FR2581064B1 - Derive antipsychotique a base de 8-(4-(4-(1-exo-1,2-benzisothiazol-3-yl)-1-piperazinyl)-butyl)-8-azaspiro(4,5)decane-7,9-dione et son procede de preparation - Google Patents

Derive antipsychotique a base de 8-(4-(4-(1-exo-1,2-benzisothiazol-3-yl)-1-piperazinyl)-butyl)-8-azaspiro(4,5)decane-7,9-dione et son procede de preparation

Info

Publication number
FR2581064B1
FR2581064B1 FR8605789A FR8605789A FR2581064B1 FR 2581064 B1 FR2581064 B1 FR 2581064B1 FR 8605789 A FR8605789 A FR 8605789A FR 8605789 A FR8605789 A FR 8605789A FR 2581064 B1 FR2581064 B1 FR 2581064B1
Authority
FR
France
Prior art keywords
benzisothiazol
azaspiro
antipsychotic
exo
decane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8605789A
Other languages
English (en)
Other versions
FR2581064A1 (fr
Inventor
Joseph P Yevich
Walter G Lobeck Jr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2581064A1 publication Critical patent/FR2581064A1/fr
Application granted granted Critical
Publication of FR2581064B1 publication Critical patent/FR2581064B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
FR8605789A 1985-04-24 1986-04-22 Derive antipsychotique a base de 8-(4-(4-(1-exo-1,2-benzisothiazol-3-yl)-1-piperazinyl)-butyl)-8-azaspiro(4,5)decane-7,9-dione et son procede de preparation Expired FR2581064B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/726,449 US4656173A (en) 1985-04-24 1985-04-24 Antipsychotic benzisothiazole S-oxide compound

Publications (2)

Publication Number Publication Date
FR2581064A1 FR2581064A1 (fr) 1986-10-31
FR2581064B1 true FR2581064B1 (fr) 1988-09-16

Family

ID=24918649

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8605789A Expired FR2581064B1 (fr) 1985-04-24 1986-04-22 Derive antipsychotique a base de 8-(4-(4-(1-exo-1,2-benzisothiazol-3-yl)-1-piperazinyl)-butyl)-8-azaspiro(4,5)decane-7,9-dione et son procede de preparation

Country Status (26)

Country Link
US (1) US4656173A (fr)
JP (1) JPH0764842B2 (fr)
KR (1) KR900000372B1 (fr)
CN (1) CN1017528B (fr)
AT (1) AT394719B (fr)
AU (1) AU592787B2 (fr)
BE (1) BE904662A (fr)
CA (1) CA1247102A (fr)
CH (1) CH666034A5 (fr)
DE (1) DE3613739C2 (fr)
DK (1) DK187686A (fr)
EG (1) EG18002A (fr)
ES (1) ES8708228A1 (fr)
FI (1) FI84604C (fr)
FR (1) FR2581064B1 (fr)
GB (1) GB2174393B (fr)
GR (1) GR861063B (fr)
HU (1) HU195654B (fr)
IE (1) IE59182B1 (fr)
IT (1) IT1208600B (fr)
LU (1) LU86405A1 (fr)
MY (1) MY102041A (fr)
NL (1) NL8601043A (fr)
PT (1) PT82450B (fr)
SE (1) SE462163B (fr)
ZA (1) ZA861531B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
EP0350145A3 (fr) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production
HUT61760A (en) * 1988-09-16 1993-03-01 Pfizer Process for producing bridged, bicyclic imides comprising 4-/4-(3-benzisothiazolyl)-1-piperazinyl/-butyl group and pharmaceutical compositions comprising such compounds
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
EP3610890A1 (fr) 2012-11-14 2020-02-19 The Johns Hopkins University Procédés et compositions de traitement de la schizophrénie

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
CH582699A5 (fr) * 1973-03-26 1976-12-15 Sandoz Ag
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
FI753625A (fr) * 1975-01-06 1976-07-07 Spofa Vereinigte Pharma Werke
JPS51144735A (en) * 1975-06-06 1976-12-13 Nippon Nohyaku Co Ltd A remedy for hepatic failure
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
DK187686D0 (da) 1986-04-23
IE861083L (en) 1986-10-24
FI861668A (fi) 1986-10-25
SE8601883L (sv) 1986-10-25
SE8601883D0 (sv) 1986-04-23
KR900000372B1 (ko) 1990-01-25
GR861063B (en) 1986-09-01
HUT42088A (en) 1987-06-29
JPS61251683A (ja) 1986-11-08
GB8609932D0 (en) 1986-05-29
IT1208600B (it) 1989-07-10
BE904662A (fr) 1986-10-23
ES8708228A1 (es) 1987-10-01
US4656173A (en) 1987-04-07
FI84604C (fi) 1991-12-27
AU5612186A (en) 1986-10-30
SE462163B (sv) 1990-05-14
AU592787B2 (en) 1990-01-25
LU86405A1 (fr) 1986-11-05
MY102041A (en) 1992-02-29
EG18002A (en) 1991-08-30
AT394719B (de) 1992-06-10
ZA861531B (en) 1986-10-29
HU195654B (en) 1988-06-28
DK187686A (da) 1986-10-25
GB2174393B (en) 1989-02-01
ES554284A0 (es) 1987-10-01
CN1017528B (zh) 1992-07-22
IT8620187A0 (it) 1986-04-23
CH666034A5 (de) 1988-06-30
PT82450A (en) 1986-05-01
GB2174393A (en) 1986-11-05
PT82450B (pt) 1988-11-30
CN86102742A (zh) 1987-02-04
CA1247102A (fr) 1988-12-20
DE3613739A1 (de) 1986-11-20
FI84604B (fi) 1991-09-13
FR2581064A1 (fr) 1986-10-31
ATA110486A (de) 1991-11-15
JPH0764842B2 (ja) 1995-07-12
KR860008174A (ko) 1986-11-12
DE3613739C2 (de) 1993-12-09
FI861668A0 (fi) 1986-04-21
NL8601043A (nl) 1986-11-17
IE59182B1 (en) 1994-01-26

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ST Notification of lapse