IL86632A0 - Derivatives substituted at methyl-amino nitrogen - Google Patents

Derivatives substituted at methyl-amino nitrogen

Info

Publication number
IL86632A0
IL86632A0 IL86632A IL8663288A IL86632A0 IL 86632 A0 IL86632 A0 IL 86632A0 IL 86632 A IL86632 A IL 86632A IL 8663288 A IL8663288 A IL 8663288A IL 86632 A0 IL86632 A0 IL 86632A0
Authority
IL
Israel
Prior art keywords
methyl
amino nitrogen
derivatives substituted
formula
stau
Prior art date
Application number
IL86632A
Other languages
English (en)
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL86632A0 publication Critical patent/IL86632A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
IL86632A 1987-06-15 1988-06-06 Derivatives substituted at methyl-amino nitrogen IL86632A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH224487 1987-06-15
CH144088 1988-04-19

Publications (1)

Publication Number Publication Date
IL86632A0 true IL86632A0 (en) 1988-11-30

Family

ID=25687663

Family Applications (1)

Application Number Title Priority Date Filing Date
IL86632A IL86632A0 (en) 1987-06-15 1988-06-06 Derivatives substituted at methyl-amino nitrogen

Country Status (20)

Country Link
EP (1) EP0296110B1 (xx)
JP (1) JP2708047B2 (xx)
KR (1) KR970001529B1 (xx)
AT (1) ATE134375T1 (xx)
AU (1) AU617324B2 (xx)
CA (1) CA1337763C (xx)
DE (1) DE3855015D1 (xx)
DK (1) DK175507B1 (xx)
ES (1) ES2083956T3 (xx)
FI (1) FI89362C (xx)
GR (1) GR3019064T3 (xx)
HK (1) HK1003788A1 (xx)
HU (1) HU201329B (xx)
IE (1) IE70523B1 (xx)
IL (1) IL86632A0 (xx)
MY (1) MY104316A (xx)
NO (1) NO170634C (xx)
NZ (1) NZ225018A (xx)
PT (1) PT87719B (xx)
YU (1) YU115488A (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１
JP2766360B2 (ja) * 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
USRE36736E (en) * 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
DE3924538A1 (de) * 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
WO1993007153A1 (en) * 1991-10-10 1993-04-15 Schering Corporation 4'-(n-substituted-n-oxide)staurosporine derivatives
EP0541486A1 (de) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclische Konjugate
WO1993018771A1 (fr) * 1992-03-24 1993-09-30 Asahi Kasei Kogyo Kabushiki Kaisha INHIBITEUR DE L'AGGLUTINATION PLAQUETTAIRE CONTENANT UN DERIVE DE STAUROSPORINE η-LACTAME
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621100A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. K-252a derivatives for treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
WO1994006799A1 (fr) * 1992-09-21 1994-03-31 Kyowa Hakko Kogyo Co., Ltd. Remede contre la thrombopenie
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ES2355184T3 (es) 1993-01-28 2011-03-23 Boston Scientific Limited Inhibidores terapéuticos de células de músculo liso vascular.
PH30300A (en) * 1993-05-07 1997-01-20 Ciba Geigy Ag Polycyclic compounds and processes for the preparation thereof
US6051221A (en) * 1993-07-09 2000-04-18 Glaxo Wellcome Inc. BRK protein tyrosine kinase and encoding nucleic acid
GB9325395D0 (en) * 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
EP0711557A1 (de) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Pharmazeutische Formulierungsgrundlage
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
