HK1014674A1 - Cell binding agent conjugates of derivatives of cc-1065 - Google Patents

Cell binding agent conjugates of derivatives of cc-1065

Info

Publication number
HK1014674A1
HK1014674A1 HK98116123A HK98116123A HK1014674A1 HK 1014674 A1 HK1014674 A1 HK 1014674A1 HK 98116123 A HK98116123 A HK 98116123A HK 98116123 A HK98116123 A HK 98116123A HK 1014674 A1 HK1014674 A1 HK 1014674A1
Authority
HK
Hong Kong
Prior art keywords
derivatives
binding agent
cell binding
agent conjugates
conjugates
Prior art date
Application number
HK98116123A
Other languages
English (en)
Inventor
Ravi V J Chari
Viktor S Goldmakher
Walter A Blattler
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of HK1014674A1 publication Critical patent/HK1014674A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
HK98116123A 1992-03-25 1998-12-28 Cell binding agent conjugates of derivatives of cc-1065 HK1014674A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85717192A 1992-03-25 1992-03-25

Publications (1)

Publication Number Publication Date
HK1014674A1 true HK1014674A1 (en) 1999-09-30

Family

ID=25325372

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98116123A HK1014674A1 (en) 1992-03-25 1998-12-28 Cell binding agent conjugates of derivatives of cc-1065

Country Status (8)

Country Link
US (3) US5475092A (fr)
EP (1) EP0563475B1 (fr)
JP (1) JP3700091B2 (fr)
CA (1) CA2076465C (fr)
DE (1) DE69231123T2 (fr)
DK (1) DK0563475T3 (fr)
ES (1) ES2149768T3 (fr)
HK (1) HK1014674A1 (fr)

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US5585499A (en) 1996-12-17
JPH0656697A (ja) 1994-03-01
EP0563475A1 (fr) 1993-10-06
ES2149768T3 (es) 2000-11-16
DE69231123D1 (de) 2000-07-06
US5846545A (en) 1998-12-08
CA2076465A1 (fr) 1993-09-26
JP3700091B2 (ja) 2005-09-28
US5475092A (en) 1995-12-12
EP0563475B1 (fr) 2000-05-31
CA2076465C (fr) 2002-11-26

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