IE881787L - Derivatives substituted at methylamino nitrogen - Google Patents

Derivatives substituted at methylamino nitrogen

Info

Publication number
IE881787L
IE881787L IE881787A IE178788A IE881787L IE 881787 L IE881787 L IE 881787L IE 881787 A IE881787 A IE 881787A IE 178788 A IE178788 A IE 178788A IE 881787 L IE881787 L IE 881787L
Authority
IE
Ireland
Prior art keywords
methylamino
nitrogen
derivatives substituted
derivatives
substituted
Prior art date
Application number
IE881787A
Other versions
IE70523B1 (en
Original Assignee
Thomas Murray
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CH224487 priority Critical
Priority to CH144088 priority
Application filed by Thomas Murray filed Critical Thomas Murray
Publication of IE881787L publication Critical patent/IE881787L/en
Publication of IE70523B1 publication Critical patent/IE70523B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
IE178788A 1987-06-15 1988-06-14 Staurosporine derivatives substituted for the nitrogen atom of the methylamino group IE70523B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CH224487 1987-06-15
CH144088 1988-04-19

Publications (2)

Publication Number Publication Date
IE881787L true IE881787L (en) 1988-12-15
IE70523B1 IE70523B1 (en) 1996-12-11

Family

ID=25687663

Family Applications (1)

Application Number Title Priority Date Filing Date
IE178788A IE70523B1 (en) 1987-06-15 1988-06-14 Staurosporine derivatives substituted for the nitrogen atom of the methylamino group

Country Status (19)

Country Link
EP (1) EP0296110B1 (en)
JP (1) JP2708047B2 (en)
KR (1) KR970001529B1 (en)
AT (1) AT134375T (en)
AU (1) AU617324B2 (en)
CA (1) CA1337763C (en)
DE (1) DE3855015D1 (en)
DK (1) DK175507B1 (en)
ES (1) ES2083956T3 (en)
FI (1) FI89362C (en)
GR (1) GR3019064T3 (en)
HK (1) HK1003788A1 (en)
HU (1) HU201329B (en)
IE (1) IE70523B1 (en)
IL (1) IL86632D0 (en)
NO (1) NO170634C (en)
NZ (1) NZ225018A (en)
PT (1) PT87719B (en)
YU (1) YU115488A (en)