UA67725C2 (en) 1996-06-03 2004-07-15 Cephalon Inc K-252a derivatives and a method for improvement of functioning and cell survival enhancement
DE69715862T2 (de) 1996-06-25 2003-04-10 Cephalon, Inc. Verwendung eines k-252a derivats zur behandlung von periphärer oder zentraler nervenerkrankungen und übermässiger cytokinbildung
ATE278397T1 (de) 1997-03-31 2004-10-15 Boston Scient Ltd Verwendung von cytoskelettinhibitoren zur vorbeugung der restenose
DK1131073T3 (da) * 1998-11-23 2004-02-02 Novartis Ag Anvendelse af staurosporinderivater til behandling af okulære neovaskulære sygdomme
LT3351246T (lt) 2001-02-19 2019-07-10 Novartis Pharma Ag Rapamicino darinys, skirtas kieto naviko, susijusio su nereguliuojama angiogeneze, gydymui
SK14042003A3 (sk) 2001-05-16 2004-05-04 Novartis Ag Kombinácia N-{5-[4-metylpiperazinometyl)benzoylamido]-2- metylfenyl}-4-(3-pyridyl)-2-pyrimidínamínu chemoterapeutického činidla a farmaceutický prostriedok, ktorý ju obsahuje
NZ532136A (en) 2001-10-30 2006-08-31 Novartis Ag Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
EP1944026B1 (en) 2002-05-16 2013-06-26 Novartis AG Use of EDG receptor binding agents in cancer
CN101897662B (zh) * 2002-07-23 2013-05-22 诺瓦提斯公司 包含药物、软膏基质和增溶剂/分散剂的眼用软膏剂组合物
CL2004001120A1 (es) 2003-05-19 2005-04-15 Irm Llc Compuestos derivados de amina sustituidas con heterociclos, inmunosupresores; composicion farmaceutica; y uso para tratar enfermedades mediadas por interacciones de linfocito, tales como enfermedades autoinmunes, inflamatorias, infecciosas, cancer.
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
US20040246627A1 (en) * 2003-06-06 2004-12-09 Durrum Thomas M. Disc drive pivot bearing assembly
EP1653973A1 (en) 2003-08-08 2006-05-10 Novartis AG Combinations comprising staurosporines
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
MX2007002415A (es) * 2004-08-31 2007-04-23 Novartis Ag Uso de midostaurina para el tratamiento de tumores estromales gastrointestinales.
JO2897B1 (en) * 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
JP2009516671A (ja) 2005-11-21 2009-04-23 ノバルティス アクチエンゲゼルシャフト ｍＴＯＲ阻害剤を使用する神経内分泌腫瘍処置
CA2746764A1 (en) 2008-12-18 2010-06-24 Novartis Ag New polymorphic form of 1- (4- { l- [ (e) -4-cyclohexyl--3-trifluoromethyl-benzyloxyimino] -ethyl) -2-ethyl-benzy l) -azetidine-3-carboxylic
IL294514A (en) 2008-12-18 2022-09-01 Novartis Ag 1-[4-[1[(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid mipomarate salt
RU2011129229A (ru) 2008-12-18 2013-01-27 Новартис Аг Новые соли
EP2327706A1 (en) * 2009-11-30 2011-06-01 Novartis AG Polymorphous forms III and IV of N-benzoyl-staurosporine
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013167403A1 (en) 2012-05-09 2013-11-14 Sanofi Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors
WO2019215759A1 (en) * 2018-05-09 2019-11-14 Alaparthi Lakshmi Prasad An improved process for preparation of midostaurin
WO2021097256A1 (en) 2019-11-14 2021-05-20 Cohbar, Inc. Cxcr4 antagonist peptides
IT202000004291A1 (it) * 2020-03-02 2021-09-02 Indena Spa Processo per la purificazione di alcaloidi indolo carbazolici
CN112812129A (zh) * 2020-12-31 2021-05-18 浙江海正药业股份有限公司 米哚妥林的新晶型及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2766360B2 (ja) * 1988-02-04 1998-06-18 協和醗酵工業株式会社 スタウロスポリン誘導体

