FI882808A - Vid metylaminokvaeve substituerade derivat. - Google Patents
Vid metylaminokvaeve substituerade derivat. Download PDFInfo
- Publication number
- FI882808A FI882808A FI882808A FI882808A FI882808A FI 882808 A FI882808 A FI 882808A FI 882808 A FI882808 A FI 882808A FI 882808 A FI882808 A FI 882808A FI 882808 A FI882808 A FI 882808A
- Authority
- FI
- Finland
- Prior art keywords
- metlaminokvaeve
- substituerade
- derivat
- vid
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH224487 | 1987-06-15 | ||
CH224487 | 1987-06-15 | ||
CH144088 | 1988-04-19 | ||
CH144088 | 1988-04-19 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI882808A0 FI882808A0 (fi) | 1988-06-13 |
FI882808A true FI882808A (fi) | 1988-12-16 |
FI89362B FI89362B (fi) | 1993-06-15 |
FI89362C FI89362C (fi) | 1993-09-27 |
Family
ID=25687663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI882808A FI89362C (fi) | 1987-06-15 | 1988-06-13 | Foerfarande foer framstaellning av nya terapeutiskt verkande i metylaminkvaeve acylerade staurosporinderivat |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0296110B1 (fi) |
JP (1) | JP2708047B2 (fi) |
KR (1) | KR970001529B1 (fi) |
AT (1) | ATE134375T1 (fi) |
AU (1) | AU617324B2 (fi) |
CA (1) | CA1337763C (fi) |
DE (1) | DE3855015D1 (fi) |
DK (1) | DK175507B1 (fi) |
ES (1) | ES2083956T3 (fi) |
FI (1) | FI89362C (fi) |
GR (1) | GR3019064T3 (fi) |
HK (1) | HK1003788A1 (fi) |
HU (1) | HU201329B (fi) |
IE (1) | IE70523B1 (fi) |
IL (1) | IL86632A0 (fi) |
MY (1) | MY104316A (fi) |
NO (1) | NO170634C (fi) |
NZ (1) | NZ225018A (fi) |
PT (1) | PT87719B (fi) |
YU (1) | YU115488A (fi) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS62220196A (ja) * | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ucn―01 |
JP2766360B2 (ja) * | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
SK278989B6 (sk) * | 1988-02-10 | 1998-05-06 | F. Hoffmann-La Roche Ag | Substituované pyroly, ich použitie na výrobu lieči |
USRE36736E (en) * | 1989-02-06 | 2000-06-13 | Hoffman-La Roche Inc. | Substituted pyrroles |
DE3924538A1 (de) * | 1989-07-25 | 1991-01-31 | Goedecke Ag | Indolocarbazol und dessen verwendung |
US5618809A (en) * | 1989-12-14 | 1997-04-08 | Schering Corporation | Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856 |
US5292747A (en) * | 1990-08-07 | 1994-03-08 | Hoffman-La Roche Inc. | Substituted pyrroles |
WO1993007153A1 (en) * | 1991-10-10 | 1993-04-15 | Schering Corporation | 4'-(n-substituted-n-oxide)staurosporine derivatives |
EP0541486A1 (de) * | 1991-11-07 | 1993-05-12 | Ciba-Geigy Ag | Polycyclische Konjugate |
WO1993018771A1 (fr) * | 1992-03-24 | 1993-09-30 | Asahi Kasei Kogyo Kabushiki Kaisha | INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME |
US5621101A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
US5461146A (en) * | 1992-07-24 | 1995-10-24 | Cephalon, Inc. | Selected protein kinase inhibitors for the treatment of neurological disorders |
US5621100A (en) * | 1992-07-24 | 1997-04-15 | Cephalon, Inc. | K-252a derivatives for treatment of neurological disorders |
US5756494A (en) * | 1992-07-24 | 1998-05-26 | Cephalon, Inc. | Protein kinase inhibitors for treatment of neurological disorders |
WO1994006799A1 (fr) * | 1992-09-21 | 1994-03-31 | Kyowa Hakko Kogyo Co., Ltd. | Remede contre la thrombopenie |
US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
