KR101025612B1 - 신규 화합물인 Ramalin 및 그 용도 - Google Patents
신규 화합물인 Ramalin 및 그 용도 Download PDFInfo
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- KR101025612B1 KR101025612B1 KR1020080111021A KR20080111021A KR101025612B1 KR 101025612 B1 KR101025612 B1 KR 101025612B1 KR 1020080111021 A KR1020080111021 A KR 1020080111021A KR 20080111021 A KR20080111021 A KR 20080111021A KR 101025612 B1 KR101025612 B1 KR 101025612B1
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- ramalin
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Abstract
Description
IC50 농도 (μg/mL) | |||||
시판항산화제 | DPPH (μg/mL) |
ABTS (μg/mL) |
Superoxide (μg/mL) |
Tyrosinage activity (μg/mL) |
Reducing Power (1 μg of BHT equivalent) |
L5-5-2 | 0.99±0.08 | 1.7 ±0.2 | 10.2±1.2 | 4±0.4 | 0.04±0.003 |
BHA | 4.97±0.9 | - | - | - | - |
Trolox | - | 46.35±5.1 | - | - | - |
Ascorbic acid | - | - | 12.7±1.2 | - | - |
Kojic acid | - | - | - | 5±0.5 | - |
분 | H2O(0.1% formic acid) | 메탄올 |
10 | 100% | 0% |
20 | 80% | 20% |
30 | 0% | 100% |
40 | 0% | 100% |
분 | H2O(0.1% formic acid) | 아세토니트릴 | 메탄올 |
0 | 90% | 10% | 0% |
30 | 50% | 50% | 0% |
31 | 0% | 100% | 0% |
Claims (9)
- 제1항에 있어서, 남극 지의류인 Ramalina terebrata 로부터 분리된 것임을 특징으로 하는 화합물(라말린).
- 삭제
- 삭제
- 제8항에 있어서, 기능성 화장품은 미백 또는 주름개선용인 것을 특징으로 하는 기능성 화장품.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020080111021A KR101025612B1 (ko) | 2008-11-10 | 2008-11-10 | 신규 화합물인 Ramalin 및 그 용도 |
JP2011535518A JP5427894B2 (ja) | 2008-11-10 | 2009-11-10 | 新規化合物ラマリン及びその用途 |
US13/128,586 US8809578B2 (en) | 2008-11-10 | 2009-11-10 | Compound ramalin and use thereof |
CN2009801466449A CN102224131B (zh) | 2008-11-10 | 2009-11-10 | 化合物ramalin及其应用 |
PCT/KR2009/006562 WO2010053327A2 (ko) | 2008-11-10 | 2009-11-10 | 신규 화합물인 r a m a l i n 및 그 용도 |
EP09825010A EP2351732B1 (en) | 2008-11-10 | 2009-11-10 | Novel compound ramalin, and use thereof |
US14/261,551 US9539227B2 (en) | 2008-11-10 | 2014-04-25 | Pharmaceutical composition for the prevention or treatment of inflammatory diseases or immune diseases containing ramalin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020080111021A KR101025612B1 (ko) | 2008-11-10 | 2008-11-10 | 신규 화합물인 Ramalin 및 그 용도 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20100052130A KR20100052130A (ko) | 2010-05-19 |
KR101025612B1 true KR101025612B1 (ko) | 2011-03-30 |
Family
ID=42153414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020080111021A KR101025612B1 (ko) | 2008-11-10 | 2008-11-10 | 신규 화합물인 Ramalin 및 그 용도 |
Country Status (6)
Country | Link |
---|---|
US (1) | US8809578B2 (ko) |
EP (1) | EP2351732B1 (ko) |
JP (1) | JP5427894B2 (ko) |
KR (1) | KR101025612B1 (ko) |
CN (1) | CN102224131B (ko) |
WO (1) | WO2010053327A2 (ko) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013058630A2 (ko) * | 2011-10-21 | 2013-04-25 | 한국해양연구원 | 신규 화합물 스테레오칼핀 a를 함유하는 동맥경화증 예방 또는 치료용 조성물 |
WO2013108959A1 (ko) * | 2012-01-19 | 2013-07-25 | 한국해양연구원 | 글루탐산 유도체와 하이드록시 아닐린 또는 하이드록시기가 보호된 하이드록시 아닐린을 이용한 라말린 및 라말린 전구체의 합성방법 |
WO2013129714A1 (ko) * | 2012-02-28 | 2013-09-06 | 한국해양연구원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
US9968576B2 (en) | 2014-10-24 | 2018-05-15 | Korea Institute Of Ocean Science And Technology | Composition for preventing or treating neurodegenerative diseases, containing Ramalin |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101290745B1 (ko) * | 2010-06-03 | 2013-07-29 | 한국해양과학기술원 | 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물 |
KR101182334B1 (ko) | 2010-07-14 | 2012-09-20 | 한국해양연구원 | 라말린의 합성방법 |
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WO2013058630A2 (ko) * | 2011-10-21 | 2013-04-25 | 한국해양연구원 | 신규 화합물 스테레오칼핀 a를 함유하는 동맥경화증 예방 또는 치료용 조성물 |
WO2013058630A3 (ko) * | 2011-10-21 | 2013-06-20 | 한국해양연구원 | 신규 화합물 스테레오칼핀 a를 함유하는 동맥경화증 예방 또는 치료용 조성물 |
WO2013108959A1 (ko) * | 2012-01-19 | 2013-07-25 | 한국해양연구원 | 글루탐산 유도체와 하이드록시 아닐린 또는 하이드록시기가 보호된 하이드록시 아닐린을 이용한 라말린 및 라말린 전구체의 합성방법 |
KR101371045B1 (ko) * | 2012-01-19 | 2014-03-14 | 한국해양과학기술원 | 글루탐산 유도체와 하이드록시 아닐린 또는 하이드록시기가 보호된 하이드록시 아닐린을 이용한 라말린 및 라말린 전구체의 합성방법 |
WO2013129714A1 (ko) * | 2012-02-28 | 2013-09-06 | 한국해양연구원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
KR101326256B1 (ko) * | 2012-02-28 | 2013-11-11 | 한국해양과학기술원 | 라말린을 함유하는 간섬유화 및 간경화의 예방 또는 치료용 약학 조성물 |
US9364452B2 (en) | 2012-02-28 | 2016-06-14 | Korea Institute Of Ocean Science And Technology | Pharmaceutical composition for preventing or treating hepatic fibrosis and cirrhosis containing ramalin |
US9968576B2 (en) | 2014-10-24 | 2018-05-15 | Korea Institute Of Ocean Science And Technology | Composition for preventing or treating neurodegenerative diseases, containing Ramalin |
Also Published As
Publication number | Publication date |
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EP2351732A2 (en) | 2011-08-03 |
EP2351732B1 (en) | 2013-01-23 |
CN102224131A (zh) | 2011-10-19 |
JP5427894B2 (ja) | 2014-02-26 |
KR20100052130A (ko) | 2010-05-19 |
JP2012508229A (ja) | 2012-04-05 |
CN102224131B (zh) | 2013-11-06 |
WO2010053327A3 (ko) | 2010-07-29 |
EP2351732A4 (en) | 2012-03-21 |
EP2351732A8 (en) | 2012-03-28 |
US20110262374A1 (en) | 2011-10-27 |
WO2010053327A2 (ko) | 2010-05-14 |
US8809578B2 (en) | 2014-08-19 |
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