FR2486098B1 - Interferons et procede pour leur preparation - Google Patents

Interferons et procede pour leur preparation

Info

Publication number
FR2486098B1
FR2486098B1 FR8112724A FR8112724A FR2486098B1 FR 2486098 B1 FR2486098 B1 FR 2486098B1 FR 8112724 A FR8112724 A FR 8112724A FR 8112724 A FR8112724 A FR 8112724A FR 2486098 B1 FR2486098 B1 FR 2486098B1
Authority
FR
France
Prior art keywords
interferons
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8112724A
Other languages
English (en)
French (fr)
Other versions
FR2486098A1 (fr
Inventor
David Van Norman Goeddel
Sidney Pestka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2486098(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FR2486098A1 publication Critical patent/FR2486098A1/fr
Application granted granted Critical
Publication of FR2486098B1 publication Critical patent/FR2486098B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR8112724A 1980-07-01 1981-06-29 Interferons et procede pour leur preparation Expired FR2486098B1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons

Publications (2)

Publication Number Publication Date
FR2486098A1 FR2486098A1 (fr) 1982-01-08
FR2486098B1 true FR2486098B1 (fr) 1985-12-27

Family

ID=27496622

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8112724A Expired FR2486098B1 (fr) 1980-07-01 1981-06-29 Interferons et procede pour leur preparation

Country Status (36)

Country Link
EP (2) EP0043980B1 (cg-RX-API-DMAC7.html)
AR (1) AR242833A1 (cg-RX-API-DMAC7.html)
AT (3) ATE79901T1 (cg-RX-API-DMAC7.html)
AU (1) AU552004B2 (cg-RX-API-DMAC7.html)
BG (1) BG42189A3 (cg-RX-API-DMAC7.html)
BR (1) BR8104189A (cg-RX-API-DMAC7.html)
CH (2) CH651308A5 (cg-RX-API-DMAC7.html)
CS (1) CS273152B2 (cg-RX-API-DMAC7.html)
DD (3) DD210304A5 (cg-RX-API-DMAC7.html)
DE (3) DE3125706C2 (cg-RX-API-DMAC7.html)
DK (1) DK173543B1 (cg-RX-API-DMAC7.html)
DZ (1) DZ312A1 (cg-RX-API-DMAC7.html)
ES (1) ES8207514A1 (cg-RX-API-DMAC7.html)
FI (1) FI82712C (cg-RX-API-DMAC7.html)
FR (1) FR2486098B1 (cg-RX-API-DMAC7.html)
GB (1) GB2079291B (cg-RX-API-DMAC7.html)
GE (1) GEP19960519B (cg-RX-API-DMAC7.html)
GR (1) GR75714B (cg-RX-API-DMAC7.html)
HK (1) HK49285A (cg-RX-API-DMAC7.html)
HU (1) HU196457B (cg-RX-API-DMAC7.html)
IE (1) IE49255B1 (cg-RX-API-DMAC7.html)
IT (1) IT1137272B (cg-RX-API-DMAC7.html)
KE (1) KE3534A (cg-RX-API-DMAC7.html)
LU (1) LU83461A1 (cg-RX-API-DMAC7.html)
MC (1) MC1396A1 (cg-RX-API-DMAC7.html)
MY (1) MY8700711A (cg-RX-API-DMAC7.html)
NL (1) NL8103151A (cg-RX-API-DMAC7.html)
NO (1) NO159392C (cg-RX-API-DMAC7.html)
NZ (1) NZ197572A (cg-RX-API-DMAC7.html)
PH (1) PH18036A (cg-RX-API-DMAC7.html)
PL (3) PL148260B1 (cg-RX-API-DMAC7.html)
PT (1) PT73289B (cg-RX-API-DMAC7.html)
RO (1) RO87590A (cg-RX-API-DMAC7.html)
SE (2) SE465223C5 (cg-RX-API-DMAC7.html)
SU (1) SU1414319A3 (cg-RX-API-DMAC7.html)
YU (1) YU47700B (cg-RX-API-DMAC7.html)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
NO811118L (no) 1980-04-03 1981-10-05 Biogen Nv Dna-sekvenser, rekombinante dna-molekyler og fremgangsmaate ved fremstilling av polypeptider
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
EP0085693A1 (en) * 1981-08-14 1983-08-17 A/S Alfred Benzon Subjects relating to human inteferon-alpha subtype proteins and corresponding antibodies
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (en) * 1982-03-15 1991-06-19 Schering Corporation Hybrid dna, binding composition prepared thereby and processes therefor
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US6936694B1 (en) 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
WO1984003300A1 (fr) * 1983-02-24 1984-08-30 Inst Organicheskogo Sinteza Ak Interferon n humain leucocytaire et son procede d'obtention dans des cellules bacteriennes
WO1985002862A1 (en) * 1983-12-23 1985-07-04 Monash University PRODUCTION OF HUMAN INTERFERON-alpha
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
ATE227133T1 (de) * 1994-03-07 2002-11-15 Imperial College Verwendung von interferon-alpha 8 subtype zur herstellung von medikamenten zur behandlung von viralinfektionen der leber
DE69522492T2 (de) * 1994-04-09 2002-05-23 F. Hoffmann-La Roche Ag, Basel Verfahren zur Herstellung von Alpha-Interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
AU761577C (en) 1997-12-08 2004-02-05 Genentech Inc. Human interferon-epsilon: a type I interferon
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
CA2338665C (en) 1998-08-06 2011-01-18 Mountain View Pharmaceuticals, Inc. Peg-urate oxidase conjugates and use thereof
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
JP2004537964A (ja) * 2000-11-03 2004-12-24 ペストカ バイオメディカル ラボラトリーズ インコーポレイテッド インターフェロン、それに関する使用及び組成物
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
PT3321359T (pt) 2005-04-11 2021-03-11 Horizon Pharma Rheumatology Llc Formas variantes de urato-oxidase e a sua utilização
CN107033233A (zh) * 2008-01-18 2017-08-11 弗·哈夫曼-拉罗切有限公司 非糖基化蛋白质的纯化
RU2535038C2 (ru) 2009-06-25 2014-12-10 Криэлта Фармасьютикалз ЭлЭлСи Способы и наборы для прогнозирования риска инфузионных реакций и опосредованной антителами потери ответа при терапии пэгилированной уриказой с помощью мониторинга содержания мочевой кислоты в сыворотке крови
WO2018089808A1 (en) 2016-11-11 2018-05-17 Horizon Pharma Rheumatology Llc Combination therapies of prednisone and uricase molecules and uses thereof
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
WO2020160325A1 (en) 2019-01-30 2020-08-06 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (cg-RX-API-DMAC7.html) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DE3165463D1 (en) * 1980-01-08 1984-09-20 Biogen Nv Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) * 1980-06-12 1987-04-23 Japan Found Cancer Plasmid
ES8302778A1 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DE3280127D1 (de) * 1981-03-27 1990-04-12 Ici Plc Genetisch modifizierte mikroorganismen.

