU (1) AU579469B2 (ko)
ES (1) ES8706695A1 (ko)
GB (1) GB2188046B (ko)
IE (1) IE58372B1 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004083217A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of cefoxitin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
JPS5899486A (ja) * 1981-12-04 1983-06-13 Sankyo Co Ltd セフアロスポリン誘導体の製法

Also Published As

Publication number Publication date
KR930004013B1 (ko) 1993-05-19
GB8613042D0 (en) 1986-07-02
IE861430L (en) 1986-11-30
ES8706695A1 (es) 1987-07-01
AU579469B2 (en) 1988-11-24
GB2188046B (en) 1989-04-05
GB2188046A (en) 1987-09-23
EP0204517A2 (en) 1986-12-10
ES555439A0 (es) 1987-07-01
EP0204517A3 (en) 1988-06-29
IE58372B1 (en) 1993-09-08
AU5748786A (en) 1986-12-04
JPS6253992A (ja) 1987-03-09

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