EP1447098A3 (en) | 1993-01-28 | 2005-06-29 | Boston Scientific Limited | Therapeutic inhibitor of vascular smooth muscle cells |
PH30300A (en) * | 1993-05-07 | 1997-01-20 | Ciba Geigy Ag | Polycyclic compounds and processes for the preparation thereof |
US6051221A (en) * | 1993-07-09 | 2000-04-18 | Glaxo Wellcome Inc. | BRK protein tyrosine kinase and encoding nucleic acid |
GB9325395D0 (en) * | 1993-12-11 | 1994-02-16 | Ciba Geigy Ag | Compositions |
EP0711556A1 (de) * | 1994-11-09 | 1996-05-15 | Ciba-Geigy Ag | Intravenöse Lösungen für ein Staurosporinderivat |
UA67725C2 (en) | 1996-06-03 | 2004-07-15 | Cephalon Inc | K-252a derivatives and a method for improvement of functioning and cell survival enhancement |
US6875865B1 (en) | 1996-06-03 | 2005-04-05 | Cephalon, Inc. | Selected derivatives of K-252a |
PT912184E (pt) | 1996-06-25 | 2002-12-31 | Cephalon Inc | Utilizacao de um derivado de k-252a para o tratamento de doencas do sietma nervoso central ou periferico e sobre-producao de citoquina |
EP0975340B2 (en) | 1997-03-31 | 2009-10-28 | Boston Scientific Limited | Therapeutic inhibitor of vascular smooth muscle cells |
AU761092B2 (en) * | 1998-11-23 | 2003-05-29 | Novartis Ag | Use of staurosporine derivatives for treating ocular neovascular diseases |
DK3143995T3 (en) | 2001-02-19 | 2019-01-28 | Novartis Pharma Ag | Rapamycin derivative for the treatment of lung cancer |
EP2253319A1 (en) | 2001-05-16 | 2010-11-24 | Novartis AG | Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent. |
NZ532136A (en) | 2001-10-30 | 2006-08-31 | Novartis Ag | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity |
US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
PL372103A1 (en) | 2002-05-16 | 2005-07-11 | Novartis Ag | Use of edg receptor binding agents in cancer |
WO2004009056A1 (en) * | 2002-07-23 | 2004-01-29 | Novartis Ag | Ophtalmic ointment composition comprising a drug, an ointment base and a solubiling/dispersing agent |
BRPI0410439A (pt) | 2003-05-19 | 2006-06-06 | Irm Llc | compostos e composições imunossupressoras |
MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
US20040246627A1 (en) * | 2003-06-06 | 2004-12-09 | Durrum Thomas M. | Disc drive pivot bearing assembly |
WO2005014004A1 (en) | 2003-08-08 | 2005-02-17 | Novartis Ag | Combinations comprising staurosporines |
TW200538433A (en) | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
GB0512324D0 (en) | 2005-06-16 | 2005-07-27 | Novartis Ag | Organic compounds |
KR20070046906A (ko) * | 2004-08-31 | 2007-05-03 | 노파르티스 아게 | 위장관 기질적 종양 치료를 위한 미도스타우린의 용도 |
JO2897B1 (en) | 2004-11-05 | 2015-09-15 | نوفارتيس ايه جي | Organic compounds |
EP2022498A3 (en) | 2005-11-21 | 2012-08-15 | Novartis AG | Neuroendocrine tumour treatment |
JP2012512885A (ja) | 2008-12-18 | 2012-06-07 | ノバルティス アーゲー | 新規な塩 |
CN104803902A (zh) | 2008-12-18 | 2015-07-29 | 诺华股份有限公司 | 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的半富马酸盐 |
ES2531831T3 (es) | 2008-12-18 | 2015-03-20 | Novartis Ag | Forma polimórfica del ácido 1-(4-{1-[(E)-4-ciclohexil-3-trifluorometil-benciloxiimino]-etil}-2-etil-bencil)-azetidin-3-carboxilico |
EP2327706A1 (en) * | 2009-11-30 | 2011-06-01 | Novartis AG | Polymorphous forms III and IV of N-benzoyl-staurosporine |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013167403A1 (en) | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