Also Published As

Publication number Publication date
FI812067L (fi) 1982-01-02
NL8103151A (nl) 1982-02-01
SU1414319A3 (ru) 1988-07-30
LU83461A1 (de) 1983-04-06
FR2486098A1 (fr) 1982-01-08
MC1396A1 (fr) 1982-04-27
NO159392C (no) 1988-12-21
ATE79901T1 (de) 1992-09-15
IT1137272B (it) 1986-09-03
CH651308A5 (de) 1985-09-13
PL148260B1 (en) 1989-09-30
DE3125706A1 (de) 1982-04-15
HK49285A (en) 1985-07-05
DK291081A (da) 1982-01-02
DD202307A5 (de) 1983-09-07
SE8104093L (sv) 1982-01-02
AT380272B (de) 1986-05-12
ES503528A0 (es) 1982-10-01
GB2079291A (en) 1982-01-20
EP0043980B1 (en) 1987-09-16
CS273152B2 (en) 1991-03-12
DE3177288T2 (de) 1992-12-10
NZ197572A (en) 1985-07-31
DZ312A1 (fr) 2004-09-13
PH18036A (en) 1985-03-06
EP0043980A3 (en) 1982-09-15
GR75714B (cg-RX-API-DMAC7.html) 1984-08-02
PT73289A (en) 1981-07-01
EP0211148B2 (en) 1999-11-24
YU47700B (sh) 1996-01-08
FI82712B (fi) 1990-12-31
DE3176448D1 (en) 1987-10-22
IT8122682A0 (it) 1981-07-01
RO87590A (ro) 1986-07-30
ATA290981A (de) 1985-09-15
KE3534A (en) 1985-06-07
NO812247L (no) 1982-01-04
DE3125706C2 (de) 1995-05-24
IE811463L (en) 1982-01-01
EP0211148A1 (en) 1987-02-25
NO159392B (no) 1988-09-12
AU552004B2 (en) 1986-05-22
DK173543B1 (da) 2001-02-05
PL148276B1 (en) 1989-09-30
YU162281A (en) 1984-02-29
PT73289B (en) 1983-05-11
ATE29727T1 (de) 1987-10-15
SE465223C5 (sv) 1998-02-10
SE465223B (sv) 1991-08-12
GEP19960519B (en) 1996-07-02
AU7246281A (en) 1982-01-07
IE49255B1 (en) 1985-09-04
ES8207514A1 (es) 1982-10-01
DE3177288T3 (de) 2000-03-16
BG42189A3 (en) 1987-10-15
DE3177288D1 (de) 1992-10-01
EP0043980A2 (en) 1982-01-20
DD210304A5 (de) 1984-06-06
CS503781A2 (en) 1990-07-12
PL231940A1 (en) 1983-07-18
CH657141A5 (de) 1986-08-15
EP0211148B1 (en) 1992-08-26
GB2079291B (en) 1984-06-13
PL148261B1 (en) 1989-09-30
AR242833A1 (es) 1993-05-31
BR8104189A (pt) 1982-03-16
DD210305A5 (de) 1984-06-06
MY8700711A (en) 1987-12-31
FI82712C (fi) 1991-04-10
HU196457B (en) 1988-11-28

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Legal Events

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TP Transmission of property
CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0122, 920430

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

Free format text: 92C0122, 810629

CL Concession to grant licences