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JPH0574595B2 (en) * 1986-03-20 1993-10-18 Kyowa Hakko Kogyo Kk
EP0383919A4 (en) * 1988-02-04 1992-08-05 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives
USRE36736E (en) * 1989-02-06 2000-06-13 Hoffman-La Roche Inc. Substituted pyrroles
CZ280738B6 (en) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituted pyrroles, their use for preparing medicaments and medicaments based thereon
DE3924538A1 (en) * 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazole and its use
US5618809A (en) * 1989-12-14 1997-04-08 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes copiosa subsp. nov SCC 1951 ATCC 53856
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
US5981568A (en) 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
AU2866992A (en) * 1991-10-10 1993-05-03 Schering Corporation 4'-(n-substituted-n-oxide)staurosporine derivatives
EP0541486A1 (en) * 1991-11-07 1993-05-12 Ciba-Geigy Ag Polycyclic conjugates
WO1993018771A1 (en) * 1992-03-24 1993-09-30 Asahi Kasei Kogyo Kabushiki Kaisha PLATELET AGGLUTINATION INHIBITOR CONTAINING STAUROSPORINE η-LACTAM DERIVATIVE
US5461146A (en) * 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
US5756494A (en) * 1992-07-24 1998-05-26 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
US5621100A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. K-252a derivatives for treatment of neurological disorders
US5621101A (en) * 1992-07-24 1997-04-15 Cephalon, Inc. Protein kinase inhibitors for treatment of neurological disorders
ES2171416T3 (en) * 1992-09-21 2002-09-16 Kyowa Hakko Kogyo Kk Remedy thrombocytopenia.
AT278397T (en) 1997-03-31 2004-10-15 Boston Scient Ltd Use of therapeutic agents for the prevention of restenosis
EP2324829A1 (en) 1993-01-28 2011-05-25 Boston Scientific Limited Therapeutic inhibitors of vascular smooth muscle cells
PH30300A (en) * 1993-05-07 1997-01-20 Ciba Geigy Ag Polycyclic compounds and processes for the preparation thereof
EP0706573A1 (en) * 1993-07-09 1996-04-17 The Institute Of Cancer Research Protein tyrosine kinase and ligands thereof
GB9325395D0 (en) * 1993-12-11 1994-02-16 Ciba Geigy Ag Compositions
EP0711557A1 (en) * 1994-11-09 1996-05-15 Ciba-Geigy Ag Base for formulating pharmaceutical agents
US6875865B1 (en) 1996-06-03 2005-04-05 Cephalon, Inc. Selected derivatives of K-252a
DE69715010T2 (en) 1996-06-03 2003-04-03 Cephalon Inc Selected k-252a derivatives
ES2184106T3 (en) 1996-06-25 2003-04-01 Cephalon Inc Use of the derivative of K252a in treating disorders of the central or peripheral, and the production of cytokines nervous system.
PT1131073E (en) * 1998-11-23 2004-03-31 Novartis Ag Use of estaurosporin derivatives for the treatment of neovascular eye diseases
SI3342411T1 (en) 2001-02-19 2019-10-30 Novartis Pharma Ag Rapamycin derivative for treating pancreas cancer
CA2444867C (en) 2001-05-16 2010-08-17 Novartis Ag Combination comprising n-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2pyrimidine-amine and a chemotherapeutic agent
CN101703509A (en) 2001-10-30 2010-05-12 诺瓦提斯公司;达纳-法伯癌症研究公司 Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives
GB0206215D0 (en) 2002-03-15 2002-05-01 Novartis Ag Organic compounds
EP1505959B1 (en) 2002-05-16 2008-10-29 Novartis AG Use of edg receptor binding agents in cancer
CN1674868B (en) * 2002-07-23 2010-09-29 诺瓦提斯公司 Ophtalmic ointment composition comprising a drug, an ointment base and a solubling/dispersing agent
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
US7417065B2 (en) 2003-05-19 2008-08-26 Irm Llc Immunosuppressant compounds and compositions
US20040246627A1 (en) * 2003-06-06 2004-12-09 Durrum Thomas M. Disc drive pivot bearing assembly
US20070191338A1 (en) 2003-08-08 2007-08-16 Atadja Peter W Combinations comprising staurosporines
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
US20090075972A1 (en) * 2004-08-31 2009-03-19 Jan Cools Use of Midostaurin for Treating Gastrointestinal Stromal Tumors
JO2897B1 (en) 2004-11-05 2015-09-15 نوفارتيس ايه جي Organic compounds
GB0512324D0 (en) 2005-06-16 2005-07-27 Novartis Ag Organic compounds
DK2275103T3 (en) 2005-11-21 2014-07-07 Novartis Ag mTOR inhibitors in the treatment of endocrine tumors
MY152669A (en) 2008-12-18 2014-10-31 Novartis Ag Hemifumarate salt of 1-[4-[1-(4-cyclohexyl-3-trifluoromethyl-benzyloxyimino)-ethyl]-2-ethyl-benzyl]-azetidine-3-carboxylic acid
JP2012512885A (en) 2008-12-18 2012-06-07 ノバルティス アーゲー New salt
US8173634B2 (en) 2008-12-18 2012-05-08 Novartis Ag Polymorphic form of 1-(4-{1-[(E)-4-cyclohexyl-3-trifluoromethyl-benzyloxyimino]-ethyl}-2-ethyl-benzyl)-azetidine-3-carboxylic
EP2327706A1 (en) * 2009-11-30 2011-06-01 Novartis AG Polymorphous forms III and IV of N-benzoyl-staurosporine
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8846712B2 (en) 2011-09-12 2014-09-30 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013167403A1 (en) 2012-05-09 2013-11-14 Sanofi Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0383919A4 (en) * 1988-02-04 1992-08-05 Kyowa Hakko Kogyo Co., Ltd. Staurosporin derivatives

Also Published As

Publication number Publication date
GR3019064T3 (en) 1996-05-31
DE3855015D1 (en) 1996-03-28
EP0296110B1 (en) 1996-02-21
HUT47587A (en) 1989-03-28
AU1757188A (en) 1988-12-15
HK1003788A1 (en) 1998-11-06
NO882613L (en) 1988-12-16
IL86632D0 (en) 1988-11-30
PT87719B (en) 1992-10-30
DK324888A (en) 1988-12-16
ES2083956T3 (en) 1996-05-01
FI882808D0 (en)
FI882808A (en) 1988-12-16
DK175507B1 (en) 2004-11-15
NO170634C (en) 1992-11-11
NO882613D0 (en) 1988-06-14
EP0296110A2 (en) 1988-12-21
PT87719A (en) 1988-07-01
YU115488A (en) 1989-12-31
FI89362B (en) 1993-06-15
NO170634B (en) 1992-08-03
FI89362C (en) 1993-09-27
CA1337763C (en) 1995-12-19
JPS6434989A (en) 1989-02-06
FI882808A0 (en) 1988-06-13
AU617324B2 (en) 1991-11-28
JP2708047B2 (en) 1998-02-04
KR890000494A (en) 1989-03-15
KR970001529B1 (en) 1997-02-11
NZ225018A (en) 1990-09-26
EP0296110A3 (en) 1991-02-27
IE70523B1 (en) 1996-12-11
DK324888D0 (en) 1988-06-14
AT134375T (en) 1996-03-15
HU201329B (en) 1990-10-28

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