WO2019215759A1 (en) * | 2018-05-09 | 2019-11-14 | Alaparthi Lakshmi Prasad | An improved process for preparation of midostaurin |
EP4058465A1 (en) | 2019-11-14 | 2022-09-21 | Cohbar Inc. | Cxcr4 antagonist peptides |
IT202000004291A1 (it) * | 2020-03-02 | 2021-09-02 | Indena Spa | Processo per la purificazione di alcaloidi indolo carbazolici |
CN112812129A (zh) * | 2020-12-31 | 2021-05-18 | 浙江海正药业股份有限公司 | 米哚妥林的新晶型及其制备方法和用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2766360B2 (ja) * | 1988-02-04 | 1998-06-18 | 協和醗酵工業株式会社 | スタウロスポリン誘導体 |
-
1988
- 1988-06-06 IL IL86632A patent/IL86632A0/xx not_active IP Right Cessation
- 1988-06-09 MY MYPI88000629A patent/MY104316A/en unknown
- 1988-06-09 AT AT88810383T patent/ATE134375T1/de not_active IP Right Cessation
- 1988-06-09 ES ES88810383T patent/ES2083956T3/es not_active Expired - Lifetime
- 1988-06-09 DE DE3855015T patent/DE3855015D1/de not_active Expired - Lifetime
- 1988-06-09 EP EP88810383A patent/EP0296110B1/de not_active Expired - Lifetime
- 1988-06-10 AU AU17571/88A patent/AU617324B2/en not_active Expired
- 1988-06-13 CA CA000569303A patent/CA1337763C/en not_active Expired - Lifetime
- 1988-06-13 FI FI882808A patent/FI89362C/fi active IP Right Grant
- 1988-06-14 NZ NZ225018A patent/NZ225018A/xx unknown
- 1988-06-14 HU HU883048A patent/HU201329B/hu unknown
- 1988-06-14 PT PT87719A patent/PT87719B/pt not_active IP Right Cessation
- 1988-06-14 DK DK198803248A patent/DK175507B1/da not_active IP Right Cessation
- 1988-06-14 YU YU01154/88A patent/YU115488A/xx unknown
- 1988-06-14 NO NO882613A patent/NO170634C/no not_active IP Right Cessation
- 1988-06-14 IE IE178788A patent/IE70523B1/en not_active IP Right Cessation
- 1988-06-14 KR KR1019880007102A patent/KR970001529B1/ko not_active IP Right Cessation
- 1988-06-15 JP JP63145937A patent/JP2708047B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-22 GR GR960400221T patent/GR3019064T3/el unknown
-
1998
- 1998-04-04 HK HK98102862A patent/HK1003788A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NO170634B (no) | 1992-08-03 |
ES2083956T3 (es) | 1996-05-01 |
EP0296110B1 (de) | 1996-02-21 |
HU201329B (en) | 1990-10-28 |
EP0296110A2 (de) | 1988-12-21 |
HK1003788A1 (en) | 1998-11-06 |
KR970001529B1 (ko) | 1997-02-11 |
MY104316A (en) | 1994-03-31 |
NO170634C (no) | 1992-11-11 |
DK324888A (da) | 1988-12-16 |
NO882613L (no) | 1988-12-16 |
DE3855015D1 (de) | 1996-03-28 |
FI882808A0 (fi) | 1988-06-13 |
PT87719A (pt) | 1988-07-01 |
HUT47587A (en) | 1989-03-28 |
IL86632A0 (en) | 1988-11-30 |
IE70523B1 (en) | 1996-12-11 |
CA1337763C (en) | 1995-12-19 |
EP0296110A3 (de) | 1991-02-27 |
FI89362B (fi) | 1993-06-15 |
FI89362C (fi) | 1993-09-27 |
PT87719B (pt) | 1992-10-30 |
JP2708047B2 (ja) | 1998-02-04 |
YU115488A (en) | 1989-12-31 |
DK324888D0 (da) | 1988-06-14 |
DK175507B1 (da) | 2004-11-15 |
NZ225018A (en) | 1990-09-26 |
IE881787L (en) | 1988-12-15 |
AU1757188A (en) | 1988-12-15 |
NO882613D0 (no) | 1988-06-14 |
KR890000494A (ko) | 1989-03-15 |
JPS6434989A (en) | 1989-02-06 |
AU617324B2 (en) | 1991-11-28 |
ATE134375T1 (de) | 1996-03-15 |
GR3019064T3 (en) | 1996-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
BB | Publication of examined application | ||
PC | Transfer of assignment of patent |
Owner name: NOVARTIS AG |
|
FG | Patent granted |
Owner name: NOVARTIS AG |