ATE159029T1 - Phosphonsäurederivate, verfahren zur herstellung und ihre verwendung - Google Patents
Phosphonsäurederivate, verfahren zur herstellung und ihre verwendungInfo
- Publication number
- ATE159029T1 ATE159029T1 AT92109769T AT92109769T ATE159029T1 AT E159029 T1 ATE159029 T1 AT E159029T1 AT 92109769 T AT92109769 T AT 92109769T AT 92109769 T AT92109769 T AT 92109769T AT E159029 T1 ATE159029 T1 AT E159029T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphonic acid
- isobutyl
- production
- acid derivatives
- unsubstituted
- Prior art date
Links
- 229940042400 direct acting antivirals phosphonic acid derivative Drugs 0.000 title 1
- 150000003007 phosphonic acid derivatives Chemical class 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
- -1 phosphonic acid derivative compound Chemical class 0.000 abstract 2
- 102000048186 Endothelin-converting enzyme 1 Human genes 0.000 abstract 1
- 108030001679 Endothelin-converting enzyme 1 Proteins 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14209991 | 1991-06-13 | ||
| JP4089111A JPH05105698A (ja) | 1991-06-13 | 1992-04-09 | ホスホン酸誘導体、その製造法および用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE159029T1 true ATE159029T1 (de) | 1997-10-15 |
Family
ID=26430544
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92109769T ATE159029T1 (de) | 1991-06-13 | 1992-06-10 | Phosphonsäurederivate, verfahren zur herstellung und ihre verwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5330978B1 (de) |
| EP (1) | EP0518299B1 (de) |
| JP (1) | JPH05105698A (de) |
| AT (1) | ATE159029T1 (de) |
| CA (1) | CA2071106A1 (de) |
| DE (1) | DE69222570T2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9300048D0 (en) * | 1993-01-04 | 1993-03-03 | Wellcome Found | Endothelin converting enzyme inhibitors |
| EP0618224A1 (de) * | 1993-03-30 | 1994-10-05 | Merrell Dow Pharmaceuticals Inc. | Phosophonomethyldipeptide |
| US5608078A (en) * | 1993-03-30 | 1997-03-04 | Merrell Pharmaceuticals Inc. | Phosphonomethyldipeptides and process for preparation thereof |
| WO1994028012A1 (en) * | 1993-05-28 | 1994-12-08 | Warner-Lambert Company | Hydroxamate inhibitors of endothelin converting enzyme |
| FR2707089B1 (fr) * | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'acide phosphonique, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| IT1274673B (it) * | 1994-04-14 | 1997-07-24 | Zambon Spa | Derivati dell'acido fosfonico utili nel trattamento delle malattie car.iovascolari |
| US5658902A (en) * | 1994-12-22 | 1997-08-19 | Warner-Lambert Company | Quinazolines as inhibitors of endothelin converting enzyme |
| US5958905A (en) * | 1996-03-26 | 1999-09-28 | Texas Biotechnology Corporation | Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin |
| WO1998042308A1 (en) * | 1997-03-25 | 1998-10-01 | Kao Corporation | Preventives for skin aging |
| JP3973748B2 (ja) | 1998-01-14 | 2007-09-12 | 花王株式会社 | 発毛抑制剤 |
| DK1313714T3 (da) * | 2000-07-19 | 2008-12-15 | Novartis Ag | Valsartansalte |
| US9078808B2 (en) * | 2009-03-26 | 2015-07-14 | Warsaw Orthopedic, Inc. | Device to deliver magnesium in PEG formulation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4379146A (en) * | 1981-02-17 | 1983-04-05 | Merck & Co., Inc. | Substituted phosphonamides as antihypertensives |
| US4432972A (en) * | 1981-08-03 | 1984-02-21 | E. R. Squibb & Sons, Inc. | Phosphonamidate compounds |
-
1992
- 1992-04-09 JP JP4089111A patent/JPH05105698A/ja active Pending
- 1992-06-03 US US07892768 patent/US5330978B1/en not_active Ceased
- 1992-06-10 AT AT92109769T patent/ATE159029T1/de not_active IP Right Cessation
- 1992-06-10 DE DE69222570T patent/DE69222570T2/de not_active Expired - Fee Related
- 1992-06-10 EP EP92109769A patent/EP0518299B1/de not_active Expired - Lifetime
- 1992-06-12 CA CA002071106A patent/CA2071106A1/en not_active Abandoned
-
1996
- 1996-07-12 US US08/680,295 patent/USRE35886E/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| USRE35886E (en) | 1998-09-01 |
| EP0518299A3 (en) | 1993-04-07 |
| US5330978B1 (en) | 1996-06-18 |
| JPH05105698A (ja) | 1993-04-27 |
| CA2071106A1 (en) | 1992-12-14 |
| US5330978A (en) | 1994-07-19 |
| EP0518299A2 (de) | 1992-12-16 |
| EP0518299B1 (de) | 1997-10-08 |
| DE69222570D1 (de) | 1997-11-13 |
| DE69222570T2 (de) | 1998-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |