ATE71083T1 - L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung. - Google Patents

L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung.

Info

Publication number
ATE71083T1
ATE71083T1 AT88115183T AT88115183T ATE71083T1 AT E71083 T1 ATE71083 T1 AT E71083T1 AT 88115183 T AT88115183 T AT 88115183T AT 88115183 T AT88115183 T AT 88115183T AT E71083 T1 ATE71083 T1 AT E71083T1
Authority
AT
Austria
Prior art keywords
optionally substituted
denotes
processes
preparation
additional salts
Prior art date
Application number
AT88115183T
Other languages
English (en)
Inventor
Yoshimi Tsuchiya
Masahiro Hayashi
Hiroshi Takehana
Akihiro Hisaka
Yoshio Sawasaki
Masaki Ihara
Original Assignee
Banyu Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd
Application granted granted Critical
Publication of ATE71083T1 publication Critical patent/ATE71083T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT88115183T 1987-09-18 1988-09-16 L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung. ATE71083T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP23429987 1987-09-18
JP3126088 1988-02-13
EP88115183A EP0309827B1 (de) 1987-09-18 1988-09-16 L-Dopa-Derivate oder ihre Säureadditionssalze, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ATE71083T1 true ATE71083T1 (de) 1992-01-15

Family

ID=26369718

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88115183T ATE71083T1 (de) 1987-09-18 1988-09-16 L-dopa-derivate oder ihre saeureadditionssalze, verfahren zu ihrer herstellung und ihre verwendung.

Country Status (12)

Country Link
US (1) US4966915A (de)
EP (1) EP0309827B1 (de)
JP (1) JPH02138A (de)
KR (1) KR890005031A (de)
CN (1) CN1032785A (de)
AT (1) ATE71083T1 (de)
AU (1) AU2234088A (de)
CA (1) CA1316180C (de)
DE (1) DE3867403D1 (de)
DK (1) DK517588A (de)
IL (1) IL87765A0 (de)
PT (1) PT88526B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE406896T1 (de) * 2002-02-15 2008-09-15 Darpharma Inc Monoester und asymmetrisch substituierte diester prodrugs der dopamin-d1-rezeptor-agonisten
US7101912B2 (en) 2002-12-06 2006-09-05 Xenoport, Inc. Carbidopa prodrugs and derivatives, and compositions and uses thereof
US7471862B2 (en) 2002-12-19 2008-12-30 Corning Cable Systems, Llc Dry fiber optic cables and assemblies
US20090190890A1 (en) 2002-12-19 2009-07-30 Freeland Riley S Fiber optic cable having a dry insert and methods of making the same
US6970629B2 (en) 2002-12-19 2005-11-29 Corning Cable Systems Llc Optical tube assembly having a dry insert and methods of making the same
IL154318A (en) * 2003-02-06 2010-05-31 Sarah Herzog Memorial Hospital Pharmaceutical compositions for the treatment of movement disorders
JP4781352B2 (ja) 2004-06-04 2011-09-28 ゼノポート，インコーポレーテッド レボドパプロドラッグおよびその組成物ならびにその使用
WO2005121070A1 (en) 2004-06-04 2005-12-22 Xenoport, Inc. Levodopa prodrugs, and compositions and uses thereof
US7563821B2 (en) 2005-12-05 2009-07-21 Xenoport, Inc. Levodopa prodrug mesylate, compositions thereof, and uses thereof
US7829592B2 (en) 2006-12-21 2010-11-09 Xenoport, Inc. Catechol protected levodopa diester prodrugs, compositions, and methods of use
US7709527B2 (en) 2006-12-21 2010-05-04 Xenoport, Inc. Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
WO2010047775A2 (en) 2008-10-20 2010-04-29 Xenoport, Inc. Methods of synthesizing a levodopa ester prodrug
US8399513B2 (en) 2008-10-20 2013-03-19 Xenoport, Inc. Levodopa prodrug mesylate hydrate
KR101025612B1 (ko) * 2008-11-10 2011-03-30 한국해양연구원 신규 화합물인 Ｒａｍａｌｉｎ 및 그 용도
NZ601747A (en) 2009-11-09 2014-08-29 Xenoport Inc Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use
US20130137729A1 (en) 2010-03-04 2013-05-30 Orion Corporation Use of levodopa, carbidopa and entacapone for treating parkinson's disease
CN103694127B (zh) * 2013-12-30 2015-04-01 上海交通大学 链霉菌属菌种所产的化合物及该化合物的制备方法和应用
RU2743347C2 (ru) 2014-10-21 2021-02-17 Эббви Инк. Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона
CN113197851A (zh) 2015-05-06 2021-08-03 辛纳吉勒公司 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法
WO2019097120A1 (en) 2017-11-16 2019-05-23 Orion Corporation New use and pharmaceutical dosage forms
US20220213128A1 (en) * 2021-01-03 2022-07-07 RockGen Therapeutics LLC L-Dopa Enhanced with a Neuroprotective Agent as a Therapy for Parkinson's Disease
WO2023064783A1 (en) * 2021-10-11 2023-04-20 The Johns Hopkins University Dopa and caffiec acid analogs as novel gcpii inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US393923A (en) * 1888-12-04 Samuel preston
US2868818A (en) * 1953-12-15 1959-01-13 Merck & Co Inc Alpha methyl phenylalanines
US3725470A (en) * 1969-05-14 1973-04-03 Hoffmann La Roche Amino acid derivatives
CH562199A5 (de) * 1970-10-30 1975-05-30 Hoffmann La Roche
BE793426A (fr) * 1971-12-28 1973-06-28 Lannacher Heilmittel G M B H Derives de phenylalanine
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
US3891696A (en) * 1973-11-02 1975-06-24 Interx Research Corp Novel, transient pro-drug forms of l-dopa
US3939253A (en) * 1973-11-02 1976-02-17 Interx Research Corporation Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease
US4401676A (en) * 1977-06-01 1983-08-30 Merck & Co., Inc. Novel α-amino acids
US4311706A (en) * 1980-01-22 1982-01-19 Interx Research Corporation Novel dopa/dopamine prodrugs

Also Published As

Publication number Publication date
KR890005031A (ko) 1989-05-11
DK517588A (da) 1989-03-19
US4966915A (en) 1990-10-30
PT88526B (pt) 1992-11-30
DE3867403D1 (de) 1992-02-13
IL87765A0 (en) 1989-02-28
CN1032785A (zh) 1989-05-10
PT88526A (pt) 1988-10-01
JPH02138A (ja) 1990-01-05
JPH0541626B2 (de) 1993-06-24
DK517588D0 (da) 1988-09-16
CA1316180C (en) 1993-04-13
EP0309827B1 (de) 1992-01-02
EP0309827A1 (de) 1989-04-05
AU2234088A (en) 1989-03-23

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