Also Published As

Publication number Publication date
CA1337763C (en) 1995-12-19
PT87719A (pt) 1988-07-01
JPS6434989A (en) 1989-02-06
FI89362B (fi) 1993-06-15
HUT47587A (en) 1989-03-28
NZ225018A (en) 1990-09-26
ATE134375T1 (de) 1996-03-15
DK324888D0 (da) 1988-06-14
YU115488A (en) 1989-12-31
IE881787L (en) 1988-12-15
NO882613D0 (no) 1988-06-14
KR890000494A (ko) 1989-03-15
DK175507B1 (da) 2004-11-15
GR3019064T3 (en) 1996-05-31
DE3855015D1 (de) 1996-03-28
NO882613L (no) 1988-12-16
FI882808A (fi) 1988-12-16
NO170634B (no) 1992-08-03
ES2083956T3 (es) 1996-05-01
FI89362C (fi) 1993-09-27
FI882808A0 (fi) 1988-06-13
PT87719B (pt) 1992-10-30
EP0296110A3 (de) 1991-02-27
KR970001529B1 (ko) 1997-02-11
NO170634C (no) 1992-11-11
HK1003788A1 (en) 1998-11-06
MY104316A (en) 1994-03-31
DK324888A (da) 1988-12-16
EP0296110A2 (de) 1988-12-21
HU201329B (en) 1990-10-28
AU1757188A (en) 1988-12-15
IE70523B1 (en) 1996-12-11
EP0296110B1 (de) 1996-02-21
AU617324B2 (en) 1991-11-28
JP2708047B2 (ja) 1998-02-04

Similar Documents

Publication Publication Date Title
IL86632A0 (en) Derivatives substituted at methyl-amino nitrogen
EP0167919A3 (en) Benzodiazepine derivatives and pharmaceutical compositions containing them
HU9302330D0 (en) 7-(substituted)-9-|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them
HU9302329D0 (en) 7-(substituted)-9-|(substituted glycyl)-amino¨-6-desmethyl-6-desoxy-tetracyclines, pharmaceutical preparatives containing them and methods for producing them
HUT61779A (en) Hidantoine derivatives
MC2103A1 (fr) Derives d'aminoacides
SE8502017D0 (sv) 1,4-dihydro-4-oxonaphthyridine derivatives and salts thereof, process for producing the same and antibacterial agents comprising the same
MA22251A1 (fr) Procede de preparation de derives de piperidine substitues en position 3
FR2627493B1 (fr) Procede de preparation de derives d'isoquinoleine
HUT50142A (en) Process for producing allyl-mercapto-acetyl-sidnonimine derivatives and pharmaceutical compositions containing them
FR2632521B1 (fr) Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent
ES503895A0 (es) Procedimiento para preparar 3b-hidroximetil-4a-hidroxi-8b- alcoxi-2,9-dioxatriciclo(4,3,1,03,7)decanos
FR2555578B1 (fr) Procede de preparation de derives d'azetidinone
FR2564833B1 (fr) Procede de preparation de derives d'imidazolidine
FR2659651B1 (fr) Procede de preparation de n-phenyl n'-(cyclo)alkyl paraphenylene diamines.
ES8505363A1 (es) Un procedimiento para preparar una 3-(2-furoil)-5-2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridina
FR2659650B1 (fr) Procede de preparation de n-phenyl n'-(cyclo)alkyl paraphnylene diamines.
FR2647450B1 (fr) Procede de preparation des derives de 2(prime), 3(prime)-dideshydro-2(prime),3(prime)-didesoxynucleoside
FR2618781B2 (fr) Procede de preparation de derives de la 4,4-dimethyl tetrahydro pyr-2-one
RO92697A2 (ro) Procedeu pentru prepararea unor derivati de cumarina
FR2620449B1 (fr) Procede de preparation de derives de benzodiazepine-1,4 one-2
MX12187A (es) Procedimiento para preparar derivados de 2,4-dihidro-3h-1,2,4-triazol-3-ona
AR240046A1 (es) Procedimiento de preparacion de derivados de 5-/3"-(3'-aminometilfenoxi)-propil¯-amino-3-amino-1h-1,2,4-triazol.

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
EXP Patent expired